公开(公告)号：US07677482B2

公开(公告)日：2010-03-16

申请号：US11781714

申请日：2007-07-23

申请人： Beom-seok Lee ,  Jeong-gun Lee ,  Hye-jung Cho

发明人： Beom-seok Lee ,  Jeong-gun Lee ,  Hye-jung Cho

IPC分类号： B05B5/00

CPC分类号： B05B5/0255 ,  B01J2219/00367 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01L3/0268 ,  B01L2300/0838 ,  B01L2300/161 ,  B01L2400/027 ,  B01L2400/0406 ,  B01L2400/0487 ,  B05B1/14 ,  B05B5/0533 ,  B41J2/06

摘要： Provided is a droplet dispensing device having a nonconductive capillary nozzle. The droplet dispensing device comprises: a nonconductive capillary nozzle disposed in a downward position; a pump connected with the nonconductive capillary nozzle through a hermetically sealed fluid tube and generating a negative pressure to decrease the influence of gravity on a solution within the nonconductive capillary nozzle and the fluid tube; and an open circuit voltage supplier applying a voltage to the solution. The droplet dispensing device supplies the solution by capillary force to regularly maintain the shape of a droplet surface in the tip of the nonconductive capillary nozzle without using a separate driving device.

摘要翻译： 提供了具有非导电毛细管喷嘴的液滴分配装置。 液滴分配装置包括：设置在向下位置的非导电毛细管喷嘴; 泵，其通过气密密封的流体管与非导电毛细管喷嘴连接并产生负压，以减少重力对非导电毛细管喷嘴和流体管内的溶液的影响; 以及向该溶液施加电压的开路电压供给器。 液滴分配装置通过毛细管力提供溶液以在不使用单独的驱动装置的情况下规定地保持非导电毛细管喷嘴的尖端中的液滴表面的形状。

公开(公告)号：US20090189932A1

公开(公告)日：2009-07-30

申请号：US12141988

申请日：2008-06-19

申请人： Beom-seok Lee ,  Dustin Moon ,  Jeong-gun Lee ,  Hye-jung Cho ,  In-seok Kang ,  Jin-seok Hong

发明人： Beom-seok Lee ,  Dustin Moon ,  Jeong-gun Lee ,  Hye-jung Cho ,  In-seok Kang ,  Jin-seok Hong

IPC分类号： B41J25/308 ,  B41J29/38

CPC分类号： B41J2/175 ,  B01L3/0268 ,  B01L2400/0415 ,  B41J2/04 ,  Y10T436/2575

摘要： Provided are a droplet emitting apparatus and a method of emitting droplets using the same. The apparatus includes a solution tank for containing a solution; a nozzle including an opening through which at least a droplet of the solution is emitted; and a voltage generator including a piezoelectric material for generating a voltage by instantaneous pressure application, wherein the voltage generated by the pressure to the piezoelectric material is applied to the solution in order for the at least a droplet of the solution to be emitted through the nozzle

摘要翻译： 提供了一种液滴喷射装置和使用其发射液滴的方法。 该装置包括用于容纳溶液的溶液罐; 喷嘴，其包括开口，所述溶液的至少一个液滴通过所述开口发射; 以及电压发生器，其包括用于通过瞬时压力施加产生电压的压电材料，其中由压电材料的压力产生的电压被施加到溶液，以便溶液的至少一个液滴通过喷嘴发射

公开(公告)号：US20070035567A1

公开(公告)日：2007-02-15

申请号：US11503786

申请日：2006-08-14

申请人： Su-hyeon Kim ,  Jeong-gun Lee ,  Jong-suk Chung ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

发明人： Su-hyeon Kim ,  Jeong-gun Lee ,  Jong-suk Chung ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

IPC分类号： B41J29/38

CPC分类号： B41J2/06 ,  B01J19/0046 ,  B01J2219/00364 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00743 ,  B41J2/04535 ,  B41J2/0456 ,  B41J2/04576

摘要： A device for printing a droplet onto a substrate includes: a droplet generating member which is needle-shaped and comprises a receiving portion disposed vertically to receive a solution, and a discharge hole connected to the receiving portion and formed on a bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate disposed below the droplet generating member, the substrate includes a target portion to which the droplet discharged from the discharge hole of the droplet generating member is dropped and attached; a voltage applier applying a voltage to the droplet so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet.

