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28 条记录 (耗时 0.028 秒)

    Coating compositions
    5.
    发明授权
    Coating compositions 失效
    涂料组合物

    公开(公告)号：US06254634B1

    公开(公告)日：2001-07-03

    申请号：US09095371

    申请日：1998-06-10

    申请人： Aron B. Anderson ,  Ralph A. Chappa ,  Terrence P. Everson

    发明人： Aron B. Anderson ,  Ralph A. Chappa ,  Terrence P. Everson

    IPC分类号： A61F206

    CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0029 ,  Y10S623/901 ,  C08L83/04

    摘要： An article (e.g., in the form of an implantable medical article) in the form of a support material bearing an intermediate layer consisting of a functional silicone polymer formulation, the intermediate layer having photoimmobilized thereon a target compound. In another aspect, a method of fabricating an article including the steps of providing a support material, applying an intermediate layer and photoimmobilizing a target compound onto the intermediate layer, and optionally, reforming the support material into a final desired article.

    摘要翻译： 支撑材料形式的制品（例如，可植入医疗制品的形式），该支撑材料具有由功能性硅氧烷聚合物制剂组成的中间层，该中间层在其上具有光固化性的目标化合物。 在另一方面，一种制造制品的方法，包括以下步骤：提供支撑材料，施加中间层并将目标化合物光固化到中间层上，以及任选地将载体材料重整成最终期望的制品。

    PHOTOCHROME- OR NEAR IR DYE-COUPLED POLYMERIC MATRICES FOR MEDICAL ARTICLES
    6.
    发明申请
    PHOTOCHROME- OR NEAR IR DYE-COUPLED POLYMERIC MATRICES FOR MEDICAL ARTICLES 失效
    医学文章的红外线耦合聚合物基片

    公开(公告)号：US20120082713A1

    公开(公告)日：2012-04-05

    申请号：US13248203

    申请日：2011-09-29

    申请人： Emily R. Rolfes Meyering ,  Aron B. Anderson

    发明人： Emily R. Rolfes Meyering ,  Aron B. Anderson

    IPC分类号： A61K9/00 ,  A61P37/02 ,  A61L31/10 ,  A61P31/00 ,  C08F20/36 ,  A61P29/00 ,  A61P23/00

    CPC分类号： C08F20/36 ,  A61L29/085 ,  A61L29/14 ,  A61L2400/10

    摘要： The invention provides polymers comprising pendent photochrome or near IR dye groups, as well as polymeric matrices made from these polymers, which can be used as or in association with a medical article. The polymers can be synthesized using methods that facilitate the preparation of medical articles having good biocompatibility. Exemplary polymeric matrices are in the form of lubricious coatings on medical devices, such as catheters. Visualization by irradiation of the photochrome or near IR dye can improve detection of the polymeric matrix on a device or in the body. This, in turn can improve aspects of a medical procedure, such as device insertion or matrix formation, as well as being useful for assessing the quality of the matrix.

    摘要翻译： 本发明提供了包含侧基光色素或近红外染料基团的聚合物，以及由这些聚合物制成的聚合物基质，其可以作为或与医疗制品结合使用。 可以使用促进制备具有良好生物相容性的医疗制品的方法来合成聚合物。 示例性的聚合物基质是医疗装置如导管上的润滑涂层的形式。 通过照射光斑或靠近IR染料的可视化可以改善在装置或身体中的聚合物基质的检测。 这反过来可以改善诸如装置插入或矩阵形成之类的医疗过程的方面，并且可用于评估矩阵的质量。

    Controlled release bioactive agent delivery device
    7.
    发明授权
    Controlled release bioactive agent delivery device 失效
    控制释放生物活性剂输送装置

    公开(公告)号：US08034369B2

    公开(公告)日：2011-10-11

    申请号：US11225301

    申请日：2005-09-12

    申请人： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

    发明人： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

    IPC分类号： A61F2/00

    CPC分类号： A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

    摘要： The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.

    摘要翻译： 本发明提供一种用于治疗眼睛的控制释放生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中至少一部分 身体构件偏离延伸方向，以及与本体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 第一聚合物和第二聚合物是疏水性的，并且本体构件具有这样的长度，使得当将该装置放置在眼睛后部的植入部位时，该装置不进入眼睛的中心视野。 本发明还提供了将生物活性剂递送到眼后部区域的方法。

    Photochrome- or near IR dye-coupled polymeric matrices for medical articles
    8.
    发明授权
    Photochrome- or near IR dye-coupled polymeric matrices for medical articles 失效
    用于医疗用品的光致变色或近红外染料偶联聚合物基质

    公开(公告)号：US08722076B2

    公开(公告)日：2014-05-13

    申请号：US13248203

    申请日：2011-09-29

    申请人： Emily R. Rolfes Meyering ,  Aron B. Anderson

    发明人： Emily R. Rolfes Meyering ,  Aron B. Anderson

    IPC分类号： A61F2/00 ,  A61K9/00 ,  A61F13/00 ,  C08F26/06

    CPC分类号： C08F20/36 ,  A61L29/085 ,  A61L29/14 ,  A61L2400/10

    摘要： The invention provides polymers comprising pendent photochrome or near IR dye groups, as well as polymeric matrices made from these polymers, which can be used as or in association with a medical article. The polymers can be synthesized using methods that facilitate the preparation of medical articles having good biocompatibility. Exemplary polymeric matrices are in the form of lubricious coatings on medical devices, such as catheters. Visualization by irradiation of the photochrome or near IR dye can improve detection of the polymeric matrix on a device or in the body. This, in turn can improve aspects of a medical procedure, such as device insertion or matrix formation, as well as being useful for assessing the quality of the matrix.

    摘要翻译： 本发明提供了包含侧基光色素或近红外染料基团的聚合物，以及由这些聚合物制成的聚合物基质，其可以作为或与医疗制品结合使用。 可以使用促进制备具有良好生物相容性的医疗制品的方法来合成聚合物。 示例性的聚合物基质是医疗装置如导管上的润滑涂层的形式。 通过照射光斑或靠近IR染料的可视化可以改善在装置或身体中的聚合物基质的检测。 这又可以改善诸如装置插入或矩阵形成之类的医疗过程的方面，并且可用于评估矩阵的质量。

    Bioactive agent release coating and controlled humidity method
    9.
    发明授权
    Bioactive agent release coating and controlled humidity method 有权
    生物活性剂释放涂层和受控湿度法

    公开(公告)号：US07833548B2

    公开(公告)日：2010-11-16

    申请号：US11207380

    申请日：2005-08-19

    申请人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    发明人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    IPC分类号： A61K9/14

    CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/606

    摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

    摘要翻译： 一种或多种制剂形式的涂料组合物，以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。 涂料组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。 组合物包括与第一聚合物组分如（甲基）丙烯酸聚烷基酯，（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰基烷基酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）。