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公开(公告)号：US20130133439A1
公开(公告)日：2013-05-30
申请号：US13460969
申请日：2012-05-01
IPC分类号： G01L1/22
CPC分类号： G01L1/22 , G01L5/0033 , G01L5/0038 , G01N33/502 , G01N33/5073 , Y10S977/724 , Y10S977/956 , Y10S977/958
摘要： An apparatus, system, device, and method provide the ability to measure forces a cell exerts on its surroundings. A platform is suspended across an opening using support legs. The platform is able to move horizontally in a plane of the opening. A piezoresistive strain sensor is integrated into the platform and measures strain induced in the support legs when the platform moves horizontally thereby measuring displacement of the platform.
摘要翻译： 装置，系统，装置和方法提供了测量细胞对其周围环境的作用力的能力。 平台通过支撑腿悬挂在开口处。 平台能够在开口的平面内水平移动。 压平应变传感器集成在平台上，当平台水平移动时，测量支撑腿中产生的应变，从而测量平台的位移。
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公开(公告)号：US08857275B2
公开(公告)日：2014-10-14
申请号：US13460969
申请日：2012-05-01
CPC分类号： G01L1/22 , G01L5/0033 , G01L5/0038 , G01N33/502 , G01N33/5073 , Y10S977/724 , Y10S977/956 , Y10S977/958
摘要： An apparatus, system, device, and method provide the ability to measure forces a cell exerts on its surroundings. A platform is suspended across an opening using support legs. The platform is able to move horizontally in a plane of the opening. A piezoresistive strain sensor is integrated into the platform and measures strain induced in the support legs when the platform moves horizontally thereby measuring displacement of the platform.
摘要翻译： 装置，系统，装置和方法提供了测量细胞对其周围环境的作用力的能力。 平台通过支撑腿悬挂在开口处。 平台能够在开口的平面内水平移动。 压平应变传感器集成在平台上，当平台水平移动时，测量支撑腿中产生的应变，从而测量平台的位移。
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3.发明申请POLYMER NEMS FOR CELL PHYSIOLOGY AND MICROFABRICATED CELL POSITIONING SYSTEM FOR MICRO-BIOCALORIMETER 有权用于细胞生物学的聚合物微球和用于微生物分子的微生物细胞定位系统公开(公告)号：US20110216804A1
公开(公告)日：2011-09-08
申请号：US13110684
申请日：2011-05-18
申请人： Michael L. Roukes , Chung-Wah Fon , Wonhee Lee , Hongxing Tang , Blake Waters Axelrod , John Liang Tan
发明人： Michael L. Roukes , Chung-Wah Fon , Wonhee Lee , Hongxing Tang , Blake Waters Axelrod , John Liang Tan
IPC分类号： G01K17/00
CPC分类号： G01N33/54373 , B82Y35/00 , G01L1/044 , G01N33/5026 , G01N33/5029 , G01N33/5032 , Y10S977/724 , Y10S977/956 , Y10S977/958
摘要： A microfluidic embedded nanoelectromechanical system (NEMs) force sensor provides an electrical readout. The force sensor contains a deformable member that is integrated with a strain sensor. The strain sensor converts a deformation of the deformable member into an electrical signal. A microfluidic channel encapsulates the force sensor, controls a fluidic environment around the force sensor, and improves the read out. In addition, a microfluidic embedded vacuum insulated biocalorimeter is provided. A calorimeter chamber contains a parylene membrane. Both sides of the chamber are under vacuum during measurement of a sample. A microfluidic cannel (built from parylene) is used to deliver a sample to the chamber. A thermopile, used as a thermometer is located between two layers of parylene.
