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公开(公告)号：US07642272B2
公开(公告)日：2010-01-05
申请号：US10803577
申请日：2004-03-18
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D213/80 , C07C317/14 , C07C317/22 , C07C317/36 , C07C2601/02 , C07D209/30 , C07D211/54 , C07D213/71 , C07D213/89 , C07D239/38 , C07D295/205 , C07D307/64 , C07D333/34 , C07D401/12 , C07D405/12 , C07D493/08
摘要： There are disclosed compounds of the formula I a pharmaceutically acceptable salt or solvate of the compound, which exhibit anti-inflammatory and immunomodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds.
摘要翻译： 公开了式I的化合物的化合物的药学上可接受的盐或溶剂化物，其表现出抗炎和免疫调节活性。 还公开了含有所述化合物的药物组合物。
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公开(公告)号：US07067539B2
公开(公告)日：2006-06-27
申请号：US10214897
申请日：2002-08-07
申请人： Joseph A. Kozlowski , Neng-Yang Shih , Brian J. Lavey , Razia K. Rizvi , Bandarpalle B. Shankar , James M. Spitler , Ling Tong , Ronald L. Wolin , Michael K. Wong
发明人： Joseph A. Kozlowski , Neng-Yang Shih , Brian J. Lavey , Razia K. Rizvi , Bandarpalle B. Shankar , James M. Spitler , Ling Tong , Ronald L. Wolin , Michael K. Wong
IPC分类号： A61K31/444 , A61K31/435 , C07D213/70 , C07D213/71 , C07D213/89
CPC分类号： C07D213/70 , C07C31/24 , C07C317/22 , C07C317/32 , C07C317/36 , C07C317/44 , C07C323/41 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D213/71 , C07D213/74 , C07D213/89 , C07D215/36 , C07D233/42 , C07D233/84 , C07D239/38 , C07D307/64 , C07D333/20 , C07D333/34 , C07D333/38
摘要： The invention relates to compounds of the formula a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit anti-inflammatory and immunodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds and methods of using the compounds for the treatment of various diseases and conditions.
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公开(公告)号：US07750158B2
公开(公告)日：2010-07-06
申请号：US11157510
申请日：2005-06-21
申请人： Bandarpalle B. Shankar , Eric Gilbert , Razia K. Rizvi , Chunli Huang , Joseph A. Kozlowski , Stuart McCombie , Neng-Yang Shih
发明人： Bandarpalle B. Shankar , Eric Gilbert , Razia K. Rizvi , Chunli Huang , Joseph A. Kozlowski , Stuart McCombie , Neng-Yang Shih
IPC分类号： C07D221/00 , A61K31/44
CPC分类号： C07D221/20 , C07D209/52 , C07D401/12 , C07D471/08
摘要： Compounds of Formula I: and/or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions containing such compounds exhibit anti-inflammatory and immunomodulatory activity, and can be effective in treating cancer and inflammatory, immunomodulatory or respiratory diseases or conditions.
摘要翻译： 式I化合物和/或其药学上可接受的盐，溶剂化物或前药，或含有这些化合物的药物组合物表现出抗炎和免疫调节活性，并且可有效治疗癌症和炎症，免疫调节或呼吸系统疾病或病症。
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公开(公告)号：US07507767B2
公开(公告)日：2009-03-24
申请号：US10072354
申请日：2002-02-06
申请人： Joseph A. Kozlowski , Neng-Yang Shih , Brian J. Lavey , Razia K. Rizvi , Bandarpalle B. Shankar , James M. Spitler , Ling Tong , Ronald L. Wolin , Michael K. Wong
发明人： Joseph A. Kozlowski , Neng-Yang Shih , Brian J. Lavey , Razia K. Rizvi , Bandarpalle B. Shankar , James M. Spitler , Ling Tong , Ronald L. Wolin , Michael K. Wong
IPC分类号： A61K31/16 , A61K31/40 , A61K31/435 , A61K31/445 , C07D211/06 , C07D211/68 , C07D207/04 , C07D207/18 , C07C211/01
CPC分类号： C07D213/70 , C07C31/24 , C07C317/22 , C07C317/32 , C07C317/36 , C07C317/44 , C07C323/41 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D213/71 , C07D213/74 , C07D213/89 , C07D215/36 , C07D233/42 , C07D233/84 , C07D239/38 , C07D307/64 , C07D333/20 , C07D333/34 , C07D333/38
摘要： There are disclosed compounds of the formula a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit anti-inflammatory and immunodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds and methods of using the compounds for the treatment of various diseases and conditions.
