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公开(公告)号：US20100009437A1
公开(公告)日：2010-01-14
申请号：US12319796
申请日：2009-01-12
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Uses of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-3的核酸分子。 还公开了利用核酸分子和任选的编码人白细胞抗原HLA-A1的分子的载体，细胞系等。 这些材料在治疗和诊断环境中的使用也是本发明的一部分。
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公开(公告)号：US20070219349A1
公开(公告)日：2007-09-20
申请号：US11713865
申请日：2007-03-05
IPC分类号： C07K14/00
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to new members of the GAGE family referred to as GAGE-7B and GAGE-8. There are differences between these two molecules and the previously described members of the GAGE family on the genomic DNA, complementary DNA, and amino acid level.
摘要翻译： 本发明涉及GAGE家族的新成员，称为GAGE-7B和GAGE-8。 在基因组DNA，互补DNA和氨基酸水平上，这两个分子和前述GAGE家族成员之间存在差异。
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公开(公告)号：US07572885B2
公开(公告)日：2009-08-11
申请号：US10271617
申请日：2002-10-16
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to new members of the GAGE family referred to as GAGE-7B and GAGE-8. There are differences between these two molecules and the previously described members of the GAGE family on the genomic DNA, complementary DNA, and amino acid level.
摘要翻译： 本发明涉及GAGE家族的新成员，称为GAGE-7B和GAGE-8。 在基因组DNA，互补DNA和氨基酸水平上，这两个分子和前述GAGE家族成员之间存在差异。
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4.发明授权Method for diagnosing a disorder by determining expression of gage tumor rejection antigen precursors 失效通过测定计量肿瘤排斥抗原前体的表达来诊断病症的方法
公开(公告)号：US5610013A
公开(公告)日：1997-03-11
申请号：US250162
申请日：1994-05-27
IPC分类号： G01N33/566 , A61K35/12 , A61K38/00 , A61K48/00 , A61K49/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/74 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/574 , C07H19/00 , C12N1/20 , C12N5/00
CPC分类号： C07K14/4748 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为GAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。
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5.发明授权Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-2 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-2的分离的核酸分子及其用途公开(公告)号：US06552180B1
公开(公告)日：2003-04-22
申请号：US09579197
申请日：2000-05-26
IPC分类号： C07H2104
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： Isolated nucleic acid molecules are described, which have complements that hybridize to a nucleic acid molecule referred to as MAGE-2. The isolated nucleic acid molecules are expressed in some melanoma cells, as well as other types of cancer cells. The invention also relates to nucleic acid molecules which encode fragments of the proteins encoded by these nucleic acid molecules, and nucleic acid molecules which encode the ultimate product, the so-called tumor rejection antigens.
摘要翻译： 描述了分离的核酸分子，其具有与被称为MAGE-2的核酸分子杂交的互补序列。 分离的核酸分子在一些黑素瘤细胞以及其它类型的癌细胞中表达。 本发明还涉及编码由这些核酸分子编码的蛋白质的片段的核酸分子和编码最终产物的核酸分子，所谓的肿瘤排斥抗原。
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6.发明授权Isolated, truncated nucleic acid which are members of the gage, and uses thereof 有权作为量规成员的分离的截短的核酸及其用途公开(公告)号：US06509172B1
公开(公告)日：2003-01-21
申请号：US09163748
申请日：1998-09-30
IPC分类号： C12P2106
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to new members of the GAGE family referred to as GAGE-7B and GAGE-8. There are differences between these two molecules and the previously described members of the GAGE family on the genomic DNA, complementary DNA, and amino acid level.
摘要翻译： 本发明涉及GAGE家族的新成员，称为GAGE-7B和GAGE-8。 在基因组DNA，互补DNA和氨基酸水平上，这两个分子和前述GAGE家族成员之间存在差异。
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7.发明授权Isolated, truncated nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof 失效编码计量肿瘤排斥抗原的分离的截短的核酸分子，肿瘤排斥抗原及其用途
公开(公告)号：US6069001A
公开(公告)日：2000-05-30
申请号：US602039
申请日：1996-02-15
IPC分类号： G01N33/566 , A61K35/12 , A61K38/00 , A61K48/00 , A61K49/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/74 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , Y10S530/828
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described. Tumor rejection antigens are also shown.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为GAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。 还显示肿瘤排斥抗原。
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8.发明授权Isolated RAGE-1 derived peptides which complex with HLA-B7 molecules and uses thereof 失效与HLA-B7分子复合的分离的RAGE-1衍生肽及其用途
公开(公告)号：US5939526A
公开(公告)日：1999-08-17
申请号：US530569
申请日：1995-09-20
申请人： Beatrice Gaugler , Benoit Van den Eynde , Peter Schrier , Nathalie Brouwenstijn , Thierry Boon-Falleur
发明人： Beatrice Gaugler , Benoit Van den Eynde , Peter Schrier , Nathalie Brouwenstijn , Thierry Boon-Falleur
CPC分类号： C07K14/4748 , A61K38/00 , Y10S530/828
摘要： The invention describes the RAGE tumor rejection antigen precursor family, including nucleic acids encoding such tumor rejection antigen precursors, tumor rejection antigen peptides or precursors thereof and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a RAGE tumor rejection antigen precursor.
摘要翻译： 本发明描述了RAGE肿瘤排斥抗原前体家族，包括编码这种肿瘤排斥抗原前体的核酸，肿瘤排斥抗原肽或其前体以及与之相关的抗体。 还提供了用于诊断和治疗以RAGE肿瘤排斥抗原前体的表达为特征的病症的方法和产品。
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公开(公告)号：US5648226A
公开(公告)日：1997-07-15
申请号：US370648
申请日：1995-01-10
IPC分类号： G01N33/566 , A61K35/12 , A61K38/00 , A61K48/00 , A61K49/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/74 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/574 , C07K7/00 , C07K14/82
CPC分类号： C07K14/4748 , A61K38/00 , Y10S530/828
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described. Tumor rejection antigens are also shown.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为GAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。 还显示肿瘤排斥抗原。
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10.再颁专利Nucleic acid molecules encoding the MAGE-1 tumor rejection antigen precursor 失效编码MAGE-1肿瘤排斥抗原前体的核酸分子公开(公告)号：USRE40089E1
公开(公告)日：2008-02-19
申请号：US08590097
申请日：1996-01-24
申请人： Thierry Boon-Falleur , Pierre Van der Bruggen , Benoit Van den Eynde , Aline Van Pel , Etienne De Plaen , Christophe Lurquin , Patrick Chomez , Catia Traversari
发明人： Thierry Boon-Falleur , Pierre Van der Bruggen , Benoit Van den Eynde , Aline Van Pel , Etienne De Plaen , Christophe Lurquin , Patrick Chomez , Catia Traversari
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which is recognized by cytotoxic T cells, leading to lysis of the tumor which expresses it. Also described are cells transfected by the DNA sequence, and various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes.
摘要翻译： 本发明涉及编码由细胞毒性T细胞识别的肿瘤细胞表达的抗原的分离的DNA序列，导致表达肿瘤的裂解。 还描述了由DNA序列转染的细胞，以及由其编码的DNA和抗原的性质产生的各种治疗和诊断用途。
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