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公开(公告)号:US20120077740A1
公开(公告)日:2012-03-29
申请号:US12928422
申请日:2010-12-10
申请人: Avi J. Ashkenazi , Sarah Hymowitz , Robert F. Kelley , Iphigenia Koumenis , Woon-Lam Susan Leung , Mark O'Connell , Roger Pai , Zahra Shahrokh , Laura Simmons
发明人: Avi J. Ashkenazi , Sarah Hymowitz , Robert F. Kelley , Iphigenia Koumenis , Woon-Lam Susan Leung , Mark O'Connell , Roger Pai , Zahra Shahrokh , Laura Simmons
IPC分类号: A61K38/19 , C12N15/19 , C12N15/63 , C12N1/21 , B01D15/36 , C07K1/14 , C07K1/18 , C07K1/20 , B01D15/32 , C12P21/02 , C07K14/52
CPC分类号: A61K9/19 , A61K9/0019 , A61K38/00 , A61K47/02 , C07K14/525 , C07K14/70575
摘要: Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.
摘要翻译: 提供使用二价金属离子制备Apo-2配体和Apo-2配体制剂的方法。 这种二价金属离子包括改善Apo-2配体三聚体形成和稳定性的锌和钴。 还提供了Apo-2配体的晶体结构,以及使用寡核苷酸定向突变鉴定的Apo-2配体变体多肽。
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公开(公告)号:US07855066B1
公开(公告)日:2010-12-21
申请号:US11528948
申请日:2006-09-28
申请人: Avi J. Ashkenazi , Sarah Hymowitz , Robert F. Kelley , Iphigenia Koumenis , Woon-Lam Susan Leung , Mark O'Connell , Roger Pai , Zahra Shahrokh , Laura Simmons
发明人: Avi J. Ashkenazi , Sarah Hymowitz , Robert F. Kelley , Iphigenia Koumenis , Woon-Lam Susan Leung , Mark O'Connell , Roger Pai , Zahra Shahrokh , Laura Simmons
CPC分类号: A61K9/19 , A61K9/0019 , A61K38/00 , A61K47/02 , C07K14/525 , C07K14/70575
摘要: Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.
摘要翻译: 提供使用二价金属离子制备Apo-2配体和Apo-2配体制剂的方法。 这种二价金属离子包括改善Apo-2配体三聚体形成和稳定性的锌和钴。 还提供了Apo-2配体的晶体结构,以及使用寡核苷酸定向突变鉴定的Apo-2配体变体多肽。
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公开(公告)号:US06740739B1
公开(公告)日:2004-05-25
申请号:US09582450
申请日:2000-06-26
IPC分类号: C07K14525
CPC分类号: C07K14/70575 , A61K38/00 , C07K2319/00
摘要: A novel cytokine, designated Apo-2 ligand, which induces mammalian cancer cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.
摘要翻译: 提供了诱导哺乳动物癌细胞凋亡的新型细胞因子,称为Apo-2配体。 Apo-2配体被认为是TNF细胞因子家族的成员。 还提供了包括Apo-2配体嵌合体,编码Apo-2配体的核酸和Apo-2配体的抗体的组合物。 进一步提供了使用Apo-2配体诱导细胞凋亡和治疗病理状况如癌症的方法。
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公开(公告)号:US20100269184A1
公开(公告)日:2010-10-21
申请号:US12653340
申请日:2009-12-10
IPC分类号: A01K67/00 , C07K14/705 , C07K19/00 , C07K16/28 , C07H21/04 , C12N15/63 , C12N1/19 , A61K38/16 , C12P21/02 , C12N5/02 , A61P35/00
CPC分类号: C07K14/70575 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/70578 , C07K2319/00 , C07K2319/30
摘要: Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
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公开(公告)号:US07691978B2
公开(公告)日:2010-04-06
申请号:US11535718
申请日:2006-09-27
申请人: Avi J. Ashkenazi , Dan L. Eaton , Audrey Goddard , Austin L. Gurney , William I. Wood , Thomas D. Wu
发明人: Avi J. Ashkenazi , Dan L. Eaton , Audrey Goddard , Austin L. Gurney , William I. Wood , Thomas D. Wu
CPC分类号: C07K16/30 , C12Q1/6886 , C12Q2600/158
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译: 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物,以及使用这些物质组合物的方法。
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公开(公告)号:US07547507B2
公开(公告)日:2009-06-16
申请号:US11046650
