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公开(公告)号：US20060040877A1
公开(公告)日：2006-02-23
申请号：US11254686
申请日：2005-10-20
申请人： Lesley Burns , Paul Graupner , Paul Lewer , Christine Martin , William Vousden , Clive Waldron , Barrie Wilkinson
发明人： Lesley Burns , Paul Graupner , Paul Lewer , Christine Martin , William Vousden , Clive Waldron , Barrie Wilkinson
摘要： The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
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公开(公告)号：US20100068785A1
公开(公告)日：2010-03-18
申请号：US12616470
申请日：2009-11-11
申请人： Lesley S. Burns , Paul R. Graupner , Paul Lewer , Christine J. Martin , William A. Vousden , Clive Waldron , Barrie Wilkinson
发明人： Lesley S. Burns , Paul R. Graupner , Paul Lewer , Christine J. Martin , William A. Vousden , Clive Waldron , Barrie Wilkinson
IPC分类号： C12N9/00
摘要： The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
摘要翻译： 本发明提供了生物活性多杀菌素，能够在多孢子虫中产生多杀菌素的杂交多杀菌素聚酮化合物合酶，以及使用多杀菌素来控制昆虫的方法。
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公开(公告)号：US20110178036A1
公开(公告)日：2011-07-21
申请号：US13073226
申请日：2011-03-28
申请人： Lesley S. Burns , Paul R. Graupner , Paul Lewer , Christine J. Martin , William A. Vousden , Clive Waldron , Barrie Wilkinson
发明人： Lesley S. Burns , Paul R. Graupner , Paul Lewer , Christine J. Martin , William A. Vousden , Clive Waldron , Barrie Wilkinson
摘要： The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
摘要翻译： 本发明提供了生物活性多杀菌素，能够在多孢子虫中产生多杀菌素的杂交多杀菌素聚酮化合物合酶，以及使用多杀菌素来控制昆虫的方法。
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公开(公告)号：US08624009B2
公开(公告)日：2014-01-07
申请号：US13073226
申请日：2011-03-28
申请人： Lesley S. Burns , Paul R. Graupner , Paul Lewer , Christine J. Martin , William A. Vousden , Clive Waldron , Barrie Wilkinson
发明人： Lesley S. Burns , Paul R. Graupner , Paul Lewer , Christine J. Martin , William A. Vousden , Clive Waldron , Barrie Wilkinson
摘要： The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
摘要翻译： 本发明提供了生物活性多杀菌素，能够在多孢子虫中产生多杀菌素的杂交多杀菌素聚酮化合物合酶，以及使用多杀菌素来控制昆虫的方法。
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公开(公告)号：US07626010B2
公开(公告)日：2009-12-01
申请号：US11254686
申请日：2005-10-20
申请人： Lesley S. Burns , Paul R. Graupner , Paul Lewer , Christine J. Martin , William A. Vousden , Clive Waldron , Barrie Wilkinson
发明人： Lesley S. Burns , Paul R. Graupner , Paul Lewer , Christine J. Martin , William A. Vousden , Clive Waldron , Barrie Wilkinson
摘要： The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
摘要翻译： 本发明提供了生物活性多杀菌素，能够在多孢子虫中产生多杀菌素的杂交多杀菌素聚酮化合物合酶，以及使用多杀菌素来控制昆虫的方法。
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公开(公告)号：US20090117127A1
公开(公告)日：2009-05-07
申请号：US12294099
申请日：2007-03-30
申请人： Sabine Gaisser , Christine Martin , Ming Zhang , Barrie Wilkinson , Lesley Sheehan , Nigel Coates , Mohammed Nur-E-Alam , William Vousden , Nikolaos Gaitatzis
发明人： Sabine Gaisser , Christine Martin , Ming Zhang , Barrie Wilkinson , Lesley Sheehan , Nigel Coates , Mohammed Nur-E-Alam , William Vousden , Nikolaos Gaitatzis
IPC分类号： A61K39/395 , C07D225/06 , C12P17/10 , C12N1/21 , A61P35/04
CPC分类号： C07D225/06
摘要： The present invention relates to 11-O-desmethylmacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
摘要翻译： 本发明涉及11-O-去甲基锍类似物，其可用于，例如， 在治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫疾病和/或作为癌症的预防性预处理。 本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。
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公开(公告)号：US20110027185A1
公开(公告)日：2011-02-03
申请号：US12667625
申请日：2008-07-14
IPC分类号： A61K39/395 , G01N33/566 , C07K16/18 , A61K49/00 , A61K31/365 , C07D313/00 , A61P35/00 , A61P29/00 , A61P17/06 , A61P27/02 , A61P9/10
CPC分类号： G01N33/574 , G01N33/6893 , G01N2500/00 , G01N2800/164
摘要： The present invention relates to methods of screening for agents that bind to FBP21. In particular the present invention provides a method of identifying anti-angiogenic agents by screening for agents which are able to bind to FBP21. Compounds identified using the methods and screens of the present invention are useful in the prevention and treatment of conditions associated with angiogenesis.
