利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

33 条记录 (耗时 0.021 秒)

    High performance fluorescent optical sensor
    2.
    发明授权
    High performance fluorescent optical sensor 有权
    高性能荧光光学传感器

    公开(公告)号：US07190445B2

    公开(公告)日：2007-03-13

    申请号：US11165129

    申请日：2005-06-24

    申请人： Arthur E. Colvin, Jr. ,  Steven J. Walters

    发明人： Arthur E. Colvin, Jr. ,  Steven J. Walters

    IPC分类号： G01J1/42 ,  G01N21/01

    CPC分类号： G01N21/645 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2201/0642

    摘要： An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.

    摘要翻译： 用于确定分析物的存在或浓度的光学传感器装置包含设置在光源上的波导和安装在基板的表面上并由内部挡板隔开的光检测器，其中波导具有对应于远的 由光源和光检测器之间的遮光挡板确定的光源的场发射点。 分析物指示矩阵设置在波导的外表面上。 传感器装置的几何形状仅利用指示矩阵的直接照明，并且直接收集指示矩阵照明，而不会被所述波导的任何明显的反射。 由光源产生的不良光线噪声通过波导直接从器件中流出。

    High performance fluorescent optical sensor
    5.
    发明授权
    High performance fluorescent optical sensor 有权
    高性能荧光光学传感器

    公开(公告)号：US06940590B2

    公开(公告)日：2005-09-06

    申请号：US10316188

    申请日：2002-12-11

    申请人： Arthur E. Colvin, Jr. ,  Steven J. Walters

    发明人： Arthur E. Colvin, Jr. ,  Steven J. Walters

    IPC分类号： G01N21/64 ,  G01N21/77 ,  G01J1/42 ,  G01N21/01

    CPC分类号： G01N21/645 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2201/0642

    摘要： An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.

    摘要翻译： 用于确定分析物的存在或浓度的光学传感器装置包含设置在光源上的波导和安装在基板的表面上并由内部挡板隔开的光检测器，其中波导具有对应于远的 由光源和光检测器之间的遮光挡板确定的光源的场发射点。 分析物指示矩阵设置在波导的外表面上。 传感器装置的几何形状仅利用指示矩阵的直接照明，并且直接收集指示矩阵照明，而不会被所述波导的任何明显的反射。 由光源产生的不良光线噪声通过波导直接从器件中流出。

    Optical-based sensing devices
    6.
    发明授权
    Optical-based sensing devices 有权
    光传感器

    公开(公告)号：US08233953B2

    公开(公告)日：2012-07-31

    申请号：US11925272

    申请日：2007-10-26

    申请人： Arthur E. Colvin, Jr.

    发明人： Arthur E. Colvin, Jr.

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/076 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6861 ,  A61B2560/0219 ,  A61B2562/12 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/77 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  Y10S128/903

    摘要： An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.

    摘要翻译： 一种光学传感器，用于使用指示器和参考通道来检测分析物的存在或量。 该传感器具有一个传感器体，其中嵌有辐射源。 源发射的辐射与靠近身体表面的指示剂膜指示剂分子相互作用。 这些指示剂分子的至少一种光学特性随分析物浓度而变化。 例如，荧光指示剂分子的荧光水平或光吸收指示剂分子吸收的光量可以作为分析物浓度的函数而变化。 此外，源发射的辐射也与靠近身体表面的参考膜指示剂分子相互作用。 由这些指示剂分子发射或反射的辐射（例如，光）进入并在内部反射在传感器主体中。 传感器体内的感光元件产生指示通道和参考通道信号，以提供分析物浓度的准确指示。 优选的实施方案是完全独立的并且其尺寸和形状用于人体内的体内。 这样的实施例优选地包括电源，例如电源。 电感器，其使用外部装置为辐射源供电，以及发射器，例如， 电感器，用于向外部拾取装置传输表示分析物水平的信号。

    Fluorescence sensing device
    7.
    发明授权
    Fluorescence sensing device 失效
    荧光检测装置

    公开(公告)号：US5917605A

    公开(公告)日：1999-06-29

    申请号：US855236

    申请日：1997-05-13

    申请人： Arthur E. Colvin, Jr.

