公开(公告)号：US5454788A

公开(公告)日：1995-10-03

申请号：US228550

申请日：1994-04-15

申请人： Blair Walker ,  Manouchehr Miraki ,  William Rice ,  Kambiz Ghaerzadeh ,  Brett Trauthen ,  Hey Lee ,  Greg Welsh ,  Henry Nita ,  Shawn O'Leary ,  Mark Dehdashtian ,  Sheryl W. Higgins ,  Nora Pham

发明人： Blair Walker ,  Manouchehr Miraki ,  William Rice ,  Kambiz Ghaerzadeh ,  Brett Trauthen ,  Hey Lee ,  Greg Welsh ,  Henry Nita ,  Shawn O'Leary ,  Mark Dehdashtian ,  Sheryl W. Higgins ,  Nora Pham

IPC分类号： A61F2/958 ,  A61L29/04 ,  A61M25/00 ,  A61M29/02 ,  A61M29/00

CPC分类号： A61M25/104 ,  A61L29/04 ,  A61M25/09 ,  A61M25/10 ,  A61M2025/0047 ,  A61M2025/09008 ,  A61M2025/091 ,  A61M2025/1052 ,  A61M2025/1063 ,  A61M2025/1079 ,  A61M2025/1093 ,  A61M25/0075 ,  A61M25/1002

摘要： A balloon catheter includes a flexible small-diameter guide wire provided with an enlarged-diameter distal end portion, and a flexible elongated tubular shaft with at least one dual-function fluid-conducting lumen adapted to both receive the guide wire extending therethrough, and to communicate pressurized inflation fluid to a distal balloon of the catheter. A distal orifice of the catheter communicates with the balloon and is provided with selective valving means for releasably engaging sealingly with the enlarged distal end portion of the guide wire. Apparatus is disclosed for axially moving the guide wire to effect engagement and disengagement of the enlarged distal end portion with the selective valving means of the catheter shaft. A torquer device is also provided by means of which the guide wire may be rotated relative to the catheter shaft for steering of the guide wire along a vascular pathway. A distal end tapered portion of the catheter shaft provides protection for a joint of the guide wire assembly. The tubular shaft of the catheter may extend through the balloon to provide better pushability for the catheter, especially in versions which employ a comparatively limp material for the balloon. Several alternative constructions for the selective valving means of the catheter shaft and for the enlarged distal end portion of the guide wire assembly are presented.

摘要翻译： 球囊导管包括设置有扩大直径的远端部分的柔性小直径导丝线和具有至少一个双功能流体导流腔的柔性细长管状轴，其适于两者都容纳延伸穿过其中的导丝，并且 将加压的充气流体传递到导管的远端球囊。 导管的远端孔与球囊连通并设置有选择性阀门装置，用于可释放地与引导线的扩大的远端部分紧密接合。 公开了用于轴向移动导丝以使扩大的远端部分与导管轴的选择性阀装置的接合和分离的装置。 还提供了一种绞盘装置，通过该装置，引导线可以相对于导管轴旋转，以沿着血管通路转向导丝。 导管轴的远端锥形部分为导丝组件的接头提供保护。 导管的管状轴可以延伸穿过气囊以为导管提供更好的推动性，特别是在采用气囊相对较差的材料的形式中。 提出了用于导管轴的选择性阀装置和导丝组件的扩大的远端部分的几种替代结构。

公开(公告)号：US6070415A

公开(公告)日：2000-06-06

申请号：US75374

申请日：1998-05-07

申请人： John D. Dobak, III ,  Terry L. Brown ,  Kambiz Ghaerzadeh ,  Xiaoyu Yu

发明人： John D. Dobak, III ,  Terry L. Brown ,  Kambiz Ghaerzadeh ,  Xiaoyu Yu

摘要： A miniature refrigeration system and method of operation. A primary refrigerant is pressurized by a compressor to a relatively low pressure, for safety reasons. The compressed primary refrigerant is passed through a primary-to-secondary heat exchanger, to precool the gas mixture. The secondary side of the primary-to-secondary heat exchanger is cooled by a secondary refrigeration system. The primary refrigerant exiting the primary outlet of the primary-to-secondary heat exchanger passes to a primary Joule-Thomson expansion element where the high pressure gas is expanded to a lower temperature. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter or cryoprobe, to cool surrounding tissue. Return gas can flow back through a distal primary-to-primary heat exchanger to further cool the incoming high pressure gas mixture. A proximal primary-to-primary heat exchanger can be added between the primary-to-secondary heat exchanger and the primary compressor.

