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    Implantable pressure sensors and methods for making and using them
    3.
    再颁专利
    Implantable pressure sensors and methods for making and using them 有权
    可植入压力传感器及其制造和使用的方法

    公开(公告)号：USRE42378E1

    公开(公告)日：2011-05-17

    申请号：US11491533

    申请日：2006-07-20

    申请人： Lone Wolinsky ,  Eyal Doron ,  Alon Ben-Yoseph ,  Avi Penner

    发明人： Lone Wolinsky ,  Eyal Doron ,  Alon Ben-Yoseph ,  Avi Penner

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0028 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/031 ,  A61B5/053 ,  A61B5/076 ,  A61B5/14539 ,  A61B2560/0219 ,  A61B2562/0247 ,  A61B2562/028 ,  A61N1/37217 ,  A61N1/3787 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0651

    摘要： An implant includes a pressure sensor, a controller for acquiring pressure data from the sensor, and an acoustic transducer for converting energy between electrical energy and acoustic energy. A capacitor is coupled to the acoustic transducer for storing electrical energy converted by the transducer and/or for providing electrical energy to operate the implant. The acoustic transducer may operate alternatively or simultaneously as an energy exchanger or an acoustic transmitter. During use, the implant is implanted within a patient's body, and an external transducer transmits a first acoustic signal into the patient's body, to energize the capacitor. The implant then obtains pressure data, and transmits a second acoustic signal to the external transducer, the second acoustic signal including the pressure data.

    摘要翻译： 植入物包括压力传感器，用于从传感器获取压力数据的控制器和用于在电能和声能之间转换能量的声换能器。 电容器耦合到声换能器，用于存储由换能器转换的电能和/或用于提供电能以操作植入物。 声换能器可以作为能量交换器或声发射器交替地或同时地操作。 在使用期间，将植入物植入患者体内，并且外部换能器将第一声信号传送到患者体内，以激励电容器。 然后，植入物获得压力数据，并将第二声学信号发送到外部换能器，第二声学信号包括压力数据。

    SYSTEMS AND METHODS FOR COMMUNICATING WITH IMPLANTABLE DEVICES
    4.
    发明申请
    SYSTEMS AND METHODS FOR COMMUNICATING WITH IMPLANTABLE DEVICES 有权
    用于与可移植设备通信的系统和方法

    公开(公告)号：US20080103553A1

    公开(公告)日：2008-05-01

    申请号：US11876620

    申请日：2007-10-22

    申请人： Avi Penner ,  Eyal Doron

    发明人： Avi Penner ,  Eyal Doron

    IPC分类号： A61N1/08

    CPC分类号： A61N1/37217 ,  A61B5/00 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0215 ,  A61B5/076 ,  A61B5/1112 ,  A61B5/14539 ,  A61B5/4839 ,  A61B8/4281 ,  A61B8/4472 ,  A61B8/56 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2560/0242 ,  A61B2560/0257 ,  A61B2560/0412 ,  A61B2562/028 ,  A61N1/08 ,  A61N1/37235 ,  A61N1/37252 ,  A61N1/3787 ,  Y10S128/903

    摘要： Systems and methods for communicating with an implant within a patient's body using acoustic telemetry includes an external communications device attachable to the patient's skin. The device includes an acoustic transducer for transmitting acoustic signals into the patient's body and/or for receiving acoustic signals from the implant. The device includes a battery for providing electrical energy to operate the device, a processor for extracting data from acoustic signals received from the implant, and memory for storing the data. The device may include an interface for communicating with a recorder or computer, e.g., to transfer data from the implant and/or to receive instructions for controlling the implant. The device is secured to the patient's skin for controlling, monitoring, or otherwise communicating with the implant, while allowing the patient to remain mobile.

    摘要翻译： 使用声学遥测与患者体内的植入物进行通信的系统和方法包括可附接到患者皮肤的外部通信装置。 该装置包括用于将声信号传送到患者体内和/或用于从植入物接收声信号的声换能器。 该装置包括用于提供电能以操作装置的电池，用于从从植入物接收的声信号中提取数据的处理器，以及用于存储数据的存储器。 该装置可以包括用于与记录器或计算机通信的接口，例如从植入物传送数据和/或接收用于控制植入物的指令。 该装置被固定到患者的皮肤上，用于控制，监测或以其他方式与植入物通信，同时允许患者保持移动。

    Acoustic switch and apparatus and methods for using acoustic switches within a body
    5.
    发明授权
    Acoustic switch and apparatus and methods for using acoustic switches within a body 有权
    声学开关以及在体内使用声学开关的装置和方法

