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公开(公告)号:US08524682B2
公开(公告)日:2013-09-03
申请号:US12778739
申请日:2010-05-12
申请人: Arul M. Chinnaiyan , Sooryanarayana Lnu , Qi Cao
发明人: Arul M. Chinnaiyan , Sooryanarayana Lnu , Qi Cao
IPC分类号: C12N15/11
CPC分类号: A61K31/35
摘要: The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in prostate cancer.
摘要翻译: 本发明涉及癌症的治疗靶点。 特别地,本发明涉及靶向前列腺癌中EZH2表达的小分子和核酸。
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公开(公告)号:US20100222420A1
公开(公告)日:2010-09-02
申请号:US12778739
申请日:2010-05-12
申请人: Arul M. Chinnaiyan , Sooryanarayana Lnu , Qi Cao
发明人: Arul M. Chinnaiyan , Sooryanarayana Lnu , Qi Cao
IPC分类号: A61K31/7088 , C12N5/02
CPC分类号: A61K31/35
摘要: The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in prostate cancer.
摘要翻译: 本发明涉及癌症的治疗靶点。 特别地,本发明涉及靶向前列腺癌中EZH2表达的小分子和核酸。
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公开(公告)号:US20100311815A1
公开(公告)日:2010-12-09
申请号:US12710706
申请日:2010-02-23
申请人: Arul M. Chinnaiyan , Sooryanarayana Lnu , Qi Cao
发明人: Arul M. Chinnaiyan , Sooryanarayana Lnu , Qi Cao
IPC分类号: A61K31/7088 , A61P35/00 , C12N5/09
CPC分类号: A61K31/7088 , C12Q1/6816 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207
摘要: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. The present invention further provides novel markers useful for the diagnosis, characterization, and treatment of prostate cancers.
摘要翻译: 本发明涉及用于癌症诊断的组合物和方法,包括但不限于癌症标志物。 本发明还提供了可用于诊断,鉴定和治疗前列腺癌的新型标志物。
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公开(公告)号:US20090012031A1
公开(公告)日:2009-01-08
申请号:US12167520
申请日:2008-07-03
申请人: Arul M. Chinnaiyan , Sooryanarayana Lnu , Qi Cao
发明人: Arul M. Chinnaiyan , Sooryanarayana Lnu , Qi Cao
IPC分类号: A61K31/7105 , C12N5/06 , A61P31/00 , A61K31/35
CPC分类号: A61K31/35
摘要: The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in prostate cancer.
摘要翻译: 本发明涉及癌症的治疗靶点。 特别地,本发明涉及靶向前列腺癌中EZH2表达的小分子和核酸。
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公开(公告)号:US20110207198A1
公开(公告)日:2011-08-25
申请号:US13025290
申请日:2011-02-11
申请人: Arul M. Chinnaiyan , Sooryanaryana Lnu , Qi Cao , Irfan Asangani
发明人: Arul M. Chinnaiyan , Sooryanaryana Lnu , Qi Cao , Irfan Asangani
IPC分类号: C12N5/09 , C07H21/00 , C12N9/99 , C07K16/00 , C07D241/44
CPC分类号: C07D241/44 , C12N5/0693 , C12N2501/70
摘要: The present invention relates to agents that find use in the treatment, management, and/or study of cancer. In particular, the present invention relates to agents (e.g., small molecules, nucleic acids) that affect MMSET expression or activity.
摘要翻译: 本发明涉及可用于治疗,管理和/或研究癌症的药剂。 特别地,本发明涉及影响MMSET表达或活性的试剂(例如小分子,核酸)。
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公开(公告)号:US20110251216A1
公开(公告)日:2011-10-13
申请号:US13024559
申请日:2011-02-10
申请人: Arul M. Chinnaiyan , Sooryanaryana Lnu , Qi Cao
发明人: Arul M. Chinnaiyan , Sooryanaryana Lnu , Qi Cao
IPC分类号: A61K31/519 , C07D307/91 , C07D491/052 , C07D231/40 , C07D333/38 , C07C63/70 , C07C335/26 , C07D277/64 , C07D261/14 , C07D271/06 , C12N5/07 , C12N5/09 , A61K31/426 , A61K31/343 , A61K31/415 , A61K31/381 , A61K31/17 , A61K31/428 , A61K31/42 , A61K31/4245 , A61P35/00 , C07D277/56
CPC分类号: A61K31/343 , A61K31/4152 , A61K31/426 , A61K31/517 , C12N5/0693 , C12N2501/65 , G01N33/5011
摘要: The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in cancer (e.g., prostate cancer, breast cancer, other solid tumors, multiple myeloma).
摘要翻译: 本发明涉及癌症的治疗靶点。 特别地,本发明涉及靶向癌症中的EZH2表达的小分子和核酸(例如前列腺癌,乳腺癌,其他实体瘤,多发性骨髓瘤)。
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公开(公告)号:US08697407B2
公开(公告)日:2014-04-15
申请号:US13025290
申请日:2011-02-11
申请人: Arul M. Chinnaiyan , Sooryanaryana Lnu , Qi Cao , Irfan Asangani
发明人: Arul M. Chinnaiyan , Sooryanaryana Lnu , Qi Cao , Irfan Asangani
CPC分类号: C07D241/44 , C12N5/0693 , C12N2501/70
摘要: The present invention relates to agents that find use in the treatment, management, and/or study of cancer. In particular, the present invention relates to agents (e.g., small molecules, nucleic acids) that affect MMSET expression or activity.
