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公开(公告)号：US10730856B2
公开(公告)日：2020-08-04
申请号：US15105832
申请日：2014-12-16
发明人： Olaf Peters , Nico Bräuer , Ulrich Bothe , Marcus Koppitz , Jens Nagel , Gernot Langer
IPC分类号： C07D403/04 , A61K45/06
摘要： The present invention relates to novel benzimidazole derivatives of the general formula (I), to processes for their preparation and to their use for preparing pharmaceutical compositions for the treatment of disorders and indications associated with the EP4 receptor.
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公开(公告)号：US09655887B2
公开(公告)日：2017-05-23
申请号：US14893508
申请日：2014-05-16
发明人： Bernhard Lindenthal , Nico Bräuer , Peter Serno , Andrea Rotgeri , Ulrike Fuhrmann , Bernd Buchmann , Anne Mengel , Ulrike Röhn , Antonius Ter Laak
IPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/196 , A61K31/405 , A61K31/5415 , A61K31/18 , A61K31/192 , A61K31/365 , A61K31/407 , A61K31/42 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/542 , A61K31/635
CPC分类号： A61K31/454 , A61K31/18 , A61K31/192 , A61K31/196 , A61K31/365 , A61K31/405 , A61K31/407 , A61K31/416 , A61K31/42 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/5415 , A61K31/542 , A61K31/635 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition for non-hormonal, on-demand contraception and to processes for preparing this pharmaceutical composition. The latter comprises 2H-indazole as novel EP2 receptor antagonists in combination with COX inhibitors. The invention furthermore provides a method for non-hormonal female-controlled on-demand contraception where a pharmaceutical composition comprising EP2 receptor antagonists in combination with COX inhibitors is taken on demand prior to expected sexual intercourse.
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公开(公告)号：US11524938B2
公开(公告)日：2022-12-13
申请号：US17067434
申请日：2020-10-09
发明人： Stefan Werner , Stefanie Mesch , Arwed Cleve , Nico Bräuer , Simon Anthony Herbert , Markus Koch , Henrik Dahllöf , Maren Osmers , Elizabeth Hardaker , Anton Lishchynskyi
IPC分类号： C07D213/64 , C07D403/06 , C07D231/14 , C07D231/16 , C07D231/18 , C07D233/61 , C07D233/64 , C07D233/68 , C07D401/04 , C07D403/04 , C07D405/06 , C07D239/34 , C07D249/06 , C07D249/08 , C07D249/14 , C07D471/04 , C07D261/08 , C07D271/06 , C07C311/46 , C07F5/02 , C07D207/416 , C07D231/56 , C07D213/85 , C07D277/56 , C07D249/20 , C07D213/60 , C07C311/17 , C07D213/61 , C07D239/30 , C07D239/42 , C07D249/10 , C07D213/65 , C07D249/12 , C07D233/16 , C07C323/62 , C07D237/08 , C07D213/40 , C07D239/26 , C07D235/06 , C07C311/40 , C07D213/74 , C07D405/04 , C07D271/04 , C07D277/26 , C07D249/18 , C07D277/34 , C07D275/02 , C07D263/32 , C07D231/38 , C07D207/333 , A61P29/00 , C07D235/08 , C07D401/12 , C07D231/12
摘要： Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.
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公开(公告)号：US10172814B2
公开(公告)日：2019-01-08
申请号：US15537280
申请日：2015-12-16
发明人： Nico Bräuer , Jens Nagel , Horst Irlbacher , Andrea Rotgeri , Wolfgang Schwede , Henrik Dahllöf , Marcus Koppitz , Michaele Peters , Anne-Marie Godinho-Coelho
IPC分类号： A61K31/167 , C07D213/56 , C07D213/84 , C07D405/12 , C07D213/61 , C07D213/64 , C07D213/65 , A61K31/44
摘要： The present invention relates to substituted Pyridyl-cycloalkyl-carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.
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公开(公告)号：US09708311B2
公开(公告)日：2017-07-18
申请号：US14649896
申请日：2013-12-03
发明人： Olaf Peters , Nico Bräuer , Thorsten Blume , Antonius Ter Laak , Ludwig Zorn , Jens Nagel , Stefan Kaulfuss , Gernot Langer , Joachim Kuhnke
IPC分类号： C07D403/04 , C07D403/14 , C07D405/14 , C07D471/04 , A61K31/437 , A61K31/4184 , A61P5/00 , A61K31/5377 , A61K45/06
CPC分类号： C07D471/04 , A61K31/4184 , A61K31/437 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14
摘要： The present invention relates to novel benzimidazole derivatives of the general formula processes for their preparation and their use for the production of pharmaceutical compositions for the treatment of diseases and indications that are connected with the receptor EP4.
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公开(公告)号：US11319324B2
公开(公告)日：2022-05-03
申请号：US16759262
申请日：2018-10-18
发明人： Marcus Koppitz , Holger Siebeneicher , Nico Bräuer , Elisabeth Pook , Andrea Rotgeri , Roland Neuhaus , Oliver Martin Fischer , Jens Nagel , Adam James Davenport , James Lindsay Carr , Robert James Townsend , Nina Connelly Ursinyova , Shelley Anne Parrott
IPC分类号： C07D487/14
摘要： The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.
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