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公开(公告)号：US06555587B1
公开(公告)日：2003-04-29
申请号：US10207944
申请日：2002-07-29
IPC分类号： A01N3500
CPC分类号： A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
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公开(公告)号：US07071235B2
公开(公告)日：2006-07-04
申请号：US10422160
申请日：2003-04-24
申请人： Patrick E. Guire , Aron B. Anderson , Richard A. Amos , Terrence P. Everson , Peter H. Duquette
发明人： Patrick E. Guire , Aron B. Anderson , Richard A. Amos , Terrence P. Everson , Peter H. Duquette
CPC分类号： A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
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公开(公告)号：US06465525B1
公开(公告)日：2002-10-15
申请号：US09177318
申请日：1998-10-22
IPC分类号： A01N3500
CPC分类号： A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
摘要翻译： 用于钝化生物材料表面的试剂和相关方法，所述试剂包括潜在反应性基团和双官能脂族酸（例如，脂肪酸），与间接基团组合，所述间隔基团以潜在的反应性基团与脂肪酸连接 这保留了每个组的所需功能。 一旦结合到表面，通过潜在的反应性基团，试剂以足以保持和定向白蛋白的方式（例如，浓度和取向）在体内将脂肪酸呈现给生理环境。
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公开(公告)号：US07144573B2
公开(公告)日：2006-12-05
申请号：US11212930
申请日：2005-08-26
申请人： Patrick E. Guire , Aron B. Anderson , Richard A. Amos , Terrence P. Everson , Peter H. Duquette
发明人： Patrick E. Guire , Aron B. Anderson , Richard A. Amos , Terrence P. Everson , Peter H. Duquette
IPC分类号： A61K31/74 , A61K31/785 , A61K31/765 , A61F13/00 , A61F2/00
CPC分类号： A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
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公开(公告)号：US06254634B1
公开(公告)日：2001-07-03
申请号：US09095371
申请日：1998-06-10
IPC分类号： A61F206
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61L33/0029 , Y10S623/901 , C08L83/04
摘要： An article (e.g., in the form of an implantable medical article) in the form of a support material bearing an intermediate layer consisting of a functional silicone polymer formulation, the intermediate layer having photoimmobilized thereon a target compound. In another aspect, a method of fabricating an article including the steps of providing a support material, applying an intermediate layer and photoimmobilizing a target compound onto the intermediate layer, and optionally, reforming the support material into a final desired article.
摘要翻译： 支撑材料形式的制品（例如，可植入医疗制品的形式），该支撑材料具有由功能性硅氧烷聚合物制剂组成的中间层，该中间层在其上具有光固化性的目标化合物。 在另一方面，一种制造制品的方法，包括以下步骤：提供支撑材料，施加中间层并将目标化合物光固化到中间层上，以及任选地将载体材料重整成最终期望的制品。
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公开(公告)号：US07794751B2
公开(公告)日：2010-09-14
申请号：US11387508
申请日：2006-03-23
IPC分类号： A61K9/14
CPC分类号： A61L31/145 , A61L27/34 , A61L27/52 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/22 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/404 , A61L2300/406 , A61L2300/606 , Y10S514/944 , C08L71/02
摘要： A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.
摘要翻译： 一种涂料组合物，以其未交联和交联的形式，用于从体内定位的医疗装置的表面递送药物。 一旦交联，涂层组合物提供了一种凝胶基质，其适于以允许药物在体内以延长，受控，可预测和有效的方式从基质释放的形式容纳药物。 组合物包括聚醚单体，例如烷氧基聚（亚烷基二醇），含羧酸的单体如（甲基）丙烯酸，光衍生化单体和亲水性单体如丙烯酰胺。
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7.发明授权Polybifunctional reagent having a polymeric backbone and latent reactive moieties and bioactive groups 有权具有聚合物骨架和潜在反应性部分和生物活性基团的多功能试剂公开(公告)号：US06514734B1
公开(公告)日：2003-02-04
申请号：US09591564
申请日：2000-06-09
IPC分类号： C12N1108
CPC分类号： G01N33/6845 , A61L27/14 , A61L27/34 , A61L29/04 , A61L29/085 , A61L31/04 , A61L31/10 , A61L33/0011 , A61L33/0047 , C08J7/12 , C12N11/08 , C12Q1/56 , C12Q1/6834 , G01N33/54353 , G01N33/54366 , G01N33/68 , G01N33/6854 , G01N2333/78 , G01N2333/8128 , G01N2333/815 , G01N2333/974 , Y10S530/815 , Y10S530/816
摘要： A polybifunctional reagent is provided having a polymeric backbone, one or more pendent latent reactive (preferably photoreactive) moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.
