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公开(公告)号：US06780840B1
公开(公告)日：2004-08-24
申请号：US09973263
申请日：2001-10-09
IPC分类号： A61K3800
CPC分类号： A61B18/22 , A61B17/00491 , A61B2017/0007 , A61B2017/00084 , A61B2017/005 , A61B2017/00508 , A61B2017/00517 , A61L24/102
摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 800 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films, which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space.
摘要翻译： 根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。 组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至800mg / ml（80％））的胶原蛋白。 特别地，例如，首先通过从牛或猪皮提取而制备I型胶原并纯化。 然后将胶原蛋白制剂用巯基试剂进行化学衍生，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。 然后将组合物形成粘稠溶液，凝胶或固体膜，当暴露于由红外激光产生的能量时，例如经历热诱导相变。 固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。 随着热能释放到周围环境中，蛋白质组合物再次变得固体或半固体，粘附到处理过的组织或组织空间。
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公开(公告)号：US06773699B1
公开(公告)日：2004-08-10
申请号：US09973385
申请日：2001-10-09
IPC分类号： A61K3800
CPC分类号： A61B18/22 , A61B17/00491 , A61B2017/0007 , A61B2017/00084 , A61B2017/005 , A61B2017/00508 , A61B2017/00517 , A61L31/044
摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 80 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films which are used to encapsulate structural components such as a cojoinal network or mesh. The resultant patch which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space and are reinforced by the embedded cojoinal network or mesh.
摘要翻译： 根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。 组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至80mg / ml（80％））的胶原蛋白。 特别地，例如，I型胶原首先通过从牛或猪皮提取而纯化而制备。 然后将胶原蛋白制剂用巯基试剂进行化学衍生化，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。 然后将组合物形成粘稠溶液，凝胶或固体膜，其用于包封结构组分如共同网络或网状物。 例如，当暴露于由红外激光器产生的能量时，产生的贴片经历热诱导相变。 固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。 随着热能释放到周围环境中，蛋白质组合物再次变成固体或半固体，粘附到经处理的组织或组织空间，并通过嵌入的共同网络或网来加强。
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公开(公告)号：US06875427B1
公开(公告)日：2005-04-05
申请号：US09973332
申请日：2001-10-09
CPC分类号： A61L31/044 , A61K38/39 , A61L24/001 , A61L24/102 , A61L31/14
摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 800 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films, which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space.
摘要翻译： 根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。 组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至800mg / ml（80％））的胶原蛋白。 特别地，例如，I型胶原首先通过从牛或猪皮提取而纯化而制备。 然后将胶原蛋白制剂用巯基试剂进行化学衍生化，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。 然后将组合物形成粘稠溶液，凝胶或固体膜，当暴露于由红外激光产生的能量时，例如经历热诱导相变。 固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。 随着热能释放到周围环境中，蛋白质组合物再次变得固体或半固体，粘附到处理过的组织或组织空间。
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公开(公告)号：US06939364B1
公开(公告)日：2005-09-06
申请号：US09973335
申请日：2001-10-09
CPC分类号： A61B18/22 , A61B17/00491 , A61B2017/0007 , A61B2017/00084 , A61B2017/005 , A61B2017/00508 , A61B2017/00517
摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 800 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films, which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space.
摘要翻译： 根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。 组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至800mg / ml（80％））的胶原蛋白。 特别地，例如，I型胶原首先通过从牛或猪皮提取而纯化而制备。 然后将胶原蛋白制剂用巯基试剂进行化学衍生化，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。 然后将组合物形成粘稠溶液，凝胶或固体膜，当暴露于由红外激光产生的能量时，例如经历热诱导相变。 固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。 随着热能释放到周围环境中，蛋白质组合物再次变得固体或半固体，粘附到处理过的组织或组织空间。
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公开(公告)号：US20160250377A1
公开(公告)日：2016-09-01
申请号：US14656994
申请日：2015-03-13
申请人： Barbara A. Soltz , Robert Soltz
发明人： Barbara A. Soltz , Robert Soltz
CPC分类号： A61L24/102 , A61B17/00491 , A61B2017/00004 , A61B2017/005 , A61B2017/00517 , A61B2017/00884 , A61B2017/00951 , A61K9/7007 , A61K31/525 , A61K38/39 , A61K47/42 , A61L24/0015 , A61L31/044 , A61L31/14 , A61L2300/428 , A61K2300/00
摘要： A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound.
