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公开(公告)号：US20080306051A1
公开(公告)日：2008-12-11
申请号：US12132145
申请日：2008-06-03
IPC分类号： A61K31/505 , C07D239/22 , A61K31/54 , A61P31/18 , C07D279/02
CPC分类号： C07D405/04 , C07D405/14 , C07D417/14
摘要： The invention encompasses a series pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译： 本发明包括抑制HIV整合酶并防止病毒整合入人DNA的式I的一系列嘧啶酮化合物。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。
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公开(公告)号：US08835411B2
公开(公告)日：2014-09-16
申请号：US13312483
申请日：2011-12-06
申请人： Yasutsuga Ueda , Timothy P. Connolly , Barry L. Johnson , Chen Li , B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Margaret E. Sorenson , Michael A. Walker , Michael S. Bowsher , Rongti Li
发明人： Yasutsuga Ueda , Timothy P. Connolly , Barry L. Johnson , Chen Li , B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Margaret E. Sorenson , Michael A. Walker , Michael S. Bowsher , Rongti Li
IPC分类号： C07D519/00 , C07D487/08
CPC分类号： C07D487/08 , C07D519/00
摘要： The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译： 本公开一般涉及式I的新化合物，包括其盐，其抑制HIV整合酶并防止病毒整合入人DNA。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。
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公开(公告)号：US07763630B2
公开(公告)日：2010-07-27
申请号：US12132145
申请日：2008-06-03
IPC分类号： C07D405/04 , C07D405/14 , C07D417/14 , A61K31/513
CPC分类号： C07D405/04 , C07D405/14 , C07D417/14
摘要： The invention encompasses a series pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译： 本发明包括抑制HIV整合酶并防止病毒整合入人DNA的式I的一系列嘧啶酮化合物。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。
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公开(公告)号：US08129398B2
公开(公告)日：2012-03-06
申请号：US12406268
申请日：2009-03-18
申请人： Francis Beaulieu , Carl Ouellet , B. Narasimhulu Naidu , Manoj Patel , Yasutsugu Ueda , Timothy P. Connolly , Jonathan R. Weiss , Michael A. Walker , Nicholas A. Meanwell , Kevin M. Peese , Margaret E. Sorenson , Chen Li
发明人： Francis Beaulieu , Carl Ouellet , B. Narasimhulu Naidu , Manoj Patel , Yasutsugu Ueda , Timothy P. Connolly , Jonathan R. Weiss , Michael A. Walker , Nicholas A. Meanwell , Kevin M. Peese , Margaret E. Sorenson , Chen Li
IPC分类号： A61K31/505 , C07D487/12
CPC分类号： C07D498/18 , C07D471/08 , C07D471/18 , C07D487/08 , C07D493/18
摘要： The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译： 本公开一般涉及式I的新化合物，包括其盐，其抑制HIV整合酶并防止病毒整合入人DNA。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。
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公开(公告)号：US20120309698A1
公开(公告)日：2012-12-06
申请号：US13312483
申请日：2011-12-06
申请人： Yasutsugu Ueda , Timothy P. Connolly , Barry L. Johnson , Chen Li , B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Margaret E. Sorenson , Michael A. Walker , Michael S. Bowsher , Rongti Li
发明人： Yasutsugu Ueda , Timothy P. Connolly , Barry L. Johnson , Chen Li , B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Margaret E. Sorenson , Michael A. Walker , Michael S. Bowsher , Rongti Li
IPC分类号： A61K31/55 , A61K31/655 , A61K31/553 , A61P31/18 , A61K31/7028 , C07J43/00 , A61K31/58 , C07D487/08 , C07H15/26
CPC分类号： C07D487/08 , C07D519/00
摘要： The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
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公开(公告)号：US20090253677A1
公开(公告)日：2009-10-08
申请号：US12406268
申请日：2009-03-18
申请人： Francis Beaulieu , Carl Ouellet , B. Narasimhulu Naidu , Manoj Patel , Yasutsugu Ueda , Timothy P. Connolly , Jonathan R. Weiss , Michael A. Walker , Nicholas A. Meanwell , Kevin M. Peese , Margaret E. Sorenson
