公开(公告)号：US07599737B2

公开(公告)日：2009-10-06

申请号：US10679763

申请日：2003-10-06

申请人： Barry M. Yomtov ,  Stephen J. Herman ,  John T. Santini, Jr.

发明人： Barry M. Yomtov ,  Stephen J. Herman ,  John T. Santini, Jr.

IPC分类号： A61N1/00

CPC分类号： A61N1/30 ,  A61K9/0097 ,  A61N1/08 ,  A61N1/36071 ,  G06F19/00

摘要： Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least one drug contained in each of the reservoirs, and control means for selectively releasing a pharmaceutically effective amount of drug from each reservoir; a neural electrical stimulator which comprises a signal generator connected to at least one stimulation electrode for operable engagement with a neural tissue of the patient; and at least one microcontroller for controlling operational interaction of the drug delivery module and the neural electrical stimulator. The microcontroller may control the signal generator and the control means of the drug delivery module. The device may further include a sensor operable to deliver a signal to the microcontroller, for example to indicate when to deliver electrical stimulation, drug, or both.

摘要翻译： 提供医疗装置和方法用于电刺激神经组织和控制药物递送给患者。 该装置包括可植入药物递送模块，其包括多个储存器，包含每个储存器中的至少一种药物的释放系统和用于从每个储存器中选择性释放药学有效量的药物的控制装置; 神经电刺激器，其包括连接到至少一个刺激电极的信号发生器，用于与患者的神经组织可操作地接合; 以及用于控制药物递送模块和神经电刺激器的操作相互作用的至少一个微控制器。 微控制器可以控制药物递送模块的信号发生器和控制装置。 该装置还可以包括可操作以将信号传送到微控制器的传感器，例如以指示何时传递电刺激，药物或两者。

公开(公告)号：US20100023071A1

公开(公告)日：2010-01-28

申请号：US12572899

申请日：2009-10-02

申请人： Barry M. Yomtov ,  Stephen J. Herman ,  John T. Santini, JR.

发明人： Barry M. Yomtov ,  Stephen J. Herman ,  John T. Santini, JR.

IPC分类号： A61M37/00 ,  A61N1/36

CPC分类号： A61N1/30 ,  A61K9/0097 ,  A61N1/08 ,  A61N1/36071

摘要： Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least one drug contained in each of the reservoirs, and control means for selectively releasing a pharmaceutically effective amount of drug from each reservoir; a neural electrical stimulator which comprises a signal generator connected to at least one stimulation electrode for operable engagement with a neural tissue of the patient; and at least one microcontroller for controlling operational interaction of the drug delivery module and the neural electrical stimulator. The microcontroller may control the signal generator and the control means of the drug delivery module. The device may further include a sensor operable to deliver a signal to the microcontroller, for example to indicate when to deliver electrical stimulation, drug, or both.

摘要翻译： 提供医疗装置和方法用于电刺激神经组织和控制药物递送给患者。 该装置包括可植入药物递送模块，其包括多个储存器，包含每个储存器中的至少一种药物的释放系统和用于从每个储存器中选择性释放药学有效量的药物的控制装置; 神经电刺激器，其包括连接到至少一个刺激电极的信号发生器，用于与患者的神经组织可操作地接合; 以及用于控制药物递送模块和神经电刺激器的操作相互作用的至少一个微控制器。 微控制器可以控制药物递送模块的信号发生器和控制装置。 该装置还可以包括可操作以将信号传送到微控制器的传感器，例如以指示何时传递电刺激，药物或两者。

公开(公告)号：US20090030404A1

公开(公告)日：2009-01-29

申请号：US12243791

申请日：2008-10-01

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, JR. ,  Stephen J. Herman ,  Barry M. Yomtov

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, JR. ,  Stephen J. Herman ,  Barry M. Yomtov

IPC分类号： A61K9/22

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.

摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法。 该装置包括基板，基板中的多个储存器，设置在储存器中的储存器内容物，覆盖每个储存器的分立存储器盖，用于密封储存器中的储存器内容物;以及控制电路，用于选择性地分解储存器盖以释放或暴露 水库内容物。 储存器盖中的至少一个包括涂覆有一个或多个保护层的第一导电层。 在一个实施例中，控制电路包括电输入引线和连接到并直接接触每个所述储存器盖的电输出引线和电源，用于以有效破裂每个储存器盖 水箱盖。

公开(公告)号：US08211092B2

公开(公告)日：2012-07-03

申请号：US12243791

申请日：2008-10-01

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry M. Yomtov

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry M. Yomtov

IPC分类号： A61K9/22

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.

摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法。 该装置包括基板，基板中的多个储存器，设置在储存器中的储存器内容物，覆盖每个储存器的分立存储器盖，用于密封储存器中的储存器内容物，以及控制电路，用于选择性地分解储存器盖以释放或暴露 水库内容物。 储存器盖中的至少一个包括涂覆有一个或多个保护层的第一导电层。 在一个实施例中，控制电路包括电输入引线和连接到并直接接触每个所述储存器盖的电输出引线和电源，用于以有效破裂每个储存器盖 水箱盖。

公开(公告)号：US07917208B2

公开(公告)日：2011-03-29

申请号：US10679772

申请日：2003-10-06

申请人： Barry M. Yomtov ,  Stephen J. Herman

发明人： Barry M. Yomtov ,  Stephen J. Herman

IPC分类号： A61N1/362

CPC分类号： A61M5/14276 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2205/0244 ,  A61M2205/3523 ,  A61M2230/04 ,  A61N1/362 ,  A61N1/3956

摘要： Medical device and methods are provided for controlled drug delivery in a cardiac patient. The device includes an implantable drug delivery module comprising reservoirs containing a drug and a control means for selectively releasing an effective amount of drug from each reservoir; one or more electrodes or sensors for cardiac monitoring, stimulation, or both; and a microcontroller for controlling operational interaction of the drug delivery module and the cardiac electrode. The electrodes may comprise ECG monitoring, cardioversion, or cardiac pacing electrodes. A medical device also is provided for controlled delivery of drug to a patient having congestive heart failure, which includes an implantable drug delivery module comprising a natriuretic peptide and a release mechanism for selectively releasing a pharmaceutically effective amount of the natriuretic peptide into the patient; and a microcontroller for controlling the release mechanism, for example, in response to one or more monitored patient parameters.

摘要翻译： 提供医疗装置和方法用于在心脏病人中控制药物递送。 该装置包括可植入药物递送模块，其包含含有药物的储存器和用于从每个储存器选择性释放有效量的药物的控制装置; 用于心脏监测，刺激或两者的一个或多个电极或传感器; 以及用于控制药物递送模块和心脏电极的操作相互作用的微控制器。 电极可以包括ECG监测，心脏复律或心脏起搏电极。 还提供医疗装置用于将药物控制递送给具有充血性心力衰竭的患者，其包括可植入药物递送模块，其包含利尿钠肽和用于选择性释放药学有效量的利钠肽到患者体内的释放机制; 以及用于例如响应于一个或多个监视的患者参数来控制释放机构的微控制器。

公开(公告)号：US5388578A

公开(公告)日：1995-02-14

申请号：US43269

申请日：1993-04-06

申请人： Barry M. Yomtov ,  Paul E. Kreyenhagen

发明人： Barry M. Yomtov ,  Paul E. Kreyenhagen

IPC分类号： A61B5/00 ,  A61B5/0245 ,  A61B5/04 ,  A61B5/0452 ,  A61B5/0472 ,  A61N1/37 ,  A61B5/042

CPC分类号： A61B5/04525 ,  A61B5/0031 ,  A61N1/3702

摘要： An implantable cardiac monitor is arranged for detecting both arrhythmias and ischemia of the human heart. The monitor includes subcutaneous electrodes for establishing electrical contact with the heart and a sense amplifier coupled to each electrode for generating an electrocardiogram of a heart beat sensed at each of the electrodes. The electrocardiograms are digitized and the digital samples thereof are stored in a memory. A microprocessor processes the digital samples of the electrocardiograms and generates characterizing data indicative of the physiology of the heart. The cardiac monitor includes telemetry to permit the cardiac data to be interrogated externally of the patient for obtaining the generated cardiac data indicative of arrhythmic and ischemic episodes.

摘要翻译： 一种植入式心脏监测器被安排用于检测人心脏的心律失常和缺血。 监测器包括用于与心脏建立电接触的皮下电极和耦合到每个电极的感测放大器，用于产生在每个电极处感测到的心跳的心电图。 将心电图数字化，并将其数字样本存储在存储器中。 微处理器处理心电图的数字样本并产生指示心脏生理学的特征数据。 心脏监测器包括遥测以允许心脏数据在患者外部询问，以获得指示心律失常和缺血发作的产生的心脏数据。

公开(公告)号：US5522850A

公开(公告)日：1996-06-04

申请号：US264319

申请日：1994-06-23

申请人： Barry M. Yomtov ,  David P. Finch

发明人： Barry M. Yomtov ,  David P. Finch

IPC分类号： A61N1/39

CPC分类号： A61N1/3925 ,  A61N1/395

摘要： An implantable atrial defibrillator applies cardioverting electrical energy to the atria of a human heart in response to detection of an atrial fibrillation episode and stores selected data associated with the detected atrial fibrillation episode. The atrial defibrillator includes a cardiovertor which provides successive applications of cardioverting electrical energy to the atria of the heart until one of the pulses successfully cardioverts the atria. A memory system stores selected heart activity data in connection with the detected episode including heart activity data related to initial detection of the atrial fibrillation episode and heart activity data occurring from before and until after the application of the cardioverting electrical energy which successfully cardioverts the atria of the heart.

