公开(公告)号：US20070275912A1

公开(公告)日：2007-11-29

申请号：US11643464

申请日：2006-12-21

申请人： Balkrishen Bhat ,  Anne Eldrup ,  Thazha Prakash ,  Phillip Cook ,  Robert LeFemina ,  Amy Simcoe ,  Carrie Rutkowski ,  Mario Valenciano

发明人： Balkrishen Bhat ,  Anne Eldrup ,  Thazha Prakash ,  Phillip Cook ,  Robert LeFemina ,  Amy Simcoe ,  Carrie Rutkowski ,  Mario Valenciano

IPC分类号： A61K31/706 ,  A61K31/7076 ,  A61P31/14 ,  C07H19/06 ,  C07H19/16

CPC分类号： C07H19/16 ,  A61K9/4858 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/21 ,  A61K45/06 ,  C07D473/00 ,  C07D487/04 ,  C07H19/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12 ,  C07H19/14 ,  C07H19/20 ,  Y02P20/582 ,  A61K2300/00

摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。 还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

公开(公告)号：US20050272676A1

公开(公告)日：2005-12-08

申请号：US11200499

申请日：2005-08-09

申请人： Balkrishen Bhat ,  Anne Eldrup ,  Thazha Prakash ,  Phillip Cook ,  Robert LaFemina ,  Amy Simcoe ,  Carrie Rutkowski ,  Mario Valenciano

发明人： Balkrishen Bhat ,  Anne Eldrup ,  Thazha Prakash ,  Phillip Cook ,  Robert LaFemina ,  Amy Simcoe ,  Carrie Rutkowski ,  Mario Valenciano

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/70 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/7105 ,  A61K31/712 ,  A61K38/21 ,  A61K45/00 ,  A61K45/06 ,  A61P1/16 ,  A61P31/14 ,  A61P43/00 ,  C07D473/00 ,  C07D487/02 ,  C07H20060101 ,  C07H19/00 ,  C07H19/04 ,  C07H19/048 ,  C07H19/06 ,  C07H19/067 ,  C07H19/09 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/167 ,  C07H19/173 ,  C07H19/19 ,  C07H19/20 ,  C12N20060101

CPC分类号： C07H19/16 ,  A61K9/4858 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/21 ,  A61K45/06 ,  C07D473/00 ,  C07D487/04 ,  C07H19/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12 ,  C07H19/14 ,  C07H19/20 ,  Y02P20/582 ,  A61K2300/00

摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。 还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

公开(公告)号：US20060205686A1

公开(公告)日：2006-09-14

申请号：US11236224

申请日：2005-09-27

申请人： Balkrishen Bhat ,  Anne Eldrup ,  Thazha Prakash ,  Phillip Cook ,  Steven Carroll ,  Malcolm MacCoss ,  David Olsen

发明人： Balkrishen Bhat ,  Anne Eldrup ,  Thazha Prakash ,  Phillip Cook ,  Steven Carroll ,  Malcolm MacCoss ,  David Olsen

IPC分类号： A61K31/7056 ,  A61K31/7076

CPC分类号： C07H19/16 ,  A61K9/4858 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/21 ,  A61K45/06 ,  C07D473/00 ,  C07D487/04 ,  C07H19/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12 ,  C07H19/14 ,  C07H19/20 ,  Y02P20/582 ,  A61K2300/00

摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

公开(公告)号：US20060264390A1

公开(公告)日：2006-11-23

申请号：US11496338

申请日：2006-07-31

申请人： Anne Eldrup ,  Marija Prhavc ,  Phillip Cook ,  Steven Carroll ,  David Olsen

发明人： Anne Eldrup ,  Marija Prhavc ,  Phillip Cook ,  Steven Carroll ,  David Olsen

IPC分类号： A61K31/7076 ,  C07H19/00

CPC分类号： C07H19/16 ,  A61K9/4858 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/21 ,  A61K45/06 ,  C07D473/00 ,  C07D487/04 ,  C07H19/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12 ,  C07H19/14 ,  C07H19/20 ,  Y02P20/582 ,  A61K2300/00

摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

公开(公告)号：US20050171052A1

公开(公告)日：2005-08-04

申请号：US10989064

申请日：2004-11-15

申请人： Phillip Cook ,  George Zima ,  Danessa Sexton

发明人： Phillip Cook ,  George Zima ,  Danessa Sexton

IPC分类号： A23L2/52 ,  A23L2/62 ,  A23L29/00 ,  A61K8/60 ,  A61K31/7024 ,  A61Q19/00

CPC分类号： A23L2/52 ,  A23L2/62 ,  A61K8/60 ,  A61Q19/00

摘要： The present invention provides a solid sucrose acetate isobutyrate formulation having improved handling characteristics.

摘要翻译： 本发明提供具有改进的处理特性的固体蔗糖醋酸酯异丁酸酯制剂。

公开(公告)号：US20050053712A1

公开(公告)日：2005-03-10

申请号：US10844074

申请日：2004-05-12

申请人： George Zima ,  Terry Oldfield ,  Suzanne Dobbs ,  Phillip Cook ,  Charles Kelly ,  Mary Crow ,  Craig Hoyme

发明人： George Zima ,  Terry Oldfield ,  Suzanne Dobbs ,  Phillip Cook ,  Charles Kelly ,  Mary Crow ,  Craig Hoyme

IPC分类号： A21D2/10 ,  A21D2/14 ,  A23D7/005 ,  A23D7/01 ,  A23D7/015 ,  A23D9/013 ,  A23L1/24 ,  A23L1/30 ,  A23L2/52 ,  A61K8/92 ,  A61Q19/00 ,  B01D1/06 ,  B01D1/22 ,  B01D1/26 ,  B01D3/10 ,  B01D3/12 ,  B01D3/14 ,  C07C7/04 ,  C07J9/00 ,  C11B11/00 ,  C11B13/00 ,  C07D311/04

