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    Curable urethane resin composition comprising a mixture of polyisocyanate, active hydrogen compound and diketo compound
    3.
    发明授权
    Curable urethane resin composition comprising a mixture of polyisocyanate, active hydrogen compound and diketo compound 失效
    包含多异氰酸酯，活性氢化合物和二酮化合物的混合物的可固化聚氨酯树脂组合物

    公开(公告)号：US3972846A

    公开(公告)日：1976-08-03

    申请号：US519213

    申请日：1974-10-30

    申请人： Atsuo Mori ,  Shuji Kitamura ,  Kohji Yamatsuta

    发明人： Atsuo Mori ,  Shuji Kitamura ,  Kohji Yamatsuta

    IPC分类号： C08G18/00 ,  C08G18/08 ,  C08K5/07 ,  C08L75/00

    CPC分类号： C08G18/089 ,  C08K5/07 ,  C08G2101/00

    摘要： The present invention provides for a curable polyurethane composition comprising a keto compound and a liquid mixture of an organic aliphatic polyfunctional polyisocyanate and a compound having active hydrogen, the keto compound having the general formula: ##EQU1## wherein R.sub.1 and R.sub.2 are each an alkyl group, an aromatic group, and a heterocyclic group, which may be the same or different, and R.sub.2 is a lower alkylene or alkenyl group having 1 to 2 carbon atoms. The curable polyurethane composition is characterized by exhibiting a long pot life due to the existence of the aforementioned keto compound therein.

    摘要翻译： 本发明提供了一种可固化的聚氨酯组合物，其包含酮化合物和有机脂肪族多官能多异氰酸酯与具有活性氢的化合物的液体混合物，所述酮化合物具有以下通式：R1-C-R2-C-R3并行性平行O 其中R 1和R 2各自为可以相同或不同的烷基，芳族基团和杂环基，并且R 2为具有1至2个碳原子的低级亚烷基或链烯基。 可固化的聚氨酯组合物的特征在于由于其中存在上述酮化合物而表现出长的适用期。

    Method for preparing highly absorbent hydro-gel polymers
    5.
    发明授权
    Method for preparing highly absorbent hydro-gel polymers 失效
    制备高吸水性水凝胶聚合物的方法

    公开(公告)号：US4320040A

    公开(公告)日：1982-03-16

    申请号：US160451

    申请日：1980-06-18

    申请人： Fumio Fujita ,  Shuji Kitamura ,  Toshifumi Tamura ,  Tsuneyuki Nagase

    发明人： Fumio Fujita ,  Shuji Kitamura ,  Toshifumi Tamura ,  Tsuneyuki Nagase

    IPC分类号： A61L15/60 ,  C08F8/32 ,  C08F8/44 ,  C08F20/06 ,  C08F261/04 ,  C08L29/04 ,  C08L33/02

    CPC分类号： C08F8/44 ,  A61L15/60 ,  C08F20/06 ,  C08F261/04 ,  C08F8/32 ,  Y10S524/916

    摘要： A method for producing a hydrophilic gel comprising polymerizing acrylic acid and/or methacrylic acid in the presence of polyvinyl alcohol to obtain a polymer (A) which is then subjected to neutralization followed by heat treatment or to heat treatment followed by neutralization, or polymerizing a neutralized product of acrylic acid and/or methacrylic acid in the presence of polyvinyl alcohol to obtain a polymer (B) which is then subjected to heat treatment, wherein said polymerization is carried out in an aqueous solution having a total concentration of acrylic acid and/or methacrylic acid or its neutralized product (the weight of the neutralized product is converted to the acid basis) and polyvinyl alcohol of 10 to 60% by weight, said heat treatment temperature is 50.degree. to 150.degree. C., and the weight ratio of polyvinylalcohol is acrylic acid and/or methacrylic acid or its salt (the weight of the neutralized product is converted to the acid basis) is 5 to 95: 95 to 5.