    发明人： Arthur E. Colvin, Jr.

    IPC分类号： G01N21/64 ,  G01N21/77 ,  G01N21/78 ,  G01N21/25

    CPC分类号： G01N21/6454 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2021/6484

    摘要： A fluorescence sensing device for determining the presence or concentration of an analyte in a liquid or gaseous medium is constructed of a fiber optic plate comprising optical fibers having relatively small numerical apertures. The fiber optic plate is positioned on a photodetector and has a layer of analyte permeable fluorescent matrix or coated waveguide material on its top surface. The fluorescent matrix or waveguide coating contains indicator molecules whose fluorescence is affected by the local presence of analyte. A light source emits light into the fluorescent matrix in a direction generally parallel to the top surface of the fiber optic plate. Upon absorbing light from the light source, indicator molecules in the fluorescent matrix emit fluorescent light which is transmitted through the fiber optic plate to the photodetector.

    摘要翻译： 用于确定液体或气体介质中分析物的存在或浓度的荧光检测装置由包括具有相对较小数值孔径的光纤的光纤板构成。 光纤板位于光电检测器上，并且在其顶表面上具有分析物可渗透的荧光矩阵或涂覆的波导材料层。 荧光基质或波导涂层含有指示剂分子，其荧光受到分析物局部存在的影响。 光源在大致平行于光纤板的顶表面的方向上将光发射到荧光矩阵中。 在从光源吸收光时，荧光矩阵中的指示剂分子发射荧光，其通过光纤板传输到光电检测器。

    Reflectance gradient densitometer
    8.
    发明授权
    Reflectance gradient densitometer 失效
    反射梯度密度计

    公开(公告)号：US4868767A

    公开(公告)日：1989-09-19

    申请号：US79641

    申请日：1987-07-30

    申请人： Arthur E. Colvin, Jr. ,  Stephen C. Scott

    发明人： Arthur E. Colvin, Jr. ,  Stephen C. Scott

    IPC分类号： G01N21/86

    CPC分类号： G01N21/8483 ,  G01N2201/124 ,  G01N2201/126

    摘要： Apparatus and method are disclosed for detecting the presence of a analyte in a sample. The apparatus includes an optical transmitter and receiver for transmitting light toward the sample and receiving a portion of the reflected light. The optical receiver acts in conjunction with a data processor to convert the reflected light to data representing the density of analyte in the sample. The apparatus thus disclosed is portable and can be transported to remote testing sites.

    摘要翻译： 公开了用于检测样品中分析物的存在的装置和方法。 该装置包括用于向样品发射光并接收一部分反射光的光发射器和接收器。 光学接收器与数据处理器结合操作，将反射光转换为表示样品中分析物密度的数据。 所公开的装置是便携式的，并且可以被运送到远程测试地点。

    Integrated catalytic protection of oxidation sensitive materials
    9.
    发明授权
    Integrated catalytic protection of oxidation sensitive materials 有权

    公开(公告)号：US09681824B2

    公开(公告)日：2017-06-20

    申请号：US13421013

    申请日：2012-03-15

    申请人： Arthur E. Colvin, Jr. ,  Hui Jiang

    发明人： Arthur E. Colvin, Jr. ,  Hui Jiang

    IPC分类号： A61B5/1455 ,  A61B5/07 ,  A61B5/145 ,  A61B5/1459

    CPC分类号： A61B5/076 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/1459 ,  A61B2562/028 ,  A61B2562/162 ,  A61B2562/18

    摘要： An implantable device with in vivo functionality, where the functionality of the device is negatively affected by ROS typically associated with inflammation reaction as well as chronic foreign body response as a result of tissue injury, is at least partially surrounded by a protective material, structure, and/or a coating that prevents damage to the device from any inflammation reactions. The protective material, structure, and/or coating is a biocompatible metal, preferably silver, platinum, palladium, gold, manganese, or alloys or oxides thereof that decomposes reactive oxygen species (ROS), such as hydrogen peroxide, and prevents ROS from oxidizing molecules on the surface of or within the device. The protective material, structure, and/or coating thereby prevents ROS from degrading the in vivo functionality of the implantable device.