摘要翻译： 公开了下式的化合物其化合物或所述前药的前药，或其药学上可接受的盐，溶剂合物或立体异构体; 其具有抗炎和免疫调节活性。 还公开了含有所述化合物的药物组合物和使用该化合物治疗各种疾病和病症的方法。
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公开(公告)号：US07718702B2
公开(公告)日：2010-05-18
申请号：US11203946
申请日：2005-08-15
申请人： Joseph A. Kozlowski , Neng-Yang Shih , Brian J. Lavey , Razia K. Rizvi , Bandarpalle B. Shankar , James M. Spitler , Ling Tong , Ronald L. Wolin , Michael K. Wong
发明人： Joseph A. Kozlowski , Neng-Yang Shih , Brian J. Lavey , Razia K. Rizvi , Bandarpalle B. Shankar , James M. Spitler , Ling Tong , Ronald L. Wolin , Michael K. Wong
IPC分类号： A61K31/16 , A61K31/40 , A61K31/435 , A61K31/445 , C07D211/06 , C07D211/68 , C07D207/04 , C07D207/18
CPC分类号： C07D213/70 , C07C31/24 , C07C317/22 , C07C317/32 , C07C317/36 , C07C317/44 , C07C323/41 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D213/71 , C07D213/74 , C07D213/89 , C07D215/36 , C07D233/42 , C07D233/84 , C07D239/38 , C07D307/64 , C07D333/20 , C07D333/34 , C07D333/38
摘要： There are disclosed compounds of the formula a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit anti-inflammatory and immunodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds and methods of using the compounds for the treatment of various diseases and conditions.
摘要翻译： 公开了下式的化合物其化合物或所述前药的前药，或其药学上可接受的盐，溶剂合物或立体异构体; 其具有抗炎和免疫调节活性。 还公开了含有所述化合物的药物组合物和使用该化合物治疗各种疾病和病症的方法。
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公开(公告)号：US08569336B2
公开(公告)日：2013-10-29
申请号：US13127953
申请日：2009-11-09
申请人： Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Joseph A. Kozlowski , Michael K. C. Wong , Lei Chen , Guowei Zhou , Razia K. Rizvi , Robert Feltz , Aneta Maria Kosinski , De-Yi Yang , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristin E. Rosner , M. Arshad Siddiqui , Liping Yang
发明人： Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Joseph A. Kozlowski , Michael K. C. Wong , Lei Chen , Guowei Zhou , Razia K. Rizvi , Robert Feltz , Aneta Maria Kosinski , De-Yi Yang , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristin E. Rosner , M. Arshad Siddiqui , Liping Yang
IPC分类号： A61K31/4166 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/506 , C07D233/76 , C07D213/24
CPC分类号： C07D498/04 , C07D513/00 , C07D519/00
摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译： 本发明涉及式（I）的化合物：（化学式应该插在这里，它以纸的形式出现）（I）或其药学上可接受的盐，其可用于治疗疾病或病症介导 通过MMP，ADAM，TACE，聚蛋白聚糖蛋白聚糖酶，TNF-或其组合。
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公开(公告)号：US08541572B2
公开(公告)日：2013-09-24
申请号：US13127952
申请日：2009-11-09
申请人： Joseph A. Kozlowski , Wensheng Yu , Michael K. C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristin E. Rosner , M. Arshad Siddiqui , Liping Yang
发明人： Joseph A. Kozlowski , Wensheng Yu , Michael K. C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristin E. Rosner , M. Arshad Siddiqui , Liping Yang
IPC分类号： C07D295/03 , C07D241/20 , C07D211/30 , C07D213/46 , C07D403/06 , C07D203/16
CPC分类号： C07D403/14
摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.
