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    Novel Microbial Succinic Acid Producers and Purification of Succinic Acid
    3.
    发明申请
    Novel Microbial Succinic Acid Producers and Purification of Succinic Acid 审中-公开
    新型微生物琥珀酸生产商和琥珀酸的纯化

    公开(公告)号：US20150197776A1

    公开(公告)日：2015-07-16

    申请号：US14676317

    申请日：2015-04-01

    Applicant: BASF SE

    Inventor： Hartwig Schröder ,  Stefan Haefner ,  Gregory Von Abendroth ,  Rajan Hollmann ,  Aline Raddatz ,  Hansgeorg Ernst ,  Hans Gurski

    IPC: C12P7/46

    CPC classification number: C12P7/46 ,  C12N1/32 ,  C12N9/1029 ,  C12R1/01 ,  C12Y203/01054

    Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.

    Abstract translation: 本发明涉及能够利用甘油作为发酵生产琥珀酸的碳源的细菌菌株，其中所述菌株被遗传修饰，使得它们包含其内源性丙酮酸 - 甲酸裂解酶活性的失调，以及 涉及通过利用这种微生物生产有机酸，特别是琥珀酸的方法。 本发明还涉及通过阳离子交换层析对所生产的有机酸的下游加工。

    Microbial succinic acid producers and purification of succinic acid
    4.
    发明授权
    Microbial succinic acid producers and purification of succinic acid 有权
    微生物琥珀酸生产商和琥珀酸的纯化

    公开(公告)号：US09023632B2

    公开(公告)日：2015-05-05

    申请号：US14150206

    申请日：2014-01-08

    Applicant: BASF SE

    Inventor： Hartwig Schröder ,  Stefan Haefner ,  Gregory Von Abendroth ,  Rajan Hollmann ,  Aline Raddatz ,  Hansgeorg Ernst ,  Hans Gurski

    IPC: C12P7/46 ,  C12P7/44 ,  C12N1/32 ,  C12N9/10 ,  C12R1/01

    CPC classification number: C12P7/46 ,  C12N1/32 ,  C12N9/1029 ,  C12R1/01 ,  C12Y203/01054

    Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.

    Abstract translation: 本发明涉及能够利用甘油作为发酵生产琥珀酸的碳源的细菌菌株，其中所述菌株被遗传修饰，使得它们包含其内源性丙酮酸 - 甲酸裂解酶活性的失调，以及 涉及通过利用这种微生物生产有机酸，特别是琥珀酸的方法。 本发明还涉及通过阳离子交换层析对所生产的有机酸的下游加工。

    PROCESS FOR THE PREPARATION OF OXOVINYLIONOL AND ITS O-PROTECTED DERIVATIVES
    6.
    发明申请
    PROCESS FOR THE PREPARATION OF OXOVINYLIONOL AND ITS O-PROTECTED DERIVATIVES 有权
    氧化亚油和其保护的衍生物的制备方法

    公开(公告)号：US20130116473A1

    公开(公告)日：2013-05-09

    申请号：US13673278

    申请日：2012-11-09

    Applicant: BASF SE

    Inventor： Hansgeorg Ernst ,  Michael Puhl ,  Stefan Benson ,  Wolfgang Siegel

    IPC: C07C45/28 ,  C07F9/54 ,  C07C409/18

    CPC classification number: C07C45/28 ,  C07C403/08 ,  C07C407/00 ,  C07C409/18 ,  C07C2601/16 ,  C07F9/5442 ,  Y02P20/55 ,  C07C409/14

    Abstract: The present invention relates to the preparation of oxovinylionol and its O-protected derivatives of the formula I in which R is hydrogen or an OH protecting group, for example a group Si(Ra)3, by reacting a compound of the general formula II in which R has the meanings given above for formula I, i.e. β-vinyl ionol (formula II, R=hydrogen) or an O-protected derivative thereof (formula II, R═OH protecting group) with an oxidant in the presence of at least one transition metal, where the oxidant comprises at least one oxygen-containing compound which is selected from among hydrogen peroxide and organic hydroperoxides.

