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公开(公告)号：US07599737B2
公开(公告)日：2009-10-06
申请号：US10679763
申请日：2003-10-06
IPC分类号： A61N1/00
CPC分类号： A61N1/30 , A61K9/0097 , A61N1/08 , A61N1/36071 , G06F19/00
摘要： Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least one drug contained in each of the reservoirs, and control means for selectively releasing a pharmaceutically effective amount of drug from each reservoir; a neural electrical stimulator which comprises a signal generator connected to at least one stimulation electrode for operable engagement with a neural tissue of the patient; and at least one microcontroller for controlling operational interaction of the drug delivery module and the neural electrical stimulator. The microcontroller may control the signal generator and the control means of the drug delivery module. The device may further include a sensor operable to deliver a signal to the microcontroller, for example to indicate when to deliver electrical stimulation, drug, or both.
摘要翻译： 提供医疗装置和方法用于电刺激神经组织和控制药物递送给患者。 该装置包括可植入药物递送模块，其包括多个储存器，包含每个储存器中的至少一种药物的释放系统和用于从每个储存器中选择性释放药学有效量的药物的控制装置; 神经电刺激器，其包括连接到至少一个刺激电极的信号发生器，用于与患者的神经组织可操作地接合; 以及用于控制药物递送模块和神经电刺激器的操作相互作用的至少一个微控制器。 微控制器可以控制药物递送模块的信号发生器和控制装置。 该装置还可以包括可操作以将信号传送到微控制器的传感器，例如以指示何时传递电刺激，药物或两者。
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2.发明申请公开(公告)号：US20100023071A1
公开(公告)日：2010-01-28
申请号：US12572899
申请日：2009-10-02
CPC分类号： A61N1/30 , A61K9/0097 , A61N1/08 , A61N1/36071
摘要： Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least one drug contained in each of the reservoirs, and control means for selectively releasing a pharmaceutically effective amount of drug from each reservoir; a neural electrical stimulator which comprises a signal generator connected to at least one stimulation electrode for operable engagement with a neural tissue of the patient; and at least one microcontroller for controlling operational interaction of the drug delivery module and the neural electrical stimulator. The microcontroller may control the signal generator and the control means of the drug delivery module. The device may further include a sensor operable to deliver a signal to the microcontroller, for example to indicate when to deliver electrical stimulation, drug, or both.
摘要翻译： 提供医疗装置和方法用于电刺激神经组织和控制药物递送给患者。 该装置包括可植入药物递送模块，其包括多个储存器，包含每个储存器中的至少一种药物的释放系统和用于从每个储存器中选择性释放药学有效量的药物的控制装置; 神经电刺激器，其包括连接到至少一个刺激电极的信号发生器，用于与患者的神经组织可操作地接合; 以及用于控制药物递送模块和神经电刺激器的操作相互作用的至少一个微控制器。 微控制器可以控制药物递送模块的信号发生器和控制装置。 该装置还可以包括可操作以将信号传送到微控制器的传感器，例如以指示何时传递电刺激，药物或两者。
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公开(公告)号：US20090030404A1
公开(公告)日：2009-01-29
申请号：US12243791
申请日：2008-10-01
申请人： Scott A. Uhland , Benjamin F. Polito , John M. Maloney , Norman F. Sheppard, JR. , Stephen J. Herman , Barry M. Yomtov
发明人： Scott A. Uhland , Benjamin F. Polito , John M. Maloney , Norman F. Sheppard, JR. , Stephen J. Herman , Barry M. Yomtov
IPC分类号： A61K9/22
CPC分类号： A61M25/0082 , A61B5/0215 , A61B5/042 , A61B5/1459 , A61B5/1473 , A61B5/4839 , A61M5/14276 , A61M25/0069 , A61M37/00 , A61M2005/1726 , A61M2205/0244 , A61M2205/123 , A61M2205/3653 , A61N1/32 , Y10T436/25
摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.
摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法。 该装置包括基板，基板中的多个储存器，设置在储存器中的储存器内容物，覆盖每个储存器的分立存储器盖，用于密封储存器中的储存器内容物;以及控制电路，用于选择性地分解储存器盖以释放或暴露 水库内容物。 储存器盖中的至少一个包括涂覆有一个或多个保护层的第一导电层。 在一个实施例中，控制电路包括电输入引线和连接到并直接接触每个所述储存器盖的电输出引线和电源，用于以有效破裂每个储存器盖 水箱盖。
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公开(公告)号：US20110172587A1
公开(公告)日：2011-07-14
申请号：US13012426
申请日：2011-01-24
申请人： John T. Santini, JR. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, JR. , Stephen J. Herman
发明人： John T. Santini, JR. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, JR. , Stephen J. Herman
IPC分类号： A61F9/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.