申请日:2005-01-28
申请人: Avi J. Ashkenazi , Dan L. Eaton , Audrey Goddard , Austin L. Gurney , William I. Wood , Thomas D. Wu
发明人: Avi J. Ashkenazi , Dan L. Eaton , Audrey Goddard , Austin L. Gurney , William I. Wood , Thomas D. Wu
CPC分类号: C07K16/30 , C12Q1/6886 , C12Q2600/158
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译: 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物,以及使用这些物质组合物的方法。
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公开(公告)号:US20090004204A1
公开(公告)日:2009-01-01
申请号:US11542473
申请日:2006-10-03
申请人: Avi J. Ashkenazi , Klaus W. Wagner
发明人: Avi J. Ashkenazi , Klaus W. Wagner
IPC分类号: A61K39/395 , C12Q1/68 , G01N33/53 , A61P31/00 , G01N33/574
CPC分类号: G01N33/574 , A61K38/1703 , A61K38/19 , C12Q1/37 , C12Q1/6834 , C12Q1/686 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/5008 , G01N33/5011 , G01N33/5023 , G01N2333/91102 , G01N2510/00
摘要: Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of GalNac-T related molecules, such as GalNac-T14 or GalNac-T3, is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Kits and articles of manufacture are also provided.
摘要翻译: 提供检查哺乳动物组织或细胞样品中一种或多种生物标志物的表达的方法和试验。 根据所公开的方法和测定法,检测GalNac-T相关分子(例如GalNac-T14或GalNac-T3)的表达是预测或指示组织或细胞样品对凋亡诱导剂如Apo2L敏感 / TRAIL和抗DR5激动剂抗体。 还提供了工具包和制品。
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公开(公告)号:US20080182277A1
公开(公告)日:2008-07-31
申请号:US11542061
申请日:2006-10-03
申请人: Avi J. Ashkenazi , Klaus W. Wagner
发明人: Avi J. Ashkenazi , Klaus W. Wagner
IPC分类号: G01N33/574
CPC分类号: G01N33/574 , A61K38/1703 , A61K38/19 , C12Q1/37 , C12Q1/6834 , C12Q1/686 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/5008 , G01N33/5011 , G01N33/5023 , G01N2333/91102 , G01N2510/00
摘要: Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of GalNac-T related molecules, such as GalNac-T14 or GalNac-T3, is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Kits and articles of manufacture are also provided.
摘要翻译: 提供检查哺乳动物组织或细胞样品中一种或多种生物标志物的表达的方法和试验。 根据所公开的方法和测定法,检测GalNac-T相关分子(例如GalNac-T14或GalNac-T3)的表达是预测或指示组织或细胞样品对凋亡诱导剂如Apo2L敏感 / TRAIL和抗DR5激动剂抗体。 还提供了工具包和制品。
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公开(公告)号:US07314619B2
公开(公告)日:2008-01-01
申请号:US10052798
申请日:2001-11-02
CPC分类号: C07K14/4747 , A61K38/00 , C07K14/70578 , C07K16/2878 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/20 , C07K2319/21 , C07K2319/30
摘要: Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
摘要翻译: 提供了能够调节细胞凋亡的新型多肽,称为Apo-2。 还提供了包含Apo-2嵌合体,编码Apo-2的核酸和Apo-2抗体的组合物。
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公开(公告)号:US07056736B2
公开(公告)日:2006-06-06
申请号:US09989328
申请日:2001-11-19
申请人: Avi J. Ashkenazi , Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Ivar J. Kljavin , Mary A. Napier , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Zemin Zhang
发明人: Avi J. Ashkenazi , Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Ivar J. Kljavin , Mary A. Napier , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Zemin Zhang
CPC分类号: C07K14/47
摘要: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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