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1.发明授权Crystals of whole antibodies and fragments thereof and methods for making and using them 有权全抗体及其片段的晶体及其制备和使用方法公开(公告)号：US07833525B2
公开(公告)日：2010-11-16
申请号：US10034950
申请日：2001-12-26
IPC分类号： A61K39/395 , A61K39/00 , G01N31/00
CPC分类号： G01N33/6857 , A61K9/0019 , A61K9/1688 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/36 , C07K16/00 , C07K2299/00 , C07K2317/732 , C07K2317/734 , G01N33/6854 , G01N2469/10
摘要： This invention relates to crystals of whole antibodies and fragments thereof, and formulations and compositions comprising such crystals. More particularly, methods are provided for the crystallization of high concentrations of whole antibodies, and fragments thereof, in large batches, and for the preparation of stabilized whole antibody crystals for use alone, or in dry or slurry formulations or compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active whole antibody crystals.
摘要翻译： 本发明涉及全抗体及其片段的晶体，以及包含这种晶体的制剂和组合物。 更具体地，提供了用于大批量结晶高浓度全抗体及其片段，以及单独使用稳定的全抗体晶体的制备，或在干燥或浆液制剂或组合物中结晶的方法。 本发明还涉及稳定，储存和递送生物活性整体抗体晶体的方法。
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公开(公告)号：US09310379B2
公开(公告)日：2016-04-12
申请号：US12237917
申请日：2008-09-25
CPC分类号： G01N33/6857 , A61K9/0019 , A61K9/1688 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/36 , C07K16/00 , C07K2299/00 , C07K2317/732 , C07K2317/734 , G01N33/6854 , G01N2469/10
摘要： This invention relates to crystals of whole antibodies and fragments thereof, and formulations and compositions comprising such crystals. More particularly, methods are provided for the crystallization of high concentrations of whole antibodies, and fragments thereof, in large batches, and for the preparation of stabilized whole antibody crystals for use alone, or in dry or slurry formulations or compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active whole antibody crystals. The present invention further relates to methods using whole antibody crystals, antibody fragment crystals, or compositions or formulations comprising such crystals for biomedical applications, including biological delivery to humans and animals. More particularly, whole antibody crystals or antibody fragment crystals, or crystal compositions or formulations thereof, are used as a carrier-free delivery system which can slowly release active whole antibodies or fragments thereof, to a subject, where and when they are needed.
摘要翻译： 本发明涉及全抗体及其片段的晶体，以及包含这种晶体的制剂和组合物。 更具体地，提供了用于大批量结晶高浓度全抗体及其片段，以及单独使用稳定的全抗体晶体的制备，或在干燥或浆液制剂或组合物中结晶的方法。 本发明还涉及稳定，储存和递送生物活性整体抗体晶体的方法。 本发明还涉及使用全抗体晶体，抗体片段晶体或包含用于生物医学应用的晶体的组合物或制剂，包括向人和动物的生物递送的方法。 更具体地，使用全抗体晶体或抗体片段晶体或其晶体组合物或其制剂作为无载体递送系统，其可以在需要时和时间上缓慢释放活性整体抗体或其片段。
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公开(公告)号：US20090093617A1
公开(公告)日：2009-04-09
申请号：US12237917
申请日：2008-09-25
IPC分类号： C07K16/00
CPC分类号： G01N33/6857 , A61K9/0019 , A61K9/1688 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/36 , C07K16/00 , C07K2299/00 , C07K2317/732 , C07K2317/734 , G01N33/6854 , G01N2469/10
摘要： This invention relates to crystals of whole antibodies and fragments thereof, and formulations and compositions comprising such crystals. More particularly, methods are provided for the crystallization of high concentrations of whole antibodies, and fragments thereof, in large batches, and for the preparation of stabilized whole antibody crystals for use alone, or in dry or slurry formulations or compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active whole antibody crystals. The present invention further relates to methods using whole antibody crystals, antibody fragment crystals, or compositions or formulations comprising such crystals for biomedical applications, including biological delivery to humans and animals. More particularly, whole antibody crystals or antibody fragment crystals, or crystal compositions or formulations thereof, are used as a carrier-free delivery system which can slowly release active whole antibodies or fragments thereof, to a subject, where and when they are needed.
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公开(公告)号：US06500933B1
公开(公告)日：2002-12-31
申请号：US09518849
申请日：2000-03-03
IPC分类号： C07K100
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/555 , A61K2039/64 , C07K1/1077 , C07K2/00 , C07K9/00 , C07K14/00 , C07K16/00 , C07K2299/00 , C12N9/96 , C12N11/02 , C12N2740/16134 , Y10S530/813 , Y10S530/815 , Y10S530/816
摘要： The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integrity of the glycoprotein backbone. According to one embodiment, this invention relates to methods for concentrating proteins that have been modified by carbohydrates and for releasing their activity at controlled rates. This invention also provides methods for producing carbohydrate crosslinked glycoprotein crystals and methods for using them in pharmaceutical formulations, vaccines, immunotherapeutics, personal care compositions, including cosmetics, veterinary pharmaceutical compositions and vaccines, foods, feeds, diagnostics, cleaning agents, including detergents and decontamination formulations. The physical and chemical characteristics of carbohydrate crosslinked glycoprotein crystals render them particularly useful as sorbents for separations, such as chiral chromatography, or affinity chromatography—which are based on specific interactions between the active binding site of the glycoprotein component of the crystals and the substance or molecule of interest. Such characteristics also render carbohydrate crosslinked glycoprotein crystals useful as catalytic and binding components for the production of biosensing devices.
