公开(公告)号：US11905270B2

公开(公告)日：2024-02-20

申请号：US16472118

申请日：2017-12-18

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Stefan Baeurle ,  Adam James Davenport ,  Christopher Stimson ,  Jens Nagel ,  Nicole Schmidt ,  Andrea Rotgeri ,  Ina Groeticke ,  Alexandra Rausch ,  Juergen Klar ,  Thomas Dyrks

IPC: C07D333/28 ,  A61P13/10 ,  C07D231/12 ,  C07D231/56 ,  C07D495/04 ,  C07D333/38 ,  C07D233/64 ,  C07D405/04 ,  C07D277/56 ,  C07D241/12 ,  C07D333/58 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00 ,  A61P19/02 ,  C07D213/56 ,  C07D231/16

CPC classification number: C07D333/28 ,  A61P3/04 ,  A61P3/10 ,  A61P13/10 ,  A61P19/02 ,  A61P35/00 ,  C07D213/56 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D241/12 ,  C07D277/56 ,  C07D333/38 ,  C07D333/58 ,  C07D405/04 ,  C07D495/04

Abstract: The present invention relates to carboxylic acid aromatic amides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a diseaseas a sole agent or in combination with other active ingredients.

公开(公告)号：US20190177279A1

公开(公告)日：2019-06-13

申请号：US16211486

申请日：2018-12-06

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Stefan Bäurle ,  Jens Nagel ,  Andrea Rotgeri ,  Adam James Davenport ,  Christopher Charles Stimson

IPC: C07D231/12 ,  C07D213/55 ,  A61P29/00

Abstract: The present invention relates to carboxylic acid aromatic 1,2-cyclopropylamides of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

公开(公告)号：US10172814B2

公开(公告)日：2019-01-08

申请号：US15537280

申请日：2015-12-16

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Nico Bräuer ,  Jens Nagel ,  Horst Irlbacher ,  Andrea Rotgeri ,  Wolfgang Schwede ,  Henrik Dahllöf ,  Marcus Koppitz ,  Michaele Peters ,  Anne-Marie Godinho-Coelho

IPC: A61K31/167 ,  C07D213/56 ,  C07D213/84 ,  C07D405/12 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  A61K31/44

Abstract: The present invention relates to substituted Pyridyl-cycloalkyl-carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.

公开(公告)号：US09708311B2

公开(公告)日：2017-07-18

申请号：US14649896

申请日：2013-12-03

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Olaf Peters ,  Nico Bräuer ,  Thorsten Blume ,  Antonius Ter Laak ,  Ludwig Zorn ,  Jens Nagel ,  Stefan Kaulfuss ,  Gernot Langer ,  Joachim Kuhnke

IPC: C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D471/04 ,  A61K31/437 ,  A61K31/4184 ,  A61P5/00 ,  A61K31/5377 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/5377 ,  A61K45/06 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14

Abstract: The present invention relates to novel benzimidazole derivatives of the general formula processes for their preparation and their use for the production of pharmaceutical compositions for the treatment of diseases and indications that are connected with the receptor EP4.

公开(公告)号：US20190194148A1

公开(公告)日：2019-06-27

申请号：US16211456

申请日：2018-12-06

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Stefan Bäurle ,  Jens Nagel ,  Andrea Rotgeri ,  Adam James Davenport ,  Christopher Charles Stimson

IPC: C07D257/04 ,  C07D403/12 ,  C07D401/10 ,  C07D409/10 ,  C07D401/14

CPC classification number: C07D257/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D409/10

Abstract: The present invention relates to N-(tetrazolylaryl) amide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20160318905A1

公开(公告)日：2016-11-03

申请号：US15105832

申请日：2014-12-16

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Olaf Peters ,  Nico Brauer ,  Ulrich Bothe ,  Marcus Koppitz ,  Jens Nagel ,  Gernot Langef

IPC: C07D403/04 ,  A61K45/06

Abstract: The present invention relates to novel benzimidazole derivatives of the general formula (I), to processes for their preparation and to their use for preparing pharmaceutical compositions for the treatment of disorders and indications associated with the EP4 receptor.

Abstract translation: 本发明涉及通式（I）的新型苯并咪唑衍生物，其制备方法及其用于制备用于治疗与EP4受体相关的病症和适应症的药物组合物的用途。

公开(公告)号：US11136296B2

公开(公告)日：2021-10-05

申请号：US16603719

申请日：2018-04-04

Applicant: Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

Inventor： Hartmut Beck ,  Raimund Kast ,  Mark Meininghaus ,  Lisa Dietz ,  Chantal Fuerstner ,  Timo Stellfeld ,  Sonja Anlauf ,  Clemens-Jeremias Von Buehler ,  Michaela Bairlein ,  Johanna Anlahr ,  Uwe Muenster ,  Carsten Terjung ,  Hannah Joerissen ,  Peter Hauff ,  Joerg Mueller ,  Karoline Droebner ,  Jens Nagel

IPC: C07D215/50

Abstract: The present application relates to novel substituted N-arylethyl-2-arylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.

公开(公告)号：US10730856B2

公开(公告)日：2020-08-04

申请号：US15105832

申请日：2014-12-16

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Olaf Peters ,  Nico Bräuer ,  Ulrich Bothe ,  Marcus Koppitz ,  Jens Nagel ,  Gernot Langer

IPC: C07D403/04 ,  A61K45/06

Abstract: The present invention relates to novel benzimidazole derivatives of the general formula (I), to processes for their preparation and to their use for preparing pharmaceutical compositions for the treatment of disorders and indications associated with the EP4 receptor.

公开(公告)号：US11319324B2

公开(公告)日：2022-05-03

申请号：US16759262

申请日：2018-10-18

Applicant: Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

Inventor： Marcus Koppitz ,  Holger Siebeneicher ,  Nico Bräuer ,  Elisabeth Pook ,  Andrea Rotgeri ,  Roland Neuhaus ,  Oliver Martin Fischer ,  Jens Nagel ,  Adam James Davenport ,  James Lindsay Carr ,  Robert James Townsend ,  Nina Connelly Ursinyova ,  Shelley Anne Parrott

IPC: C07D487/14

Abstract: The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.

公开(公告)号：US11149018B2

公开(公告)日：2021-10-19

申请号：US16604157

申请日：2018-04-04

Applicant: Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

Inventor： Hartmut Beck ,  Raimund Kast ,  Mark Meininghaus ,  Chantal Fuerstner ,  Timo Stellfeld ,  Clemens-Jeremias Von Buehler ,  Lisa Dietz ,  Michaela Bairlein ,  Johanna Anlahr ,  Hannah Joerissen ,  Peter Hauff ,  Joerg Mueller ,  Karoline Droebner ,  Jens Nagel

IPC: C07D401/04 ,  A61P1/16 ,  A61P13/12 ,  A61P11/00 ,  C07D215/50 ,  C07D417/04 ,  A61K45/06 ,  C07D413/04

Abstract: The present application relates to novel substituted N-arylethyl-2-aminoquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.