    公开(公告)号：US06628989B1

    公开(公告)日：2003-09-30

    申请号：US09690615

    申请日：2000-10-16

    申请人： Avi Penner ,  Eyal Doron

    发明人： Avi Penner ,  Eyal Doron

    IPC分类号： A61N1372

    CPC分类号： A61N1/3787 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/031 ,  A61B5/053 ,  A61B5/076 ,  A61B5/14539 ,  A61B2560/0219 ,  A61B2562/0247 ,  A61B2562/028 ,  A61N1/37217 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0651

    摘要： An implant for insertion or implantation within a body includes an electrical circuit for performing one or more commands when the implant is activated, an energy storage device, and a switch coupled to the electrical circuit and the energy storage device. An acoustic transducer is coupled to the switch, the acoustic transducer being activatable upon acoustic excitation by an external acoustic energy source for closing the switch to allow current flow from the energy storage device to the electrical circuit. The one or more commands includes measuring a physiological parameter with a biosensor coupled to the electrical circuit, or controlling a therapeutic device coupled to the electrical circuit. The therapeutic device or biosensor may be activated for a predetermined time or until the switch is opened in response to another acoustic excitation of the acoustic transducer.

    摘要翻译： 用于在体内插入或植入的植入物包括用于在植入物被激活时执行一个或多个命令的电路，能量存储装置和耦合到电路和能量存储装置的开关。 声换能器耦合到开关，声换能器可在通过用于闭合开关的外部声能源进行声激励时激活，以允许电流从能量存储装置流向电路。 一个或多个命令包括使用耦合到电路的生物传感器测量生理参数，或者控制耦合到电路的治疗装置。 治疗装置或生物传感器可以被激活预定时间，或者直到响应于声换能器的另一声激发而打开开关。

    Acoustic biosensor for monitoring physiological conditions in a body implantation site
    6.
    发明授权
    Acoustic biosensor for monitoring physiological conditions in a body implantation site 有权
    用于监测身体植入部位生理状况的声学生物传感器

    公开(公告)号：US06486588B2

    公开(公告)日：2002-11-26

    申请号：US09872129

    申请日：2001-06-01

    申请人： Eyal Doron ,  Avi Penner

    发明人： Eyal Doron ,  Avi Penner

    IPC分类号： H01L4108

    CPC分类号： A61B5/031 ,  A61B5/0031 ,  A61B5/02014 ,  A61B5/413 ,  A61B2562/028 ,  A61M2205/3523 ,  H01L41/1132 ,  H04R17/00

    摘要： An acoustic biosensor is provided for deployment at an implantation site within a body, such as an abdominal aortic aneurysm. The biosensor includes a sensor element for measuring a physiological condition at the implantation site, and for generating an information signal representative of the physiological condition. The biosensor further includes a piezoelectric transducer element for converting an externally originated acoustic interrogation signal into energy for operating the sensor, and for modulating the interrogation signal, e.g., by employing a switching element to alternate the mechanical impedance of the transducer element, to transmit the information signal outside of the body.

    摘要翻译： 提供声学生物传感器用于在体内的植入部位，例如腹主动脉瘤。 生物传感器包括用于测量植入部位的生理状况的传感器元件，并且用于生成表示生理状态的信息信号。 生物传感器还包括用于将外部产生的声讯讯信号转换成用于操作传感器的能量的压电换能器元件，并且例如通过使用开关元件来交替换能器元件的机械阻抗来调制询问信号， 身体外的信息信号。

    Acoustic telemetry system and method for monitoring a rejection reaction of a transplanted organ
    8.
    发明授权
    Acoustic telemetry system and method for monitoring a rejection reaction of a transplanted organ 失效
    用于监测移植器官排斥反应的声学遥测系统和方法

    公开(公告)号：US06198965B1

    公开(公告)日：2001-03-06

    申请号：US09312760

    申请日：1999-05-17

    申请人： Avi Penner ,  Eyal Doron ,  Yariv Porat

    发明人： Avi Penner ,  Eyal Doron ,  Yariv Porat

    IPC分类号： A61B500

    CPC分类号： A61B5/0031 ,  A61B5/0535 ,  A61B5/413 ,  A61B2562/028 ,  A61N1/37252 ,  A61N1/37288 ,  H04R17/00

    摘要： A telemetry system for monitoring a rejection reaction of a transplanted organ being transplanted within a patient's body is provided. The telemetry system includes (a) a telemetry control unit located outside the body of the patient; and (b) a telemetry monitoring unit implanted within the body of the patient, the telemetry monitoring unit including: (i) at least one acoustic transducer being for receiving an acoustic signal from the telemetry control unit and converting the acoustic signal into a first electrical signal, the at least one acoustic transducer further being for receiving a second electrical signal and converting the second electrical signal into a transmitted acoustic signal receivable by the telemetry monitoring unit; and (ii) a plurality of electrodes positionable in intimate contact with, or deep within, the transplanted organ and being in communication with the at least one acoustic transducer, the plurality of electrodes being for passing the first electrical signal through the transplanted organ for monitoring the electrical impedance thereof and further being for relaying the second electrical signal corresponding to the electrical impedance to the at least one acoustic transducer so as to enable the monitoring of the presence or absence of the rejection reaction.