摘要翻译： 用于将液滴印刷到基板上的装置包括：液滴产生构件，其为针状并且包括垂直设置以接收溶液的接收部分，以及连接到接收部分并形成在接收部分的底部上的排出孔 使得溶液可以从接收部分排出; 设置在所述液滴产生部件下方的基板，所述基板包括从所述液滴产生部件的排出孔排出的液滴滴落并附着到的目标部分; 电压施加器，向所述液滴施加电压，使得所述液滴能够落到所述基板的所述目标部分上; 体积测量单元，测量液滴的体积; 以及液滴控制单元，其基于所测量的液滴体积将液滴的体积保持在预定水平。

公开(公告)号：US07910379B2

公开(公告)日：2011-03-22

申请号：US12888927

申请日：2010-09-23

申请人： Beom-seok Lee ,  Jeong-gun Lee ,  Hye-jung Cho ,  In-seok Kang ,  Jae-suk Moon ,  Jin-seok Hong

发明人： Beom-seok Lee ,  Jeong-gun Lee ,  Hye-jung Cho ,  In-seok Kang ,  Jae-suk Moon ,  Jin-seok Hong

IPC分类号： B01L3/02 ,  B01L99/00

CPC分类号： B01L3/0262 ,  B01J19/0046 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00689 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01J2219/00743 ,  B01L2300/0819 ,  B01L2300/0838 ,  B01L2400/027 ,  Y10T436/11 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/25 ,  Y10T436/2575

摘要： Disclosed is an apparatus and method for ejecting droplets using charge concentration and liquid bridge breakup. The droplet ejection apparatus includes a reservoir storing a liquid; a capillary nozzle having a lower end submerged in the liquid stored in the reservoir and an upper end exposed outside the surface of the liquid, the capillary nozzle transferring the liquid to the upper end using capillary force; a potentiostat for applying a voltage to the liquid; a substrate mount on which a substrate is disposed to face the upper end of the capillary nozzle; and a distance adjusting unit for reciprocatingly moving the substrate between first and second positions with respect to the capillary nozzle, wherein the first position denotes a position where a distance between the upper end of the capillary nozzle and the surface of the substrate is less than a effective distance.

摘要翻译： 公开了一种使用电荷浓度和液桥分解喷射液滴的装置和方法。 液滴喷射装置包括储存液体的储存器; 毛细喷嘴，其下端浸没在存储在储存器中的液体中，上端暴露在液体表面之外，毛细喷嘴使用毛细管力将液体传送到上端; 用于向液体施加电压的恒电位仪; 基板安装件，基板设置在其上面对毛细管喷嘴的上端; 以及距离调节单元，用于使所述基板相对于所述毛细管喷嘴在第一位置和所述第二位置之间往复移动，其中所述第一位置表示所述毛细管喷嘴的上端与所述基板的表面之间的距离小于 有效距离。

公开(公告)号：US07909427B2

公开(公告)日：2011-03-22

申请号：US12552567

申请日：2009-09-02

申请人： Su-hyeon Kim ,  Jeong-gun Lee ,  Jong-suk Chung ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

发明人： Su-hyeon Kim ,  Jeong-gun Lee ,  Jong-suk Chung ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

IPC分类号： B41J29/393

CPC分类号： B41J2/06 ,  B01J19/0046 ,  B01J2219/00364 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00743 ,  B41J2/04535 ,  B41J2/0456 ,  B41J2/04576

摘要： A device for printing a droplet onto a substrate includes: a droplet generating member which is needle-shaped and comprises a receiving portion disposed vertically to receive a solution, and a discharge hole connected to the receiving portion and formed on a bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate disposed below the droplet generating member, the substrate includes a target portion to which the droplet discharged from the discharge hole of the droplet generating member is dropped and attached; a voltage applier applying a voltage to the droplet so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet.