摘要翻译： 本发明涉及式（I）的化合物：（化学式应该插在这里，它以纸的形式出现）（I）或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗 由MMP，ADAM，TACE，聚蛋白聚糖蛋白聚糖酶，TNF-或其组合介导的疾病或病症。
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公开(公告)号：US20110288077A1
公开(公告)日：2011-11-24
申请号：US13120730
申请日：2009-09-22
申请人： Michael K.C. Wong , Wensheng Yu , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Joseph A. Kozlowski , Seong Heon Kim , Guowei Zhou , De-Yi Yang , Razia K. Rizvi , Lei Chen , Aneta Maria Kosinski , Kristen E. Rosner , Luke Fire , Judson E. Richard , Dansu Li
发明人： Michael K.C. Wong , Wensheng Yu , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Joseph A. Kozlowski , Seong Heon Kim , Guowei Zhou , De-Yi Yang , Razia K. Rizvi , Lei Chen , Aneta Maria Kosinski , Kristen E. Rosner , Luke Fire , Judson E. Richard , Dansu Li
IPC分类号： A61K31/4178 , C07D405/14 , C07D401/14 , C07D491/048 , A61K31/517 , A61K31/4355 , A61K31/4439 , A61K31/496 , A61K31/551 , A61P19/02 , A61P1/02 , A61P35/04 , A61P27/06 , A61P1/00 , A61P17/06 , A61P9/00 , A61P31/00 , A61P31/18 , C07D403/06
CPC分类号： C07D405/14 , C07D403/06 , C07D403/14 , C07D491/048
摘要： This invention relates to compounds of the Formula (I)-(IX):, as defined herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α combinations thereof.
摘要翻译： 本发明涉及如本文定义的式（I） - （IX）：或其药学上可接受的盐，溶剂合物或酯的化合物，其可用于治疗由MMP，ADAM，TACE介导的疾病或病症 ，聚集蛋白聚糖酶，TNF-α组合。
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公开(公告)号：US20120010181A1
公开(公告)日：2012-01-12
申请号：US13127952
申请日：2009-11-09
申请人： Joseph A. Kozlowski , Wensheng Yu , Michael K.C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristen E. Rosner , M. Arshad Siddiqui , Liping Yang
发明人： Joseph A. Kozlowski , Wensheng Yu , Michael K.C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristen E. Rosner , M. Arshad Siddiqui , Liping Yang
IPC分类号： A61K31/4178 , C07D401/14 , C07D491/052 , C07D413/14 , C07D417/14 , C07D403/14 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/436 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P29/00 , A61P19/02 , A61P1/02 , A61P35/00 , A61P35/04 , A61P25/00 , A61P27/06 , A61P1/00 , A61P17/06 , A61P9/00 , A61P31/18 , A61P31/04 , C07D403/06
CPC分类号： C07D403/14
摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.
摘要翻译： 本发明涉及式（I）的化合物：（化学式应该插在这里，它以纸的形式出现）（I）或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗 由MMP，ADAM，TACE，聚蛋白聚糖蛋白聚糖酶，TNF-或其组合介导的疾病或病症。
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公开(公告)号：US08859529B2
公开(公告)日：2014-10-14
申请号：US13120728
申请日：2009-09-22
申请人： Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Ling Tong , Michael K. C. Wong , Brian J. Lavey , Joseph A. Kozlowski , Lei Chen , Razia K. Rizvi , Aneta Maria Kosinski , De-Yi Yang , Guowei Zhou , Kristen E. Rosner , Luke Fire , Judson E. Richard , Dansu Li
发明人： Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Ling Tong , Michael K. C. Wong , Brian J. Lavey , Joseph A. Kozlowski , Lei Chen , Razia K. Rizvi , Aneta Maria Kosinski , De-Yi Yang , Guowei Zhou , Kristen E. Rosner , Luke Fire , Judson E. Richard , Dansu Li
IPC分类号： C07D205/06 , C07D413/14 , C07D239/02 , C07D401/14 , C07F9/02 , C07D491/04 , C07D471/02 , C07D233/54 , C07D403/14 , A61K31/675 , A61K31/397 , A61K31/5377 , A61K31/497 , A61K31/505 , A61K31/4427 , A61K31/4155 , C07D405/14 , C07D403/06 , C07D491/048
CPC分类号： C07D403/14 , C07D403/06 , C07D405/14 , C07D491/048
摘要： This invention relates to compounds of the Formula (I) as described herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译： 本发明涉及本文所述的式（I）化合物或其药学上可接受的盐，溶剂化物或酯，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-或介导的疾病或病症 其组合。
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