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1.发明授权公开(公告)号：US12138274B2
公开(公告)日：2024-11-12
申请号：US17290912
申请日：2019-11-08
Inventor： Hanjun Wang , Dong Wang , Thomas Nicholas , Michael Lankhorst , Steven Lisco , Irving Zucker , Lie Gao , Juan Hong
IPC: A61K31/65 , A61K9/00 , A61K31/573 , A61K45/06 , A61P9/14
Abstract: Compositions and methods for the treatment of peripheral artery disease and cardiopulmonary diseases or disorders are provided. In accordance with the instant invention, methods of inhibiting, treating, and/or preventing peripheral artery disease or symptoms associated therewith are provided. In a particular embodiment, the methods inhibit, treat, and/or prevent claudication associated with peripheral artery disease.
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2.发明授权公开(公告)号：US11583541B2
公开(公告)日：2023-02-21
申请号：US17188309
申请日：2021-03-01
Inventor： Dong Wang , Fang Yuan , Zhenshan Jia , Xiaobei Wang
Abstract: Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.
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3.发明申请公开(公告)号：US20210252018A1
公开(公告)日：2021-08-19
申请号：US17188309
申请日：2021-03-01
Inventor： Dong Wang , Fang Yuan , Zhenshan Jia , Xiaobei Wang
Abstract: Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.
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4.发明申请公开(公告)号：US20180318318A1
公开(公告)日：2018-11-08
申请号：US15775647
申请日：2016-11-12
Inventor： Dong Wang , Fang Yuan , Zhenshan Jia , Xiaobei Wang
CPC classification number: A61K31/57 , A61K9/1075 , A61K47/10 , A61K47/34 , C07J41/0005 , C07J41/0016 , C07J51/00
Abstract: Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.
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公开(公告)号：US20150290106A1
公开(公告)日：2015-10-15
申请号：US14436609
申请日：2013-10-17
Inventor： Dong Wang , Zhenshan Jia , Chen Fu
CPC classification number: A61K8/55 , A61K8/34 , A61K31/045 , A61K31/683 , A61K2800/592 , A61Q11/00 , A61Q11/02 , A61K2300/00
Abstract: Compositions and methods for targeting agents, particularly a flavoring, fragrant, or cooling agent such as menthol, to tooth are provided.
Abstract translation: 提供了将针对试剂，特别是调味香料或冷却剂如薄荷醇给牙齿的组合物和方法。
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Patent Agency Ranking
公开(公告)号：US20150202313A1
公开(公告)日：2015-07-23
申请号：US14424737
申请日：2013-09-03
Applicant: New York Society for The Ruptured and Crippled Maintaining The Hospital for Special Surgery , Board of Regents of the University of Nebraska
Inventor： Dong Wang , Zhenshan Jia , Yijia Zhang , Steven R. Goldring , Aaron Daluiski
IPC: A61K47/48 , A61K49/00 , A61K31/366
CPC classification number: A61K47/48215 , A61K31/366 , A61K31/74 , A61K47/55 , A61K47/60 , A61K47/6907 , A61K49/00
Abstract: Methods and compositions for treating bone disorders are disclosed.
Abstract translation: 公开了用于治疗骨骼疾病的方法和组合物。
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7.发明授权公开(公告)号：US12011450B2
公开(公告)日：2024-06-18
申请号：US18172024
申请日：2023-02-21
Inventor： Dong Wang , Fang Yuan , Zhenshan Jia , Xiaobei Wang
CPC classification number: A61K31/57 , A61K9/1075 , A61K47/10 , A61K47/34 , C07J41/0005 , C07J41/0016 , C07J51/00
Abstract: Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.
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公开(公告)号：US20220218571A1
公开(公告)日：2022-07-14
申请号：US17604659
申请日：2020-04-20
Inventor： Dong Wang , Yosif Almoshari , Rongguo Ren , Ningrong Chen
Abstract: Disclosed is a hydrogel drug delivery composition comprising a therapeutic agent and a poloxamer, wherein the poloxamer is modified to be capable of adhering to a surface of bones or teeth, and wherein the poloxamer is modified by pyrophosphate, bisphosphonates, acidic peptides or tetracycline and its derivatives.
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9.发明申请公开(公告)号：US20210386764A1
公开(公告)日：2021-12-16
申请号：US17290912
申请日：2019-11-08
Inventor： Hanjun Wang , Dong Wang , Thomas Nicholas , Michael Lankhorst , Steven Lisco , Irving Zucker , Lie Gao , Juan Hong
IPC: A61K31/65 , A61K31/573 , A61P9/14 , A61K9/00 , A61K45/06
Abstract: Compositions and methods for the treatment of peripheral artery disease and cardiopulmonary diseases or disorders are provided. In accordance with the instant invention, methods of inhibiting, treating, and/or preventing peripheral artery disease or symptoms associated therewith are provided. In a particular embodiment, the methods inhibit, treat, and/or prevent claudication associated with peripheral artery disease.
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10.发明申请公开(公告)号：US20200085842A1
公开(公告)日：2020-03-19
申请号：US16694722
申请日：2019-11-25
Inventor： Dong Wang , Fang Yuan , Zhenshan Jia , Xiaobei Wang
Abstract: Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.
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