摘要翻译： 应用包含核黄素的光活化胶原蛋白 - 黄素复合物层作为感染病变的治疗。 这些复合材料也被发现是有效的关闭和密封伤口，移植物/植入物的固定和吻合的强力组织粘合剂。 优点包括闭合速度，消除异物减少的感染，加速伤口愈合的证据和复杂手术中的易用性，特别是当密封密封，限制进入或小修复尺寸是重要因素时。 将胶原层中的核黄素暴露于光（例如，波长在360-375nm或440-480nm之间的光），分解核黄素以形成活性氧（ROS）。 胶原蛋白复合物和组织之间的强烈交联结果。 此外，类似的暴露可以消除伤口中的病原体。
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公开(公告)号：US09006182B2
公开(公告)日：2015-04-14
申请号：US12943763
申请日：2010-11-10
申请人： Barbara A. Soltz , Robert Soltz
发明人： Barbara A. Soltz , Robert Soltz
IPC分类号： A61K38/39 , A61K47/48 , A61K38/00 , A61P43/00 , A61B17/50 , A61B17/08 , A61D1/00 , A61K38/17 , C07K1/00 , C07K14/00 , C07K16/00 , C09H1/00 , C07K17/00 , C08H1/00 , A61F13/00 , A61F2/00 , A61K9/70 , A61B17/00 , A61K31/525 , A61K47/42 , A61L31/04 , A61L31/14
CPC分类号： A61L24/102 , A61B17/00491 , A61B2017/00004 , A61B2017/005 , A61B2017/00517 , A61B2017/00884 , A61B2017/00951 , A61K9/7007 , A61K31/525 , A61K38/39 , A61K47/42 , A61L24/0015 , A61L31/044 , A61L31/14 , A61L2300/428 , A61K2300/00
摘要： A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adheives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound.
摘要翻译： 应用包含核黄素的光活化胶原蛋白 - 黄素复合物层作为感染病变的治疗。 这些复合材料也被发现是有效的关闭和密封伤口，移植物/植入物的固定和吻合的强组织粘附。 优点包括闭合速度，消除异物减少的感染，加速伤口愈合的证据和复杂手术中的易用性，特别是当密封密封，限制进入或小修复尺寸是重要因素时。 将胶原层中的核黄素暴露于光（例如，波长在360-375nm或440-480nm之间的光），分解核黄素以形成活性氧（ROS）。 胶原蛋白复合物和组织之间的强烈交联结果。 此外，类似的暴露可以消除伤口中的病原体。
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公开(公告)号：US20130190245A1
公开(公告)日：2013-07-25
申请号：US12943771
申请日：2010-11-10
申请人： Barbara A. Soltz , Robert Soltz
发明人： Barbara A. Soltz , Robert Soltz
IPC分类号： A61L24/00
CPC分类号： A61L24/001 , A61L24/102 , A61L29/043 , Y10S514/801 , C08L89/06
摘要： A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions caused by bacteria and as the consequence of surgical procedures. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound is eradicated resulting in a sterile wound. In other examples, the composite film may instead contain lumichrome or lumiflavin.
