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1.发明申请Regulation of the apj receptor for use in the treatment or prophylaxis of cardiac diseases 审中-公开调节apj受体用于治疗或预防心脏病公开(公告)号：US20050075275A1
公开(公告)日：2005-04-07
申请号：US10486061
申请日：2002-07-24
CPC分类号： A61K38/1709
摘要： The invention relates to the use of APJ receptor agonists for producing a medicament for the treatment and/or prophylaxis of coronary heart diseases, in particular stable and unstable angina pectoris, acute myocardial infarction, myocardial infarction prophylaxis, sudden heart death, heart failure, and high blood pressure and the sequelae of atherosclerosis.
摘要翻译： 本发明涉及APJ受体激动剂在制备用于治疗和/或预防冠状动脉心脏病，特别是稳定和不稳定型心绞痛，急性心肌梗塞，心肌梗塞预防，心脏骤停，心力衰竭和 高血压和动脉粥样硬化的后遗症。
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公开(公告)号：US08088584B2
公开(公告)日：2012-01-03
申请号：US12444596
申请日：2007-10-02
申请人： Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht-Küpper , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'Urso , Michael Seewald , Hendrik Milting
发明人： Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht-Küpper , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'Urso , Michael Seewald , Hendrik Milting
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , Y10S530/841
摘要： The invention provides LTBP2, which is associated with cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of LTBP2 as well as pharmaceutical compositions comprising such compounds. The invention also provides LTBP2 as a biomarker for diseases such as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases.
摘要翻译： 本发明提供了与心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病相关的LTBP2。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制LTBP2的活性的化合物以及包含这些化合物的药物组合物。 本发明还提供LTBP2作为心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病等疾病的生物标志物。
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公开(公告)号：US20100104501A1
公开(公告)日：2010-04-29
申请号：US12445494
申请日：2007-10-02
申请人： Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'urso , Michael Seewald , Hendrik Milting
发明人： Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'urso , Michael Seewald , Hendrik Milting
CPC分类号： G01N33/573 , C12Q1/37 , G01N2333/948
摘要： The invention provides PRSS23, which is associated with cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSS23 as well as pharmaceutical compositions comprising such compounds. The invention also provides PRSS23 as a biomarker for diseases such as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases.
摘要翻译： 本发明提供了与心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病有关的PRSS23。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制PRSS23的活性的化合物以及包含这些化合物的药物组合物。 本发明还提供了PRSS23作为心血管疾病，血液病，神经疾病，癌症，内分泌疾病和泌尿系疾病等疾病的生物标志物。
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公开(公告)号：US20100028264A1
公开(公告)日：2010-02-04
申请号：US12444596
申请日：2007-10-02
申请人： Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht-Küpper , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'Urso , Michael Seewald , Hendrik Milting
发明人： Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht-Küpper , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'Urso , Michael Seewald , Hendrik Milting
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , Y10S530/841
摘要： The invention provides LTBP2, which is associated with cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of LTBP2 as well as pharmaceutical compositions comprising such compounds. The invention also provides LTBP2 as a biomarker for diseases such as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases.
摘要翻译： 本发明提供了与心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病相关的LTBP2。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制LTBP2的活性的化合物以及包含这些化合物的药物组合物。 本发明还提供LTBP2作为心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病等疾病的生物标志物。
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公开(公告)号：US20110111394A1
公开(公告)日：2011-05-12
申请号：US12445737
申请日：2007-10-04
申请人： Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht-Küpper , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'Urso , Michael Seewald , Hendrik Milting
发明人： Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht-Küpper , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'Urso , Michael Seewald , Hendrik Milting
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/06 , G01N2800/12 , G01N2800/22 , G01N2800/28 , G01N2800/32 , G01N2800/34
摘要： The invention provides CTGF which is associated with the cardiovascular diseases and hematological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases and hematological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CTGF as well as pharmaceutical compositions comprising such compounds. The invention also provides CTGF as a biomarker for diseases as cardiovascular diseases and hematological diseases
摘要翻译： 本发明提供了与心血管疾病和血液疾病相关的CTGF。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病和血液疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制CTGF活性的化合物以及包含这些化合物的药物组合物。 本发明还提供CTGF作为心血管疾病和血液疾病疾病的生物标志物
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6.发明申请Modulators of the potassium channels twik-1, task-1 gorl1. sk2 pr pcn1, used to treat arrhythmia, coronary heat disease or hypertension 审中-公开钾通道调节剂twik-1，任务1 gorl1。 sk2 pr pcn1，用于治疗心律失常，冠心病或高血压公开(公告)号：US20060183665A1
公开(公告)日：2006-08-17
申请号：US10565185
申请日：2004-07-06
申请人： Peter Ellinghaus , Klaus Munter
发明人： Peter Ellinghaus , Klaus Munter
IPC分类号： A61K38/17
CPC分类号： C07K14/705 , A61K38/00
摘要： The invention relates to the use of modulators of the potassium channels TWIK-1, TASK-1, GIRK1 SK2 and PCN1 for producing a medicament for the treatment and/or prophylaxis of cardiac dysrhythmias (arrhythmias), coronary heart disease, and hypertension.
