公开(公告)号：US20150291574A1

公开(公告)日：2015-10-15

申请号：US14589575

申请日：2013-07-08

申请人： Bandi PARTHASARADHI REDDY ,  Kura RATHNAKAR REDDY ,  Dasari MURALIDHARA REDDY ,  Matta RAMAKRISHNA REDDY ,  HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Matta Ramakrishna Reddy ,  Bandi Vamsi Krishna

IPC分类号： C07D413/14

CPC分类号： C07D413/14 ,  C07B2200/13

摘要： The present invention provides a novel crystalline Form of azilsartan acid, process for its preparation and pharmaceutical compositions comprising it. The present invention also provides a novel crystalline Form of azilsartan medoxomil potassium, process for its preparation and pharmaceutical compositions comprising it.

摘要翻译： 本发明提供了一种新型的唑来硫酸结晶形式，其制备方法和包含它的药物组合物。 本发明还提供了一种新型的吖唑烷酮莫昔米尔钾的结晶形式，其制备方法和包含它的药物组合物。

公开(公告)号：US20130190368A1

公开(公告)日：2013-07-25

申请号：US13825689

申请日：2011-08-23

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Matta Ramakrishna Reddy ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Matta Ramakrishna Reddy ,  Bandi Vamsi Krishna

IPC分类号： C07D277/593

CPC分类号： C07D277/593 ,  A61K31/426 ,  C07D277/56

摘要： The present invention provides a novel 1,4-dioxane solvate form of febuxostat and process for its preparation. The present invention also provides novel crystalline forms of febuxostat, processes for their preparation and pharmaceutical compositions comprising them.

摘要翻译： 本发明提供了一种新型的1,4-二恶烷溶剂合物形式的氟康酸钠及其制备方法。 本发明还提供了昂布斯他汀的新结晶形式，其制备方法和包含它们的药物组合物。

公开(公告)号：US20140112992A1

公开(公告)日：2014-04-24

申请号：US14123875

申请日：2012-05-21

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Matta Ramakrishna Reddy ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Matta Ramakrishna Reddy ,  Bandi Vamsi Krishna

IPC分类号： C07D277/56 ,  A61K31/426

CPC分类号： C07D277/56 ,  A61K31/426

摘要： The present invention provides a process for the preparation of 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester. The present invention also provides a process for the preparation of 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester. The present invention further provides novel crystalline Forms of febuxostat, processes for their preparation and pharmaceutical compositions comprising them. The present invention further provides febuxostat crystalline particles having a mean particle size of less than about 25 μm, the methods for the manufacture of said crystalline particles, and pharmaceutical compositions comprising said crystalline particles.

摘要翻译： 本发明提供了制备2-（4-羟基苯基）-4-甲基噻唑-5-羧酸乙酯的方法。 本发明还提供了制备2-（3-甲酰基-4-羟基苯基）-4-甲基噻唑-5-甲酸乙酯的方法。 本发明进一步提供了新型的布氏抑菌素的结晶形式，其制备方法和包含它们的药物组合物。 本发明还提供平均粒度小于约25μm的Febustostat结晶颗粒，制备所述结晶颗粒的方法和包含所述结晶颗粒的药物组合物。

公开(公告)号：US20130190506A1

公开(公告)日：2013-07-25

申请号：US13805904

申请日：2010-06-28

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Matta Ramakrishna Reddy ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Matta Ramakrishna Reddy ,  Bandi Vamsi Krishna

IPC分类号： C07D405/14

CPC分类号： C07D405/14

摘要： The present invention provides a process for the preparation of substantially pure trityl olmesartan medoxomil. The present invention also provides a process for purification of trityl olmesartan medoxomil. The present invention further provides a process for purification of olmesartan medoxomil.

