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公开(公告)号：US07767393B2
公开(公告)日：2010-08-03
申请号：US11343797
申请日：2006-01-31
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/158 , Y10S436/811 , Y10S436/813
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of prostate cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
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公开(公告)号：US20080153711A1
公开(公告)日：2008-06-26
申请号：US11820646
申请日：2007-06-20
CPC分类号： C07K1/36
摘要： The present invention relates to automated methods, systems, and apparatuses for protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of protein samples. The present invention thus provides improved methods for the separation and analysis of samples containing a plurality of proteins (e.g., cells).
摘要翻译： 本发明涉及用于蛋白质分离和分析的自动化方法，系统和装置。 特别地，本发明提供了用于蛋白质样品的分离，鉴定和表征的自动化系统。 因此，本发明提供了用于分离和分析含有多种蛋白质（例如细胞）的样品的改进方法。
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公开(公告)号：US07229774B2
公开(公告)日：2007-06-12
申请号：US10210120
申请日：2002-08-01
IPC分类号： G01N33/53 , C12Q1/68 , C07K14/435
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/158 , Y10S436/811 , Y10S436/813
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of prostate cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译： 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供与前列腺癌相关的基因表达谱。 使用本发明的方法鉴定为癌症标志物的基因可用于前列腺癌的诊断和表征。 此外，这些基因为癌症药物筛选和治疗应用提供了靶标。
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公开(公告)号：US20090075284A1
公开(公告)日：2009-03-19
申请号：US12192539
申请日：2008-08-15
CPC分类号： G01N33/4833 , G01N33/493 , G01N33/57434 , G01N33/6806 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer.
摘要翻译： 本发明涉及癌症标志物。 特别地，本发明提供在前列腺癌中差异存在的代谢物。
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公开(公告)号：US20090047269A1
公开(公告)日：2009-02-19
申请号：US12192681
申请日：2008-08-15
申请人： Arul M. Chinnaiyan , Arun Sreekumar
发明人： Arul M. Chinnaiyan , Arun Sreekumar
CPC分类号： C12N5/0693 , C12N15/113 , C12N2500/33 , G01N33/57434 , G01N33/6815 , Y02A90/26
摘要： The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer and methods of inhibiting the growth of a cell by altering the level of such metabolites.
摘要翻译： 本发明涉及癌症标志物。 特别地，本发明提供在前列腺癌中差异存在的代谢物和通过改变这些代谢物的水平来抑制细胞生长的方法。
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公开(公告)号：US20080280771A1
公开(公告)日：2008-11-13
申请号：US11820377
申请日：2007-06-19
CPC分类号： C07K1/047 , B01J2219/00596 , B01J2219/00605 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , C07K1/1077 , C40B50/14 , G01N33/54386 , G01N33/6842
摘要： The present invention relates to automated methods, systems, and apparatuses for protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of the phosphorylation status of protein samples, including the generation and analysis of protein microarrays.
摘要翻译： 本发明涉及用于蛋白质分离和分析的自动化方法，系统和装置。 特别地，本发明提供了用于蛋白质样品的磷酸化状态的分离，鉴定和表征的自动化系统，包括蛋白质微阵列的产生和分析。
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公开(公告)号：US20140051601A1
公开(公告)日：2014-02-20
申请号：US13958158
申请日：2013-08-02
申请人： Arul M. Chinnaiyan , Arun Sreekumar , Matthew W. Mitchell , Kay A. Lawton , Alvin Berger , Christopher Beecher
发明人： Arul M. Chinnaiyan , Arun Sreekumar , Matthew W. Mitchell , Kay A. Lawton , Alvin Berger , Christopher Beecher
IPC分类号： G01N33/483 , G01N33/493
CPC分类号： G01N33/4833 , G01N33/493 , G01N33/57434 , G01N33/6806 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer.
摘要翻译： 本发明涉及癌症标志物。 特别地，本发明提供在前列腺癌中差异存在的代谢物。
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公开(公告)号：US07332290B2
公开(公告)日：2008-02-19
申请号：US10909035
申请日：2004-07-30
IPC分类号： G01N33/53
CPC分类号： G01N33/57434 , C07K16/3069 , C07K16/40 , C12Q1/533 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , Y10S435/96 , Y10S436/813
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. The present invention also provides novel markers useful for the diagnosis, characterization, and treatment of prostate cancers. In particular, the present invention provides methods and compositions for the detection of α-methylacyl-CoA racemase (AMACR) in the urine as a marker for prostate cancer detection.
摘要翻译： 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供与前列腺癌相关的基因表达谱。 本发明还提供了可用于诊断，表征和治疗前列腺癌的新型标志物。 特别地，本发明提供了检测尿中α-甲酰基-CoA消旋酶（AMACR）作为前列腺癌检测标记物的方法和组合物。
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公开(公告)号：US08759301B2
公开(公告)日：2014-06-24
申请号：US13024491
申请日：2011-02-10
CPC分类号： C07K14/4702 , A61K38/00 , C07K7/06 , C07K14/82
摘要： The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present invention relates to recurrent gene fusions as clinical targets for prostate cancer.
摘要翻译： 本发明涉及用于癌症治疗的组合物和方法，包括但不限于癌症标志物的靶向抑制。 特别地，本发明涉及作为前列腺癌的临床靶标的复发性基因融合体。
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公开(公告)号：US20110207198A1
公开(公告)日：2011-08-25
申请号：US13025290
申请日：2011-02-11
申请人： Arul M. Chinnaiyan , Sooryanaryana Lnu , Qi Cao , Irfan Asangani
发明人： Arul M. Chinnaiyan , Sooryanaryana Lnu , Qi Cao , Irfan Asangani
IPC分类号： C12N5/09 , C07H21/00 , C12N9/99 , C07K16/00 , C07D241/44
CPC分类号： C07D241/44 , C12N5/0693 , C12N2501/70
摘要： The present invention relates to agents that find use in the treatment, management, and/or study of cancer. In particular, the present invention relates to agents (e.g., small molecules, nucleic acids) that affect MMSET expression or activity.
摘要翻译： 本发明涉及可用于治疗，管理和/或研究癌症的药剂。 特别地，本发明涉及影响MMSET表达或活性的试剂（例如小分子，核酸）。
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