专利检索 ap:("Arthur R. Gomtsyan" OR "Erol K. Bayburt" OR "John R. Koenig" OR "Chih-Hung Lee" OR "Robert G. Schmidt" OR "Kirill A. Lukin" OR "Gilles Chambournier" OR "Margaret Chi-Ping Hsu" OR "Robert M. Leanna" OR "Russell D. Cink") AND inv:"Russell D. Cink" 第 1 页

1.

发明授权
Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor 有权
标题翻译：抑制香草素受体亚型1（VR1）受体的融合化合物

公开(公告)号：US08487116B2

公开(公告)日：2013-07-16

申请号：US13292281

申请日：2011-11-09

申请人： Arthur R. Gomtsyan , Erol K. Bayburt , John R. Koenig , Chih-Hung Lee , Robert G. Schmidt , Kirill A. Lukin , Gilles Chambournier , Margaret Chi-Ping Hsu , Robert M. Leanna , Russell D. Cink

发明人： Arthur R. Gomtsyan , Erol K. Bayburt , John R. Koenig , Chih-Hung Lee , Robert G. Schmidt , Kirill A. Lukin , Gilles Chambournier , Margaret Chi-Ping Hsu , Robert M. Leanna , Russell D. Cink

IPC分类号： C07D231/56

CPC分类号： C07D231/56 , C07D217/02 , C07D401/12 , C07D403/12

摘要： The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

摘要翻译： 本发明公开了通式（I）的新化合物或其药学上可接受的盐或前药（其中X1-X5，R5-R8b，Z1-Z2和Ar1如本文所定义），哺乳动物中抑制VR1受体的方法使用这些化合物，控制哺乳动物疼痛的方法，以及包含那些化合物的药物组合物和制备这些化合物的方法。

2.

发明申请
FUSED COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权
标题翻译：抑制VANILLOID受体亚型1（VR1）受体的融合化合物

公开(公告)号：US20080287676A1

公开(公告)日：2008-11-20

申请号：US12112105

申请日：2008-04-30

申请人： Arthur R. Gomtsyan , Erol K. Bayburt , Chih-Hung Lee , John R. Koenig , Robert G. Schmidt , Kirill A. Lukin , Gilles Chambournier , Margaret Chi-Ping Hsu , Robert M. Leanna , Russell D. Cink

发明人： Arthur R. Gomtsyan , Erol K. Bayburt , Chih-Hung Lee , John R. Koenig , Robert G. Schmidt , Kirill A. Lukin , Gilles Chambournier , Margaret Chi-Ping Hsu , Robert M. Leanna , Russell D. Cink

IPC分类号： C07D231/56 , C07D401/02 , C07D215/02 , C07D279/12

CPC分类号： C07D231/56 , C07D217/02 , C07D401/12 , C07D403/12

摘要： The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

摘要翻译： 本发明公开了通式（I）的新化合物或其药学上可接受的盐或前药（其中X 1，X 5，R 5，本文中定义的方法，其中R 1，R 2，Z 2，Z 1，Z 2，使用这些化合物抑制哺乳动物的VR1受体，抑制哺乳动物疼痛的方法，以及包括那些化合物的药物组合物和制备这些化合物的方法。

3.

发明授权
Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor 有权
标题翻译：抑制香草素受体亚型1（VR1）受体的融合化合物

公开(公告)号：US07375126B2

公开(公告)日：2008-05-20

申请号：US10864068

申请日：2004-06-09

申请人： Arthur R. Gomtsyan , Erol K. Bayburt , Chih-Hung Lee , John R. Koenig , Robert G. Schmidt , Kirill A. Lukin , Margaret Chi-Ping Hsu , Marvin R. Leanna , Russell D. Cink , Gilles Chambournier

发明人： Arthur R. Gomtsyan , Erol K. Bayburt , Chih-Hung Lee , John R. Koenig , Robert G. Schmidt , Kirill A. Lukin , Margaret Chi-Ping Hsu , Marvin R. Leanna , Russell D. Cink , Gilles Chambournier

IPC分类号： A61K31/403 , A61K31/416

CPC分类号： C07D217/02 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/08

摘要： The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

摘要翻译： 本发明公开了通式（I）的新化合物或其药学上可接受的盐或前药（其中X 1，X 5，R 5，本文中定义的方法，其中R 1，R 2，Z 2，Z 1，Z 2，使用这些化合物抑制哺乳动物的VR1受体，抑制哺乳动物疼痛的方法，以及包括那些化合物的药物组合物和制备这些化合物的方法。

4.