摘要翻译： 提供了具有聚合物主链，一个或多个潜在潜在反应性（优选光反应性）部分和两个或更多个侧悬生物活性基团的多功能试剂。 试剂可以被活化以形成散装材料，或者可以与先前形成的生物材料的表面接触并活化以形成涂层。 悬浮生物活性基团通过促进特定分子或细胞附着到大块材料或涂层表面而起作用。 生物活性基团可以包括蛋白质，肽，碳水化合物，核酸和能够非共价结合分子或细胞的特定和互补部分的其它分子。
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公开(公告)号：US08039524B2
公开(公告)日：2011-10-18
申请号：US12783907
申请日：2010-05-20
申请人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Pam Read, legal representative , Dale G. Swan , Peter H. Duquette
发明人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Dale G. Swan , Peter H. Duquette
IPC分类号： C08F2/50
CPC分类号： B82Y30/00 , A61L27/34 , C09D4/00 , Y10S522/904 , Y10T428/249991 , Y10T428/249992 , C08F220/56 , C08F220/54
摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.
摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。
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公开(公告)号：US07087658B2
公开(公告)日：2006-08-08
申请号：US10745080
申请日：2003-12-23
申请人： Dale G. Swan , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Ralph A. Chappa , Sean M. Stucke , Peter H. Duquette
发明人： Dale G. Swan , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Ralph A. Chappa , Sean M. Stucke , Peter H. Duquette
CPC分类号： C08J7/18 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/10 , A61L33/06 , A61L33/12 , B05D1/00 , B05D3/06 , B05D3/061 , B05D3/067 , B05D7/52 , G01N33/54353 , G01N33/54393 , Y10T428/31855
摘要： A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.
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10.发明授权
公开(公告)号：US5714360A
公开(公告)日：1998-02-03
申请号：US552758
申请日：1995-11-03
IPC分类号： C12N11/06 , C07B61/00 , C07C45/63 , C07C225/16 , C07C309/14 , C07D295/10 , C07D295/112 , C07D487/18 , C07K17/06 , C08J3/24 , C09K3/00 , G01N33/543 , C12N11/00 , C07C49/76 , G01N33/549
CPC分类号： C07D295/112 , C07C225/16 , C07C309/14 , C07C45/63 , C07K17/06 , G01N33/54353 , Y10S530/81 , Y10S530/816
摘要： A chemical linking agent is formed of a di- or higher functional photoactivatable compound having at least one group that is charged under the conditions of use in order to provide improved water solubility. The linking agent contains two or more photoreactive groups in order to allow the agent to be used as a cross-linking agent in aqueous systems. The charged group can be provided by a radical that includes one or more salts of organic acids, onium compounds, or protonated amines, (and optionally one or more additional photoreactive groups) and the photoreactive groups can be provided by two or more radicals that include an aryl ketone. The onium compound can provide a quaternary ammonium, sulfonium or phosphonium group. A surface can be coated with a target molecule such as a synthetic polymer, carbohydrate, protein, lipid, nucleic acid, drug, vitamin, cofactor or dye by forming an aqueous solution of the linking agent and the target molecule, placing the solution in contact with the surface and activating the photoreactive groups of the linking agent to cross-link the target molecule to the surface.
摘要翻译： 化学连接剂由具有至少一个在使用条件下带电的至少一个基团的二官能或更高官能的可光活化化合物形成，以提供改善的水溶性。 连接剂含有两种或更多种光反应性基团，以使该试剂在水性体系中用作交联剂。 带电基团可以由包括一种或多种有机酸，鎓化合物或质子化胺盐（以及任选的一种或多种另外的光反应性基团）的基团提供，并且光反应性基团可以由两个或更多个基团提供，所述基团包括 芳基酮。 鎓化合物可以提供季铵，锍或鏻基团。 通过形成连接剂和目标分子的水溶液，可以用靶分子如合成聚合物，碳水化合物，蛋白质，脂质，核酸，药物，维生素，辅因子或染料涂覆表面，将溶液接触 并且激活连接剂的光反应性基团以使靶分子与表面交联。
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