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    Magnetically-controllable delivery system for therapeutic agents
    3.
    发明申请
    Magnetically-controllable delivery system for therapeutic agents 审中-公开
    用于治疗剂的磁控制递送系统

    公开(公告)号：US20060041182A1

    公开(公告)日：2006-02-23

    申请号：US11210173

    申请日：2005-08-22

    申请人： Zachary Forbes ,  Benjamin Yellen ,  Kenneth Barbee ,  Gennady Friedman

    发明人： Zachary Forbes ,  Benjamin Yellen ,  Kenneth Barbee ,  Gennady Friedman

    IPC分类号： A61N2/10 ,  A61F2/06 ,  A61F2/28

    CPC分类号： A61L31/14 ,  A61F2/82 ,  A61F2210/009 ,  A61L27/50 ,  A61L31/022 ,  A61M37/00 ,  A61M2037/0007 ,  A61N1/30 ,  A61N2/00

    摘要： A magnetic delivery system for delivering a magnetizable particle to a location in a body, the device includes a magnetizable object implanted in the body, wherein the magnetizable object includes a plurality of segments distributed throughout the magnetizable object and wherein the segments are configured to provide a magnetic gradient for attracting the magnetizable particle and an external source of a magnetic field capable of (i) magnetizing the magnetizable particle and (ii) increasing a degree of magnetization of the magnetizable object and thereby creating the magnetic gradient. A drug delivery system including the magnetic delivery system and a magnetizable particle associated with a therapeutic agent and/or a cell. A cell delivery system based on the magnetic delivery system and a magnetizable particle associated with a cell. A method of using the magnetic delivery system for delivery of a therapeutic agent and/or a cell to a targeted location in a body.

    摘要翻译： 一种用于将可磁化颗粒输送到身体中的位置的磁性传送系统，该装置包括植入体内的可磁化物体，其中可磁化物体包括分布在整个可磁化物体上的多个区段，并且其中该区段被配置成提供 用于吸引可磁化颗粒的磁梯度和能够（i）磁化可磁化颗粒的磁场的外部源，和（ii）增加可磁化物体的磁化程度，从而产生磁梯度。 药物递送系统，包括磁性递送系统和与治疗剂和/或细胞相关联的可磁化颗粒。 基于磁传递系统的细胞递送系统和与细胞相关联的可磁化颗粒。 一种使用磁性递送系统将治疗剂和/或细胞输送到体内目标位置的方法。

    Photochemical activation of surfaces for attaching biomaterial
    4.
    发明授权
    Photochemical activation of surfaces for attaching biomaterial 有权
    用于附着生物材料的表面的光化学活化

    公开(公告)号：US08263127B2

    公开(公告)日：2012-09-11

    申请号：US12633593

    申请日：2009-12-08

    申请人： Ivan Alferiev ,  Ilia Fishbein ,  Michael Chorny ,  Robert J. Levy ,  Benjamin Yellen ,  Darryl Williams

    发明人： Ivan Alferiev ,  Ilia Fishbein ,  Michael Chorny ,  Robert J. Levy ,  Benjamin Yellen ,  Darryl Williams

    IPC分类号： A61K9/14 ,  A61K47/48

    CPC分类号： C08G63/91 ,  A61K31/765 ,  A61K31/785 ,  A61L27/50 ,  A61L2400/18 ,  C07K17/02 ,  C08F8/10 ,  C08F8/32 ,  C08F8/34 ,  C08F226/02 ,  C08F271/02 ,  C08F290/00 ,  C08F291/00 ,  C08J7/18 ,  C08L75/04 ,  C08F120/06 ,  C08F126/02

    摘要： A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.

    摘要翻译： 一种水溶性可光活化聚合物，其包括：适于被辐照源活化并在所述水溶性可光活化聚合物与具有至少一个碳的基质之间形成共价键的可光致活化基团; 适于与生物材料共价反应的反应性基团，用于随后将生物材料递送至细胞; 亲水基团; 和聚合物前体。 一种组合物，其包含水溶性可光活化聚合物的单分子层和具有至少一个碳的基质，其中单分子层通过可光致活化基团和至少一个碳之间的共价键共价连接到基质上 。 组合物还包括具有多个活性基团的生物材料，其中生物材料通过活性基团和反应性基团之间的共价键共价连接到单分子层上。 还提供了将生物材料递送到细胞的方法。

    PHOTOCHEMICAL ACTIVATION OF SURFACES FOR ATTACHING BIOMATERIAL
    5.
    发明申请
    PHOTOCHEMICAL ACTIVATION OF SURFACES FOR ATTACHING BIOMATERIAL 有权
    用于连接生物材料的表面的光化学活化

    公开(公告)号：US20100210015A1

    公开(公告)日：2010-08-19

    申请号：US12633593

    申请日：2009-12-08

    申请人： Ivan Alferiev ,  Ilia Fishbein ,  Michael Chorny ,  Robert J. Levy ,  Benjamin Yellen ,  Darryl Williams

    发明人： Ivan Alferiev ,  Ilia Fishbein ,  Michael Chorny ,  Robert J. Levy ,  Benjamin Yellen ,  Darryl Williams

    IPC分类号： C12N5/07 ,  C08F16/36 ,  C12N15/63 ,  C08L61/00

    CPC分类号： C08G63/91 ,  A61K31/765 ,  A61K31/785 ,  A61L27/50 ,  A61L2400/18 ,  C07K17/02 ,  C08F8/10 ,  C08F8/32 ,  C08F8/34 ,  C08F226/02 ,  C08F271/02 ,  C08F290/00 ,  C08F291/00 ,  C08J7/18 ,  C08L75/04 ,  C08F120/06 ,  C08F126/02

    摘要： A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.