摘要翻译: 本发明涉及可用于治疗,管理和/或研究癌症的药剂。 特别地,本发明涉及影响MMSET表达或活性的试剂(例如小分子,核酸)。
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公开(公告)号:US20160208604A1
公开(公告)日:2016-07-21
申请号:US14652322
申请日:2013-07-15
发明人: Qi Cao , Alberto Quintero , Jing Jin
IPC分类号: E21B47/16
摘要: An apparatus includes a housing. The housing includes a concentrator and a plurality of signal acquisition devices. Each signal acquisition device is coupled to a respective sensor. Each sensor measures an environmental parameter outside the housing. Each signal acquisition device includes an acoustic transducer. Each signal acquisition device includes a controller to accept measurements from the respective sensor, process the measurements and format them into a transmittable form, and transmit the formatted measurements via the acoustic transducer. A concentrator includes an acoustic transducer to receive acoustic transmissions from the plurality of signal acquisition devices, a processor to process the received acoustic transmissions, and a telemetry device through which the processor can transmit the processed transmissions.
摘要翻译: 一种装置包括壳体。 壳体包括集中器和多个信号采集装置。 每个信号采集装置耦合到相应的传感器。 每个传感器测量外壳外部的环境参数。 每个信号采集装置包括声换能器。 每个信号采集装置包括控制器,用于接受来自相应传感器的测量,处理测量并将它们格式化为可传输形式,并经由声换能器传送格式化的测量值。 集中器包括用于接收来自多个信号采集设备的声音传输的声学换能器,用于处理所接收的声音传输的处理器以及遥测设备,通过该遥测设备,处理器可以通过该遥测设备传送已处理的传输。
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公开(公告)号:US08302165B2
公开(公告)日:2012-10-30
申请号:US12611822
申请日:2009-11-03
申请人: Siddharth Bhai , Zhe (Jessie) Li , William S. Jack, III , Christopher W. McCarron , James J. Simmons , Qi Cao
发明人: Siddharth Bhai , Zhe (Jessie) Li , William S. Jack, III , Christopher W. McCarron , James J. Simmons , Qi Cao
IPC分类号: G06F7/04
CPC分类号: G06F21/33 , G06F21/445 , H04L41/0803
摘要: An offline trust system establishes a trust relationship between a trust authority computer system and a target computer system without relying on an active network connection between the computer systems. The offline trust system separates the trust establishment operation into a provisioning phase and a configuration phase. The provisioning phase can be performed entirely on the trust authority, while the configuration phase can be performed entirely on the target computer system requesting trust. The two phases can be performed at different times and do not assume any connection between the two computer systems. An administrator may perform the provisioning phase for many target computer systems at the same time. Thus, the offline trust system provides a way to establish trust between computer systems that is more reliable and less prone to failure.
摘要翻译: 离线信任系统在信任机构计算机系统和目标计算机系统之间建立信任关系,而不依赖计算机系统之间的活动网络连接。 离线信任系统将信任建立操作分为供应阶段和配置阶段。 配置阶段可以完全在信任授权机构上完成,同时配置阶段可以完全在目标计算机系统上执行请求信任。 这两个阶段可以在不同的时间执行,并且不会在两个计算机系统之间承担任何连接。 管理员可以同时为许多目标计算机系统执行供应阶段。 因此,离线信任系统提供了一种在更可靠且不容易发生故障的计算机系统之间建立信任的方法。
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公开(公告)号:US20130347063A1
公开(公告)日:2013-12-26
申请号:US13529853
申请日:2012-06-21
申请人: Sarath Madakasira , Siddharth Bhai , James J. Simmons , Ryan J. Fairfax , Qi Cao , Arun K. Nanda , Mark Fishel Novak
发明人: Sarath Madakasira , Siddharth Bhai , James J. Simmons , Ryan J. Fairfax , Qi Cao , Arun K. Nanda , Mark Fishel Novak
IPC分类号: G06F21/00
CPC分类号: G06F21/604 , H04L63/20
摘要: Sharing security claims across different security contexts. A method includes, for a first security context, identifying a first set of security claims. The method further includes for the first security context identifying a second set of security claims from the first set of security claims that is allowed to be sent from the first security context. The first set of security claims is modified to create the second set of security claims. For a second security context, security claim requirements are identified. The second set of security claims is modified to satisfy the security claim requirements for the second security context.
摘要翻译: 在不同的安全环境中共享安全声明。 对于第一安全上下文,一种方法包括识别第一组安全权利要求。 所述方法还包括用于从所述第一安全声明集合允许从所述第一安全上下文发送的所述第一安全性上下文标识第二组安全声明。 修改第一组安全声明以创建第二组安全声明。 对于第二个安全上下文,确定了安全声明要求。 修改第二组安全声明以满足第二安全上下文的安全声明要求。
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