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公开(公告)号：US20170227528A1
公开(公告)日：2017-08-10
申请号：US15515501
申请日：2014-09-30
发明人： Qiang Feng , Zhipeng Liu , Nan Meng , Jun Wang
CPC分类号： G01N33/5091 , G01N30/02 , G01N30/62 , G01N30/72 , G01N33/48 , G01N2030/027 , G01N2800/324
摘要： The present invention relates to a disease-specific metabolite profile, and particularly to a biomarker composition obtained by screening from blood plasma-specific profiles of coronary heart disease subjects. The present invention also relates to a use of the biomarker compositions in risk assessment, diagnosis, early diagnosis, or pathological staging of coronary heart disease, and to a method for risk assessment, diagnosis, early diagnosis, or pathological staging of coronary heart disease. The biomarker composition as provided by the present invention can be used for early diagnosis of coronary heart disease and has high sensitivity, good specificity and good application prospects.
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公开(公告)号：US20170234852A1
公开(公告)日：2017-08-17
申请号：US15515513
申请日：2014-09-30
发明人： Qiang Feng , Zhipeng Liu , Nan Meng , Jun Wang
IPC分类号： G01N33/493 , G06F19/24 , G01N30/72
CPC分类号： G01N33/493 , G01N30/02 , G01N30/62 , G01N30/7233 , G01N33/48 , G01N33/6893 , G01N2570/00 , G01N2800/324 , G01N2800/50 , G01N2800/56 , G06F19/324 , G16B40/00 , G16H50/30
摘要： The present invention relates to a disease-specific metabolite profile, and particularly to a biomarker composition obtained by screening from urine-specific metabolite profiles of coronary heart disease subjects. The present invention also relates to a use of the biomarker compositions in risk assessment, diagnosis, early diagnosis, or pathological staging of coronary heart disease, and to a method for risk assessment, diagnosis, early diagnosis, or pathological staging of coronary heart disease. The biomarker composition as provided by the present invention can be used for early diagnosis of coronary heart disease and has high sensitivity, good specificity and good application prospects.
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公开(公告)号：US10526659B2
公开(公告)日：2020-01-07
申请号：US15017087
申请日：2016-02-05
发明人： Qiang Feng , Dongya Zhang , Longqing Tang , Jun Wang
IPC分类号： C12Q1/68 , C07H21/04 , C12Q1/6886 , C12Q1/6806
摘要： Biomarkers and methods related to microbiota for predicting the risk of a disease, particularly colorectal cancer (CRC), are described.
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公开(公告)号：US10100360B2
公开(公告)日：2018-10-16
申请号：US14418800
申请日：2013-06-05
发明人： Shenghui Li , Qiang Feng , Zhuye Jie , Dongya Zhang , Junjie Qin , Jun Wang , Jian Wang , Huanming Yang
IPC分类号： C12Q1/68 , G06F19/22 , G16H50/20 , C12Q1/6883
摘要： Biomarkers for diabetes and usages thereof are provided. And the biomarkers are nucleotides having polynucleotide sequences defined in SEQ ID NOs: 1-50.
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公开(公告)号：US20150292011A1
公开(公告)日：2015-10-15
申请号：US14418800
申请日：2013-06-05
发明人： Shenghui Li , Qiang Feng , Zhuye Jie , Dongya Zhang , Junjie Qin , Jun Wang , Jian Wang , Huanming Yang
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , G06F19/22 , G16H50/20
摘要： Biomarkers for diabetes and usages thereof are provided. And the biomarkers are nucleotides having polynucleotide sequences defined in SEQ ID NOs: 1-50.
摘要翻译： 提供糖尿病生物标记物及其用途。 并且生物标志物是具有SEQ ID NO：1-50中定义的多核苷酸序列的核苷酸。
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公开(公告)号：US20180339034A1
公开(公告)日：2018-11-29
申请号：US15755926
申请日：2016-03-21
申请人： BGI Shenzhen
发明人： Qiang Feng , Wenbin Xue , Yuanqiang Zou , Xiaoping Li , Chuan Liu , Xin Li
摘要： Provided is an application of Butyribacter intestini in the treatment and prevention of obesity and obesity-related diseases. Also provided is a composition for the treatment and prevention of obesity and obesity-related diseases.
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公开(公告)号：US20180334703A1
公开(公告)日：2018-11-22
申请号：US15546264
申请日：2015-01-27
申请人： BGI SHENZHEN
发明人： Qiang Feng , Mo Han , Liang Xiao , Jun Wang
IPC分类号： C12Q1/6806 , A01N1/02 , C07D213/16
CPC分类号： C12Q1/6806 , A01N1/0205 , C07D213/16 , C07D213/20 , C12N9/96
摘要： Disclosed are a stabilizer for storage of a biological sample, a composition for storage of a nucleic acid and/or a polypeptide in a biological sample under non-freezing conditions, a kit comprising the composition, a mixture comprising the composition and a biological sample, and a method for storage of a nucleic acid and/or a polypeptide in a biological sample under non-freezing conditions. The integrity and stability of the nucleic acid and/or polypeptide in a biological sample can be stored for a long time under non-freezing conditions by using the stabilizer according to the invention, and therefore the stabilizer has a good application prospect.
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公开(公告)号：US11033614B2
公开(公告)日：2021-06-15
申请号：US15755926
申请日：2016-03-21
申请人： BGI Shenzhen
发明人： Qiang Feng , Wenbin Xue , Yuanqiang Zou , Xiaoping Li , Chuan Liu , Xin Li
IPC分类号： A61K39/08 , C12N1/20 , A61K35/741 , A61K9/00
摘要： Provided is an application of Butyribacter intestini in the treatment and prevention of obesity and obesity-related diseases. Also provided is a composition for the treatment and prevention of obesity and obesity-related diseases.
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公开(公告)号：US20210170009A1
公开(公告)日：2021-06-10
申请号：US17174053
申请日：2021-02-11
申请人： BGI Shenzhen
发明人： Qiang Feng , Wenbin Xue , Yuanqiang Zou , Xiaoping Li , Chuan Liu , Xin Li
IPC分类号： A61K39/08 , C12N1/20 , A61K9/00 , A61K35/741
摘要： Provided is an application of Butyribacter intestini in the treatment and prevention of obesity-related diseases. Also provided is a composition for the treatment and prevention of obesity and obesity-related diseases.
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公开(公告)号：US10883146B2
公开(公告)日：2021-01-05
申请号：US15515367
申请日：2015-07-07
申请人： BGI SHENZHEN
发明人： Qiang Feng , Dongya Zhang , Huijue Jia , Donghui Wang , Jun Wang
IPC分类号： C12Q1/689 , C12Q1/6883 , A61K35/747 , C07K14/335
摘要： Biomarkers and methods for predicting risk of a disease in particular RA are provided. Sequences of DNA are obtained. The DNA may be extracted from a sample that is collected from a subject. A relative abundance of a biomarker is then calculated based on the sequences of the DNA. The biomarker comprises a DNA sequence in a genome of Lactobacillus salivarius. A probability of the subject having the disease is obtained based on the relative abundance.
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