摘要翻译： 本发明涉及筛选结合FBP21的试剂的方法。 特别地，本发明提供了通过筛选能够结合FBP21的试剂来鉴定抗血管生成剂的方法。 使用本发明的方法和筛选鉴定的化合物可用于预防和治疗与血管发生相关的病症。
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8.发明申请15-O-Desmethylmacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies 审中-公开15-O-去甲基衍生物及其在治疗癌症或B细胞恶性肿瘤中的应用公开(公告)号：US20090209507A1
公开(公告)日：2009-08-20
申请号：US12294253
申请日：2007-03-30
申请人： Sabine Gaisser , Christine Martin , Ming Zhang , Barrie Wilkinson , Nigel Coates , Mohammed Nur-E-Alam , William Vousden
发明人： Sabine Gaisser , Christine Martin , Ming Zhang , Barrie Wilkinson , Nigel Coates , Mohammed Nur-E-Alam , William Vousden
IPC分类号： A61K31/395 , C07D225/06 , A61P35/00 , C12P17/10 , C12N5/10
CPC分类号： C07D225/06
摘要： The present invention relates to 15-O-desmethylmacbecin analogues according to the formula (IA) or (IB) herein, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 either both represent H or together they represent a bond (i.e. C4 to C5 is a double bond); and R3 represents H or CONH2 that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
摘要翻译： 本发明涉及根据本文的式（IA）或（IB）的15-O-去甲基蒿酸类似物或其药学上可接受的盐：其中：R 1和R 2都表示H或一起表示一个键（即C 4至 C5是双键）; 并且R 3表示可用的H或CONH 2，例如。 在治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫疾病和/或作为癌症的预防性预处理。 本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。
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9.发明申请4,5-Dihydromacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies 审中-公开4,5-Dihydromacbecin衍生物及其在治疗癌症或B细胞恶性肿瘤中的应用公开(公告)号：US20110091452A1
公开(公告)日：2011-04-21
申请号：US12294175
申请日：2007-03-30
申请人： Christine Martin , Ming Zhang , Sabine Gaisser , Nigel Coates , Barrie Wilkinson
发明人： Christine Martin , Ming Zhang , Sabine Gaisser , Nigel Coates , Barrie Wilkinson
IPC分类号： A61K39/395 , C07D225/06 , A61K31/395 , A61K31/519 , A61K31/704 , A61K31/573 , A61K38/14 , A61K31/675 , A61K31/513 , A61K31/337 , C12P17/10 , C12N5/07
CPC分类号： C07D225/06
摘要： The present invention relates to 4,5-dihydromacbecin analogues to the formula (IA) or (IB), or a pharmaceutically acceptable salt there of: wherein: R1 represents H or CONH2 that are useful, e.g. in the treatment of cancer, B-cell malignancies malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
摘要翻译： 本发明涉及式（IA）或（IB）的4,5-二氢in啉类似物或其药学上可接受的盐：其中：R 1表示可用的例如H或CONH 2。 在治疗癌症，B细胞恶性疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫疾病和/或作为癌症的预防性预处理。 本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。
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公开(公告)号：US20090298804A1
公开(公告)日：2009-12-03
申请号：US12294267
申请日：2007-03-30
申请人： Sabine Gaisser , Christine Martin , Ming Zhang , Barrie Wilkinson , Nigel Coates , Mohammed Nur-E-Alam , Nikolaos Galtatzis
发明人： Sabine Gaisser , Christine Martin , Ming Zhang , Barrie Wilkinson , Nigel Coates , Mohammed Nur-E-Alam , Nikolaos Galtatzis
IPC分类号： A61K31/33 , C07D225/06 , C12P17/10 , C12N1/21
CPC分类号： C07D225/06
摘要： The present invention relates to 15-desmethoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
摘要翻译： 本发明涉及15-脱甲氧基锍类似物，其可用于，例如， 在治疗癌症，B细胞恶性疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫疾病和/或作为癌症的预防性预处理。 本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。
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