发明授权
Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor 有权
标题翻译：抑制香草素受体亚型1（VR1）受体的融合化合物

公开(公告)号：US08071762B2

公开(公告)日：2011-12-06

申请号：US12112105

申请日：2008-04-30

申请人： Arthur R. Gomtsyan , Erol K. Bayburt , Chih-Hung Lee , John R. Koenig , Robert G. Schmidt , Kirill A. Lukin , Gilles Chambournier , Margaret Chi-Ping Hsu , Marvin R. Leanna , Russell D. Cink

发明人： Arthur R. Gomtsyan , Erol K. Bayburt , Chih-Hung Lee , John R. Koenig , Robert G. Schmidt , Kirill A. Lukin , Gilles Chambournier , Margaret Chi-Ping Hsu , Marvin R. Leanna , Russell D. Cink

IPC分类号： C07D401/02 , C07D231/56

CPC分类号： C07D231/56 , C07D217/02 , C07D401/12 , C07D403/12

摘要： The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

摘要翻译： 本发明公开了通式（I）的新化合物或其药学上可接受的盐或前药（其中X1-X5，R5-R8b，Z1-Z2和Ar1如本文所定义），哺乳动物中抑制VR1受体的方法使用这些化合物，控制哺乳动物疼痛的方法，以及包含那些化合物的药物组合物和制备这些化合物的方法。

5.

发明申请
FUSED COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权
标题翻译：抑制VANILLOID受体亚型1（VR1）受体的融合化合物

公开(公告)号：US20120190845A1

公开(公告)日：2012-07-26

申请号：US13292281

申请日：2011-11-09

申请人： Arthur R. Gomtsyan , Erol K. Bayburt , Chih-Hung Lee , John R. Koenig , Robert G. Schmidt , Kirill A. Lukin , Gilles Chamboumier , Margaret Chi-Ping Hsu , Robert M. Leanna , Russell D. Cink

发明人： Arthur R. Gomtsyan , Erol K. Bayburt , Chih-Hung Lee , John R. Koenig , Robert G. Schmidt , Kirill A. Lukin , Gilles Chamboumier , Margaret Chi-Ping Hsu , Robert M. Leanna , Russell D. Cink

IPC分类号： C07D413/12 , C07D401/12 , C07D417/12 , C07D401/14 , C07D451/02 , C07D231/56 , C07D403/12

CPC分类号： C07D231/56 , C07D217/02 , C07D401/12 , C07D403/12

摘要： The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

摘要翻译： 本发明公开了通式（I）的新化合物或其药学上可接受的盐或前药（其中X1-X5，R5-R8b，Z1-Z2和Ar1如本文所定义），哺乳动物中抑制VR1受体的方法使用这些化合物，控制哺乳动物疼痛的方法，以及包含那些化合物的药物组合物和制备这些化合物的方法。

6.

发明授权
Process for preparing 6-o-substituted erythromycin derivatives 有权
标题翻译：制备6-O-取代的红霉素衍生物的方法

公开(公告)号：US06437106B1

公开(公告)日：2002-08-20

申请号：US09518281

申请日：2000-03-03

申请人： Eric J. Stoner , Matthew J. Peterson , Yi-Yin Ku , Russell D. Cink , Arthur J. Cooper , Mahendra N. Deshpande , Tim Grieme , Anthony R. Haight , David R. Hill , Margaret Chi-Ping Hsu , Steven A. King , Marvin Robert Leanna , Elaine C. Lee , Maureen A. McLaughlin , Howard E. Morton , James J. Napier , Daniel J. Plata , Prasad S. Raje , Michael Rasmussen , David Riley , Jien-Heh J. Tien , Steven J. Wittenberger

发明人： Eric J. Stoner , Matthew J. Peterson , Yi-Yin Ku , Russell D. Cink , Arthur J. Cooper , Mahendra N. Deshpande , Tim Grieme , Anthony R. Haight , David R. Hill , Margaret Chi-Ping Hsu , Steven A. King , Marvin Robert Leanna , Elaine C. Lee , Maureen A. McLaughlin , Howard E. Morton , James J. Napier , Daniel J. Plata , Prasad S. Raje , Michael Rasmussen , David Riley , Jien-Heh J. Tien , Steven J. Wittenberger

IPC分类号： C07H100

CPC分类号： C07H17/08

摘要： In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2′-substituted and optionally 4″-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

摘要翻译： 一方面，本发明涉及一种制备6-O-取代的红霉素衍生物的方法，其包括在钯催化剂和膦的存在下使2'-取代的和任选的4'-取代的9-肟红霉素衍生物与烷基化剂反应。另一方面，本发明涉及使用钯催化的烷基化反应制备6-O-取代的红霉素酮内酯的方法。

7.

发明授权
Macrocyclic hepatitis C serine protease inhibitors 有权
标题翻译：大环丙型肝炎丝氨酸蛋白酶抑制剂

公开(公告)号：US08748374B2

公开(公告)日：2014-06-10

申请号：US13154721

申请日：2011-06-07

申请人： Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarllla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or

发明人： Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarllla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or

IPC分类号： A61K38/00

CPC分类号： C07K5/081 , C07D487/04

摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

摘要翻译： 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。