利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.237 秒)

    METHODS FOR THE DIAGNOSIS AND TREATMENT OF SJOGREN'S SYNDROME
    8.
    发明申请
    METHODS FOR THE DIAGNOSIS AND TREATMENT OF SJOGREN'S SYNDROME 审中-公开
    SJOGREN综合征的诊断和治疗方法

    公开(公告)号：US20160000794A1

    公开(公告)日：2016-01-07

    申请号：US14858929

    申请日：2015-09-18

    申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv ,  University of Florida Research Foundation, Incorporated ,  The General Hospital Corporation ,  Brigham and Women's Hospital Inc.

    发明人： John A. Chiorini ,  Hongen Yin ,  Cuong Nguyen ,  Donald B. Bloch ,  Paul B. Yu

    IPC分类号： A61K31/519

    CPC分类号： A61K31/519

    摘要： The finding that patients with Sjögren's syndrome exhibit a statistically significant increase in expression of BMP6 in the salivary gland, relative to healthy control subjects, is described. Also described is the finding that overexpression of BMP6 in the salivary glands of mice results in an increase in electrical potential across the salivary gland. Methods of diagnosing a subject as having Sjögren's syndrome, or at risk for developing Sjögren's syndrome, by measuring the level of BMP6 expression in a salivary gland of a subject, measuring electrical potential in a salivary gland of a subject, or both, are described. Methods of treating a subject with Sjögren's syndrome, or methods of increasing salivary flow in a subject, by administering an agent that inhibits BMP6 expression or activity are also described. The use of XIST and MECP2 as diagnostic and therapeutic targets for male Sjögren's syndrome patients is further described.

    摘要翻译： 描述了相对于健康对照受试者，Sjögren综合征患者在唾液腺中BMP6表达统计学显着增加的发现。 还描述了BMP6在小鼠唾液腺中的过表达导致跨越唾液腺的电位增加的发现。 描述了通过测量受试者唾液腺中BMP6表达的水平，测量受试者的唾液腺中的电势或两者来诊断受试者患有Sjögren综合征或具有发展Sjögren综合征风险的方法。 还描述了通过施用抑制BMP6表达或活性的药物治疗患有Sjögren综合征的受试者的方法或增加受试者中唾液流的方法。 进一步描述使用XIST和MECP2作为男性Sjögren综合征患者的诊断和治疗靶标。