CPC分类号： C07C7/04 ,  A21D2/10 ,  A21D2/14 ,  A23D7/0053 ,  A23D7/0056 ,  A23D7/011 ,  A23D7/013 ,  A23D7/015 ,  A23D9/013 ,  A23L2/52 ,  A23L27/60 ,  A23L33/105 ,  A23L33/11 ,  A61K8/922 ,  A61Q19/00 ,  A61Q19/001 ,  B01D1/065 ,  B01D1/22 ,  B01D1/222 ,  B01D1/26 ,  B01D3/10 ,  B01D3/12 ,  B01D3/14 ,  B01D3/143 ,  B01D3/146 ,  C07J9/00 ,  C11B11/00 ,  C11B13/00 ,  Y02W30/74

摘要： Disclosed is a process for the recovery of a phytolipid composition from a vegetable oil by-product. The phytolipid composition produced comprises squalene, phytosterols, mixed tocopherols and tocotrieneols, and vegetable wax and is useful as an emollient. The phytochemical composition may be applied directly to the skin to provide emolliency. Alternatively, the phytolipid composition may be formulated in various aqueous or anhydrous cosmetic compositions such as creams, lotions, gels, ointments, lip balms, sticks, or pencils for treatment of the skin and lips. The phytolipid composition also may be incorporated into foods, beverages, and nutraceuticals to provide health benefits.

摘要翻译： 公开了从植物油副产物中回收植脂油组合物的方法。 所生产的植物油脂组合物包括角鲨烯，植物甾醇，混合生育酚和邻苯三酚，以及植物蜡，并且可用作润肤剂。 植物化学成分可以直接施用于皮肤以提供润肤性。 或者，植物油脂组合物可以配制成各种水性或无水化妆品组合物，例如乳膏，洗剂，凝胶，软膏，唇膏，棒或铅笔，用于治疗皮肤和嘴唇。 植物油脂组合物还可以并入食品，饮料和营养品中以提供健康益处。

公开(公告)号：USD491874S1

公开(公告)日：2004-06-22

申请号：US29196342

申请日：2003-12-29

申请人： Phillip Cook

设计人： Phillip Cook

公开(公告)号：US20080032945A1

公开(公告)日：2008-02-07

申请号：US11764086

申请日：2007-06-15

申请人： Phillip Cook ,  Andrew Kawasaki

发明人： Phillip Cook ,  Andrew Kawasaki

IPC分类号： A61K31/7125

CPC分类号： C07H21/04 ,  A61K31/7125 ,  A61K38/00 ,  A61K48/00 ,  C07H19/04 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C07H23/00 ,  C07J43/003 ,  C12N9/0069 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/3125 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/33 ,  C12N2310/333 ,  C12N2310/336 ,  C12N2310/3521 ,  C12N2310/3523 ,  C12N2310/3527 ,  C12N2310/3531 ,  C12N2310/3533 ,  C12Q1/68 ,  C12Y113/11012

摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

摘要翻译： 提供组合物和方法用于治疗和诊断适于调节所选蛋白质生产的疾病。 根据优选实施方案，提供寡核苷酸和寡核苷酸类似物，其与所选择的RNA或DNA序列特异性杂交，其中核苷单元的2'-脱氧呋喃糖基部分中的至少一个被修饰。 提供了治疗各种病毒和其他致病因素引起的疾病。

公开(公告)号：US20070135363A1

公开(公告)日：2007-06-14

申请号：US11674954

申请日：2007-02-14

申请人： Phillip Cook ,  Gregory Ewing ,  Deborah Ewing ,  Yi Jin ,  John Lambert ,  Marija Prhavc ,  Vasanthankumar Rajappan ,  Vivek Rajwanshi ,  Kandasamy Sakthivel

发明人： Phillip Cook ,  Gregory Ewing ,  Deborah Ewing ,  Yi Jin ,  John Lambert ,  Marija Prhavc ,  Vasanthankumar Rajappan ,  Vivek Rajwanshi ,  Kandasamy Sakthivel

IPC分类号： A61K31/7052 ,  C07H19/04

CPC分类号： C07H19/04 ,  C07H19/23

摘要： Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.

摘要翻译： 含有三环碱基的核苷和核苷酸分别用于治疗感染性疾病和增殖性疾病，例如病毒感染或癌症。

公开(公告)号：US20060052589A1

公开(公告)日：2006-03-09

申请号：US11249578

申请日：2005-10-13

申请人： Michael Cyr ,  Max Weaver ,  Gerry Rhodes ,  Jason Pearson ,  Phillip Cook

发明人： Michael Cyr ,  Max Weaver ,  Gerry Rhodes ,  Jason Pearson ,  Phillip Cook

IPC分类号： C09B29/32 ,  C07D221/18

CPC分类号： C09B69/109 ,  C08F246/00 ,  C08F290/06 ,  C08F290/14 ,  C09B69/101 ,  C09B69/105 ,  C09B69/106

摘要： Disclosed are novel colorant compounds which contain one or more ethylenically-unsaturated (vinyl), photopolymerizable radicals which may be copolymewrized (or cured) with ethylenically-unsaturated monomers to produce colored compositions such as colored acrylic coatings and polymers, e.g., coatings and polymers produced from acrylate and methacrylate esters, colored polystyrenes, and similar colored polymeric materials derived from other ethylenically-unsaturated monomers. The present invention also pertains to processes for the preparation of certain of the photopolymerizable colorant compounds.