公开(公告)号：US20050254042A1

公开(公告)日：2005-11-17

申请号：US11187730

申请日：2005-07-22

申请人： Bernd Geh ,  Paul Graupner ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stuhler ,  Klaus Wurmbrand

发明人： Bernd Geh ,  Paul Graupner ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stuhler ,  Klaus Wurmbrand

IPC分类号： G02B7/02 ,  G01B11/00 ,  G02B13/00 ,  G02B27/00 ,  G03F7/20 ,  G03F7/207 ,  H01L21/027

CPC分类号： G03F7/706 ,  G01M11/0207 ,  G01M11/0242 ,  G01M11/0257 ,  G02B27/0012 ,  G03F7/70225 ,  G03F7/70258 ,  G03F7/70666

摘要： In order to optimize the image properties of several optical elements of which at least one is moved relative to at least one stationary optical element, the overall image defect resulting from the interaction of all optical elements is first of all measured. This is represented as a linear combination of the base functions of an orthogonal function set. The movable element is then moved to a new measurement position and the overall image defect is measured once again. After the linear combination representation of the new overall image defect, the image defects of the movable element and of the stationary element are calculated from the data thereby obtained. With only one movable optical element a target position in which the overall image defect is minimized can be directly calculated and adjusted there from. If several movable optical elements are available, methods are given for the efficient determination of the respective target position.

摘要翻译： 为了优化其中至少一个相对于至少一个固定光学元件移动的多个光学元件的图像特性，首先测量由所有光学元件的相互作用产生的整体图像缺陷。 这被表示为正交函数集的基函数的线性组合。 然后将可移动元件移动到新的测量位置，并再次测量整个图像缺陷。 在新的整体图像缺陷的线性组合表示之后，根据获得的数据计算可移动元件和静止元件的图像缺陷。 只有一个可移动光学元件可以直接计算和调整整个图像缺陷最小化的目标位置。 如果有多个可移动的光学元件可用，则给出用于有效确定各个目标位置的方法。

公开(公告)号：US20080068599A1

公开(公告)日：2008-03-20

申请号：US11985674

申请日：2007-11-16

申请人： Bernd Geh ,  Paul Graupner ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stuhler ,  Klaus Wurmbrand

发明人： Bernd Geh ,  Paul Graupner ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stuhler ,  Klaus Wurmbrand

IPC分类号： G01N21/00

CPC分类号： G03F7/706 ,  G01M11/0207 ,  G01M11/0242 ,  G01M11/0257 ,  G02B27/0012 ,  G03F7/70225 ,  G03F7/70258 ,  G03F7/70666

摘要： In order to optimize the image properties of several optical elements of which at least one is moved relative to at least one stationary optical element, the overall image defect resulting from the interaction of all optical elements is first of all measured. This is represented as a linear combination of the base functions of an orthogonal function set. The movable element is then moved to a new measurement position and the overall image defect is measured once again. After the linear combination representation of the new overall image defect, the image defects of the movable element and of the stationary element are calculated from the data thereby obtained. With only one movable optical element a target position in which the overall image defect is minimized can be directly calculated and adjusted there from. If several movable optical elements are available, methods are given for the efficient determination of the respective target position.

摘要翻译： 为了优化其中至少一个相对于至少一个固定光学元件移动的多个光学元件的图像特性，首先测量由所有光学元件的相互作用产生的整体图像缺陷。 这被表示为正交函数集的基函数的线性组合。 然后将可移动元件移动到新的测量位置，并再次测量整个图像缺陷。 在新的整体图像缺陷的线性组合表示之后，根据获得的数据计算可移动元件和静止元件的图像缺陷。 只有一个可移动光学元件可以直接计算和调整整个图像缺陷最小化的目标位置。 如果有多个可移动的光学元件可用，则给出用于有效确定各个目标位置的方法。

公开(公告)号：US06934011B2

公开(公告)日：2005-08-23

申请号：US10697811

申请日：2003-10-30

申请人： Bernd Geh ,  Paul Gräupner ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stühler ,  Klaus Wurmbrand

