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1.发明授权Water-soluble silsesquioxanes as organic quantum dots for sensing and imaging 失效水溶性倍半硅氧烷作为有机量子点用于感测和成像公开(公告)号：US08507290B2
公开(公告)日：2013-08-13
申请号：US13498985
申请日：2010-09-28
CPC classification number: C07F7/21 , B82Y15/00 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1051 , G01N33/54386 , G01N33/582 , G01N33/588
Abstract: The present invention generally relates to water-soluble, highly fluorescent polyhedral oligomeric silsesquioxane (POSS) compounds useful for sensing and bioimaging applications.
Abstract translation: 本发明通常涉及可用于感测和生物成像应用的水溶性，高度荧光的多面体低聚倍半硅氧烷（POSS）化合物。
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2.发明申请Methods And Compositions For Cellular Imaging And Cancer Cell Detection Using Light Harvesting Conjugated Polymer-Biomolecular Conjugates 审中-公开细胞成像的方法和组合和使用光收获共轭聚合物 - 生物分子结合体的癌细胞检测公开(公告)号：US20130109029A1
公开(公告)日：2013-05-02
申请号：US13806447
申请日：2011-06-29
Applicant: Bin Liu , Kanyi Pu , Kai Li , Liping Cai , Yanyan Wang , Dan Ding
Inventor： Bin Liu , Kanyi Pu , Kai Li , Liping Cai , Yanyan Wang , Dan Ding
IPC: C07K17/02
CPC classification number: C07K17/02 , B82Y15/00 , C07D285/10 , C09K11/06 , C09K2211/1416 , G01N33/582 , G01N33/588
Abstract: The present invention relates to conjugated polyelectrolyte (CPE) or oligoelectrolyte (COE) compounds represented by general structural formulae (I)-(IV), or a salt thereof and methods of using these compounds to detect targets in samples. In particular, the methods include: (1) exposing a sample to a compound of structural formula (I), (II) or (IV) or a salt thereof, allowing the compound to bind to a target and detecting a signal produced by the compound; (2) functionalizing a solid support with a ligand, incubating the sample with a charged CPE or COE and detecting the fluorescence of the solid support and thereby detecting the target or (3) functionalizing a surface of a solid support with a charged ligand, thereby creating a charge on the surface of the solid support; incubating the ligand-functionalized solid support with a sample, whereupon binding of the target, the charge on the surface of the solid support switches; incubating the sample with CPE or COE that has a complementary charge to the charge of the target-bound surface; and detecting the fluorescence of the solid support and thereby detecting the target. The compounds of the present invention possess high photoluminescence quantum yields in biological media, low cytotoxicity, and excellent environmental stability and photostability and can be used in biosensor and bioimaging applications.
Abstract translation: 本发明涉及由通式（I） - （IV）表示的共轭聚电解质（CPE）或低聚电解质（COE）化合物或其盐，以及使用这些化合物检测样品中靶标的方法。 特别地，所述方法包括：（1）将样品暴露于结构式（I），（II）或（IV）的化合物或其盐，使化合物与靶标结合并检测由 复合; （2）用配体官能化固体支持物，将样品与带电荷的CPE或COE孵育并检测固体支持物的荧光，从而检测靶，或（3）用带电的配体使固体支持物的表面官能化，从而 在固体支撑体的表面上产生电荷; 将配体官能化的固体支持物与样品一起孵育，随后靶标结合，固体支持开关表面上的电荷; 将样品与具有补充电荷的CPE或COE孵育到靶结合表面的电荷; 并检测固体支持物的荧光，从而检测目标物。 本发明的化合物在生物培养基中具有高的光致发光量子产率，低的细胞毒性和优异的环境稳定性和光稳定性，并可用于生物传感器和生物成像应用。
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3.发明申请WATER-SOLUBLE SILSESQUIOXANES AS ORGANIC QUANTUM DOTS FOR SENSING AND IMAGING 失效水溶性SILSESQUIOXANES作为传感和成像的有机量子公开(公告)号：US20120190125A1
公开(公告)日：2012-07-26
申请号：US13498985
申请日：2010-09-28
CPC classification number: C07F7/21 , B82Y15/00 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1051 , G01N33/54386 , G01N33/582 , G01N33/588
Abstract: This invention includes a compound represented by the following structural formula (I) or an acceptable salt thereof.
Abstract translation: 本发明包括由下列结构式（I）表示的化合物或其可接受的盐。
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Patent Agency Ranking
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公开(公告)号：US10753941B2
公开(公告)日：2020-08-25
申请号：US14342074
申请日：2012-09-03
Applicant: Benzhong Tang , Wei Qin , Jianzhao Liu , Sijie Chen , Tsz Kin Kwok , Bin Liu , Kai Li , Dan Ding , Haibin Shi , Jun Long Geng , Jingzhi Sun , Anjun Qin , Qiuli Zhao
Inventor： Benzhong Tang , Wei Qin , Jianzhao Liu , Sijie Chen , Tsz Kin Kwok , Bin Liu , Kai Li , Dan Ding , Haibin Shi , Jun Long Geng , Jingzhi Sun , Anjun Qin , Qiuli Zhao
Abstract: The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.
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公开(公告)号：US20190024246A1
公开(公告)日：2019-01-24
申请号：US14692886
申请日：2015-04-22
Applicant: Peidong Yang , Chong Liu , Jinyao Tang , Hao Ming Chen , Bin Liu
Inventor： Peidong Yang , Chong Liu , Jinyao Tang , Hao Ming Chen , Bin Liu
Abstract: This disclosure provides systems, methods, and apparatus related to solar water splitting. In one aspect, a structure includes a plurality of first nanowires, the plurality of first nanowires comprising an n-type semiconductor or a p-type semiconductor. The structure further includes a second nanowire, the second nanowire comprising the n-type semiconductor or the p-type semiconductor, the second nanowire being a different composition than the plurality of first nanowires. The second nanowire includes a first region and a second region, with the first region having a conductive layer disposed thereon, and each of the plurality of first nanowires being disposed on the conductive layer.
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公开(公告)号：US09636021B2
公开(公告)日：2017-05-02
申请号：US14740914
申请日：2015-06-16
IPC: A61B5/00 , A61B5/02 , C07D311/30 , G01N33/50 , G01N33/58
CPC classification number: A61B5/0071 , A61B5/02007 , A61B2503/02 , A61B2503/40 , A61K49/0021 , C07D311/30 , G01N33/5088 , G01N33/582 , G01N2333/4603
Abstract: Flavonoid compounds that are selective for a protein, a portion or a living cell, or a portion of an organism may be used as biological imaging agents. The flavonoid compounds are useful for methods of imaging organisms such as zebrafish embryos and zebra fish. Flavonoid compounds may also be used to detect protein. Advantageously, flavonoids that selectively bind protein, a portion of a living cell, or a portion of an organism may exhibit a florescence “turn-on” mechanism, where the flavonoids that are selectively bound exhibit a florescence response when excited.
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