摘要翻译： 用于将液滴印刷到基板上的装置包括：液滴产生构件，其为针状并且包括垂直设置以接收溶液的接收部分，以及连接到接收部分并形成在接收部分的底部上的排出孔 使得溶液可以从接收部分排出; 设置在所述液滴产生部件下方的基板，所述基板包括从所述液滴产生部件的排出孔排出的液滴滴落并附着到的目标部分; 电压施加器，向所述液滴施加电压，使得所述液滴能够落到所述基板的所述目标部分上; 体积测量单元，测量液滴的体积; 以及液滴控制单元，其基于所测量的液滴体积将液滴的体积保持在预定水平。

公开(公告)号：US08282894B2

公开(公告)日：2012-10-09

申请号：US12141988

申请日：2008-06-19

申请人： Beom-seok Lee ,  Dustin Moon ,  Jeong-gun Lee ,  Hye-jung Cho ,  In-seok Kang ,  Jin-seok Hong

发明人： Beom-seok Lee ,  Dustin Moon ,  Jeong-gun Lee ,  Hye-jung Cho ,  In-seok Kang ,  Jin-seok Hong

IPC分类号： B01L3/00

CPC分类号： B41J2/175 ,  B01L3/0268 ,  B01L2400/0415 ,  B41J2/04 ,  Y10T436/2575

摘要： Provided are a droplet emitting apparatus and a method of emitting droplets using the same. The apparatus includes a solution tank for containing a solution; a nozzle including an opening through which at least a droplet of the solution is emitted; and a voltage generator including a piezoelectric material for generating a voltage by instantaneous pressure application, wherein the voltage generated by the pressure to the piezoelectric material is applied to the solution in order for the at least a droplet of the solution to be emitted through the nozzle.

摘要翻译： 提供了一种液滴喷射装置和使用其发射液滴的方法。 该装置包括用于容纳溶液的溶液罐; 喷嘴，其包括开口，所述溶液的至少一个液滴通过所述开口发射; 以及电压发生器，其包括用于通过瞬时压力施加产生电压的压电材料，其中由压电材料的压力产生的电压被施加到溶液，以便溶液的至少一个液滴通过喷嘴发射 。

公开(公告)号：US07600840B2

公开(公告)日：2009-10-13

申请号：US11503786

申请日：2006-08-14

申请人： Su-hyeon Kim ,  Jeong-gun Lee ,  Jong-suk Chung ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

发明人： Su-hyeon Kim ,  Jeong-gun Lee ,  Jong-suk Chung ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

IPC分类号： B41J29/38

CPC分类号： B41J2/06 ,  B01J19/0046 ,  B01J2219/00364 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00743 ,  B41J2/04535 ,  B41J2/0456 ,  B41J2/04576

摘要： A device for printing a droplet onto a substrate includes: a droplet generating member which is needle-shaped and comprises a receiving portion disposed vertically to receive a solution, and a discharge hole connected to the receiving portion and formed on a bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate disposed below the droplet generating member, the substrate includes a target portion to which the droplet discharged from the discharge hole of the droplet generating member is dropped and attached; a voltage applier applying a voltage to the droplet so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet.

摘要翻译： 用于将液滴印刷到基板上的装置包括：液滴产生构件，其为针状并且包括垂直设置以接收溶液的接收部分，以及连接到接收部分并形成在接收部分的底部上的排出孔 使得溶液可以从接收部分排出; 设置在所述液滴产生部件下方的基板，所述基板包括从所述液滴产生部件的排出孔排出的液滴滴落并附着到的目标部分; 电压施加器，向所述液滴施加电压，使得所述液滴能够落到所述基板的所述目标部分上; 体积测量单元，测量液滴的体积; 以及液滴控制单元，其基于所测量的液滴体积将液滴的体积保持在预定水平。

公开(公告)号：US20070035587A1

公开(公告)日：2007-02-15

申请号：US11503721

申请日：2006-08-14

申请人： Jeong-gun Lee ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

发明人： Jeong-gun Lee ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

IPC分类号： B41J2/06

CPC分类号： B01L3/0262 ,  B01J19/0046 ,  B01J2219/00364 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00574 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00743 ,  B01L2300/0838 ,  B01L2400/027

摘要： A device and method for printing biomolecules on a substrate uses an electric charge concentration effect. The device overcomes limitations of the material and surface characteristics of a substrate, enables accurate dropping of a biomolecular droplet onto a target surface of the substrate, prevents electric discharge, and thus allows the manufacturing of a high density biochip by depositing numerous biomolecular droplets, which are small in size and volume, onto a substrate. The device includes: a needle-shaped electric field forming electrode; a substrate which is grounded and disposed below the electric field forming electrode, the substrate including a target surface; and an open circuit type voltage applying unit which supplies first electric charges to the electric field forming electrode to drop the biomolecular droplet onto the target surface of the substrate.

