利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

111 条记录 (耗时 0.044 秒)

    Amine compound and use thereof
    7.
    发明授权
    Amine compound and use thereof 有权
    胺化合物及其用途

    公开(公告)号：US07833991B2

    公开(公告)日：2010-11-16

    申请号：US11704860

    申请日：2007-02-09

    申请人： Toru Yamazaki ,  Shigeyuki Kikumoto ,  Masahiro Ono ,  Atsushi Saitou ,  Haruka Takahashi ,  Sei Kumakura ,  Kunitaka Hirose ,  Mikiro Yanaka ,  Yoshiyuki Takemura ,  Shigeru Suzuki ,  Ryo Matsui

    发明人： Toru Yamazaki ,  Shigeyuki Kikumoto ,  Masahiro Ono ,  Atsushi Saitou ,  Haruka Takahashi ,  Sei Kumakura ,  Kunitaka Hirose ,  Mikiro Yanaka ,  Yoshiyuki Takemura ,  Shigeru Suzuki ,  Ryo Matsui

    IPC分类号： C07D403/02 ,  A01N43/50

    CPC分类号： C07D233/64 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

    摘要： It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1): In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(═O) or NR11; and D is a group represented by the following general formula (4) or (6). In the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.

    摘要翻译： 旨在提供对HIV病毒感染，风湿病和癌症转移等疾病有效的新型胺化合物。 即，由以下通式（1）表示的胺化合物：在典型情况下，A1和A2各自表示任选取代的单环或多环芳族杂环; W表示环状C 3-10亚烷基，任选取代的单环或多环芳族杂环，单环或多环芳环或部分饱和多环芳环; X表示O，CH 2，C（= O）或NR 11; D为由以下通式（4）或（6）表示的基团。 在式（6）中，Q表示单键，S，O或NR 12; Y为由以下通式（7）表示的基团。 z表示任选取代的单环或多环芳环。 式（6）中，B表示NR25R26。 在上式中，R 1至R 26各自表示氢，烷基，烯基或炔基。

    Switching fluorescent nanoparticle probe and fluorescent particle imaging method using same
    9.
    发明授权
    Switching fluorescent nanoparticle probe and fluorescent particle imaging method using same 有权
    开关荧光纳米粒子探针和荧光颗粒成像方法使用相同

    公开(公告)号：US09370589B2

    公开(公告)日：2016-06-21

    申请号：US13818392

    申请日：2011-08-08

    申请人： Isao Hara ,  Eiichi Ozeki ,  Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma

    发明人： Isao Hara ,  Eiichi Ozeki ,  Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma

    IPC分类号： A61K9/14 ,  A61K49/00

    CPC分类号： A61K49/0089 ,  A61K49/0032 ,  A61K49/0093 ,  Y10S977/773 ,  Y10S977/927

    摘要： The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.

    摘要翻译： 本发明提供了具有开关功能（在纳米颗粒制备期间淬灭荧光染料并在成像期间发射荧光的功能）的新型荧光纳米颗粒成像探针。 一种开关荧光纳米颗粒探针，包括：由具有亲水嵌段链和疏水性嵌段链的两亲嵌段聚合物组成的分子组合; 以及包封在分子组合中的荧光染料，其中（a）所述亲水性嵌段链包含作为必需亲水性结构单元的选自肌氨酸单元和烯化氧单元的单元，（b）所述疏水性嵌段链包含： 必需的疏水结构单元，选自氨基酸单元和羟基酸单元的单元，和（c）荧光染料是由式（I）表示的花青化合物：和 荧光染料被封装在单分子组装中。

    CONNECTOR
    10.
    发明申请
    CONNECTOR 有权
    连接器

    公开(公告)号：US20140302724A1

    公开(公告)日：2014-10-09

    申请号：US14123285

    申请日：2012-03-14

    申请人： Masahiro Ono

    发明人： Masahiro Ono

    IPC分类号： H01R13/42

    CPC分类号： H01R13/42 ,  H01R13/4364 ,  H01R13/502 ,  H01R24/86

    摘要： A connector, including a plug terminal of a plug connected to a first electric signal line and inserted in a terminal hole of a plug body, a socket terminal of a socket connected to a second electric signal line and inserted in a terminal hole of a socket body, a plug holder of the plug, and a socket holder of the socket, where the plug holder and the socket holder are connected to each other, where the plug terminal is press fitted in and electrically connected to the socket terminal, where a position in an axial center direction is controlled by sandwiching one end portion of at least one of the plug terminal and the socket terminal between the body and a terminal holder made of an insulating material.

    摘要翻译： 一种连接器，包括连接到第一电信号线并插入插头主体的端子孔中的插头的插头端子，插座的插座端子连接到第二电信号线并插入插座的端子孔中 主体，插头的插头座和插座的插座座，其中插头保持器和插座保持器彼此连接，其中插头端子被压配合并电连接到插座端子，其中位置 通过将插头端子和插座端子中的至少一个的一个端部夹在主体和由绝缘材料制成的端子座之间来控制轴向中心方向。