    摘要翻译： 一种亲水性凝胶的制造方法，其特征在于，在聚乙烯醇存在下使丙烯酸和/或甲基丙烯酸聚合，得到聚合物（A），然后进行中和，进行热处理或热处理后中和，或聚合 在聚乙烯醇存在下中和丙烯酸和/或甲基丙烯酸的产物，得到聚合物（B），然后进行热处理，其中所述聚合在丙烯酸和/ 或甲基丙烯酸或其中和产物（中和产物的重量以酸为基准）和聚乙烯醇为10至60重量％，所述热处理温度为50-150℃，重量比为 聚乙烯醇是丙烯酸和/或甲基丙烯酸或其盐（中和产物的重量以酸为基准）为5〜95:95〜5。

    JNK inhibitor
    7.
    发明授权
    JNK inhibitor 失效
    JNK抑制剂

    公开(公告)号：US07402595B2

    公开(公告)日：2008-07-22

    申请号：US10504132

    申请日：2003-02-12

    申请人： Fumio Itoh ,  Hiroyuki Kimura ,  Hideki Igata ,  Tomohiro Kawamoto ,  Mitsuru Sasaki ,  Shuji Kitamura

    发明人： Fumio Itoh ,  Hiroyuki Kimura ,  Hideki Igata ,  Tomohiro Kawamoto ,  Mitsuru Sasaki ,  Shuji Kitamura

    IPC分类号： C07D217/02 ,  A61K31/47

    CPC分类号： A61K31/4725 ,  A61K31/472 ,  A61K31/5377 ,  C07D217/24 ,  C07D217/26

    摘要： A JNK inhibitor containing a compound having an isoquinolinone skeleton or a salt thereof, such as a compound represented by the formula wherein ring A and ring B are each an optionally substituted benzene ring, X is —O—, —N═, —NR3— or —CHR3—, R2 is an acyl group, an optionally esterified or thioesterified carboxyl group, an optionally substituted carbamoyl group or an optionally substituted amino group and the like, a broken line shows a single bond or a double bond, and R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like, and the like.

    摘要翻译： 含有异喹啉骨架或其盐的化合物的JNK抑制剂，例如下式表示的化合物，其中环A和环B各自为任选取代的苯环，X为-O-，-N-，-NR- SO 3 - 或-CHR 3 - ，R 2是酰基，任选酯化或硫酯化羧基，任选取代的氨基甲酰基或 任选取代的氨基等，虚线表示单键或双键，R 1是氢原子，任选取代的烃基，任选取代的杂环基等， 等等。

    Carbamate derivatives, process for producing the same and use thereof
    8.
    发明授权
    Carbamate derivatives, process for producing the same and use thereof 失效
    氨基甲酸酯衍生物，其制备方法及其用途

    公开(公告)号：US07109200B2

    公开(公告)日：2006-09-19

    申请号：US10416240

    申请日：2001-11-08

    申请人： Fumio Itoh ,  Hiroshi Banno ,  Masaki Kawamura ,  Shuji Kitamura

    发明人： Fumio Itoh ,  Hiroshi Banno ,  Masaki Kawamura ,  Shuji Kitamura

    IPC分类号： A61K31/497 ,  C07D241/01 ,  C07D401/00

    CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D405/14

    摘要： Novel carbamate derivatives which are useful as drugs because of inhibiting activated blood coagulation factor X and thus exerting an anticoagulant effect. Compounds represented by the formula: wherein R1 represents a group represented by the formula: (wherein Y1 represents CH═CH, etc.), which may be substituted, etc.; the ring A represents an oxo-substituted nitrogen-containing heterocyclic ring which may be further substituted; R2 represents a hydrogen atom, optionally substituted C1-4 alkyl, etc.; R3 represents optionally substituted C1-4 alkyl, etc.; and Z represents an optionally substituted nitrogen containing heterocyclic group, etc., or salts thereof.

    摘要翻译： 新型氨基甲酸酯衍生物由于抑制活化凝血因子X而作为药物有用，因此起抗凝作用。 由下式表示的化合物：其中R 1表示由式（其中Y 1表示CH-CH等）表示的基团，其可以被取代等 。 环A表示可被进一步取代的含氧取代的含氮杂环; R 2表示氢原子，任选取代的C 1-4烷基等; R 3表示任选取代的C 1-4烷基等; Z表示任选取代的含氮杂环基等，或其盐。

    Method for producing fermented milk containing angiotensin converting enzyme inhibitory peptide and method for producing whey
    9.
    发明申请
    Method for producing fermented milk containing angiotensin converting enzyme inhibitory peptide and method for producing whey 审中-公开
    含有血管紧张素转换酶抑制肽的发酵乳的制造方法以及乳清的制造方法