摘要翻译： 用于在基板上印刷生物分子的装置和方法使用电荷浓度效应。 该器件克服了衬底的材料和表面特性的局限性，能够将生物分子液滴精确地滴落到衬底的靶表面上，防止放电，从而允许通过沉积许多生物分子液滴来制造高密度生物芯片， 尺寸和体积小到衬底上。 该装置包括：针状电场形成电极; 基板，其接地并设置在所述电场形成电极下方，所述基板包括目标表面; 以及开路型电压施加单元，其向所述电场形成电极提供第一电荷，以将所述生物分子液滴落到所述基板的所述目标表面上。

公开(公告)号：US07824621B2

公开(公告)日：2010-11-02

申请号：US11970301

申请日：2008-01-07

申请人： Beom-seok Lee ,  Jeong-gun Lee ,  Hye-jung Cho ,  In-seok Kang ,  Jae-suk Moon ,  Jin-seok Hong

发明人： Beom-seok Lee ,  Jeong-gun Lee ,  Hye-jung Cho ,  In-seok Kang ,  Jae-suk Moon ,  Jin-seok Hong

IPC分类号： B01L3/02 ,  B01L99/00

CPC分类号： B01L3/0262 ,  B01J19/0046 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00689 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01J2219/00743 ,  B01L2300/0819 ,  B01L2300/0838 ,  B01L2400/027 ,  Y10T436/11 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/25 ,  Y10T436/2575

摘要： Disclosed is an apparatus and method for ejecting droplets using charge concentration and liquid bridge breakup. The droplet ejection apparatus includes a reservoir storing a liquid; a capillary nozzle having a lower end submerged in the liquid stored in the reservoir and an upper end exposed outside the surface of the liquid, the capillary nozzle transferring the liquid to the upper end using capillary force; a potentiostat for applying a voltage to the liquid; a substrate mount on which a substrate is disposed to face the upper end of the capillary nozzle; and a distance adjusting unit for reciprocatingly moving the substrate between first and second positions with respect to the capillary nozzle, wherein the first position denotes a position where a distance between the upper end of the capillary nozzle and the surface of the substrate is less than a effective distance.

摘要翻译： 公开了一种使用电荷浓度和液桥分解喷射液滴的装置和方法。 液滴喷射装置包括储存液体的储存器; 毛细喷嘴，其下端浸没在存储在储存器中的液体中，上端暴露在液体表面之外，毛细喷嘴使用毛细管力将液体传送到上端; 用于向液体施加电压的恒电位仪; 基板安装件，基板设置在其上面对毛细管喷嘴的上端; 以及距离调节单元，用于使所述基板相对于所述毛细管喷嘴在第一位置和所述第二位置之间往复移动，其中所述第一位置表示所述毛细管喷嘴的上端与所述基板的表面之间的距离小于 有效距离。

公开(公告)号：US20060051248A1

公开(公告)日：2006-03-09

申请号：US11221176

申请日：2005-09-07

申请人： Hye-jung Cho ,  Jeong-gun Lee ,  Sang-Kyun Kang ,  Sang-chae Kim ,  Tae-gyun Kim ,  Jae-yong Lee

发明人： Hye-jung Cho ,  Jeong-gun Lee ,  Sang-Kyun Kang ,  Sang-chae Kim ,  Tae-gyun Kim ,  Jae-yong Lee

IPC分类号： B01L3/00

CPC分类号： B01L3/502715 ,  B01J2219/00286 ,  B01J2219/00495 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/0081 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/0097 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2300/0816 ,  B01L2400/0487

摘要： Disclosed is a microfluidic bio sample processing apparatus including a processing module configured for processing the bio sample and having a hole through which the processed bio sample, a solution for processing the bio sample or both flow, a board having a flowing channel connected with the hole so as to allow the bio sample, the solution for processing the bio sample or both to flow between processing modules and a bonding feature for bonding the processing module with the board. The processing modules are configured to be assembled and/or disassembled onto or from the board so that the processing apparatus is adapted to various kinds of bio samples having different processing steps.

摘要翻译： 公开了一种微流体生物样品处理设备，其包括处理模块，该处理模块被配置用于处理生物样品并具有孔，经处理的生物样品，用于处理生物样品或两者的流体的溶液通过该孔流动，具有与孔连接的流动通道的板 以便允许生物样品，用于处理生物样品或两者的溶液在处理模块之间流动，以及用于将处理模块与板接合的结合特征。 处理模块被配置为在板上或从板上组装和/或拆卸，使得处理装置适用于具有不同处理步骤的各种生物样品。