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1.发明申请公开(公告)号：US20150301014A1
公开(公告)日：2015-10-22
申请号：US14686367
申请日：2015-04-14
发明人： David Vrane , Pierce O. Norton
IPC分类号： G01N33/483
CPC分类号： G01N33/4833 , G01N15/14 , G01N35/0099
摘要： Flow cytometer systems that include a sample manipulation chamber having an access hole that is adjustably sealed by a slider tape sealing cartridge are provided. Also provided are methods of using such systems, as well as components for use in such systems.
摘要翻译： 提供了流式细胞仪系统，其包括具有通过滑块带密封盒可调节地密封的进入孔的样本操纵室。 还提供了使用这种系统的方法以及用于这种系统的部件。
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2.发明授权Slider tape sealing cartridge for adjustably sealing a flow cytometer sample manipulation chamber 有权滑块胶带密封胶囊，用于可调节地密封流式细胞仪样品操纵室公开(公告)号：US09575050B2
公开(公告)日：2017-02-21
申请号：US14686367
申请日：2015-04-14
发明人： David Vrane , Pierce O. Norton
IPC分类号： G01N33/483 , B01L99/00
CPC分类号： G01N33/4833 , G01N15/14 , G01N35/0099
摘要： Flow cytometer systems that include a sample manipulation chamber having an access hole that is adjustably sealed by a slider tape sealing cartridge are provided. Also provided are methods of using such systems, as well as components for use in such systems.
摘要翻译： 提供了流式细胞仪系统，其包括具有通过滑块带密封盒可调节地密封的进入孔的样本操纵室。 还提供了使用这种系统的方法以及用于这种系统的部件。
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公开(公告)号：US10173220B2
公开(公告)日：2019-01-08
申请号：US14817789
申请日：2015-08-04
摘要： Tissue dissociators configured to disrupt a biological tissue sample are provided. Aspects of the tissue dissociators may include a housing having a distal end and a proximal end, a cutting blade positioned at the distal end of the housing and a tissue actuator configured to be displaced along a longitudinal axis within the housing. Also provided are methods of using the tissue dissociators, as well as kits including the tissue dissociators.
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公开(公告)号：US09092034B2
公开(公告)日：2015-07-28
申请号：US13960681
申请日：2013-08-06
发明人： David Vrane , Pierce O. Norton
CPC分类号： G05D16/00 , G01N15/1404 , G01N2015/1409 , Y10T137/0379
摘要： The present invention relates to a vacuum-driven fluidic system for a flow-type particle analyzer. The system includes a vacuum pump which creates a pressure drop downstream of the flow cell, which pulls sheath fluid and sample fluid through the flow cell. A variable-resistance fluidic resistor is configured to control the ratio of sample fluid flow to sheath fluid flow. Dual feedback circuits, one configured to modulate the vacuum pump power in response to the pressure drop across the flow cell, referred to as the dynamic pressure drop, and a second configured to modulate the vacuum pump power in response to the pressure drop created by the vacuum pump relative to ambient pressure, referred to as the static pressure drop, are used to automatically control the system. The present invention enables adjustment of the sample fluid flow rate while maintaining a constant total fluid flow through the flow cell, and further, enables pausing the system without significant fluctuations in the vacuum.
摘要翻译： 本发明涉及一种用于流式粒子分析仪的真空驱动流体系统。 该系统包括真空泵，该真空泵在流动池下游产生压力降，其将护套流体和样品流体拉过流动池。 可变阻力流体电阻器被配置为控制样品流体流与鞘液流量的比率。 双反馈电路，一个被配置成响应于流动池中的压降而调节真空泵功率，被称为动态压降，以及第二配置以响应于由所述动压压降产生的压降来调节真空泵功率 真空泵相对于环境压力，被称为静压力，用于自动控制系统。 本发明能够在保持流过流动池的恒定的总流体流量的同时调节样品流体流速，并且还能够在没有真空的显着波动的情况下暂停该系统。
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公开(公告)号：US20140158212A1
公开(公告)日：2014-06-12
申请号：US13960681
申请日：2013-08-06
发明人： David Vrane , Pierce O. Norton
IPC分类号： G05D16/00
CPC分类号： G05D16/00 , G01N15/1404 , G01N2015/1409 , Y10T137/0379
摘要： The present invention relates to a vacuum-driven fluidic system for a flow-type particle analyzer. The system includes a vacuum pump which creates a pressure drop downstream of the flow cell, which pulls sheath fluid and sample fluid through the flow cell. A variable-resistance fluidic resistor is configured to control the ratio of sample fluid flow to sheath fluid flow. Dual feedback circuits, one configured to modulate the vacuum pump power in response to the pressure drop across the flow cell, referred to as the dynamic pressure drop, and a second configured to modulate the vacuum pump power in response to the pressure drop created by the vacuum pump relative to ambient pressure, referred to as the static pressure drop, are used to automatically control the system. The present invention enables adjustment of the sample fluid flow rate while maintaining a constant total fluid flow through the flow cell, and further, enables pausing the system without significant fluctuations in the vacuum.
摘要翻译： 本发明涉及一种用于流式粒子分析仪的真空驱动流体系统。 该系统包括真空泵，该真空泵在流动池下游产生压力降，其将护套流体和样品流体拉过流动池。 可变阻力流体电阻器被配置为控制样品流体流与鞘液流量的比率。 双反馈电路，一个被配置成响应于流动池中的压降而调节真空泵功率，被称为动态压降，以及第二配置以响应于由所述动压压降产生的压降来调节真空泵功率 真空泵相对于环境压力，被称为静压力，用于自动控制系统。 本发明能够在保持流过流动池的恒定的总流体流量的同时调节样品流体流速，并且还能够在没有真空的显着波动的情况下暂停该系统。
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公开(公告)号：US20160069781A1
公开(公告)日：2016-03-10
申请号：US14817789
申请日：2015-08-04
IPC分类号： G01N1/28
摘要： Tissue dissociators configured to disrupt a biological tissue sample are provided. Aspects of the tissue dissociators may include a housing having a distal end and a proximal end, a cutting blade positioned at the distal end of the housing and a tissue actuator configured to be displaced along a longitudinal axis within the housing. Also provided are methods of using the tissue dissociators, as well as kits including the tissue dissociators.
摘要翻译： 提供了构造成破坏生物组织样品的组织解离器。 组织解离器的方面可以包括具有远端和近端的壳体，设置在壳体的远端处的切割刀片和构造成沿壳体内的纵向轴线移位的组织致动器。 还提供了使用组织解离器的方法，以及包括组织解离器的试剂盒。
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