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1.发明授权公开(公告)号：US11458467B2
公开(公告)日：2022-10-04
申请号：US16532766
申请日：2019-08-06
IPC分类号： B01L3/02 , G01N33/543 , B01L3/00
摘要： A microfluidic probe head is provided. The microfluidic probe head comprises a processing surface. The processing surface has a first and second aperture and a fluid injection channel, which leads to the first aperture. The microfluidic probe head comprises also a first fluid aspiration channel which leads to the second aperture. Thereby, the second aperture forms a slot in the processing surface. Furthermore, a microfluidic probe may be provided comprising the microfluidic probe head.
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公开(公告)号：US20230372926A1
公开(公告)日：2023-11-23
申请号：US18227218
申请日：2023-07-27
发明人： Lorenzo Franco Teodoro Petrini , Iago Pereiro Pereiro , Robert Dean Lovchik , Anna Fomitcheva Khartchenko , Anel Zulji , Govind Kaigala , Cristina Boero , Olivier Michel Christian Noël , Christophe Guex , Stéphane Guillod , Aurélie Bolon
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01L13/02 , B01L2300/14 , B01L2200/0642
摘要： A method comprises providing a microfluidic device including a reservoir; an injection nozzle at the bottom of the reservoir, the injection nozzle being wider at its top than at its bottom; an injection channel below the injection nozzle; and a microfluidic channel below the injection channel. The method further comprises placing fluid in the reservoir, and allowing the fluid to passively flow through the injection nozzle and the injection channel.
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公开(公告)号：US11130125B2
公开(公告)日：2021-09-28
申请号：US16532825
申请日：2019-08-06
发明人： Govind Kaigala , Robert Dean Lovchik , Anna Fomitcheva Khartchenko , Iago Pereiro Pereiro , Lorenzo Franco Teodoro Petrini
IPC分类号： B01L3/00
摘要： A method for manufacturing a fluidic device is provided. The method comprises providing a capillary, providing a structure having a fluidic channel and an opening, reducing an outer diameter of a portion of the capillary to be smaller than the opening of the structure. Furthermore, the method comprises inserting, at least partly, the portion of the capillary through the opening of the structure into the fluidic channel and applying heat to the structure to expand the inserted portion of the capillary to fit the capillary to the structure.
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公开(公告)号：US20230364614A1
公开(公告)日：2023-11-16
申请号：US18227212
申请日：2023-07-27
发明人： Iago Pereiro Pereiro , Anna Fomitcheva Khartchenko , Robert Dean Lovchik , Govind Kaigala , Lorenzo Franco Teodoro Petrini , Anel Zulji , Frédéric M. Buffière , Johann Guégan , Eliane Rivalin , Sylvie Villard-Saussine
IPC分类号： B01L3/00
CPC分类号： B01L3/502784 , B01L3/502746 , B01L2200/027 , B01L2300/0832 , B01L2400/0487 , B01L2400/0622
摘要： In one implementation, a microfluidic probe has a non-planar processing surface and an inlet aperture. The shape of the surface may be selected to produce a specific velocity gradient profile across a surface onto which fluid is deposited using the microfluidic probe, for example a constant velocity gradient or a velocity gradient that decreases linearly with distance from the inlet aperture. The microfluidic probe may define and overflow notch in a perimeter edge of the processing surface.
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公开(公告)号：US20210039100A1
公开(公告)日：2021-02-11
申请号：US16532798
申请日：2019-08-06
摘要： A microfluidic device may be provided. The microfluidic device comprises a processing surface having an aperture. The microfluidic device comprises a liquid ejection channel. The liquid ejection channel guides to the aperture. The microfluidic device comprises a first liquid injection channel guiding to the liquid ejection channel. The first liquid injection channel has a first end and a second end and is arranged to provide a fluid flow from the first end to the second end. At least a portion of the first liquid injection channel is closer to the processing surface than (both) the first and second ends to sediment particles.
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6.发明申请公开(公告)号：US20210039083A1
公开(公告)日：2021-02-11
申请号：US16532766
申请日：2019-08-06
IPC分类号： B01L3/02 , B01L3/00 , G01N33/543
摘要： A microfluidic probe head is provided. The microfluidic probe head comprises a processing surface. The processing surface has a first and second aperture and a fluid injection channel, which leads to the first aperture. The microfluidic probe head comprises also a first fluid aspiration channel which leads to the second aperture. Thereby, the second aperture forms a slot in the processing surface. Furthermore, a microfluidic probe may be provided comprising the microfluidic probe head.
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公开(公告)号：US12128408B2
公开(公告)日：2024-10-29
申请号：US16532798
申请日：2019-08-06
CPC分类号： B01L3/502761 , B01D21/283 , B03C1/288 , B03C1/30 , B03C5/005 , G01N27/44791 , B01L2200/0647 , B01L2300/0877 , B01L2300/12 , B01L2300/123 , B01L2400/0424 , B01L2400/043 , B03C2201/18 , B03C2201/20
摘要： A microfluidic device may be provided. The microfluidic device comprises a processing surface having an aperture. The microfluidic device comprises a liquid ejection channel. The liquid ejection channel guides to the aperture. The microfluidic device comprises a first liquid injection channel guiding to the liquid ejection channel. The first liquid injection channel has a first end and a second end and is arranged to provide a fluid flow from the first end to the second end. At least a portion of the first liquid injection channel is closer to the processing surface than (both) the first and second ends to sediment particles.
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公开(公告)号：US20210039092A1
公开(公告)日：2021-02-11
申请号：US16532825
申请日：2019-08-06
发明人： Govind Kaigala , Robert Dean Lovchik , Anna Fomitcheva Khartchenko , Iago Pereiro Pereiro , Lorenzo Franco Teodoro Petrini
IPC分类号： B01L3/00
摘要： A method for manufacturing a fluidic device is provided. The method comprises providing a capillary, providing a structure having a fluidic channel and an opening, reducing an outer diameter of a portion of the capillary to be smaller than the opening of the structure. Furthermore, the method comprises inserting, at least partly, the portion of the capillary through the opening of the structure into the fluidic channel and applying heat to the structure to expand the inserted portion of the capillary to fit the capillary to the structure.
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