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    Magnetically-Controllable Delivery System for Therapeutic Agents
    5.
    发明申请
    Magnetically-Controllable Delivery System for Therapeutic Agents 审中-公开
    用于治疗药物的磁控制递送系统

    公开(公告)号：US20100204674A1

    公开(公告)日：2010-08-12

    申请号：US12763925

    申请日：2010-04-20

    申请人： Zachary G. Forbes ,  Benjamin B. Yellen ,  Kenneth A. Barbee ,  Gennady Friedman

    发明人： Zachary G. Forbes ,  Benjamin B. Yellen ,  Kenneth A. Barbee ,  Gennady Friedman

    IPC分类号： A61M37/00 ,  A61B19/00

    CPC分类号： A61L31/14 ,  A61F2/82 ,  A61F2210/009 ,  A61L27/50 ,  A61L31/022 ,  A61M37/00 ,  A61M2037/0007 ,  A61N1/30 ,  A61N2/00

    摘要： A magnetic delivery system for delivering a magnetizable particle to a location in a body, the device includes a magnetizable object implanted in the body, wherein the magnetizable object includes a plurality of segments distributed throughout the magnetizable object and wherein the segments are configured to provide a magnetic gradient for attracting the magnetizable particle and an external source of a magnetic field capable of (i) magnetizing the magnetizable particle and (ii) increasing a degree of magnetization of the magnetizable object and thereby creating the magnetic gradient. A drug delivery system including the magnetic delivery system and a magnetizable particle associated with a therapeutic agent and/or a cell. A cell delivery system based on the magnetic delivery system and a magnetizable particle associated with a cell. A method of using the magnetic delivery system for delivery of a therapeutic agent and/or a cell to a targeted location in a body.

    摘要翻译： 一种用于将可磁化颗粒输送到身体中的位置的磁性传送系统，该装置包括植入体内的可磁化物体，其中可磁化物体包括分布在整个可磁化物体上的多个区段，并且其中该区段被配置成提供 用于吸引可磁化颗粒的磁梯度和能够（i）磁化可磁化颗粒的磁场的外部源，和（ii）增加可磁化物体的磁化程度，从而产生磁梯度。 药物递送系统，包括磁性递送系统和与治疗剂和/或细胞相关联的可磁化颗粒。 基于磁传递系统的细胞递送系统和与细胞相关联的可磁化颗粒。 一种使用磁性递送系统将治疗剂和/或细胞输送到体内目标位置的方法。

    Methods and devices for the treatment and prevention of malignancy in enteric diseases using non-thermal plasma
    7.
    发明授权
    Methods and devices for the treatment and prevention of malignancy in enteric diseases using non-thermal plasma 有权
    使用非热等离子体治疗和预防肠道疾病恶性肿瘤的方法和装置

    公开(公告)号：US08992518B2

    公开(公告)日：2015-03-31

    申请号：US13256313

    申请日：2010-03-16

    申请人： Gregory Fridman ,  Danil V. Dobrynin ,  Alexander Fridman ,  Gennady Friedman ,  Kalyan Chakravarthy ,  Sreekant Murthy

    发明人： Gregory Fridman ,  Danil V. Dobrynin ,  Alexander Fridman ,  Gennady Friedman ,  Kalyan Chakravarthy ,  Sreekant Murthy

    IPC分类号： A61B18/18 ,  A61N1/40 ,  H05H1/24

    CPC分类号： A61N1/40 ,  H05H1/24 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2001/245 ,  H05H2240/20 ,  H05H2245/122

    摘要： Non-thermal plasma is a partly ionized gas, which can be generated by a high-voltage electric field at a low pressure. Disclosed herein are apparatuses and methods for treating an enteric disease in vivo using non-thermal plasma. The disclosed apparatuses have a first conduit comprising a lumen and a tip; a first electrode disposed within the lumen of the first conduit; a second electrode comprised of a metal conduit disposed within the first conduit; an insulator disposed within the lumen of the first conduit, the insulator configured to electrically insulate the first electrode from the second electrode; and a gas channel disposed between the outer surface of the metal conduit and the inner surface of the first conduit, the gas channel being capable of feeding a gas from a gas source to the tip, wherein when the potential is applied, the gas is ionized to produce the non-thermal plasma.

