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    Measurement Head For Non-Invasive Blood Analysis
    2.
    发明申请
    Measurement Head For Non-Invasive Blood Analysis 失效
    非侵入性血液分析测量头

    公开(公告)号：US20080262324A1

    公开(公告)日：2008-10-23

    申请号：US11568743

    申请日：2005-05-03

    申请人： Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker ,  Gerald Lucassen ,  Hendrikus Antonius Cornelus Maria Compen ,  Michael Cornelis Van Beek ,  Wouter Harry Jacinth Rensen

    发明人： Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker ,  Gerald Lucassen ,  Hendrikus Antonius Cornelus Maria Compen ,  Michael Cornelis Van Beek ,  Wouter Harry Jacinth Rensen

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0059 ,  A61B5/0062 ,  A61B5/68 ,  A61B5/6843

    摘要： The present invention provides an efficient approach of attaching and fixing a measurement head for a spectroscopic system to a variety of different parts of the skin of a patient. The measurement head preferably features a compact design providing a flexible handling and offering a huge variety of application areas taking into account the plurality of properties of various portions of the skin. Furthermore, the measurement head features a robust and uncomplicated optical design not requiring a lateral shifting of the optical axis of the objective. Such transverse relative movements between the objective and a capillary vessel in the skin are preferably performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors measuring the contact pressure between the measurement head and the skin. This pressure information can further be exploited in order to calibrate the spectroscopic analysis means, to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.

    摘要翻译： 本发明提供了将用于分光系统的测量头附接和固定到患者皮肤的各种不同部分的有效方法。 测量头优选地具有紧凑的设计，提供灵活的处理，并且考虑到皮肤的各个部分的多个性质，提供了各种各样的应用领域。 此外，测量头具有坚固且不复杂的光学设计，不需要物镜的光轴的横向偏移。 物体和皮肤中的毛细血管之间的这种横向相对移动优选通过相对于测量头的目标机械地移动皮肤来执行。 此外，测量头适于承载测量测量头与皮肤之间的接触压力的一个或多个压力传感器。 可以进一步利用该压力信息来校准光谱分析装置，以调节预定余量内的接触压力，从而规定用于毛细血管的光谱检查的最佳接触压力范围。

    Alignment System for Spectroscopic Analysis
    4.
    发明申请
    Alignment System for Spectroscopic Analysis 失效
    光谱分析校准系统

    公开(公告)号：US20080129991A1

    公开(公告)日：2008-06-05

    申请号：US11574161

    申请日：2005-08-24

    申请人： Bernardus Leonardus Gerardus Bakker ,  Michael Cornelis Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Harry Jacinth Rensen

    发明人： Bernardus Leonardus Gerardus Bakker ,  Michael Cornelis Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Harry Jacinth Rensen

    IPC分类号： G01J3/44

    CPC分类号： G01J3/02 ,  G01J1/4228 ,  G01J3/0229 ,  G01J3/0289

    摘要： The present invention provides a spectroscopic system as well as a method of autonomous tuning of a spectroscopic system and a corresponding computer program product. By detecting the position of return radiation in a transverse plane of an aperture of a spectroscopic analysis unit, a control signal can be generated that allows to drive servo driven translation or tilting stages of optical components. In this way a transverse misalignment of a spectroscopic system can be effectively detected. Generally, a plurality of different detection schemes are realizable allowing for an autonomous, tuning of the spectroscopic system and for autonomous elimination of misalignment of a spectroscopic system.

    摘要翻译： 本发明提供一种光谱系统以及自动调谐光谱系统和相应的计算机程序产品的方法。 通过检测光谱分析单元的孔径的横向平面中的返回辐射的位置，可以产生允许驱动光学部件的伺服驱动的平移或倾斜级的控制信号。 以这种方式，可以有效地检测光谱系统的横向偏移。 通常，多个不同的检测方案是可实现的，允许对分光系统进行自主调谐，并自动消除光谱系统的未对准。

    Protection Mechanism for Spectroscopic Analysis of Biological Tissue
    5.
    发明申请
    Protection Mechanism for Spectroscopic Analysis of Biological Tissue 审中-公开
    生物组织光谱分析保护机制

    公开(公告)号：US20080249380A1

    公开(公告)日：2008-10-09

    申请号：US11568549

    申请日：2005-04-19

    申请人： Michael Cornelis Van Beek ,  Wouter Harry Jacinth Rensen ,  Marjolein Van Der Voort

    发明人： Michael Cornelis Van Beek ,  Wouter Harry Jacinth Rensen ,  Marjolein Van Der Voort

    IPC分类号： A61B5/145

    CPC分类号： A61B5/0059 ,  A61B5/0531 ,  A61B2090/065

    摘要： The present invention provides a protection mechanism for a spectroscopic analysis system being adapted to determine a property of a biological structure in a volume of interest of a patient. The spectroscopic system preferably makes use of high power radiation, and provides a protection mechanism for preventing an accidental exposure of light sensitive tissue of a body. The invention provides a variety of approaches to detect whether a measurement head of the spectroscopic system is in a measurement position. The measurement position of the measurement head can effectively be determined by making use of e.g. a pressure sensor, a sensor measuring the electric resistance of the skin of the patient, or even by optical means analyzing the intensity or the spatial structure of a monitoring beam providing a visual image of the volume of interest.