摘要翻译： 本发明涉及碳水化合物交联糖蛋白晶体领域。 有利地，这种交联的糖蛋白晶体在恶劣的环境条件下显示稳定性，同时保持糖蛋白主链的结构和功能完整性。 根据一个实施方案，本发明涉及用于浓缩已被碳水化合物修饰并以受控速率释放其活性的蛋白质的方法。 本发明还提供了生产碳水化合物交联糖蛋白晶体的方法及其用于药物制剂，疫苗，免疫治疗剂，个人护理组合物，包括化妆品，兽医药物组合物和疫苗，食品，饲料，诊断，清洁剂，包括洗涤剂和去污剂中的方法 配方。 碳水化合物交联的糖蛋白晶体的物理和化学特性使得它们特别可用作分离的吸附剂，例如手性色谱法或亲和色谱法，其基于晶体的糖蛋白组分的活性结合位点与物质之间的特异性相互作用，或 感兴趣的分子 这些特征还使碳水化合物交联的糖蛋白晶体可用作生物传感装置的催化和结合组分。
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公开(公告)号：US07998477B2
公开(公告)日：2011-08-16
申请号：US10741861
申请日：2003-12-19
IPC分类号： A61K39/395
CPC分类号： A61K39/39591 , A61K9/1688 , A61K9/5146 , B82Y5/00 , C07K14/00 , C07K16/00 , C07K16/241 , C07K16/2887 , C07K16/32 , C07K2317/732 , C07K2317/734 , C30B7/06 , C30B29/58 , C30B29/60 , Y02A50/466 , Y10S977/904 , Y10T428/2982
摘要： This invention relates to SPPs, spherical nanocrystalline composite particles or crystalline SPPs of biologically active proteins or compositions, including formulations, comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs.More particularly, methods are provided for the production of SPPs, spherical nanocrystalline composite particles or crystalline SPPs of high concentrations of biologically active proteins, and for the preparation of stabilized SPPs, spherical nanocrystalline composite particles or crystalline SPPs for use alone, or in dry or slurry compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active proteins using SPPs, spherical nanocrystalline composite particles or crystalline SPPs.The present invention further relates to methods using SPPs, spherical nanocrystalline composite particles or crystalline SPPs, or compositions or formulations comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs, for biomedical applications, including biological delivery to humans and animals.
摘要翻译： 本发明涉及SPP，球形纳米晶复合颗粒或生物活性蛋白质或组合物的结晶SPP，包括制剂，包含这种SPP，球形纳米晶复合颗粒或结晶SPP。 更具体地，提供了用于生产SPP，球形纳米晶复合颗粒或高浓度生物活性蛋白质的结晶SPP的方法，以及用于制备稳定的SPP，球形纳米晶复合颗粒或单独使用的结晶SPP，或在干燥或 浆料组合物。 本发明还涉及使用SPP，球形纳米晶复合颗粒或结晶SPP来稳定，储存和递送生物活性蛋白质的方法。 本发明还涉及使用SPP，球形纳米晶复合颗粒或结晶SPP的方法，或包含这种SPP的组合物或制剂，球形纳米晶复合颗粒或结晶SPP，用于生物医学应用，包括向人和动物的生物递送。
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公开(公告)号：US20120282464A1
公开(公告)日：2012-11-08
申请号：US13192345
申请日：2011-07-27
CPC分类号： A61K39/39591 , A61K9/1688 , A61K9/5146 , B82Y5/00 , C07K14/00 , C07K16/00 , C07K16/241 , C07K16/2887 , C07K16/32 , C07K2317/732 , C07K2317/734 , C30B7/06 , C30B29/58 , C30B29/60 , Y02A50/466 , Y10S977/904 , Y10T428/2982
摘要： This invention relates to SPPs, spherical nanocrystalline composite particles or crystalline SPPs of biologically active proteins or compositions, including formulations, comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs. More particularly, methods are provided for the production of SPPs, spherical nanocrystalline composite particles or crystalline SPPs of high concentrations of biologically active proteins, and for the preparation of stabilized SPPs, spherical nanocrystalline composite particles or crystalline SPPs for use alone, or in dry or slurry compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active proteins using SPPs, spherical nanocrystalline composite particles or crystalline SPPs. The present invention further relates to methods using SPPs, spherical nanocrystalline composite particles or crystalline SPPs, or compositions or formulations comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs, for biomedical applications, including biological delivery to humans and animals.
摘要翻译： 本发明涉及SPP，球形纳米晶复合颗粒或生物活性蛋白质或组合物的结晶SPP，包括制剂，包含这种SPP，球形纳米晶复合颗粒或结晶SPP。 更具体地，提供了用于生产SPP，球形纳米晶复合颗粒或高浓度生物活性蛋白质的结晶SPP的方法，以及用于制备稳定的SPP，球形纳米晶复合颗粒或单独使用的结晶SPP，或在干燥或 浆料组合物。 本发明还涉及使用SPP，球形纳米晶复合颗粒或结晶SPP来稳定，储存和递送生物活性蛋白质的方法。 本发明还涉及使用SPP，球形纳米晶复合颗粒或结晶SPP的方法，或包含这种SPP的组合物或制剂，球形纳米晶复合颗粒或结晶SPP，用于生物医学应用，包括向人和动物的生物递送。
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