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1.发明授权Topically applied idebenone-containing agent with protective and regenerative effect 有权具有保护和再生作用的局部应用的含有艾地苯醌的药剂公开(公告)号：US06756045B1
公开(公告)日：2004-06-29
申请号：US10030842
申请日：2002-01-09
IPC分类号： A61K700
CPC分类号： A61K8/355 , A61K8/463 , A61K8/466 , A61K2800/522 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/08 , Y10S514/845
摘要： A regenerative or protective topical skin preparation includes idebenone (6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzochinol) or a derivative of idebenone.
摘要翻译： 再生或保护性局部皮肤制剂包括艾地苯醌（6-（10-羟基癸基）-2,3-二甲氧基-5-甲基-1,4-苯醌）或艾地苯醌的衍生物。
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2.发明申请Method and preparation for reducing irritation and/or inflammatory reaction in human skin 审中-公开减少人体皮肤刺激和/或炎症反应的方法和制剂公开(公告)号：US20050197407A1
公开(公告)日：2005-09-08
申请号：US11057364
申请日：2005-02-14
IPC分类号： A61K31/12
CPC分类号： A61K8/355 , A61K31/12 , A61K31/122 , A61K2800/75 , A61Q19/005
摘要： A method for reducing an occurrence of irritation and/or inflammatory reaction in human skin includes applying a topical preparation to the skin. The preparation includes an amount of an agent effective to reduce an occurrence of irritation and/or inflammatory reaction in human skin. The agent includes idebenone or a derivative of idebenone.
摘要翻译： 减少人皮肤刺激和/或炎症反应发生的方法包括将局部制剂施用于皮肤。 该制剂包含一定量的有效减少人皮肤刺激和/或炎症反应发生的药剂。 该药剂包括艾地苯醌或艾地苯醌衍生物。
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公开(公告)号：US20050152857A1
公开(公告)日：2005-07-14
申请号：US10825265
申请日：2004-04-15
摘要： A method for reducing sunburn cells in human skin includes applying a topical preparation comprising an amount of an agent effective to reduce the formation of sunburn cells in human skin, and exposing the skin to ultraviolet radiation. The agent includes idebenone or a derivative of idebenone.
摘要翻译： 减少人皮肤晒伤细胞的方法包括施用包含有效减少人皮肤中晒伤细胞形成的剂量的局部制剂，以及使皮肤暴露于紫外线辐射。 该药剂包括艾地苯醌或艾地苯醌衍生物。
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4.发明授权Skin treatments containing carboxylic acid-substituted idebenone derivatives and methods of preparation and use thereof 有权含有羧酸取代的艾地苯醌衍生物的皮肤处理及其制备方法及用途公开(公告)号：US08354550B2
公开(公告)日：2013-01-15
申请号：US13349651
申请日：2012-01-13
申请人： Falko Diedrich , Birgit Neudecker , Eberhard Wieland , Joseph A. Lewis, II , Joseph C. Dinardo , Andrew S. Thompson , James Alan Kerschen , Peter C. Wade
发明人： Falko Diedrich , Birgit Neudecker , Eberhard Wieland , Joseph A. Lewis, II , Joseph C. Dinardo , Andrew S. Thompson , James Alan Kerschen , Peter C. Wade
IPC分类号： C07C59/31 , A61K31/225 , A61K8/00
CPC分类号： A61K8/37 , A61K8/375 , A61K8/67 , A61K8/671 , A61K8/673 , A61K8/676 , A61K8/678 , A61K8/97 , A61Q17/04 , A61Q19/004 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08 , A61Q19/10 , A61Q90/00 , C07C67/08 , C07C67/14 , C07C67/28 , C07C67/31 , C07C69/67 , C07C69/95 , C07C2601/16 , C07C69/28 , C07C69/675
摘要： The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted idebenone derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
摘要翻译： 本发明涉及新的羧酸取代的艾地苯醌衍生物，含有这些羧酸取代的艾地苯醌衍生物的皮肤处理组合物，通过局部施用这些羧酸取代的艾地苯醌衍生物来治疗皮肤变化的方法及其合成方法。 本发明的羧酸取代的艾地苯醌衍生物在治疗皮肤方面是意想不到的，特别是在皮肤耐受性方面。 当包含在局部组合物中时，本发明的羧酸取代的艾地苯醌衍生物具有可用于治疗皮肤变化的抗氧化作用。
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公开(公告)号：US20050175559A1
公开(公告)日：2005-08-11
申请号：US11010854
申请日：2004-12-13
IPC分类号： A61K8/35 , A61K31/445 , A61Q19/02 , A61K7/135
CPC分类号： A61Q19/02 , A61K8/355 , A61K31/445
摘要： A method for reducing an occurrence of hyperpigmentation in human skin includes applying to the skin a topical preparation including an amount of an agent effective to reduce an occurrence of hyperpigmentation in human skin. The agent includes idebenone or a derivative of idebenone.