摘要翻译： 提供了将药物输送到眼睛的方法和系统。 该方法和系统可以包括将包括两个或更多个离散储器的装置植入眼中，每个储存器包含药物; 以及将聚焦光引导到所述植入装置以打开所述储存器中的第一个，从而允许所述药物从所述第一储存器扩散到所述患者的眼睛。
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公开(公告)号：US07537590B2
公开(公告)日：2009-05-26
申请号：US11194157
申请日：2005-08-01
IPC分类号： A61K9/22
CPC分类号： A61K9/703 , A61F2013/00642 , A61K9/0009 , A61K9/0021 , A61K9/0097 , A61K9/7084 , A61K9/7092 , A61M37/0015 , A61M2037/0023 , A61N1/30
摘要： Devices and methods are provided for transdermal administration of a pharmaceutical agent to a patient in need thereof. The device includes a substrate, a plurality of discrete reservoirs in the substrate, one or more pharmaceutical agents stored in the reservoirs, discrete reservoir caps that prevent the pharmaceutical agent from passing out from the reservoirs until desired, control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps, means for securing the device to the skin of the patient, and means for transporting the pharmaceutical agent to the skin following release from the one or more of the reservoirs. In another embodiment, the device is adapted for diagnostic sensing instead of or in addition to drug delivery.
摘要翻译： 提供了用于向有需要的患者透皮施用药剂的装置和方法。 该装置包括衬底，衬底中的多个分立贮存器，储存在储存器中的一个或多个药剂，防止药剂从储存器中流出直到期望的离散贮存器盖，用于致动释放一个 或更多的药剂从一个或多个储存器中分解或渗透储存器盖，用于将装置固定到患者皮肤的装置，以及用于在药物释放之后将药剂运送到皮肤的装置 水库 在另一个实施方案中，该装置适用于代替药物递送或除药物递送之外的诊断感测。
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公开(公告)号：US06827250B2
公开(公告)日：2004-12-07
申请号：US10184259
申请日：2002-06-28
申请人： Scott A. Uhland , Benjamin F. Polito , Stephen J. Herman , John T. Santini, Jr. , John M. Maloney
发明人： Scott A. Uhland , Benjamin F. Polito , Stephen J. Herman , John T. Santini, Jr. , John M. Maloney
IPC分类号： B23K106
CPC分类号： A61K9/0097
摘要： Methods are provided for hermetically sealing the reservoirs of microchip devices and for hermetically sealing the substrate assemblies in a hermetic packaging structure. In one embodiment, the method comprises (1) providing a primary substrate having a front side and a back side, the substrate comprising a plurality of reservoirs positioned between the front side and the back side, each reservoir being loaded with molecules or a secondary device for controlled release or exposure, the reservoirs having at least one opening in need of sealing, the primary substrate including one or more hermetic sealing materials; (2) providing a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; (3) positioning the hermetic sealing substrate over the reservoir openings and contacting said hermetic sealing materials of the primary substrate with said hermetic sealing materials of the hermetic sealing substrate; and (4) applying energy or a mechanical force to the contacted sealing materials effective to form a hermetic seal between the hermetic sealing substrate and the primary substrate to hermetically seal the reservoir openings.
摘要翻译： 提供了用于气密地密封微芯片装置的储存器的方法，以及用于密封密封封装结构中的基板组件。 在一个实施例中，该方法包括（1）提供具有前侧和后侧的主基底，所述基底包括位于前侧和后侧之间的多个储存器，每个储存器装载有分子或辅助装置 为了控制释放或暴露，储存器具有至少一个需要密封的开口，主基底包括一个或多个气密密封材料; （2）提供具有由一种或多种密封材料构成的表面的气密密封基材; （3）将气密密封基板定位在储存器开口上，并使主基板的气密密封材料与气密密封基板的气密密封材料接触; 和（4）将能量或机械力施加到接触的密封材料上，以有效地在气密密封基底和初级基底之间形成气密密封，从而气密地密封储层开口。
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公开(公告)号：US06730072B2
公开(公告)日：2004-05-04
申请号：US09867976
申请日：2001-05-30
申请人： Rebecca S. Shawgo , Norman F. Sheppard, Jr. , Michael J. Cima , John T. Santini, Jr. , Stephen J. Herman , Benjamin F. Polito , Scott A. Uhland
发明人： Rebecca S. Shawgo , Norman F. Sheppard, Jr. , Michael J. Cima , John T. Santini, Jr. , Stephen J. Herman , Benjamin F. Polito , Scott A. Uhland
IPC分类号： A61K922
CPC分类号： A61B5/145 , A61B5/03 , A61B5/14539 , A61K9/0009 , A61K9/0097 , A61N1/303 , B01L3/50853 , B01L2300/0819
摘要： Methods and devices are provided for mechanically sealing the reservoirs of microchip devices to prevent leakage from or between any of the reservoirs. In one embodiment, the method includes sandwiching a microchip device and a gasket material covering the reservoir openings between a front sealing frame and a backplate, such that the gasket material is compressed against the back side of the microchip device by the back plate. The front sealing frame is secured to the back sealing plate using fasteners or welding. The gasket material is preferably a flexible polymeric sheet, which is biocompatible and compatible with the reservoir contents. In another embodiment, a composite backplate is used in place of the back sealing plate and separate gasket material. The composite backplate can include a substrate having sealing plugs defined thereon. The composite backplate also can be designed to hold the drug, thereby combining the assembly steps of reservoir filling and sealing.