公开(公告)号：US06475212B2

公开(公告)日：2002-11-05

申请号：US09791415

申请日：2001-02-22

申请人： John D. Dobak, III ,  Kambiz Ghaerzadeh ,  Xiaoyu Yu

发明人： John D. Dobak, III ,  Kambiz Ghaerzadeh ,  Xiaoyu Yu

IPC分类号： A61B1818

CPC分类号： A61B18/02 ,  A61B17/42 ,  A61B18/0206 ,  A61B18/24 ,  A61B2017/00084 ,  A61B2017/0023 ,  A61B2017/00336 ,  A61B2018/00041 ,  A61B2018/00095 ,  A61B2018/00101 ,  A61B2018/00166 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2090/306 ,  A61B2090/378 ,  A61B2218/002

摘要： A sheath for use on a closed loop Joule-Thomson cryosurgical probe, and the combination of the and the closed loop probe. The sheath is slipped over the probe, thereby separating the probe from the environment. The sheath has a grip which fits over the handle of the cryosurgical probe, and an extendible shroud which can be longitudinally extended to cover tubing and which are attached to the handle. The sheath has a hollow multi-lumen catheter shaped and sized to fit snugly over the cannula of the cryosurgical probe. The catheter is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations along the catheter. A thermally conductive cap or tip is attached to the distal end of the hollow catheter. The thermally conductive cap or tip fits snugly over the cold tip on the probe, and it efficiently transfers heat from the target tissue to the cold tip, which in turn transfers heat to the expanded gas mixture. Various forms of auxiliary instrumentation can be mounted on the catheter or conductive tip, such as a temperature sensor, a heater, an ultrasonic transducer, or an optical element of a viewing, illumination, or laser system. Connections between the instrumentation near the distal end of the catheter and the probe are made via a plurality of lumens passing longitudinally through the wall of the catheter.

摘要翻译： 用于闭环焦耳汤姆逊冷冻手术探针的鞘，以及闭环探针的组合。 护套滑过探头，从而将探头与环境分开。 护套具有装配在冷冻手术探针的手柄上的把手，以及可延伸的护罩，其可以纵向延伸以覆盖管道并且附接到手柄。 护套具有中空的多腔导管，其形状和尺寸适于紧贴在冷冻手术探针的套管上方。 导管不是导热的，防止热量从环境转移到气体混合物，并且防止沿着导管在不期望的位置处冷冻组织。 导热帽或尖端连接到中空导管的远端。 导热盖或尖端紧贴在探针上的冷尖端上，并且有效地将热量从目标组织传递到冷尖端，冷尖端又将热量传递到膨胀气体混合物。 各种形式的辅助仪器可以安装在导管或导电尖端上，例如温度传感器，加热器，超声波换能器或观察，照明或激光系统的光学元件。 在导管远端附近的仪器与探针之间的连接通过纵向穿过导管的壁的多个管腔制成。

公开(公告)号：US5820542A

公开(公告)日：1998-10-13

申请号：US891545

申请日：1997-07-11

申请人： John D. Dobak, III ,  Kambiz Ghaerzadeh

发明人： John D. Dobak, III ,  Kambiz Ghaerzadeh

IPC分类号： A61M1/10 ,  A61M1/12 ,  A61B19/00

CPC分类号： A61M1/1072 ,  A61M1/1037 ,  A61M1/1062 ,  A61M1/122 ,  A61M1/125 ,  A61M1/106

摘要： A circulatory assist device, having a housing and a pumping membrane, with a control chamber and a pumping chamber. The device is mounted on a catheter, collapsed to a sufficiently small diameter to allow insertion into the vascular system of a patient. An expansion mechanism in the device, such as a stent, can be expanded to hold the housing in an expanded substantially rigid state, while control fluid is pumped into and evacuated from the control chamber to repeatedly deflect the pumping membrane. At least one opening is formed in the device, to allow vascular fluid to enter and exit the pumping chamber as the pumping membrane deflects. Introduction and evacuation of control fluid can be synchronized with the heart cycle of the patient. After use, the housing is contracted to a smaller diameter to allow withdrawal from the vascular system.

