公开(公告)号：US20240034741A1

公开(公告)日：2024-02-01

申请号：US18377544

申请日：2023-10-06

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： HONGXIA ZENG ,  JONATHAN PASCAL CHAKY ,  YEN-LANE CHEN

IPC: C07D493/16

CPC classification number: C07D493/16 ,  C07B2200/13

Abstract: Methods are disclosed including methods for crystallizing a material such as a drug. An example method may include combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension. The method may also include incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.

公开(公告)号：US20160262917A1

公开(公告)日：2016-09-15

申请号：US15066649

申请日：2016-03-10

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： JOHN J. CHEN ,  STEVEN L. KANGAS ,  YEN-LANE CHEN ,  HONGXIA ZENG ,  RAGHAV GOEL

IPC: A61F2/90 ,  A61L31/14 ,  B29C35/08 ,  A61L2/00 ,  B29C47/00 ,  B29C35/02 ,  A61L31/06 ,  A61F2/04

CPC classification number: A61F2/90 ,  A61F2/04 ,  A61F2210/0076 ,  A61F2230/0069 ,  A61F2240/001 ,  A61L2/007 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148 ,  A61L2400/18 ,  B29C35/0266 ,  B29C35/0805 ,  B29C35/0866 ,  B29C48/0022 ,  B29C48/022 ,  B29C48/09 ,  B29C2035/0827 ,  B29C2035/0877 ,  B29K2995/006 ,  B29L2023/22 ,  B29L2031/7546 ,  C08L67/04

Abstract: A medical device includes a tubular network of struts including a bioerodible polymer. The tubular network can include a plurality of bands and a plurality of connector struts. Each band can include a plurality of peaks between adjacent band struts. Each band can be connected to one or more adjacent bands by at least two connector struts at a plurality of connector intersections. The bioerodible polymer can include a plurality of polymer chains functionalized with a photo active group.

Abstract translation: 医疗装置包括支柱的管状网络，其包括生物可蚀解聚合物。 管状网络可以包括多个带和多个连接器支柱。 每个带可以包括相邻带支柱之间的多个峰。 每个带可以通过在多个连接器交叉点处的至少两个连接器支柱连接到一个或多个相邻带。 生物可腐蚀的聚合物可以包括多个用光活性基团官能化的聚合物链。

公开(公告)号：US20210300938A1

公开(公告)日：2021-09-30

申请号：US17200434

申请日：2021-03-12

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： HONGXIA ZENG ,  JONATHAN PASCAL CHAKY ,  YEN-LANE CHEN

IPC: C07D493/16

Abstract: Methods are disclosed including methods for crystallizing a material such as a drug. An example method may include combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension. The method may also include incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.

公开(公告)号：US20200038559A1

公开(公告)日：2020-02-06

申请号：US16526912

申请日：2019-07-30

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： HONGXIA ZENG ,  JONATHAN PASCAL CHAKY ,  MING DANG ,  YEN-LANE CHEN

IPC: A61L29/08 ,  A61K47/34 ,  A61K47/38 ,  A61K31/436 ,  A61L29/16

Abstract: In one aspect, the present disclosure pertains to elutable coating compositions that comprise an excipient comprising a bio-degradable or bio-stable polymer selected from a poly(lactic-co-glycolic acid) (PLGA) or methyl cellulose (MCC), a binding agent; a therapeutic agent. In some embodiments, the elutable coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently dried, thereby forming an elutable coating on the substrate.

公开(公告)号：US20180344248A1

公开(公告)日：2018-12-06

申请号：US15995564

申请日：2018-06-01

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： HONGXIA ZENG ,  DONGMING HOU ,  HONG CAO ,  BIN MI

IPC: A61B5/00 ,  A61M5/00 ,  A61B5/053 ,  A61M1/00 ,  A61M25/10

CPC classification number: A61B5/01 ,  A61B5/0538 ,  A61B5/1032 ,  A61B5/6853 ,  A61B5/746 ,  A61B6/481 ,  A61B6/504 ,  A61M1/0025

Abstract: Medical systems and methods for making and using medical systems are disclosed. An example may include a catheter, a sensor, and a pump configured to remove contrast from a vascular system. The catheter may have a lumen through which the pump may suction contrast. The sensor may be positioned distal of and upstream of a distal end of the aspiration lumen and the pump may initiate suction through the lumen in response to a value sensed by the sensor reaching and/or going beyond a threshold value. The catheter may include an expandable member configured to expand in response to a value sensed by the sensor reaching and/or going beyond a threshold value. The sensor may be supported by a distal extension of the catheter or an elongate member configured to extend through and/or along the catheter to position the sensor distal of the distal end of the aspiration lumen.