摘要翻译： 应用含有核黄素的光活化胶原蛋白复合材料层作为由细菌引起的感染病变的治疗，作为外科手术的结果。 这些复合材料也被发现是有效的关闭和密封伤口，移植物/植入物的固定和吻合的强力组织粘合剂。 优点包括闭合速度，消除异物减少的感染，加速伤口愈合的证据和复杂手术中的易用性，特别是当密封密封，限制进入或小修复尺寸是重要因素时。 将胶原层中的核黄素暴露于光（例如，波长在360-375nm或440-480nm之间的光），分解核黄素以形成活性氧（ROS）。 胶原蛋白复合物和组织之间的强烈交联结果。 此外，消除伤口中类似的根除病原体的暴露导致无菌伤口。 在其它实例中，复合膜可以替代地含有lumichrome或lumiflavin。
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公开(公告)号：US20130035629A1
公开(公告)日：2013-02-07
申请号：US13567985
申请日：2012-08-06
申请人： Barbara A. Soltz , Robert Soltz
发明人： Barbara A. Soltz , Robert Soltz
CPC分类号： A61L15/56 , A61L15/325 , A61L15/42 , A61L15/44 , A61L2300/404 , A61M35/00 , A61N5/0616 , A61N5/062 , A61N5/0624 , A61N2005/0645 , A61N2005/0652 , A61N2005/0662
摘要： A pad is provided that supplies light to a composite layer, which may be provided on a wound. The composite layer may include a combination including a form of collagen and a chromophore that releases a reactive oxygen species upon exposure to the light. The reactive oxygen species may then act to kill bacteria or other microorganisms in the wound.
摘要翻译： 提供了一种将光提供给可以设置在伤口上的复合层的垫。 复合层可以包括包含胶原形式和在暴露于光时释放活性氧物质的发色团的组合。 然后，活性氧可以起到杀伤伤口中的细菌或其他微生物的作用。
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公开(公告)号：US09012406B2
公开(公告)日：2015-04-21
申请号：US12943771
申请日：2010-11-10
申请人： Barbara A. Soltz , Robert Soltz
发明人： Barbara A. Soltz , Robert Soltz
CPC分类号： A61L24/001 , A61L24/102 , A61L29/043 , Y10S514/801 , C08L89/06
摘要： Disclosed herein are compositions comprising gelatin, collagen, and a chromophore that produces a reactive oxygen species upon exposure to electromagnetic radiation. These compositions have also been found to be strong tissue adhesives that crosslinks the composition and tissue and are effective in closing and sealing wounds, fixation of grafts/implants and anastomoses.
摘要翻译： 本文公开了包含明胶，胶原和在暴露于电磁辐射时产生活性氧物质的发色团的组合物。 这些组合物也被发现是强的组织粘合剂，其使组合物和组织交联并且有效地封闭和密封伤口，固定移植物/植入物和吻合。
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公开(公告)号：US20110125187A1
公开(公告)日：2011-05-26
申请号：US12943763
申请日：2010-11-10
申请人： Barbara A. Soltz , Robert Soltz
发明人： Barbara A. Soltz , Robert Soltz
CPC分类号： A61L24/102 , A61B17/00491 , A61B2017/00004 , A61B2017/005 , A61B2017/00517 , A61B2017/00884 , A61B2017/00951 , A61K9/7007 , A61K31/525 , A61K38/39 , A61K47/42 , A61L24/0015 , A61L31/044 , A61L31/14 , A61L2300/428 , A61K2300/00
摘要： A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions caused by bacteria and as the consequence of surgical procedures. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound is eradicated resulting in a sterile wound. In other examples, the composite film may instead contain lumichrome or lumiflavin.
摘要翻译： 应用含有核黄素的光活化胶原蛋白复合材料层作为由细菌引起的感染病变的治疗，作为外科手术的结果。 这些复合材料也被发现是有效的关闭和密封伤口，移植物/植入物的固定和吻合的强力组织粘合剂。 优点包括闭合速度，消除异物减少的感染，加速伤口愈合的证据和复杂手术中的易用性，特别是当密封密封，限制进入或小修复尺寸是重要因素时。 将胶原层中的核黄素暴露于光（例如，波长在360-375nm或440-480nm之间的光），分解核黄素以形成活性氧（ROS）。 胶原蛋白复合物和组织之间的强烈交联结果。 此外，消除伤口中类似的根除病原体的暴露导致无菌伤口。 在其它实例中，复合膜可以替代地含有lumichrome或lumiflavin。
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