摘要翻译： 具有壳体和泵送膜的循环辅助装置，其具有控制室和泵送室。 该装置安装在导管上，塌陷至足够小的直径以允许插入患者的血管系统。 可以扩展装置中的膨胀机构，例如支架，以将壳体保持在膨胀的基本上刚性的状态，同时将控制流体泵入并从控制室抽空以重复地偏转泵送膜。 在装置中形成至少一个开口，以在泵送膜偏转时允许血液流体进入和离开泵送室。 控制液的介绍和疏散可以与患者的心脏周期同步。 使用后，外壳收缩到较小的直径以允许从血管系统撤出。

公开(公告)号：US5910104A

公开(公告)日：1999-06-08

申请号：US774148

申请日：1996-12-26

申请人： John D. Dobak, III ,  Kambiz Ghaerzadeh ,  Xiaoyu Yu

发明人： John D. Dobak, III ,  Kambiz Ghaerzadeh ,  Xiaoyu Yu

IPC分类号： A61B19/02 ,  A61B17/00 ,  A61B17/42 ,  A61B18/00 ,  A61B18/02 ,  A61B18/24 ,  A61B19/00 ,  A61B1/00

CPC分类号： A61B18/02 ,  A61B17/42 ,  A61B18/0206 ,  A61B18/24 ,  A61B2017/00084 ,  A61B2017/0023 ,  A61B2017/00336 ,  A61B2018/00041 ,  A61B2018/00095 ,  A61B2018/00101 ,  A61B2018/00166 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2090/306 ,  A61B2090/378 ,  A61B2218/002

摘要： A disposable, sterilizable sheath for use on a closed loop Joule-Thomson cryosurgical probe, and the combination of the disposable sheath and the closed loop probe. The sheath is slipped over the probe, thereby separating the probe from the environment. The sheath has a grip which fits over the handle of the cryosurgical probe, and an extendible shroud which can be longitudinally extended to cover tubing and which are attached to the handle. The sheath has a hollow multi-lumen catheter shaped and sized to fit snugly over the cannula of the cryosurgical probe. The catheter is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations along the catheter. A thermally conductive cap or tip is attached to the distal end of the hollow catheter. The thermally conductive cap or tip fits snugly over the cold tip on the probe, and it efficiently transfers heat from the target tissue to the cold tip, which in turn transfers heat to the expanded gas mixture. Various forms of auxiliary instrumentation can be mounted on the catheter or conductive tip, such as a temperature sensor, a heater, an ultrasonic transducer, or an optical element of a viewing, illumination, or laser system. Connections between the instrumentation near the distal end of the catheter and the probe are made via a plurality of lumens passing longitudinally through the wall of the catheter.

摘要翻译： 用于闭环焦耳汤姆逊冷冻手术探针的一次性灭菌鞘，以及一次性鞘和闭环探针的组合。 护套滑过探头，从而将探头与环境分开。 护套具有装配在冷冻手术探针的手柄上的把手，以及可延伸的护罩，其可以纵向延伸以覆盖管道并且附接到手柄。 护套具有中空的多腔导管，其形状和尺寸适于紧贴在冷冻手术探针的套管上方。 导管不是导热的，防止热量从环境转移到气体混合物，并且防止沿着导管在不期望的位置处冷冻组织。 导热帽或尖端连接到中空导管的远端。 导热盖或尖端紧贴在探针上的冷尖端上，并且有效地将热量从目标组织传递到冷尖端，冷尖端又将热量传递到膨胀气体混合物。 各种形式的辅助仪器可以安装在导管或导电尖端上，例如温度传感器，加热器，超声波换能器或观察，照明或激光系统的光学元件。 在导管远端附近的仪器与探针之间的连接通过纵向穿过导管的壁的多个管腔制成。

公开(公告)号：US5342303A

公开(公告)日：1994-08-30

申请号：US132603

申请日：1993-10-06

申请人： Kambiz Ghaerzadeh

发明人： Kambiz Ghaerzadeh

IPC分类号： A61F2/958 ,  A61M29/00

CPC分类号： A61M25/10 ,  A61M25/1011

摘要： Non-occluding balloon inflation-deflation aperture(s) which may be formed in any medical catheter, scope or other device having an inflatable formed thereon. In a preferred embodiment, the non-occluding aperture(s) are configured to include at least one angular corner. Specific configurations in which the non-occluding apertures of the invention may be formed include wedge-shaped configurations, generally rectangular configurations, trapezoidal configurations and/or round-concave configurations having angular sub-notches formed therein.