    摘要翻译： 一种水溶性可光活化聚合物，其包括：适于被辐照源活化并在所述水溶性可光活化聚合物与具有至少一个碳的基质之间形成共价键的可光致活化基团; 适于与生物材料共价反应的反应性基团，用于随后将生物材料递送至细胞; 亲水基团; 和聚合物前体。 一种组合物，其包含水溶性可光活化聚合物的单分子层和具有至少一个碳的基质，其中单分子层通过可光致活化基团和至少一个碳之间的共价键共价连接到基质上 。 组合物还包括具有多个活性基团的生物材料，其中生物材料通过活性基团和反应性基团之间的共价键共价连接到单分子层上。 还提供了将生物材料递送到细胞的方法。

    Magnetic markers for position sensing
    7.
    发明申请
    Magnetic markers for position sensing 审中-公开
    用于位置检测的磁标记

    公开(公告)号：US20070276218A1

    公开(公告)日：2007-11-29

    申请号：US11417601

    申请日：2006-05-04

    申请人： Benjamin Yellen

    发明人： Benjamin Yellen

    IPC分类号： A61B5/05

    CPC分类号： A61B5/06 ,  A61B5/062 ,  A61B5/4528 ,  A61B2090/3958 ,  A61F2/3868

    摘要： An imaging system is provided for locating implants within a patient, and for determining the spatial relationship and orientation between components of an implant within a patient. Magnets are fixed to an implant in pre-determined locations, the magnets having pre-determined quantity, magnetic field map, and moment orientations. An array of sensors is arranged around the implant. The locations of the magnets are estimated by iteratively solving for the position vector coordinates using multi-poles approximating the pre-determined quantity, magnetic field map, and moment orientations of the magnets and the magnetic field measurements for each sensor. The positions and orientations of the implant or components of the implant are inferred from the estimated locations of the magnets.

    摘要翻译： 提供了一种成像系统，用于定位患者内的植入物，并且用于确定患者体内植入物的组件之间的空间关系和取向。 磁体固定在预定位置的植入物上，磁体具有预定量，磁场图和力矩方向。 传感器阵列布置在植入物周围。 磁体的位置通过迭代求解位置矢量坐标来估计，该坐标使用多极近似预定量，磁场映射以及磁体的力矩取向和每个传感器的磁场测量值。 根据磁体的估计位置推断植入物或植入物的部件的位置和取向。

    NONLINEAR MAGNETOPHORETIC SEPARATION OF BIOLOGICAL SUBSTANCES
    10.
    发明申请
    NONLINEAR MAGNETOPHORETIC SEPARATION OF BIOLOGICAL SUBSTANCES 审中-公开
    生物物质的非线性磁共振分离

    公开(公告)号：US20100279887A1

    公开(公告)日：2010-11-04

    申请号：US12452031

    申请日：2008-06-14

    申请人： Gil U. Lee ,  Benjamin Yellen ,  Randall Morgan Erb

    发明人： Gil U. Lee ,  Benjamin Yellen ,  Randall Morgan Erb

    IPC分类号： C40B30/04 ,  C40B40/18

    CPC分类号： G01N27/745

    摘要： A method of separating a target biological analyte from a mixture of substances in a fluid sample employs nonlinear magnetophoresis. Magnetic particles having the capacity to bind to the target analyte are contacted with the fluid sample so that the analyte is immobilized on the surface of at least some of the particles. The magnetic particles are provided adjacent an array of micromagnets patterned on a substrate so that the particles are attracted the micromagnets. The magnetic particles are then subjected to a traveling magnetic field operating at or above a frequency effective to sweep those particles not bound to analyte to an adjacent micromagnet. Those magnetic particles bound to analyte have a larger size or smaller magnetic moment that prevents them from being moved to adjacent micromagnets, thereby affording separation of the analyte.

    摘要翻译： 从流体样品中的物质混合物中分离目标生物分析物的方法采用非线性磁电泳法。 具有结合目标分析物的能力的磁性颗粒与流体样品接触，使得分析物固定在至少一些颗粒的表面上。 磁性颗粒被设置在图案化在基板上的微阵列附近，使得颗粒被吸引到微型磁体。 然后磁性颗粒经受有效扫描未结合分析物的颗粒到相邻微型磁体上或高于频率的行进磁场。 与分析物结合的那些磁性颗粒具有更大的尺寸或更小的磁矩，从而防止它们被移动到相邻的微型磁体，从而提供分析物的分离。