公开(公告)号：US06254634B1

公开(公告)日：2001-07-03

申请号：US09095371

申请日：1998-06-10

申请人： Aron B. Anderson ,  Ralph A. Chappa ,  Terrence P. Everson

发明人： Aron B. Anderson ,  Ralph A. Chappa ,  Terrence P. Everson

IPC分类号： A61F206

CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0029 ,  Y10S623/901 ,  C08L83/04

摘要： An article (e.g., in the form of an implantable medical article) in the form of a support material bearing an intermediate layer consisting of a functional silicone polymer formulation, the intermediate layer having photoimmobilized thereon a target compound. In another aspect, a method of fabricating an article including the steps of providing a support material, applying an intermediate layer and photoimmobilizing a target compound onto the intermediate layer, and optionally, reforming the support material into a final desired article.

摘要翻译： 支撑材料形式的制品（例如，可植入医疗制品的形式），该支撑材料具有由功能性硅氧烷聚合物制剂组成的中间层，该中间层在其上具有光固化性的目标化合物。 在另一方面，一种制造制品的方法，包括以下步骤：提供支撑材料，施加中间层并将目标化合物光固化到中间层上，以及任选地将载体材料重整成最终期望的制品。

公开(公告)号：US20100240789A1

公开(公告)日：2010-09-23

申请号：US12783907

申请日：2010-05-20

申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

IPC分类号： C08F2/46

CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

公开(公告)号：US06669994B2

公开(公告)日：2003-12-30

申请号：US09840406

申请日：2001-04-23

申请人： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

发明人： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

IPC分类号： C08F248

CPC分类号： C08J7/18 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/06 ,  A61L33/12 ,  B05D1/00 ,  B05D3/06 ,  B05D3/061 ,  B05D3/067 ,  B05D7/52 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/31855

摘要： A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.

公开(公告)号：US08039524B2

公开(公告)日：2011-10-18

申请号：US12783907

申请日：2010-05-20

申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Pam Read, legal representative ,  Dale G. Swan ,  Peter H. Duquette

发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

IPC分类号： C08F2/50

CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

公开(公告)号：US07087658B2

公开(公告)日：2006-08-08

申请号：US10745080

申请日：2003-12-23

申请人： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

发明人： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

IPC分类号： C08F2/50 ,  C08J3/28 ,  C08J7/18

CPC分类号： C08J7/18 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/06 ,  A61L33/12 ,  B05D1/00 ,  B05D3/06 ,  B05D3/061 ,  B05D3/067 ,  B05D7/52 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/31855

摘要： A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.

公开(公告)号：US07348055B2

公开(公告)日：2008-03-25

申请号：US10028518

申请日：2001-12-21

申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

IPC分类号： B32B27/00

CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

公开(公告)号：US20120004339A1

公开(公告)日：2012-01-05

申请号：US13234270

申请日：2011-09-16

申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

IPC分类号： C08F8/00

CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

公开(公告)号：US07736689B2

公开(公告)日：2010-06-15

申请号：US11846955

申请日：2007-08-29

申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

IPC分类号： A61L33/00

CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

公开(公告)号：US07071235B2

公开(公告)日：2006-07-04

申请号：US10422160

申请日：2003-04-24

申请人： Patrick E. Guire ,  Aron B. Anderson ,  Richard A. Amos ,  Terrence P. Everson ,  Peter H. Duquette

发明人： Patrick E. Guire ,  Aron B. Anderson ,  Richard A. Amos ,  Terrence P. Everson ,  Peter H. Duquette

IPC分类号： A01N35/00 ,  A01N37/00 ,  A61K31/74 ,  A61M25/00 ,  A61F2/06

CPC分类号： A61K31/12 ,  A61K31/74 ,  A61K47/6957 ,  A61L27/227 ,  A61L27/34 ,  A61L27/507 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0082

摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.

公开(公告)号：US06555587B1

公开(公告)日：2003-04-29

申请号：US10207944

申请日：2002-07-29

申请人： Patrick E. Guire ,  Aron B. Anderson ,  Richard A. Amos ,  Terrence P. Everson

发明人： Patrick E. Guire ,  Aron B. Anderson ,  Richard A. Amos ,  Terrence P. Everson

IPC分类号： A01N3500

CPC分类号： A61K31/12 ,  A61K31/74 ,  A61K47/6957 ,  A61L27/227 ,  A61L27/34 ,  A61L27/507 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0082

摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.