    摘要翻译： 非热等离子体是部分电离的气体，其可以通过低压下的高压电场产生。 本文公开了使用非热等离子体在体内治疗肠道疾病的装置和方法。 所公开的装置具有包括内腔和尖端的第一导管; 设置在所述第一导管的内腔内的第一电极; 第二电极，包括设置在第一导管内的金属导管; 设置在所述第一导管的内腔内的绝缘体，所述绝缘体被配置为使所述第一电极与所述第二电极电绝缘; 以及设置在金属导管的外表面和第一导管的内表面之间的气体通道，气体通道能够将气体从气体源供给到尖端，其中当施加电位时，气体被电离 以产生非热等离子体。

    METHODS AND DEVICES FOR THE TREATMENT AND PREVENTION OF MALIGNANCY IN ENTERIC DISEASES USING NON-THERMAL PLASMA
    8.
    发明申请
    METHODS AND DEVICES FOR THE TREATMENT AND PREVENTION OF MALIGNANCY IN ENTERIC DISEASES USING NON-THERMAL PLASMA 有权
    使用非热等离子体治疗和预防肠疾病恶性肿瘤的方法和装置

    公开(公告)号：US20120253265A1

    公开(公告)日：2012-10-04

    申请号：US13256313

    申请日：2010-03-16

    申请人： Gregory Fridman ,  Danil V. Dobrynin ,  Alexander Fridman ,  Gennady Friedman ,  Kaylan Chakravarthy ,  Sreekant Murthy

    发明人： Gregory Fridman ,  Danil V. Dobrynin ,  Alexander Fridman ,  Gennady Friedman ,  Kaylan Chakravarthy ,  Sreekant Murthy

    IPC分类号： A61M37/00

    CPC分类号： A61N1/40 ,  H05H1/24 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2001/245 ,  H05H2240/20 ,  H05H2245/122

    摘要： Non-thermal plasma is a partly ionized gas, which can be generated by a high-voltage electric field at a low pressure. Disclosed herein are apparatuses and methods for treating an enteric disease in vivo using non-thermal plasma. The disclosed apparatuses have a first conduit comprising a lumen and a tip; a first electrode disposed within the lumen of the first conduit; a second electrode comprised of a metal conduit disposed within the first conduit; an insulator disposed within the lumen of the first conduit, the insulator configured to electrically insulate the first electrode from the second electrode; and a gas channel disposed between the outer surface of the metal conduit and the inner surface of the first conduit, the gas channel being capable of feeding a gas from a gas source to the tip, wherein when the potential is applied, the gas is ionized to produce the non-thermal plasma.

    摘要翻译： 非热等离子体是部分电离的气体，其可以通过低压下的高压电场产生。 本文公开了使用非热等离子体在体内治疗肠道疾病的装置和方法。 所公开的装置具有包括内腔和尖端的第一导管; 设置在所述第一导管的内腔内的第一电极; 第二电极，包括设置在第一导管内的金属导管; 设置在所述第一导管的内腔内的绝缘体，所述绝缘体被配置为使所述第一电极与所述第二电极电绝缘; 以及设置在金属导管的外表面和第一导管的内表面之间的气体通道，气体通道能够将气体从气体源供给到尖端，其中当施加电位时，气体被电离 以产生非热等离子体。

    METHODS FOR NON-THERMAL APPLICATION OF GAS PLASMA TO LIVING TISSUE
    9.
    发明申请
    METHODS FOR NON-THERMAL APPLICATION OF GAS PLASMA TO LIVING TISSUE 有权
    将气体等离子体非热应用于生活组织的方法

    公开(公告)号：US20100145253A1

    公开(公告)日：2010-06-10

    申请号：US11911479

    申请日：2006-04-25

    申请人： Alexander F. Gutsol ,  Alexander Fridman ,  Gennady Friedman ,  Gregory Fridman ,  Manjula Balasubramanian

    发明人： Alexander F. Gutsol ,  Alexander Fridman ,  Gennady Friedman ,  Gregory Fridman ,  Manjula Balasubramanian

    IPC分类号： A61B18/18 ,  A61N1/00 ,  A61M31/00

    CPC分类号： A61B18/042 ,  A61N1/40 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2240/20 ,  H05H2245/122

    摘要： Method for the non-thermal treatment of human or animal tissue with high-voltage electrical discharge plasma is disclosed. The disclosed method employs current through plasma and through tissue not for the purpose of heating the tissue, but instead to maintain the plasma proximate to the tissue being treated. Also disclosed is a method of limiting the current through plasma and through tissue to minimize tissue heating by placement of an insulator or semiconductor between an electrode and tissue resulting in generation of a high-voltage discharge similar to a dielectric barrier discharge. The disclosed non-thermal plasma treatment can be employed to promote coagulation of blood, sterilization, disinfection, re-connection of tissue, and treatment of tissue disorders without causing significant thermal tissue damage.

    摘要翻译： 公开了用高压放电等离子体对人体或动物组织进行非热处理的方法。 所公开的方法采用电流通过等离子体和通过组织而不是用于加热组织的目的，而是将血浆保持在靠近待治疗组织的位置。 还公开了一种限制通过等离子体和通过组织的电流的方法，以通过在电极和组织之间放置绝缘体或半导体来最小化组织加热，导致产生类似于电介质阻挡放电的高压放电。 所公开的非热等离子体处理可用于促进血液凝结，消毒，消毒，组织再连接，以及治疗组织疾病而不引起明显的热组织损伤。