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    MULTI-RESERVOIR MEDICAL DEVICE HAVING PROTECTED INTERIOR WALLS
    2.
    发明申请
    MULTI-RESERVOIR MEDICAL DEVICE HAVING PROTECTED INTERIOR WALLS 审中-公开
    具有保护性内部墙壁的多储存医疗设备

    公开(公告)号：US20090024113A1

    公开(公告)日：2009-01-22

    申请号：US12193523

    申请日：2008-08-18

    申请人： John M. Maloney ,  Zouhair Sbiaa ,  John T. Santini, JR. ,  Norman F. Sheppard, JR. ,  Scott A. Uhland

    发明人： John M. Maloney ,  Zouhair Sbiaa ,  John T. Santini, JR. ,  Norman F. Sheppard, JR. ,  Scott A. Uhland

    IPC分类号： A61K9/22

    CPC分类号： B01L3/50853 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2400/0677

    摘要： An implantable medical device is provided for controlled delivery or exposure of reservoir contents. The device may include a substrate; a plurality of discrete reservoirs in the substrate, wherein the reservoirs have interior walls and at least one opening in the substrate; reservoir contents disposed in the reservoirs; a reservoir cap closing the at least one opening of each of the reservoirs to seal the reservoir contents in each of the reservoirs; and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo, wherein the interior walls of the reservoirs comprise a material to protect the substrate in vivo. For example, to enhance the resistance of the substrate to etching in vivo, the interior sidewalls of the reservoirs may include a protective coating (such as gold, platinum, carbon, silicon carbide, silicon dioxide, or platinum silicide), or the sidewalls may include a doped silicon.

    摘要翻译： 提供可植入医疗装置用于控制输送或暴露储存器内容物。 该装置可以包括基板; 在所述基板中的多个分立储存器，其中所述储存器具有内壁和所述基板中的至少一个开口; 蓄水池内容物; 储存器盖封闭每个储存器的至少一个开口以密封每个储存器中的储存器内容物; 以及用于选择性地分解储存器盖以释放或暴露储存器内容物在体内的控制电路，其中储存器的内壁包括在体内保护基板的材料。 例如，为了增强衬底在体内蚀刻的电阻，储存器的内侧壁可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅或硅化铂），或者侧壁可以 包括掺杂硅。

    ELECTROCHEMICAL BIOSENSORS AND ARRAYS
    6.
    发明申请
    ELECTROCHEMICAL BIOSENSORS AND ARRAYS 有权
    电化学传感器和阵列

    公开(公告)号：US20080302659A1

    公开(公告)日：2008-12-11

    申请号：US12134966

    申请日：2008-06-06

    申请人： Norman F. Sheppard, JR. ,  John T. Santini, JR.

    发明人： Norman F. Sheppard, JR. ,  John T. Santini, JR.

    IPC分类号： G01N33/487 ,  A61M25/00

    CPC分类号： A61B5/14865 ,  A61B5/14532 ,  C12Q1/004 ,  G01N27/3272

    摘要： Electrochemical sensor devices are provided, in various amperometric, potentiometric, and conductometric sensor device configurations. An amperometric sensor device may include a structural body which has at least one reservoir that has at least one opening; a working electrode located within the reservoir; analyte sensor chemistry located within the reservoir and deposited on at least the working electrode; an auxiliary electrode located outside of the reservoir; a reference electrode; at least one reservoir cap closing the opening to isolate the working electrode and analyte sensor chemistry within the reservoir and to prevent an analyte outside of the reservoir from contacting the analyte sensor chemistry; and means for rupturing or displacing the reservoir cap to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry.

    摘要翻译： 以各种电流，电位和电导率的传感器装置配置提供电化学传感器装置。 电流传感器装置可以包括具有至少一个具有至少一个开口的储存器的结构体; 位于储存器内的工作电极; 分析物传感器化学位于储存器内并沉积在至少工作电极上; 位于储存器外部的辅助电极; 参考电极; 至少一个储存器盖封闭所述开口以将所述工作电极和所述分析物传感器化学物质隔离在所述储存器内并防止所述储存器外的分析物接触所述分析物传感器化学物质; 以及用于破裂或移动储存器盖以允许来自储存器外部的分析物接触分析物传感器化学物质的装置。

    MULTI-CHANNEL POTENTIOSTAT FOR BIOSENSOR ARRAYS
    7.
    发明申请
    MULTI-CHANNEL POTENTIOSTAT FOR BIOSENSOR ARRAYS 有权
    生物传感器阵列的多通道电位

    公开(公告)号：US20110089957A1

    公开(公告)日：2011-04-21

    申请号：US12905710

    申请日：2010-10-15

    申请人： Norman F. Sheppard, JR.