摘要翻译： 本发明涉及钾通道TWIK-1，TASK-1，GIRK1 SK2和PCN1的调节剂在制备用于治疗和/或预防心律失常（心律失常），冠心病和高血压的药物中的用途。
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7.发明授权Heteroaryl substituted pyrazole derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权用于治疗高增殖性疾病和与血管生成相关的疾病的杂芳基取代的吡唑衍生物公开(公告)号：US08796253B2
公开(公告)日：2014-08-05
申请号：US12600640
申请日：2008-05-08
申请人： Stephen Boyer , Michael Härter , Philip Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
发明人： Stephen Boyer , Michael Härter , Philip Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
IPC分类号： C07D403/04 , C07D413/04 , C07D413/14 , C07D471/04 , C07D491/04
CPC分类号： C07D413/04 , C07D403/04 , C07D413/14 , C07D471/04 , C07D491/04
摘要： This invention relates to novel heteroaryl substituted pyrazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients or therapeutic measures.
摘要翻译： 本发明涉及新颖的杂芳基取代的吡唑化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用作治疗高增殖和/或血管发生障碍作为唯一试剂或与其它活性成分或治疗措施组合的用途。
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公开(公告)号：US20080261990A1
公开(公告)日：2008-10-23
申请号：US11663813
申请日：2005-09-10
申请人： Elke Dittrich-Wengenroth , Lars Barfacker , Axel Kretschmer , Claudia Hirth-Dietrich , Peter Ellinghaus , Martin Raabe , Hilmar Bischoff , Christian Pilger , Ulrich Rosentreter , Stephan Bartel , Klemens Lustig , Armin Kern , Dieter Lang , Marcus Bauser
发明人： Elke Dittrich-Wengenroth , Lars Barfacker , Axel Kretschmer , Claudia Hirth-Dietrich , Peter Ellinghaus , Martin Raabe , Hilmar Bischoff , Christian Pilger , Ulrich Rosentreter , Stephan Bartel , Klemens Lustig , Armin Kern , Dieter Lang , Marcus Bauser
IPC分类号： A61K31/496 , C07D405/12 , A61K31/506 , C07D239/28 , A61K31/505
CPC分类号： C07D239/42 , C07D405/12
摘要： The present invention relates to novel pyrimidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular diseases, in particular dyslipidemias, arteriosclerosis, coronary heart disease, thrombosis and metabolic syndrome.
摘要翻译： 本发明涉及新颖的嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防心血管疾病，特别是血脂异常，动脉硬化，冠心病，血栓形成和代谢综合征。
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公开(公告)号：US20080255202A1
公开(公告)日：2008-10-16
申请号：US11547974
申请日：2005-03-26
申请人： Hilmar Bischoff , Elke Dittrich-Wengenroth , Nils Griebenow , Axel Kretschmer , Joachim Kruger , Elisabeth Woltering , Lars Barfacker , Claudia Hirth-Dietrich , Peter Ellinghaus , Martin Raabe , Stephen Bartel , Christian Pilger , Ulrich Rosentreter , Klemens Lustig , Armin Kern , Dieter Lang
发明人： Hilmar Bischoff , Elke Dittrich-Wengenroth , Nils Griebenow , Axel Kretschmer , Joachim Kruger , Elisabeth Woltering , Lars Barfacker , Claudia Hirth-Dietrich , Peter Ellinghaus , Martin Raabe , Stephen Bartel , Christian Pilger , Ulrich Rosentreter , Klemens Lustig , Armin Kern , Dieter Lang
IPC分类号： A61K31/4427 , C07D271/06 , A61K31/4245 , C07D261/06 , A61K31/42 , C07D271/10 , C07D231/10 , C07D213/02 , A61P9/00 , A61K31/4155 , C07D277/20 , A61K31/427 , C07D249/08 , A61K31/4196 , C07D233/54
CPC分类号： C07D405/12 , C07D231/12 , C07D249/04 , C07D263/32 , C07D271/06 , C07D277/28 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present application relates to novel phenylthioacetic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, in particular dyslipidaemias and arteriosclerosis.
摘要翻译： 本申请涉及新的苯硫基乙酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ /或预防心血管疾病，特别是血脂异常和动脉硬化。
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公开(公告)号：US20090215743A1
公开(公告)日：2009-08-27
申请号：US10586023
申请日：2004-12-31
申请人： Elisabeth Woltering , Michael Härter , Timo Flessner , Mario Jeske , Nils Griebenow , Frank Süssmeier , Hilmar Bischoff , Martin Raabe , Anja Buchmüller , Peter Kolkhof , Peter Ellinghaus , Olaf Weber
发明人： Elisabeth Woltering , Michael Härter , Timo Flessner , Mario Jeske , Nils Griebenow , Frank Süssmeier , Hilmar Bischoff , Martin Raabe , Anja Buchmüller , Peter Kolkhof , Peter Ellinghaus , Olaf Weber
IPC分类号： A61K31/5383 , C07D498/04
CPC分类号： C07D498/04
摘要： The present application relates to novel tricyclic benzazepine derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, especially of dyslipidaemias, arteriosclerosis, restenosis and ischaemias.
摘要翻译： 本申请涉及新型三环苯并氮杂衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或 预防心血管疾病，特别是血脂异常，动脉硬化，再狭窄和局部缺血。
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