发明人： Bernd Geh ,  Paul Gräupner ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stühler ,  Klaus Wurmbrand

IPC分类号： G02B7/02 ,  G01B11/00 ,  G02B13/00 ,  G02B27/00 ,  G03F7/20 ,  G03F7/207 ,  H01L21/027 ,  G03B27/32

CPC分类号： G03F7/706 ,  G01M11/0207 ,  G01M11/0242 ,  G01M11/0257 ,  G02B27/0012 ,  G03F7/70225 ,  G03F7/70258 ,  G03F7/70666

摘要： In order to optimize the image properties of several optical elements of which at least one is moved relative to at least one stationary optical element, the overall image defect resulting from the interaction of all optical elements is first of all measured. This is represented as a linear combination of the base functions of an orthogonal function set. The movable element is then moved to a new measurement position and the overall image defect is measured once again. After the linear combination representation of the new overall image defect, the image defects of the movable element and of the stationary element are calculated from the data thereby obtained. With only one movable optical element a target position in which the overall image defect is minimized can be directly calculated and adjusted there from. If several movable optical elements are available, methods are given for the efficient determination of the respective target position.

公开(公告)号：US07301622B2

公开(公告)日：2007-11-27

申请号：US11187730

申请日：2005-07-22

申请人： Bernd Geh ,  Paul Gräupner ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stühler ,  Klaus Wurmbrand

发明人： Bernd Geh ,  Paul Gräupner ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stühler ,  Klaus Wurmbrand

IPC分类号： G03B27/32

CPC分类号： G03F7/706 ,  G01M11/0207 ,  G01M11/0242 ,  G01M11/0257 ,  G02B27/0012 ,  G03F7/70225 ,  G03F7/70258 ,  G03F7/70666

摘要： In order to optimize the image properties of several optical elements of which at least one is moved relative to at least one stationary optical element, the overall image defect resulting from the interaction of all optical elements is first of all measured. This is represented as a linear combination of the base functions of an orthogonal function set. The movable element is then moved to a new measurement position and the overall image defect is measured once again. After the linear combination representation of the new overall image defect, the image defects of the movable element and of the stationary element are calculated from the data thereby obtained. With only one movable optical element a target position in which the overall image defect is minimized can be directly calculated and adjusted there from. If several movable optical elements are available, methods are given for the efficient determination of the respective target position.

摘要翻译： 为了优化其中至少一个相对于至少一个固定光学元件移动的多个光学元件的图像特性，首先测量由所有光学元件的相互作用产生的整体图像缺陷。 这被表示为正交函数集的基函数的线性组合。 然后将可移动元件移动到新的测量位置，并再次测量整个图像缺陷。 在新的整体图像缺陷的线性组合表示之后，根据获得的数据计算可移动元件和静止元件的图像缺陷。 只有一个可移动光学元件可以直接计算和调整整个图像缺陷最小化的目标位置。 如果有多个可移动的光学元件可用，则给出用于有效确定各个目标位置的方法。

公开(公告)号：US06678240B2

公开(公告)日：2004-01-13

申请号：US10247270

申请日：2002-09-19

申请人： Bernd Geh ,  Paul Gräupner ,  Klaus Wurmbrand ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stühler

发明人： Bernd Geh ,  Paul Gräupner ,  Klaus Wurmbrand ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stühler

IPC分类号： G03B2732

CPC分类号： G03F7/706 ,  G01M11/0207 ,  G01M11/0242 ,  G01M11/0257 ,  G02B27/0012 ,  G03F7/70225 ,  G03F7/70258 ,  G03F7/70666

摘要： In order to optimize the image properties of several optical elements of which at least one is moved relative to at least one stationary optical element, the overall image defect resulting from the interaction of all optical elements is first of all measured. This is represented as a linear combination of the base functions of an orthogonal function set. The movable element is then moved to a new measurement position and the overall image defect is measured once again. After the linear combination representation of the new overall image defect, the image defects of the movable element and of the stationary element are calculated from the data thereby obtained. With only one movable optical element a target position in which the overall image defect is minimized can be directly calculated and adjusted there from. If several movable optical elements are available, methods are given for the efficient determination of the respective target position.