    摘要翻译： 本发明提供了一种用于光谱分析系统的保护机制，其适于确定患者感兴趣体积的生物结构的性质。 光谱系统优选利用高功率辐射，并且提供用于防止身体的感光组织的意外暴露的保护机构。 本发明提供了多种方法来检测分光系统的测量头是否处于测量位置。 测量头的测量位置可以有效地通过使用例如测量头来确定。 压力传感器，测量患者皮肤电阻的传感器，或者甚至通过分析提供感兴趣体积的视觉图像的监测光束的强度或空间结构的光学装置来测量。

    Autofocus mechanism for spectroscopic system
    6.
    发明授权
    Autofocus mechanism for spectroscopic system 有权
    光谱系统的自动对焦机制

    公开(公告)号：US07663748B2

    公开(公告)日：2010-02-16

    申请号：US11570132

    申请日：2005-06-07

    申请人： Michael Cornelis Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Harry Jacinth Rensen ,  Durk Jolmer De Vries

    发明人： Michael Cornelis Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Harry Jacinth Rensen ,  Durk Jolmer De Vries

    IPC分类号： G01J3/30

    CPC分类号： G02B21/247 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/44 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/6463 ,  G01N2021/653 ,  G01N2021/655

    摘要： An autofocus mechanism for a spectroscopic system determines a time varying optical property of a volume of interest. The mechanism measures the fluctuations of the optical property of the volume of interest for determining the position of the volume of interest. The spectroscopic system focuses an excitation beam into the determined volume of interest and collects return radiation emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is measured for fluctuations of the optical property of the volume of interest. A control loop maximizes the amplitude and/or intensity of the fluctuations and specifies the position of a volume of interest e.g. the center of a capillary vessel.

    摘要翻译： 用于分光系统的自动对焦机构确定感兴趣体积的时变光学性质。 该机制测量感兴趣体积的光学性质的波动以确定感兴趣体积的位置。 光谱系统将激发光束聚焦到所确定的感兴趣体积中，并收集从感兴趣体积发出的回波辐射用于光谱分析。 优选地，激发光束的非弹性散射辐射与用于光谱分析的弹性散射辐射分离。 针对感兴趣体积的光学特性的波动来测量激发光束的弹性散射辐射。 控制回路使波动的幅度和/或强度最大化并且指定感兴趣的体积的位置，例如， 毛细血管的中心。

    Aberration correction for spectroscopic analysis
    8.
    发明授权
    Aberration correction for spectroscopic analysis 有权
    光谱分析的畸变校正

    公开(公告)号：US07511812B2

    公开(公告)日：2009-03-31

    申请号：US11570133

    申请日：2005-06-13

    申请人： Michael Cornelis Van Beek ,  Wouter Rensen ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

    发明人： Michael Cornelis Van Beek ,  Wouter Rensen ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

    IPC分类号： G01J3/30

    CPC分类号： G02B27/0025 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/28

    摘要： A spectroscopic system which determines a property of a biological structure in a volume of interest of a person includes a low cost objective lens for directing an excitation beam into a volume of interest and for collecting return radiation from the volume of interest. After detection of the return radiation and generation of spectroscopic signals, a correction unit performs a compensation for aberrations of the spectroscopic signals introduced by the low cost objective lens. Since the aberrations of the objective lens strongly depend on the lateral distance of the volume of interest from the optical axis of the objective lens, the correction unit uses a correction table providing an assignment between correction values and various lateral positions of the volume of interest.

    摘要翻译： 确定人的感兴趣体积的生物结构的性质的光谱系统包括用于将激发光束引导到感兴趣体积中并用于从感兴趣体积收集返回辐射的低成本物镜。 在检测到返回辐射和产生分光信号之后，校正单元对由低成本物镜引入的分光信号的像差进行补偿。 由于物镜的像差强烈地取决于物镜的光轴的感兴趣的体积的横向距离，所以校正单元使用校正表，该校正表提供校正值与感兴趣体积的各个横向位置之间的分配。

    OPTICAL DETECTION METHOD AND DEVICE FOR OPTICAL DETECTION OF THE CONDITION OF JOINTS
    10.
    发明申请
    OPTICAL DETECTION METHOD AND DEVICE FOR OPTICAL DETECTION OF THE CONDITION OF JOINTS 审中-公开
    光学检测方法和用于光学检测接头状态的装置

    公开(公告)号：US20110066034A1

    公开(公告)日：2011-03-17

    申请号：US12992609

    申请日：2009-05-20

    申请人： Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Rik Harbers

    发明人： Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Rik Harbers

    IPC分类号： A61B6/00

    摘要： An optical detection method is provided, wherein a body part (5) comprising at least one joint is irradiated with light. Local attenuation of the light by the body part (5) is detected as attenuation measurements (2) at the position of the at least one joint and at the position of at least one other portion of the body part (5); and wherein blood flow to and/or from the body part (5) is temporarily at least partially blocked and thereafter enabled again (3). Distinct local attenuation measurements for the at least one joint and for at least one other portion of the body part (5) are performed for at least two of the times before (I), during (II), and after (III) the blocking of blood flow.

    摘要翻译： 提供了一种光学检测方法，其中包括至少一个接头的主体部分（5）被照射光。 在身体部分（5）的光的局部衰减被检测为在至少一个关节的位置处和身体部分（5）的至少另一部分的位置处的衰减测量（2）。 并且其中进入和/或离开身体部分（5）的血液流动暂时至少部分被阻止，然后再次启动（3）。 对于至少一个关节和身体部分（5）的至少一个其他部分的不同局部衰减测量在（I）之前，（II）期间和（III）之后的至少两次中进行， 的血流。