摘要翻译： 可植入心房除颤器响应于心房颤动发作的检测，将心电转换电能施加到人心脏的心房，并存储与检测到的心房颤动发作相关的所选数据。 心房除颤器包括心脏转换器，其向心脏的心房提供心脏转复电能的连续应用，直到其中一个脉搏成功地心跳心房。 存储系统存储与检测到的发作相关的选择的心脏活动数据，包括与初始检测心房纤维性颤动发作有关的心脏活动数据和从应用转换心电图之前和之后发生的心脏活动数据，其成功地将心房的心房 心脏

公开(公告)号：US4630615A

公开(公告)日：1986-12-23

申请号：US612553

申请日：1984-05-21

申请人： Barry M. Yomtov

发明人： Barry M. Yomtov

IPC分类号： A61N1/08 ,  A61N1/36

CPC分类号： A61N1/3605 ,  A61N2001/083

摘要： The apparatus comprises: a comparator for comparing the voltage at which the constant current pulses are being supplied to the load with an increasing reference voltage; a counter for counting the number of voltage pulses that are greater in magnitude than the increasing reference voltage over a sampling period; and signal processing circuitry for correlating the count of pulses over the sampling period with the impedance of the load required to generate that number of constant current pulses at the voltage required for same.

摘要翻译： 该装置包括：比较器，用于将恒定电流脉冲提供给负载的电压与增加的参考电压进行比较; 用于计数在采样周期内幅度大于增加的参考电压的电压脉冲数的计数器; 以及信号处理电路，用于将采样周期上的脉冲计数与在相同电压下产生该数量的恒定电流脉冲所需的负载阻抗相关联。

公开(公告)号：US5411031A

公开(公告)日：1995-05-02

申请号：US157605

申请日：1993-11-24

申请人： Barry M. Yomtov

发明人： Barry M. Yomtov

IPC分类号： A61B5/00 ,  A61B5/0468 ,  A61N1/37 ,  A61B5/04

CPC分类号： A61B5/0031 ,  A61B5/0468 ,  A61N1/3702 ,  A61B5/413

摘要： A cardiac monitor which is fully implantable beneath the skin of a patient monitors heart rate variability of a human heart. The heart rate monitor includes at least one electrode which establishes electrical contact with the heart. During a heart monitoring period, time intervals between adjacent heart beats are determined for generating heart rate data. The heart rate data is stored in a memory which is accessed after the completion of the heart monitoring period for generating a heart rate variability factor. The heart rate variability factor is stored in memory for later transmission to a nonimplanted external receiver.

摘要翻译： 完全可植入患者皮肤的心脏监护仪监测人心脏的心率变异性。 心率监测器包括与心脏建立电接触的至少一个电极。 在心脏监测期间，确定相邻心跳之间的时间间隔以产生心率数据。 心率数据存储在心脏监测周期完成之后被访问的存储器中，用于产生心率变异性因子。 心率变异性因子存储在存储器中，以供稍后传输到非植入式外部接收器。

公开(公告)号：US4606349A

公开(公告)日：1986-08-19

申请号：US753593

申请日：1985-07-10

申请人： John H. Livingston ,  Barry M. Yomtov

发明人： John H. Livingston ,  Barry M. Yomtov

IPC分类号： A61N1/372 ,  A61N1/36

CPC分类号： A61N1/37252

摘要： The stimulation output of an implanted cardiac pacer is applied between a cathode at the end of a pacer lead in the heart and an anode whose location is programmable. An electronic switch accessed via programming designates the pulse generator pace as the anode for an additional electrode located near the end of the pacer lead, thus changing the pacer from unipolar to bipolar operation or vice-a-versa after implantation. Different programming pulse rates are used to program different functional characteristics. For example, pulses at one rate select mode, high or low frequency range, sensitivity and anode location while pulses at another frequency set the pulse generation rate and output current.

摘要翻译： 植入心脏起搏器的刺激输出被施加在心脏中起搏器引线端部的阴极和位置可编程的阳极之间。 通过编程访问的电子开关将脉冲发生器的速度指定为位于起搏器引线端部附近的附加电极的阳极，从而将注射器从单极性改变为双极操作，反之亦然。 不同的编程脉冲率用于编程不同的功能特性。 例如，脉冲在一个速率选择模式，高或低频率范围，灵敏度和阳极位置，而在另一个频率的脉冲设置脉冲发生率和输出电流。