摘要翻译： 为了优化其中至少一个相对于至少一个固定光学元件移动的多个光学元件的图像特性，首先测量由所有光学元件的相互作用产生的整体图像缺陷。 这被表示为正交函数集的基函数的线性组合。 然后将可移动元件移动到新的测量位置，并再次测量整个图像缺陷。 在新的整体图像缺陷的线性组合表示之后，根据获得的数据计算可移动元件和静止元件的图像缺陷。 只有一个可移动光学元件可以直接计算和调整整个图像缺陷最小化的目标位置。 如果有多个可移动的光学元件可用，则给出用于有效确定各个目标位置的方法。

公开(公告)号：US08759537B2

公开(公告)日：2014-06-24

申请号：US13211470

申请日：2011-08-17

申请人： Henning Priepke ,  Henri Doods ,  Raimund Kuelzer ,  Roland Pfau ,  Dirk Stenkamp ,  Benjamin Pelcman ,  Robert Roenn

发明人： Henning Priepke ,  Henri Doods ,  Raimund Kuelzer ,  Roland Pfau ,  Dirk Stenkamp ,  Benjamin Pelcman ,  Robert Roenn

IPC分类号： A61K31/427 ,  A61K31/428 ,  A61K31/422 ,  A61K31/4439 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D235/30 ,  C07D417/12

CPC分类号： C07D235/30 ,  C07C211/29 ,  C07C211/52 ,  C07C233/36 ,  C07C233/62 ,  C07C271/20 ,  C07C331/28 ,  C07C2601/02 ,  C07D277/56 ,  C07D277/82 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7, R8 have meanings given in the description.

摘要翻译： 本发明涉及式I化合物，其用作微粒体前列腺素E2合酶-1（mPGES-1）的抑制剂，含有它们的药物组合物及其作为用于治疗和/或预防炎性疾病及相关病症的药物的用途。 A，M，W，R 1，R 2，R 6，R 7，R 8具有说明书中给出的含义。

公开(公告)号：US08110575B2

公开(公告)日：2012-02-07

申请号：US12743007

申请日：2008-11-21

申请人： Dirk Gottschling ,  Georg Dahmann ,  Henri Doods ,  Annekatrin Heimann ,  Stephan Georg Mueller ,  Klaus Rudolf ,  Gerhard Georg Schaenzle ,  Dirk Stenkamp

发明人： Dirk Gottschling ,  Georg Dahmann ,  Henri Doods ,  Annekatrin Heimann ,  Stephan Georg Mueller ,  Klaus Rudolf ,  Gerhard Georg Schaenzle ,  Dirk Stenkamp

IPC分类号： A01N43/58 ,  A61K31/50 ,  C07D239/02

CPC分类号： C07D471/04 ,  C07D403/14 ,  C07D471/10 ,  C07D471/20 ,  C07D498/10

摘要： The present invention relates to new CGRP-antagonists of general formula I wherein U, V, X, Y, R1, R2, R3 and R4 are defined as in the description, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, medicaments containing these compounds, their use and processes for preparing them.

摘要翻译： 本发明涉及新的通式I的CGRP拮抗剂，其中U，V，X，Y，R 1，R 2，R 3和R 4如说明书所定义，互变异构体，异构体，非对映异构体，对映异构体，水合物 ，它们的混合物及其盐，以及盐的水合物，特别是其与无机或有机酸或碱的生理学上可接受的盐，含有这些化合物的药物，它们的用途和制备方法。

公开(公告)号：US20110021500A1

公开(公告)日：2011-01-27

申请号：US12743007

申请日：2008-11-21

申请人： Dirk Gottschling ,  Georg Dahmann ,  Henri Doods ,  Annekatrin Heimann ,  Stephan Georg Mueller ,  Klaus Rudolf ,  Gerhard Georg Schaenzle ,  Dirk Stenkamp