    Abstract translation: 本发明涉及通过使通式II的化合物与式（I）的化合物反应制备式I化合物的氧代乙烯基醇及其O-保护的衍生物，其中R是氢或OH保护基，例如Si（Ra） 其中R具有上述式I的定义，即β-乙烯基离子（式II，R =氢）或其保护有机化合物（式II，R = OH保护基）与氧化剂在至少 一种过渡金属，其中氧化剂包含至少一种选自过氧化氢和有机氢过氧化物的含氧化合物。

    Novel Microbial Succinic Acid Producers and Purification of Succinic Acid
    8.
    发明申请
    Novel Microbial Succinic Acid Producers and Purification of Succinic Acid 审中-公开
    新型微生物琥珀酸生产商和琥珀酸的纯化

    公开(公告)号：US20140127764A1

    公开(公告)日：2014-05-08

    申请号：US14150206

    申请日：2014-01-08

    Applicant: BASF SE

    Inventor： Hartwig Schröder ,  Stefan Haefner ,  Gregory Von Abendroth ,  Rajan Hollmann ,  Aline Raddatz ,  Hansgeorg Ernst ,  Hans Gurski

    IPC: C12P7/46

    CPC classification number: C12P7/46 ,  C12N1/32 ,  C12N9/1029 ,  C12R1/01 ,  C12Y203/01054

    Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.

    Abstract translation: 本发明涉及能够利用甘油作为发酵生产琥珀酸的碳源的细菌菌株，其中所述菌株被遗传修饰，使得它们包含其内源性丙酮酸 - 甲酸裂解酶活性的失调，以及 涉及通过利用这种微生物生产有机酸，特别是琥珀酸的方法。 本发明还涉及通过阳离子交换层析对所生产的有机酸的下游加工。

    Process for the preparation of oxovinylionol and its O-protected derivatives
    10.
    发明授权
    Process for the preparation of oxovinylionol and its O-protected derivatives 有权
    氧乙烯醇及其O保护衍生物的制备方法

    公开(公告)号：US09061982B2

    公开(公告)日：2015-06-23

    申请号：US13673278

    申请日：2012-11-09

    Applicant: BASF SE

    Inventor： Hansgeorg Ernst ,  Michael Puhl ,  Stefan Benson ,  Wolfgang Siegel

    IPC: C07C45/34 ,  C07C45/28 ,  C07C409/18 ,  C07F9/54 ,  C07C403/08 ,  C07C407/00

    CPC classification number: C07C45/28 ,  C07C403/08 ,  C07C407/00 ,  C07C409/18 ,  C07C2601/16 ,  C07F9/5442 ,  Y02P20/55 ,  C07C409/14

    Abstract: The present invention relates to the preparation of oxovinylionol and its O-protected derivatives of the formula I in which R is hydrogen or an OH protecting group, for example a group Si(Ra)3, by reacting a compound of the general formula II in which R has the meanings given above for formula I, i.e. β-vinyl ionol (formula II, R=hydrogen) or an O-protected derivative thereof (formula II, R═OH protecting group) with an oxidant in the presence of at least one transition metal, where the oxidant comprises at least one oxygen-containing compound which is selected from among hydrogen peroxide and organic hydroperoxides.

    Abstract translation: 本发明涉及通过使通式II的化合物与式（I）的化合物反应制备式I化合物的氧代乙烯基醇及其O-保护的衍生物，其中R是氢或OH保护基，例如Si（Ra） 其中R具有上面给出的式I所示的含义，即在存在下的化合物（即，b） - 乙烯基离子（式II，R =氢）或其被保护的衍生物（式II，R = OH保护基） 至少一种过渡金属，其中氧化剂包含至少一种选自过氧化氢和有机氢过氧化物的含氧化合物。

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