    发明人： Norman F. Sheppard, JR.

    IPC分类号： G01R27/08 ,  G01R1/30

    CPC分类号： G01N27/3273

    摘要： Arrays of biosensors are provided along with methods for operating the arrays of biosensors. The array of biosensors may include a first reference electrode that is connected to an input of a first control amplifier; a first working electrode and a second working electrode in proximity with the first reference electrode; and a counter electrode that is connected to at least an output of the first control amplifier, where the first control amplifier is operative with the counter electrode to maintain a first specified voltage between the first working electrode and the first reference electrode, and between the second working electrode and the first reference electrode. The array of biosensors optionally may further include a second reference electrode that is connected to an input of a second control amplifier, where the second control amplifier is operative with the counter electrode to maintain a second specified voltage between the first working electrode and the second reference electrode, and between the second working electrode and the second reference electrode.

    摘要翻译： 提供生物传感器的阵列以及用于操作生物传感器阵列的方法。 生物传感器阵列可以包括连接到第一控制放大器的输入的第一参考电极; 第一工作电极和靠近第一参考电极的第二工作电极; 以及对电极，其连接到所述第一控制放大器的至少一个输出端，其中所述第一控制放大器与所述对电极一起操作以维持所述第一工作电极和所述第一参考电极之间的第一规定电压， 工作电极和第一参考电极。 生物传感器的阵列可选地还可以包括连接到第二控制放大器的输入的第二参考电极，其中第二控制放大器与对电极一起操作以在第一工作电极和第二参考电极之间保持第二规定电压 电极，以及第二工作电极和第二参考电极之间。

    Implantable Biosensor Device and Methods of Use Thereof
    10.
    发明申请
    Implantable Biosensor Device and Methods of Use Thereof 审中-公开
    植入式生物传感器装置及其使用方法

    公开(公告)号：US20130211219A1

    公开(公告)日：2013-08-15

    申请号：US13818545

    申请日：2011-08-12

    申请人： Jonathan R. Coppeta ,  Robert Farra ,  Kenneth L. Hilts ,  Norman F. Sheppard, JR.

    发明人： Jonathan R. Coppeta ,  Robert Farra ,  Kenneth L. Hilts ,  Norman F. Sheppard, JR.

    IPC分类号： A61B5/145 ,  A61B5/1486

    CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B2562/046 ,  A61B2562/066

    摘要： Sensor devices and methods are provided for detecting the presence or concentration of an analyte in fluid. The device has a reservoir; a working electrode located within the reservoir, a catalyst covering at least part of the working electrode; an oxygen-generating auxiliary electrode in the reservoir; and a reservoir cap to isolate the working and auxiliary electrodes within the reservoir. The device further includes means for selectively rupturing the cap to permit analyte from outside the reservoir to contact the catalyst. The methods may include in vivo glucose monitoring and may include implanting the device in a patient; disintegrating a reservoir cap to permit glucose to enter the reservoir; generating oxygen using the oxygen-generating auxiliary electrode; and using a working electrode to oxidize hydrogen peroxide produced by the reaction of the oxygen with glucose in the presence of glucose oxidase, and thereby detecting endogenous glucose in the patient.

    摘要翻译： 提供了传感器装置和方法，用于检测流体中分析物的存在或浓度。 设备有一个水库; 位于储存器内的工作电极，覆盖工作电极的至少一部分的催化剂; 储存器中的产氧辅助电极; 以及用于隔离储存器内的工作和辅助电极的储存器盖。 该装置还包括用于选择性地破裂盖以允许来自储存器外部的分析物与催化剂接触的装置。 所述方法可以包括体内葡萄糖监测，并且可以包括将装置植入患者体内; 分解储存器盖以允许葡萄糖进入储存器; 使用产生氧的辅助电极产生氧气; 并且在葡萄糖氧化酶的存在下使用工作电极氧化由氧与葡萄糖的反应产生的过氧化氢，从而检测患者的内源性葡萄糖。