发明人： Dirk Gottschling ,  Georg Dahmann ,  Henri Doods ,  Annekatrin Heimann ,  Stephan Georg Mueller ,  Klaus Rudolf ,  Gerhard Georg Schaenzle ,  Dirk Stenkamp

IPC分类号： A61K31/506 ,  C07D471/04 ,  C07D471/10 ,  A61K31/527 ,  C07D498/10 ,  A61K31/5386 ,  A61K31/444 ,  A61K31/55 ,  A61K31/551 ,  A61P25/06 ,  A61P29/00

CPC分类号： C07D471/04 ,  C07D403/14 ,  C07D471/10 ,  C07D471/20 ,  C07D498/10

摘要： The present invention relates to new CGRP-antagonists of general formula I wherein U, V, X, Y, R1, R2, R3 and R4 are defined as in the description, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, medicaments containing these compounds, their use and processes for preparing them.

摘要翻译： 本发明涉及新的通式I的CGRP拮抗剂，其中U，V，X，Y，R 1，R 2，R 3和R 4如说明书所定义，互变异构体，异构体，非对映异构体，对映异构体，水合物 ，它们的混合物及其盐，以及盐的水合物，特别是其与无机或有机酸或碱的生理学上可接受的盐，含有这些化合物的药物，它们的用途和制备方法。

公开(公告)号：US07858622B2

公开(公告)日：2010-12-28

申请号：US12486026

申请日：2009-06-17

申请人： Stephan Georg Mueller ,  Klaus Rudolf ,  Philipp Lustenberger ,  Gerhard Schaenzle ,  Marco Santagostino ,  Dirk Stenkamp ,  Kirsten Arndt ,  Henri Doods

发明人： Stephan Georg Mueller ,  Klaus Rudolf ,  Philipp Lustenberger ,  Gerhard Schaenzle ,  Marco Santagostino ,  Dirk Stenkamp ,  Kirsten Arndt ,  Henri Doods

IPC分类号： C07D401/14 ,  A61K31/4545 ,  A61P25/06

CPC分类号： C07D401/14 ,  C07D405/14

摘要： The present invention relates to the CGRP antagonists of general formula I wherein R1, R2, R3 and R4 are as defined in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, as well as those compounds of general formula I wherein one or more hydrogen atoms are replaced by deuterium, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

摘要翻译： 本发明涉及通式I的CGRP拮抗剂，其中R 1，R 2，R 3和R 4如权利要求1所定义，互变异构体，异构体，非对映异构体，对映体，其水合物，其混合物及其盐 和其盐的水合物，特别是其与无机或有机酸或碱的生理上可接受的盐，以及其中一个或多个氢原子被氘代替的通式I的那些化合物，含有这些化合物的药物组合物，其使用 和制备它们的过程。

公开(公告)号：US07700598B2

公开(公告)日：2010-04-20

申请号：US12246067

申请日：2008-10-06

申请人： Stephan Georg Mueller ,  Klaus Rudolf ,  Philipp Lustenberger ,  Dirk Stenkamp ,  Alexander Dreyer ,  Kirsten Arndt ,  Henri Doods ,  Gerhard Schaenzle ,  Marco Santagostino ,  Fabio Paleari

发明人： Stephan Georg Mueller ,  Klaus Rudolf ,  Philipp Lustenberger ,  Dirk Stenkamp ,  Alexander Dreyer ,  Kirsten Arndt ,  Henri Doods ,  Gerhard Schaenzle ,  Marco Santagostino ,  Fabio Paleari

IPC分类号： A61P25/06 ,  C07D401/04 ,  C07D401/14 ,  A61K31/551

CPC分类号： C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  C07D495/04

摘要： The present invention relates to the CGRP antagonists of general formula wherein A, X, D, E, G, M, Q and R1 to R3 are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.

摘要翻译： 本发明涉及通式C的CGRP拮抗剂，其中A，X，D，E，G，M，Q和R 1至R 3如权利要求1中所定义，互变异构体，异构体，非对映异构体，对映体，水合物 它们的混合物及其盐以及盐的水合物，特别是其与无机或有机酸的生理上可接受的盐，含有这些化合物的药物组合物，其用途及其制备方法。