摘要翻译： 提供了用于机械密封微芯片装置的储存器的方法和装置，以防止任何储存器之间的泄漏。 在一个实施例中，该方法包括在前密封框架和背板之间夹着微芯片装置和覆盖储存器开口的衬垫材料，使得衬垫材料通过后板压靠在微芯片装置的后侧。 前密封框架使用紧固件或焊接固定到后密封板。 垫片材料优选是柔性聚合物片材，其是生物相容性的并且与储存器内容物相容。 在另一个实施例中，使用复合背板来代替后密封板和单独的衬垫材料。 复合背板可以包括其上限定有密封塞的基板。 复合背板也可以设计成保持药物，从而结合储液器填充和密封的组装步骤。
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公开(公告)号：US08095197B2
公开(公告)日：2012-01-10
申请号：US10980551
申请日：2004-11-03
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/1486 , A61B5/4839 , B33Y80/00
摘要： Medical devices, utilizing multiple reservoirs to protect and selectively expose sensors or other reservoir contents, are provided having (i) a reservoir contents destruction mechanism to interrupt the release or exposure of reservoir contents, for example, to deactivate an unneeded sensor and prevent it from negatively impacting other sensors, (ii) a protective covering material layer over the sensor underneath the reservoir cap, which protects the sensor membrane and sensor during reservoir cap disintegration and then is removed, (iii) a device design for containing sensors in shallow, wide reservoir structures to enhance sensor exposure by minimizing molecular diffusion distances, (iv) an implantable sensor unit and a separate drug delivery unit, or (v) combinations thereof.
摘要翻译： 提供了利用多个储存器来保护和选择性地暴露传感器或其他贮存器内容物的医疗装置，其具有（i）用于中断储存器内容物的释放或暴露的储存器内容物破坏机制，例如，去激活不需要的传感器并防止 负面影响其他传感器，（ii）储存器盖下方的传感器上方的保护性覆盖材料层，其在储存器盖分解期间保护传感器膜和传感器然后被去除，（iii）用于在浅的，宽的 储存器结构，以通过最小化分子扩散距离来增强传感器暴露，（iv）植入式传感器单元和单独的药物递送单元，或（v）其组合。
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公开(公告)号：US20090234214A1
公开(公告)日：2009-09-17
申请号：US12471973
申请日：2009-05-26
IPC分类号： A61B5/145
CPC分类号： A61K9/703 , A61F2013/00642 , A61K9/0009 , A61K9/0021 , A61K9/0097 , A61K9/7084 , A61K9/7092 , A61M37/0015 , A61M2037/0023 , A61N1/30
摘要： Devices and methods are provided for transdermal diagnostic sensing, alone or in combination with transdermal drug delivery. The device includes a substrate having a plurality of discrete reservoirs, each reservoir having at least one opening; contents disposed in the reservoirs, the contents of each reservoir including a diagnostic agent or a sensor for measuring an analyte; at least one discrete reservoir cap which cover said at least one opening; control means for disintegrating or permeabilizing the reservoir cap; means for transporting an analyte from the skin to said sensors and/or for transporting said diagnostic agent to the skin following release of said diagnostic agents from said reservoir; and means for securing the device to the skin of a patient.
摘要翻译： 提供了用于透皮诊断感测的装置和方法，单独或与透皮药物递送组合。 该装置包括具有多个分立储存器的基板，每个储存器具有至少一个开口; 设置在储存器中的内容物，每个储存器的内容物包括用于测量分析物的诊断剂或传感器; 至少一个分开的储存器盖，其覆盖所述至少一个开口; 用于使储存器盖分解或渗透的控制装置; 用于将分析物从皮肤运送到所述传感器和/或用于在从所述储存器释放所述诊断剂之后将所述诊断剂运输到皮肤的装置; 以及用于将装置固定到患者皮肤的装置。
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公开(公告)号：US07497846B2
公开(公告)日：2009-03-03
申请号：US11005391
申请日：2004-12-06
申请人： Scott A. Uhland , Benjamin F. Polito , Stephen J. Herman , John T. Santini, Jr. , John M. Maloney
发明人： Scott A. Uhland , Benjamin F. Polito , Stephen J. Herman , John T. Santini, Jr. , John M. Maloney
CPC分类号： A61K9/0097
摘要： Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reservoirs in the primary substrate positioned between the front side and the back side; reservoir contents, which comprise chemical molecules (such as drugs) or a secondary device (such as a glucose sensor), located inside the reservoirs; a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; and a hermetic seal formed between and joining the primary substrate and the hermetic sealing substrate, wherein the hermetic seal independently seals the reservoirs.
摘要翻译： 提供了用于控制曝光或释放存储在密封储存器中的内容物的装置。 这些装置包括具有前侧和后侧的主基板，并且包括一个或多个密封材料; 位于前侧和后侧之间的主要基底中的多个储存器; 包括化学分子（如药物）或位于储存器内部的次级装置（如葡萄糖传感器）的储存器内容物; 具有由一种或多种密封材料构成的表面的气密密封基材; 以及形成在主基板和气密密封基板之间并与其接合的气密密封件，其中气密密封独立地密封储存器。
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