公开(公告)号：US20230271946A1

公开(公告)日：2023-08-31

申请号：US18134564

申请日：2023-04-13

Applicant: Bristol-Myers Squibb Company

Inventor： Ke Chen ,  Joerg Deerberg ,  Dong Lin ,  Michael Dummeldinger ,  Bahar Inankur ,  Sergei Kolotuchin ,  Jun Li ,  Amanda J. Rogers ,  Victor W. Rosso ,  Eric M. Simmons ,  Maxime C.D. Soumeillant ,  Daniel S. Treitler ,  Jianji Wang ,  Bin Zheng ,  Michael J. Smith ,  Neil A. Strotman ,  Steven Tymonko ,  Tamas Benkovics

IPC: C07D403/12 ,  C07C211/09 ,  C07D237/24 ,  C07D249/08

CPC classification number: C07D403/12 ,  C07C211/09 ,  C07D237/24 ,  C07D249/08 ,  C07B2200/13

Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-5N-(methyl-d3)pyridazine-3-carboxamide of the formula:




Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

公开(公告)号：US09249171B2

公开(公告)日：2016-02-02

申请号：US14402231

申请日：2013-05-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adrian Ortiz ,  Tamas Benkovics ,  Zhongping Shi ,  Prashant P. Deshpande ,  Zhiwei Guo ,  David R. Kronenthal ,  Chris Sfouggatakis

IPC: C07H15/20 ,  C07H19/06 ,  C12P19/38 ,  C07D309/10 ,  C07D407/04 ,  C07D307/20

CPC classification number: C07H15/20 ,  C07D307/20 ,  C07D309/10 ,  C07D407/04 ,  C07H19/06 ,  C12P19/385

Abstract: A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on.

Abstract translation: 制备式I化合物的方法利用起始化合物以及稍后的亚硫酰亚胺和亚砜工艺步骤。

公开(公告)号：US20210107897A1

公开(公告)日：2021-04-15

申请号：US17131718

申请日：2020-12-22

Applicant: Bristol-Myers Squibb Company

Inventor： Ke Chen ,  Joerg Deerberg ,  Dong Lin ,  Michael Dummeldinger ,  Bahar Inankur ,  Sergei Kolotuchin ,  Jun Li ,  Amanda J. Rogers ,  Victor W. Rosso ,  Eric M. Simmons ,  Maxime C.D. Soumeillant ,  Daniel S. Treitler ,  Jianji Wang ,  Bin Zheng ,  Michael J. Smith ,  Neil A. Strotman ,  Steven Tymonko ,  Tamas Benkovics

IPC: C07D403/12 ,  C07C211/09 ,  C07D237/24 ,  C07D249/08

Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

公开(公告)号：US10899745B2

公开(公告)日：2021-01-26

申请号：US16498442

申请日：2018-03-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ke Chen ,  Joerg Deerberg ,  Dong Lin ,  Michael Dummeldinger ,  Bahar Inankur ,  Sergei Kolotuchin ,  Jun Li ,  Amanda J. Rogers ,  Victor W. Rosso ,  Eric M. Simmons ,  Daniel S. Treitler ,  Jianji Wang ,  Michael J. Smith ,  Tamas Benkovics

IPC: C07D403/12 ,  C07C211/09 ,  C07D237/24 ,  C07D249/08

Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

公开(公告)号：US20160130260A1

公开(公告)日：2016-05-12

申请号：US14896995

申请日：2014-06-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adrian Ortiz ,  Tamas Benkovics ,  Martin D. Eastgate

IPC: C07D407/04

CPC classification number: C07D407/04 ,  C07C315/04 ,  C07C319/14 ,  C07C319/20 ,  C07C317/18 ,  C07C323/65

Abstract: Tert-butyl sulphoxide method for producing festinavir is set forth.

Abstract translation: 阐述了用于制备节食者的叔丁基亚砜方法。

公开(公告)号：US20150140610A1

公开(公告)日：2015-05-21

申请号：US14402231

申请日：2013-05-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adrian Ortiz ,  Tamas Benkovics ,  Zhongping Shi ,  Prashant P. Deshpande ,  Zhiwei Guo ,  David R. Kronenthal ,  Chris Sfouggatakis

IPC: C07H15/20 ,  C07H19/06 ,  C12P19/38

CPC classification number: C07H15/20 ,  C07D307/20 ,  C07D309/10 ,  C07D407/04 ,  C07H19/06 ,  C12P19/385

Abstract: A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on.

Abstract translation: 制备式I化合物的方法利用起始化合物以及稍后的亚硫酰亚胺和亚砜工艺步骤。