摘要翻译： 可以形成在其上形成有可充气的任何医用导管，范围或其他装置中的非闭塞球囊充气 - 放气孔。 在优选实施例中，非闭塞孔被配置为包括至少一个角角。 可以形成本发明的非闭塞孔的具体构造包括楔形构造，大体矩形构造，梯形构造和/或在其中形成有角子凹口的圆形构造。

公开(公告)号：US06530234B1

公开(公告)日：2003-03-11

申请号：US09075374

申请日：1998-05-07

申请人： John D. Dobak, III ,  Terry L. Brown ,  Kambiz Ghaerzadeh ,  Xiaoyu Yu

发明人： John D. Dobak, III ,  Terry L. Brown ,  Kambiz Ghaerzadeh ,  Xiaoyu Yu

IPC分类号： F17C702

CPC分类号： C09K5/045 ,  A61B18/02 ,  A61B2018/0212 ,  A61B2018/0275 ,  A61B2018/0281 ,  C09K2205/22 ,  F25B7/00 ,  F25B9/006 ,  F25B9/02 ,  F25B2309/003 ,  F25B2309/021 ,  F25B2309/022 ,  F25B2309/023 ,  F25B2400/12

摘要： A miniature refrigeration system and method of operation. A primary refrigerant is pressurized by a compressor to a relatively low pressure, for safety reasons. The compressed primary refrigerant is passed through a primary-to-secondary heat exchanger, to precool the gas mixture. The secondary side of the primary-to-secondary heat exchanger is cooled by a secondary refrigeration system. The primary refrigerant exiting the primary outlet of the primary-to-secondary heat exchanger passes to a primary Joule-Thomson expansion element where the high pressure gas is expanded to a lower temperature. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter or cryoprobe, to cool surrounding tissue. Return gas can flow back through a distal primary-to-primary heat exchanger to further cool the incoming high pressure gas mixture. A proximal primary-to-primary heat exchanger can be added between the primary-to-secondary heat exchanger and the primary compressor.

摘要翻译： 微型制冷系统及其操作方法。 出于安全原因，一级制冷剂被压缩机加压至较低的压力。 压缩的一次制冷剂通过一次 - 二次热交换器，以预冷气体混合物。 一级到二级热交换器的次级侧由二次制冷系统冷却。 从初级到二级热交换器的主出口排出的主要制冷剂通过一次焦耳汤姆森膨胀元件，其中高压气体膨胀到较低的温度。 该低温气体冷却安装在导管或冷冻探针的外壁中的传热元件以冷却周围的组织。 回流气体可以通过远端主 - 原热交换器回流，以进一步冷却进入的高压气体混合物。 可以在初级到二级热交换器和主压缩机之间添加近端的初级至主要的热交换器。

公开(公告)号：US06193644B1

公开(公告)日：2001-02-27

申请号：US09262588

申请日：1999-03-04

申请人： John D. Dobak, III ,  Kambiz Ghaerzadeh ,  Xiaoyu Yu

发明人： John D. Dobak, III ,  Kambiz Ghaerzadeh ,  Xiaoyu Yu

IPC分类号： A61F558

CPC分类号： A61B18/02 ,  A61B17/42 ,  A61B18/0206 ,  A61B18/24 ,  A61B2017/00084 ,  A61B2017/0023 ,  A61B2017/00336 ,  A61B2018/00041 ,  A61B2018/00095 ,  A61B2018/00101 ,  A61B2018/00166 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2090/306 ,  A61B2090/378 ,  A61B2218/002

摘要： A sheath for use on a closed loop Joule-Thomson cryosurgical probe, and the combination of the and the closed loop probe. The sheath is slipped over the probe, thereby separating the probe from the environment. The sheath has a grip which fits over the handle of the cryosurgical probe, and an extendible shroud which can be longitudinally extended to cover tubing and which are attached to the handle. The sheath has a hollow multi-lumen catheter shaped and sized to fit snugly over the cannula of the cryosurgical probe. The catheter is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations along the catheter. A thermally conductive cap or tip is attached to the distal end of the hollow catheter. The thermally conductive cap or tip fits snugly over the cold tip on the probe, and it efficiently transfers heat from the target tissue to the cold tip, which in turn transfers heat to the expanded gas mixture. Various forms of auxiliary instrumentation can be mounted on the catheter or conductive tip, such as a temperature sensor, a heater, an ultrasonic transducer, or an optical element of a viewing, illumination, or laser system. Connections between the instrumentation near the distal end of the catheter and the probe are made via a plurality of lumens passing longitudinally through the wall of the catheter.