摘要翻译： 减少人皮肤中色素沉着过度发生的方法包括向皮肤施用包括一定量的有效减少人皮肤色素沉着过多的试剂的局部制剂。 该药剂包括艾地苯醌或艾地苯醌衍生物。
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6.发明授权公开(公告)号：US08173703B2
公开(公告)日：2012-05-08
申请号：US12574135
申请日：2009-10-06
申请人： Falko Diedrich , Birgit Neudecker , Eberhard Wieland , Joseph A. Lewis, II , Joseph C. DiNardo , Andrew S. Thompson , James Alan Kerschen , Peter C. Wade
发明人： Falko Diedrich , Birgit Neudecker , Eberhard Wieland , Joseph A. Lewis, II , Joseph C. DiNardo , Andrew S. Thompson , James Alan Kerschen , Peter C. Wade
IPC分类号： A61K31/225 , A61K8/00
CPC分类号： A61K8/37 , A61K8/375 , A61K8/67 , A61K8/671 , A61K8/673 , A61K8/676 , A61K8/678 , A61K8/97 , A61Q17/04 , A61Q19/004 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08 , A61Q19/10 , A61Q90/00 , C07C67/08 , C07C67/14 , C07C67/28 , C07C67/31 , C07C69/67 , C07C69/95 , C07C2601/16 , C07C69/28 , C07C69/675
摘要： The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted idebenone derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
摘要翻译： 本发明涉及新的羧酸取代的艾地苯醌衍生物，含有这些羧酸取代的艾地苯醌衍生物的皮肤处理组合物，通过局部施用这些羧酸取代的艾地苯醌衍生物来治疗皮肤变化的方法及其合成方法。 本发明的羧酸取代的艾地苯醌衍生物在治疗皮肤方面是意想不到的，特别是在皮肤耐受性方面。 当包含在局部组合物中时，本发明的羧酸取代的艾地苯醌衍生物具有可用于治疗皮肤变化的抗氧化作用。
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7.发明申请SKIN TREATMENTS CONTAINING CARBOXYLIC ACID-SUBSTITUTED IDEBENONE DERIVATIVES AND METHODS OF PREPARATION AND USE THEREOF 有权含有羧基取代的IDEBENONE衍生物的皮肤治疗及其制备和使用方法公开(公告)号：US20100086494A1
公开(公告)日：2010-04-08
申请号：US12574135
申请日：2009-10-06
CPC分类号： A61K8/37 , A61K8/375 , A61K8/67 , A61K8/671 , A61K8/673 , A61K8/676 , A61K8/678 , A61K8/97 , A61Q17/04 , A61Q19/004 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08 , A61Q19/10 , A61Q90/00 , C07C67/08 , C07C67/14 , C07C67/28 , C07C67/31 , C07C69/67 , C07C69/95 , C07C2601/16 , C07C69/28 , C07C69/675
摘要： The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted idebenone derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
摘要翻译： 本发明涉及新的羧酸取代的艾地苯醌衍生物，含有这些羧酸取代的艾地苯醌衍生物的皮肤处理组合物，通过局部施用这些羧酸取代的艾地苯醌衍生物来治疗皮肤变化的方法及其合成方法。 本发明的羧酸取代的艾地苯醌衍生物在治疗皮肤方面是意想不到的，特别是在皮肤耐受性方面。 当包含在局部组合物中时，本发明的羧酸取代的艾地苯醌衍生物具有可用于治疗皮肤变化的抗氧化作用。
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8.发明申请TOPICALLY APPLIED PROBUCOL-CONTAINING AGENT WITH PROTECTIVE AND REGENERATIVE EFFECT 审中-公开主要应用含有保护和再生效果的含有机体的试剂公开(公告)号：US20080019957A1
公开(公告)日：2008-01-24
申请号：US11780662
申请日：2007-07-20
IPC分类号： A61K31/10 , A61K31/122 , A61K31/192 , A61K31/194 , A61K31/34 , A61K31/35 , A61K31/352 , A61K31/355 , A61K31/385 , A61K31/52 , A61K31/6615 , A61K31/726 , A61K31/728 , A61K36/484 , A61K36/605 , A61K36/82 , A61K36/87 , A61K38/02 , A61K38/44 , A61Q17/04 , A61Q19/08
CPC分类号： A61K8/46 , A61K8/64 , A61K8/66 , A61K8/735 , A61K31/10 , A61K31/122 , A61K31/192 , A61K31/194 , A61K31/34 , A61K31/35 , A61K31/352 , A61K31/355 , A61K31/52 , A61K31/6615 , A61K31/726 , A61K31/728 , A61K36/484 , A61K36/605 , A61K36/82 , A61K36/87 , A61K38/446 , A61Q5/00 , A61Q17/04 , A61Q19/001 , A61Q19/004 , A61Q19/08 , A61K2300/00
摘要： A method of treating skin changes and conditions in human skin including applying a topical preparation that includes an active agent including probucol, a derivative of probucol or a combination of probucol and a derivative of probucol.
摘要翻译： 一种治疗人体皮肤变化和病症的方法，包括应用局部制剂，其包括包括普罗布考，普罗布考的衍生物或普罗布考组合的普罗布考组合的活性剂。
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公开(公告)号：US10365265B2
公开(公告)日：2019-07-30
申请号：US14695721
申请日：2015-04-24
申请人： Eberhard Wieland
发明人： Eberhard Wieland
IPC分类号： G01N33/50 , G01N33/487 , G01N33/493 , A61B10/00
摘要： The present teachings describe a method for testing a biological sample, including (a) obtaining a biological sample from a mammal, (b) acquiring at least two extracellular endogenous metabolic products from the biological sample, (c) detecting the at least two extracellular endogenous metabolic products from the extract, (d) determining a pattern on the basis of the presence or the mass ratio of the at least two extracellular endogenous metabolic products, (e) comparing the pattern with the pattern from a retention sample.
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