公开(公告)号：US20150093743A1

公开(公告)日：2015-04-02

申请号：US14479132

申请日：2014-09-05

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Amir M. SADRI ,  Kun GUO ,  Daniel Y. CHU ,  Nenad KIRCANSKI ,  Paul J. PATT ,  Tal ROSENZWEIG

IPC: G01N15/14 ,  B01L3/00 ,  C12Q1/24

CPC classification number: G01N15/1459 ,  B01L3/0265 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/027 ,  B01L2200/0652 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/088 ,  B01L2300/165 ,  B01L2300/18 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0457 ,  B01L2400/0644 ,  B01L2400/065 ,  B01L2400/0655 ,  B01L2400/0688 ,  B01L2400/082 ,  B01L2400/084 ,  C12Q1/24 ,  G01N15/1404 ,  G01N2015/1413 ,  G01N2015/149 ,  Y10T436/25 ,  Y10T436/25375

Abstract: Systems, including apparatus and methods, for the microfluidic manipulation, dispensing, and/or sorting of particles, such as cells and/or beads.

Abstract translation: 用于微流体操纵，分配和/或分选颗粒例如细胞和/或珠粒的系统，包括装置和方法。

公开(公告)号：US20140024107A1

公开(公告)日：2014-01-23

申请号：US14039682

申请日：2013-09-27

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Tom McCOLLUM ,  Paul PATT ,  Frank SHEN ,  Daniel Y. CHU ,  Don FLORY ,  Mike GRIFFIN ,  Xin HENG ,  Eli HEFNER

IPC: C12Q1/06

CPC classification number: C12Q1/06 ,  G01N15/1434 ,  G02B21/0008 ,  G02B21/34

Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000000 pixels each having an area of 2×2 μm or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.

Abstract translation: 将液体悬浮液中的生物细胞计数在自动细胞计数器中，其将悬浮液的图像聚焦在数字成像传感器上，该数字成像传感器包含至少4,000000个像素，每个具有2×2μm或更小的面积，并且图像的场 视图至少3 mm2。 该传感器使得计数器能够将光学部件压缩成高度小于20cm的光路，当垂直布置时，整个光路的方向没有变化，并且整个仪器的占地面积小于300cm 2。 光源的激活，传感器图像的自动聚焦和数字单元计数都是通过将样品架简单插入到仪器中来启动的。 将悬浮液置于样品室中，其形状为成形以确保细胞计数器中载玻片的正确取向。

公开(公告)号：US20140327757A1

公开(公告)日：2014-11-06

申请号：US14267735

申请日：2014-05-01

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Zuo Cheng SHEN ,  Daniel Y. CHU ,  Nicholas DOE ,  Emmanuel QUIROZ

IPC: G02B21/36

CPC classification number: G02B21/368 ,  G02B21/241 ,  G02B21/365

Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging.

Abstract translation: 本发明一般涉及显微系统。 特别地，本发明涉及渲染样本的数字图像的显微镜，具有数字控制显微镜系统的焦点的能力以及用于控制数字显微镜系统的操作的软件。 此外，本发明涉及一种显微镜结构，其允许显微镜的紧凑和多功能使用，为需要特定的光波长特性的样品（例如荧光）提供用于检测和成像的光屏蔽和控制。

公开(公告)号：US20180031819A1

公开(公告)日：2018-02-01

申请号：US15729503

申请日：2017-10-10

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Zuo Cheng SHEN ,  Daniel Y. CHU ,  Nicholas DOE ,  Emmanuel QUIROZ

IPC: G02B21/36 ,  G02B21/24

Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging.

公开(公告)号：US20170239663A1

公开(公告)日：2017-08-24

申请号：US15454910

申请日：2017-03-09

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Jeff CEREMONY ,  Daniel Y. CHU

IPC: B01L7/00 ,  B01L3/00 ,  B01L9/06

CPC classification number: B01L7/54 ,  B01L3/50851 ,  B01L7/52 ,  B01L9/06 ,  B01L2300/044 ,  B01L2300/0829 ,  B01L2300/12 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1838 ,  B01L2300/1883 ,  B01L2400/0475 ,  B01L2400/0487 ,  B01L2400/049

Abstract: Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat from a single region within the array, the region containing either a single reaction vessel or a group of reaction vessels.