公开(公告)号：US5827171A

公开(公告)日：1998-10-27

申请号：US740657

申请日：1996-10-31

申请人： John D. Dobak, III ,  Kambiz Ghaerzadeh

发明人： John D. Dobak, III ,  Kambiz Ghaerzadeh

IPC分类号： A61M1/10 ,  A61M1/12 ,  A61B19/00

CPC分类号： A61M1/1037 ,  A61M1/1062 ,  A61M1/1072 ,  A61M1/122 ,  A61M1/125 ,  A61M1/106

摘要： A circulatory assist device, having an outer balloon and an inner balloon, with a control space between the outer and inner balloons. The device is mounted on a catheter, collapsed to a sufficiently small diameter to allow insertion into the vascular system of a patient. An expansion mechanism in the device, such as a stent, can be expanded to hold the outer balloon in an expanded state, while control fluid is pumped into and evacuated from the control space to repeatedly collapse and expand the inner balloon. At least one port is formed in the inner balloon, to allow vascular fluid to enter and exit the inner balloon as the inner balloon expands and contracts. After use, the expansion mechanism is contracted to a smaller diameter to allow withdrawal from the vascular system.

摘要翻译： 具有外球囊和内球囊的循环辅助装置，其具有在外气囊和内球囊之间的控制空间。 该装置安装在导管上，塌陷至足够小的直径以允许插入患者的血管系统。 可以扩展装置（例如支架）中的膨胀机构以将外气囊保持在膨胀状态，同时将控制流体泵入并从控制空间排出以反复塌缩并膨胀内气囊。 至少一个端口形成在内气囊中，以允许血管流体在内气囊膨胀和收缩时进入和离开内气球。 使用后，膨胀机构收缩到较小的直径以允许从血管系统撤出。

公开(公告)号：US5758505A

公开(公告)日：1998-06-02

申请号：US726770

申请日：1996-10-07

申请人： John D. Dobak, III ,  Terry L. Brown ,  Kambiz Ghaerzadeh ,  Xiaoyu Yu

发明人： John D. Dobak, III ,  Terry L. Brown ,  Kambiz Ghaerzadeh ,  Xiaoyu Yu

IPC分类号： F25D3/10 ,  A61B18/02 ,  C09K5/04 ,  F25B7/00 ,  F25B9/00 ,  F25B9/02 ,  F25B19/02

CPC分类号： F25B9/006 ,  A61B18/02 ,  C09K5/045 ,  F25B9/02 ,  A61B2018/0212 ,  A61B2018/0275 ,  A61B2018/0281 ,  C09K2205/12 ,  C09K2205/122 ,  C09K2205/13 ,  C09K2205/132 ,  F25B2309/003 ,  F25B2309/021 ,  F25B2309/022 ,  F25B2309/023 ,  F25B2400/12 ,  F25B7/00

摘要： A miniature mixed gas refrigeration system and method of operation are disclosed. An optimum gas mixture is formulated from a group of component fluids, according to calculated thermodynamic properties of a group of candidate fluid mixtures. The gas mixture is pressurized by a compressor to a pressure less than 420 psia, for safety reasons. The compressed gas mixture is passed through a primary heat exchanger, and then through a primary-to-secondary heat exchanger, to precool the gas mixture. The secondary side of the primary/secondary heat exchanger is cooled by a secondary Joule-Thomson refrigeration system. Properly sized flow restrictions in the primary side of the primary/secondary heat exchanger can solidify and trap liquid contaminants that may be in the gas mixture. The gas mixture exiting the primary outlet of the primary/secondary heat exchanger passes to a primary Joule-Thomson expansion element where the high pressure gas is expanded isenthalpically to a lower temperature at least as low as 183K. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter, to cool an external object. Return gas flows back through the primary heat exchanger to further pre-cool the incoming high pressure gas mixture. A distal primary heat exchanger can be added between the primary/secondary heat exchanger and the primary Joule-Thomson expansion element.

摘要翻译： 公开了一种微型混合气体制冷系统和操作方法。 根据一组候选流体混合物的计算的热力学性质，从一组组分流体配制最佳气体混合物。 为了安全起见，气体混合物被压缩机压力低于420psia。 将压缩气体混合物通过主要热交换器，然后通过初级 - 二级热交换器，以预冷气体混合物。 一次/二次热交换器的二次侧通过二次焦耳 - 汤姆森制冷系统进行冷却。 主/二次换热器初级侧的适当尺寸的流量限制可以凝固并捕获可能在气体混合物中的液体污染物。 离开初级/二级热交换器的主出口的气体混合物通过到焦耳 - 汤姆逊膨胀元件，其中高压气体在等温下扩展至至少低至183K的较低温度。 该低温气体冷却安装在导管的外壁中的传热元件，以冷却外部物体。 回流气体通过主热交换器回流，以进一步预冷进入的高压气体混合物。 可以在主/辅助热交换器和初级焦耳 - 汤姆森膨胀元件之间添加远端主热交换器。