发明人： Francis Beaulieu , Carl Ouellet , B. Narasimhulu Naidu , Manoj Patel , Yasutsugu Ueda , Timothy P. Connolly , Jonathan R. Weiss , Michael A. Walker , Nicholas A. Meanwell , Kevin M. Peese , Margaret E. Sorenson
IPC分类号： A61K31/551 , A61K31/55 , A61K31/537 , A61K31/529 , C07D487/14 , C07D487/04 , C07D498/18 , C07D471/04
CPC分类号： C07D498/18 , C07D471/08 , C07D471/18 , C07D487/08 , C07D493/18
摘要： The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译： 本公开一般涉及式I的新化合物，包括其盐，其抑制HIV整合酶并防止病毒整合入人DNA。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。
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公开(公告)号：US07022667B2
公开(公告)日：2006-04-04
申请号：US10189710
申请日：2002-07-03
申请人： Thomas W. Hudyma , Xiaofan Zheng , B. Narasimhulu Naidu , Margaret E. Sorenson , Alicia Regueiro-Ren , Timothy P. Connolly , John D. Matiskella , Oak K. Kim , Yunhui Zhang , Dane M. Springer , Jason Goodrich , Yasutsugu Ueda , Joanne J. Bronson
发明人： Thomas W. Hudyma , Xiaofan Zheng , B. Narasimhulu Naidu , Margaret E. Sorenson , Alicia Regueiro-Ren , Timothy P. Connolly , John D. Matiskella , Oak K. Kim , Yunhui Zhang , Dane M. Springer , Jason Goodrich , Yasutsugu Ueda , Joanne J. Bronson
IPC分类号： A61K38/16
CPC分类号： C07H17/08 , C07D513/22 , C07H15/26 , C07H17/02 , C07H17/04
摘要： The present invention provides compounds of formula I having potent antibiotic activity, including activity towards Gram-positive bacteria and mycobacteria.
摘要翻译： 本发明提供具有有效抗生素活性的式I化合物，包括对革兰氏阳性菌和分枝杆菌的活性。
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![N-[4-Fluorophenyl)methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide as an HIV integrase inhibitor](/abs-image/US/2009/02/17/US07491819B1/abs.jpg.150x150.jpg)
8.发明授权N-[4-Fluorophenyl)methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide as an HIV integrase inhibitor 失效N - [（4-氟苯基）甲基] -4,6,7,9-四氢-3-羟基-9,9-二甲基-4-氧代 - 嘧啶并[2,1-c] [1,4] 2-甲酰胺作为HIV整合酶抑制剂公开(公告)号：US07491819B1
公开(公告)日：2009-02-17
申请号：US11525740
申请日：2006-09-22
IPC分类号： C07D498/04 , A61K31/5365 , A61P31/18
CPC分类号： C07D498/04
摘要： The invention encompasses a series of bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译： 本发明包括抑制HIV整合酶并防止病毒整合入人DNA的一系列式I的双环嘧啶酮化合物。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。
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公开(公告)号：US20070281917A1
公开(公告)日：2007-12-06
申请号：US11754462
申请日：2007-05-29
IPC分类号： A61K31/553 , A61K31/519 , A61K31/5383 , C07D491/04
CPC分类号： C07D471/18 , C07D498/18
摘要： The invention encompasses series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译： 本发明包括抑制HIV整合酶并防止病毒整合入人DNA的式I的系列双环嘧啶酮化合物。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。
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公开(公告)号：US07157447B2
公开(公告)日：2007-01-02
申请号：US11288533
申请日：2005-11-29
申请人： B. Narasimhulu Naidu , Jacques Banville , Francis Beaulieu , Timothy P. Connolly , Mark R. Krystal , John D. Matiskella , Carl Ouellet , Serge Plamondon , Roger Remillard , Margaret E. Sorenson , Yasutsugu Ueda , Michael A. Walker
发明人： B. Narasimhulu Naidu , Jacques Banville , Francis Beaulieu , Timothy P. Connolly , Mark R. Krystal , John D. Matiskella , Carl Ouellet , Serge Plamondon , Roger Remillard , Margaret E. Sorenson , Yasutsugu Ueda , Michael A. Walker
IPC分类号： C07K33/42 , C07D267/14 , C07D279/02 , C07D205/08 , C07F90/542 , A61K31/533
CPC分类号： C07D498/04 , A61K31/519 , A61K31/5383 , A61K31/541 , A61K31/675 , A61K31/683 , A61K45/06 , A61K2300/00
摘要： The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV
摘要翻译： 本发明包括抑制HIV整合酶并防止病毒整合入人DNA的式I的系列双环嘧啶酮化合物。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法
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