    公开(公告)号：US20050074500A1

    公开(公告)日：2005-04-07

    申请号：US10719173

    申请日：2003-11-20

    申请人： Shuji Kitamura ,  Takashi Ueyama

    发明人： Shuji Kitamura ,  Takashi Ueyama

    IPC分类号： A23C9/123 ,  A23C19/045 ,  A23C19/05 ,  A23C21/00 ,  A61K35/20

    CPC分类号： A23C21/026 ,  A23C9/123 ,  A23C9/1234 ,  A23C19/045 ,  A23C19/05 ,  A23C21/00 ,  A23C2260/05 ,  A23L33/18 ,  A23V2002/00 ,  A23Y2220/39 ,  A23V2200/326 ,  A23V2250/5424

    摘要： There are disclosed methods for producing fermented milk and whey that enable effective production in high yield of fermented milk and whey having high content of an ACEI peptide that is highly safe and applicable to pharmaceuticals, functional foods, health foods, and the like. The methods are: a method including the steps of mixing lactic acid bacteria and a starting material containing milk by stirring to prepare a mixed material, and fermenting the mixed material under stirring so that curd pieces and whey containing an angiotensin converting enzyme inhibitory peptide are generated, whereby fermented milk containing the curd pieces and the whey containing the angiotensin converting enzyme inhibitory peptide is produced; and a method including the steps of subjecting the resulting fermented milk to centrifugation and/or filter pressing to separate and recover whey.

    摘要翻译： 公开了生产发酵乳和乳清的方法，所述方法能够有效地生产高产量的发酵乳和具有高含量ACEI肽的乳清，其高度安全且适用于药物，功能性食品，保健食品等。 所述方法包括以下步骤：通过搅拌混合乳酸菌和含有乳的原料以制备混合物，并在搅拌下发酵混合物，从而产生包含血管紧张素转换酶抑制肽的凝乳片和乳清 制造含有凝乳片的发酵乳和含有血管紧张素转换酶抑制肽的乳清液; 以及包括以下步骤的方法：使得到的发酵乳进行离心和/或过滤以分离和回收乳清。

    Process for producing granules containing angiotensin-converting enzyme inhibiting peptides
    10.
    发明授权
    Process for producing granules containing angiotensin-converting enzyme inhibiting peptides 有权
    生产含有血管紧张素转换酶抑制肽的颗粒的方法

    公开(公告)号：US06428812B1

    公开(公告)日：2002-08-06

    申请号：US09231449

    申请日：1999-01-14

    申请人： Shuji Kitamura ,  Takashi Ueyama

    发明人： Shuji Kitamura ,  Takashi Ueyama

    IPC分类号： A61K916

    CPC分类号： A61K38/556 ,  A61K9/1623 ,  Y10S530/833

    摘要： Granules and tablets for oral administration, containing angiotensin-converting enzyme inhibiting peptides and treated whey with a mixing fluid bed processor, wherein said whey is obtained from lactic acid fermentation liquid. The granules have properties of narrow particle distributions, low moisture absorption, and heavy specific gravity, as well as high free flowing. A process is also provided for producing the granules by the steps of: a) onto seed granules obtained in an earlier operation in a mixing fluid bed processor, spraying purified whey of lactic acid fermentation liquid to form preliminary granules; b) treating the preliminary granules thus obtained to reduce particle size in a size reduction mill; c) returning the treated powder to the mixing fluid bed processor, and, d) spraying additional purified whey onto the returned powder in the mixing fluid bed processor to form granules, while fluidizing the said powder.

    摘要翻译： 用于口服的颗粒剂和片剂，其含有血管紧张素转化酶抑制肽和用混合流化床处理剂处理的乳清，其中所述乳清获自乳酸发酵液。 颗粒具有粒子分布窄，吸湿性低，重比重，以及高自由流动的特性。 还提供了一种通过以下步骤生产颗粒的方法：a）在混合流化床处理器中早期操作获得的种子颗粒上，喷洒乳酸发酵液的精制乳清以形成初步颗粒; b） 从而获得减小研磨机中的粒度; c）将处理​​后的粉末返回到混合流化床处理器，以及d）将另外的精制乳清喷洒到混合流化床处理器中的返回的粉末上以形成颗粒，同时使 说粉