    摘要翻译： 提供了一种用于监测被移植在患者体内的移植器官的排斥反应的遥测系统。 遥测系统包括（a）位于患者体外的遥测控制单元; 遥测监测单元植入患者体内，遥测监测单元包括：（i）至少一个声换能器，用于接收来自遥测单元的声信号，并将声信号转换为第一电 信号，所述至少一个声换能器还用于接收第二电信号并将所述第二电信号转换成可由所述遥测监测单元接收的传输声信号; 和（ii）多个电极，其定位成与移植的器官紧密接触或深入移动的器官并且与至少一个声换能器连通，所述多个电极用于使第一电信号通过移植器官用于监测 其电阻抗并且还用于将对应于电阻抗的第二电信号中继到至少一个声换能器，以便能够监测是否存在排斥反应。

    Systems and methods for communicating with implantable devices
    9.
    发明授权
    Systems and methods for communicating with implantable devices 有权
    用于与可植入装置通信的系统和方法

    公开(公告)号：US07756587B2

    公开(公告)日：2010-07-13

    申请号：US11876620

    申请日：2007-10-22

    申请人： Avi Penner ,  Eyal Doron

    发明人： Avi Penner ,  Eyal Doron

    IPC分类号： A61N1/18

    CPC分类号： A61N1/37217 ,  A61B5/00 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0215 ,  A61B5/076 ,  A61B5/1112 ,  A61B5/14539 ,  A61B5/4839 ,  A61B8/4281 ,  A61B8/4472 ,  A61B8/56 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2560/0242 ,  A61B2560/0257 ,  A61B2560/0412 ,  A61B2562/028 ,  A61N1/08 ,  A61N1/37235 ,  A61N1/37252 ,  A61N1/3787 ,  Y10S128/903

    摘要： Systems and methods for communicating with an implant within a patient's body using acoustic telemetry includes an external communications device attachable to the patient's skin. The device includes an acoustic transducer for transmitting acoustic signals into the patient's body and/or for receiving acoustic signals from the implant. The device includes a battery for providing electrical energy to operate the device, a processor for extracting data from acoustic signals received from the implant, and memory for storing the data. The device may include an interface for communicating with a recorder or computer, e.g., to transfer data from the implant and/or to receive instructions for controlling the implant. The device is secured to the patient's skin for controlling, monitoring, or otherwise communicating with the implant, while allowing the patient to remain mobile.

    摘要翻译： 使用声学遥测与患者体内的植入物进行通信的系统和方法包括可附接到患者皮肤的外部通信装置。 该装置包括用于将声信号传送到患者体内和/或用于从植入物接收声信号的声换能器。 该装置包括用于提供电能以操作装置的电池，用于从从植入物接收的声信号中提取数据的处理器，以及用于存储数据的存储器。 该装置可以包括用于与记录器或计算机通信的接口，例如从植入物传送数据和/或接收用于控制植入物的指令。 该装置被固定到患者的皮肤上，用于控制，监测或以其他方式与植入物通信，同时允许患者保持移动。

    Devices for intrabody delivery of molecules and systems and methods utilizing same
    10.
    发明申请
    Devices for intrabody delivery of molecules and systems and methods utilizing same 失效
    用于体内递送分子和系统的装置以及利用其的方法

    公开(公告)号：US20080191581A9

    公开(公告)日：2008-08-14

    申请号：US10638405

    申请日：2003-08-12

    申请人： Avi Penner ,  Eyal Doron

    发明人： Avi Penner ,  Eyal Doron

    IPC分类号： H01L41/08

    CPC分类号： H01L41/04 ,  A61K9/0009 ,  A61K9/0024 ,  A61K9/0097

    摘要： A device for controlled release of molecules is provided. The device including: (a) a device body having at least one reservoir therein for containing the molecules, the at least one reservoir being formed with a barrier impermeable to the molecules thereby preventing release thereof from the at least one reservoir; and (b) at least one acoustic transducer being attached to, or forming a part of, the device body, the at least one acoustic transducer being for converting an acoustic signal received thereby into an electrical signal, the electrical signal leading to barrier permeabilization and therefore release of the molecules from the at least one reservoir.

    摘要翻译： 提供了用于控制释放分子的装置。 该装置包括：（a）装置本体，其中具有用于容纳分子的至少一个储存器，所述至少一个储存器形成有不可渗透到该分子的屏障，从而防止其从至少一个储存器的释放; 所述至少一个声换能器用于将由此接收的声信号转换为电信号，所述电信号导致屏障透化，并且（b）至少一个声换能器附接到所述装置主体或形成所述装置主体的一部分， 因此从至少一个储器释放分子。