摘要翻译： 本发明提供了制备基本上纯的三苯甲基奥美沙坦酯的方法。 本发明还提供了三苯甲基奥美沙坦酯的纯化方法。 本发明还提供了一种纯化奥美沙坦酯的方法。

公开(公告)号：US20150252045A1

公开(公告)日：2015-09-10

申请号：US14436962

申请日：2013-11-01

申请人： Bandi PARTHASARADHI REDDY ,  Kura RATHNAKAR REDDY ,  Dasari MURALIDHARA REDDY ,  Katham SRINIVASA REDDY ,  Bandi VAMSI KRISHNA ,  HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Katham Srinivasa Reddy ,  Bandi Vamsi Krishna

IPC分类号： C07D475/08 ,  C07C67/52

CPC分类号： C07D475/08 ,  C07C67/343 ,  C07C67/52 ,  C07C69/76

摘要： The present invention provides a novel process for the purification of alpha-propargylhomoterephthalic acid dimethyl ester substantially free of homoterephthalic acid dimethyl ester. The present invention also provides a novel process for the purification of pralatrexate.

摘要翻译： 本发明提供了用于纯化基本上不含对苯二甲酸二甲酯的α-炔丙基对苯二甲酸二甲酯的新方法。 本发明还提供了一种纯化普拉钠精油的新方法。

公开(公告)号：US09150547B2

公开(公告)日：2015-10-06

申请号：US13989541

申请日：2011-11-11

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Thungathurthy Srinivasa Rao ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Thungathurthy Srinivasa Rao ,  Bandi Vamsi Krishna

IPC分类号： C07D403/12 ,  C07D239/42

CPC分类号： C07D403/12 ,  C07D239/42

摘要： The present invention provides a commercially viable process for preparing pazopanib and its pharmaceutically acceptable acid addition salts thereof in high yields using novel intermediate. The present invention also provides a process for the purification of pazopanib hydrochloride.

摘要翻译： 本发明提供了使用新型中间体以高产率制备比唑帕尼及其药学上可接受的酸加成盐的商业上可行的方法。 本发明还提供了盐酸帕唑帕尼的纯化方法。

公开(公告)号：US09096556B2

公开(公告)日：2015-08-04

申请号：US14122158

申请日：2012-05-21

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Bandi Vamsi Krishna

IPC分类号： A61K31/427 ,  C07D417/12 ,  C07D277/28 ,  A61K45/06 ,  A61K47/32

CPC分类号： C07D277/28 ,  A61K31/427 ,  A61K45/06 ,  A61K47/32

摘要： The present invention relates to amorphous ritonavir co-precipitated on copovidone, process for its preparation and pharmaceutical compositions comprising it.

摘要翻译： 本发明涉及在共聚维酮上共沉淀的无定形利托那韦，其制备方法和包含它的药物组合物。

公开(公告)号：US08703788B2

公开(公告)日：2014-04-22

申请号：US13989602

申请日：2011-11-11

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Thungathurthy Srinivasa Rao ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Thungathurthy Srinivasa Rao ,  Bandi Vamsi Krishna

IPC分类号： A01N43/54 ,  A61K31/505

CPC分类号： C07D401/14 ,  A61K31/506

摘要： The present invention provides a novel crystalline form of nilotinib hydrochloride, process for its preparation and pharmaceutical compositions comprising it.

摘要翻译： 本发明提供了盐酸尼洛替尼的新型结晶形式，其制备方法和包含其的药物组合物。

公开(公告)号：US20140066468A1

公开(公告)日：2014-03-06

申请号：US14003535

申请日：2012-03-05

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC分类号： A61K31/513 ,  A61K31/427

CPC分类号： A61K31/513 ,  A61K31/427 ,  C07D239/10 ,  C07D417/12 ,  A61K2300/00

摘要： The present invention relates to a novel amorphous Form of lopinavir and ritonavir mixture in the ratio of 3.8:1.2 to 4.2:0.8, process for its preparation and pharmaceutical compositions comprising it.

摘要翻译： 本发明涉及以3.8:1.2至4.2:0.8的比例的洛匹那韦和利托那韦混合物的新型无定形形式，其制备方法和包含它的药物组合物。

公开(公告)号：US09624236B2

公开(公告)日：2017-04-18

申请号：US13530844

申请日：2012-06-22

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC分类号： A01N43/08 ,  A61K31/34 ,  C07D493/04 ,  A61K9/20

CPC分类号： C07D493/04 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/34

摘要： Described herein is pure amorphous darunavir, methods of making pure amorphous darunavir and pharmaceutical compositions containing amorphous darunavir and a pharmaceutically acceptable excipient.