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公开(公告)号：US20190099506A1
公开(公告)日：2019-04-04
申请号：US16148604
申请日：2018-10-01
Applicant: Bristol-Myers Squibb Company
Inventor： Michael J. Smith , Haiying Tang , Paul E. Morin , Harold J. Malone
Abstract: Deuterated polymer-biomolecule conjugates and the synthesis and use of deuterated polymer-biomolecule conjugates for detecting the location of specific molecules, e.g., cell surface molecules, in a subject, and for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.
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公开(公告)号：US11623013B2
公开(公告)日：2023-04-11
申请号：US17093941
申请日：2020-11-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael J. Smith , Haiying Tang , Paul E. Morin , Harold J. Malone , Luciano Mueller
Abstract: Deuterated polymer-biomolecule conjugates and the synthesis and use of deuterated polymer-biomolecule conjugates for detecting the location of specific molecules, e.g., cell surface molecules, in a subject, and for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.
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公开(公告)号：US20210107897A1
公开(公告)日：2021-04-15
申请号：US17131718
申请日：2020-12-22
Applicant: Bristol-Myers Squibb Company
Inventor： Ke Chen , Joerg Deerberg , Dong Lin , Michael Dummeldinger , Bahar Inankur , Sergei Kolotuchin , Jun Li , Amanda J. Rogers , Victor W. Rosso , Eric M. Simmons , Maxime C.D. Soumeillant , Daniel S. Treitler , Jianji Wang , Bin Zheng , Michael J. Smith , Neil A. Strotman , Steven Tymonko , Tamas Benkovics
IPC: C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08
Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.
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公开(公告)号：US10899745B2
公开(公告)日：2021-01-26
申请号：US16498442
申请日：2018-03-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ke Chen , Joerg Deerberg , Dong Lin , Michael Dummeldinger , Bahar Inankur , Sergei Kolotuchin , Jun Li , Amanda J. Rogers , Victor W. Rosso , Eric M. Simmons , Daniel S. Treitler , Jianji Wang , Michael J. Smith , Tamas Benkovics
IPC: C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08
Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.
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Patent Agency Ranking
公开(公告)号：US20230271946A1
公开(公告)日：2023-08-31
申请号：US18134564
申请日：2023-04-13
Applicant: Bristol-Myers Squibb Company
Inventor： Ke Chen , Joerg Deerberg , Dong Lin , Michael Dummeldinger , Bahar Inankur , Sergei Kolotuchin , Jun Li , Amanda J. Rogers , Victor W. Rosso , Eric M. Simmons , Maxime C.D. Soumeillant , Daniel S. Treitler , Jianji Wang , Bin Zheng , Michael J. Smith , Neil A. Strotman , Steven Tymonko , Tamas Benkovics
IPC: C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08
CPC classification number: C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08 , C07B2200/13
Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-5N-(methyl-d3)pyridazine-3-carboxamide of the formula:
Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.-
公开(公告)号：US20230265050A1
公开(公告)日：2023-08-24
申请号：US18003232
申请日：2021-06-22
Applicant: Bristol-Myers Squibb Company
Inventor： Gregory Louis Beutner , Ronald Carrasquillo-Flores , Federico Lora Gonzalez , Michael J. Smith
IPC: C07C237/22 , C07C231/02
CPC classification number: C07C237/22 , C07C231/02
Abstract: The present application provides processes for synthesizing cationic lipids of Formula I useful in the synthesis of fat-soluble compositions for targeting and enhancing activity of therapeutic molecules, including siRNA.
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公开(公告)号：US20230250056A1
公开(公告)日：2023-08-10
申请号：US18003228
申请日：2021-06-22
Applicant: Bristol-Myers Squibb Company
Inventor： Gregory Louis Beutner , Federico Lora Gonzalez , Patricia Y. Cho , Michael J. Smith
IPC: C07C323/41 , C07C319/14
CPC classification number: C07C323/41 , C07C319/14
Abstract: The present application provides processes for synthesizing lipids of Formula I useful in the synthesis of fat-soluble compounds for targeting and enhancing activity of therapeutic molecules, including siRNA.
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公开(公告)号：US20230075422A1
公开(公告)日：2023-03-09
申请号：US17787461
申请日：2020-12-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ping XU , Anurag Khetan , Rodney Lawrence Parsons , Michael J. Smith , Michael Anthony Schmidt
Abstract: The present invention provides inhibitors of fucosylation during protein expression from mammalian cells. The inhibitors are derived from rhamnose and act by inhibition of GDP-mannose 4,6-dehydratase (GMD). The invention further provides methods of making proteins with reduced level of fucosylation, such as antibodies and antibodies made by the methods of the present invention. Such hypofucosylated or nonfucosylated antibodies may find use, for example, in treatment of human disease in which is it therapeutically eneficial to direct antibody dependent cellular cytotoxicity (ADCC) mediated killing of cells expressing the antibody target on their surface, for example in depletion of Tregs in cancer patients using a hypofucosylated or nonfucosylated anti-CTLA-4 antibody.
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公开(公告)号：US20230250053A1
公开(公告)日：2023-08-10
申请号：US18003227
申请日：2021-06-22
Applicant: Bristol-Myers Squibb Company
Inventor： Zhongping Shi , Yichen Tan , Federico Lora Gonzalez , Ronald Carrasquillo-Flores , Michael J. Smith
IPC: C07C271/20 , C07C233/38 , C07C269/04 , C07C231/14
CPC classification number: C07C271/20 , C07C233/38 , C07C269/04 , C07C231/14
Abstract: The present application provides processes for synthesizing targeting molecules of Formula (I) comprising a retinoid moiety useful in the synthesis of fat-soluble compounds for targeting and enhancing activity of therapeutic molecules, including siRNA.
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