摘要翻译： 微流体嵌入式纳米机电系统（NEM）力传感器提供电子读数。 力传感器包含与应变传感器集成的可变形构件。 应变传感器将可变形部件的变形转换为电信号。 微流体通道封装力传感器，控制力传感器周围的流体环境，并改善读数。 此外，还提供了微流体嵌入式真空绝缘生物量热计。 量热器室包含聚对二甲苯膜。 在测量样品期间，室的两侧都处于真空状态。 使用微流控管（由聚对二甲苯构建）将样品输送到室中。 用作温度计的热电堆位于两层聚对二甲苯之间。
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4.发明授权Polymer NEMs for cell physiology and microfabricated cell positioning system for micro-biocalorimeter 有权用于微生物量热计的细胞生理学和微生物细胞定位系统的聚合物NEM公开(公告)号：US08827548B2
公开(公告)日：2014-09-09
申请号：US13110684
申请日：2011-05-18
申请人： Michael L. Roukes , Chung-Wah Fon , Wonhee Lee , Hongxing Tang , Blake Waters Axelrod , John Liang Tan
发明人： Michael L. Roukes , Chung-Wah Fon , Wonhee Lee , Hongxing Tang , Blake Waters Axelrod , John Liang Tan
CPC分类号： G01N33/54373 , B82Y35/00 , G01L1/044 , G01N33/5026 , G01N33/5029 , G01N33/5032 , Y10S977/724 , Y10S977/956 , Y10S977/958
摘要： A microfluidic embedded nanoelectromechanical system (NEMs) force sensor provides an electrical readout. The force sensor contains a deformable member that is integrated with a strain sensor. The strain sensor converts a deformation of the deformable member into an electrical signal. A microfluidic channel encapsulates the force sensor, controls a fluidic environment around the force sensor, and improves the read out. In addition, a microfluidic embedded vacuum insulated biocalorimeter is provided. A calorimeter chamber contains a parylene membrane. Both sides of the chamber are under vacuum during measurement of a sample. A microfluidic cannel (built from parylene) is used to deliver a sample to the chamber. A thermopile, used as a thermometer is located between two layers of parylene.
摘要翻译： 微流体嵌入式纳米机电系统（NEM）力传感器提供电子读数。 力传感器包含与应变传感器集成的可变形构件。 应变传感器将可变形部件的变形转换为电信号。 微流体通道封装力传感器，控制力传感器周围的流体环境，并改善读数。 此外，还提供了微流体嵌入式真空绝缘生物量热计。 量热器室包含聚对二甲苯膜。 在测量样品期间，室的两侧都处于真空状态。 使用微流控管（由聚对二甲苯构建）将样品输送到室中。 用作温度计的热电堆位于两层聚对二甲苯之间。
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5.发明授权Polymer NEMS for cell physiology and microfabricated cell positioning system for micro-biocalorimeter 有权用于细胞生理学的聚合物NEMS和用于微生物量热计的微细胞定位系统公开(公告)号：US07966898B2
公开(公告)日：2011-06-28
申请号：US11830612
申请日：2007-07-30
申请人： Michael L. Roukes , Chung-Wah Fon , Wonhee Lee , Hongxing Tang , Blake Waters Axelrod , John Liang Tan
发明人： Michael L. Roukes , Chung-Wah Fon , Wonhee Lee , Hongxing Tang , Blake Waters Axelrod , John Liang Tan
IPC分类号： G01L1/22
CPC分类号： G01N33/54373 , B82Y35/00 , G01L1/044 , G01N33/5026 , G01N33/5029 , G01N33/5032 , Y10S977/724 , Y10S977/956 , Y10S977/958
摘要： A microfluidic embedded nanoelectromechanical system (NEMs) force sensor provides an electrical readout. The force sensor contains a deformable member that is integrated with a strain sensor. The strain sensor converts a deformation of the deformable member into an electrical signal. A microfluidic channel encapsulates the force sensor, controls a fluidic environment around the force sensor, and improves the read out. In addition, a microfluidic embedded vacuum insulated biocalorimeter is provided. A calorimeter chamber contains a parylene membrane. Both sides of the chamber are under vacuum during measurement of a sample. A microfluidic cannel (built from parylene) is used to deliver a sample to the chamber. A thermopile, used as a thermometer is located between two layers of parylene.
摘要翻译： 微流体嵌入式纳米机电系统（NEM）力传感器提供电子读数。 力传感器包含与应变传感器集成的可变形构件。 应变传感器将可变形部件的变形转换为电信号。 微流体通道封装力传感器，控制力传感器周围的流体环境，并改善读数。 此外，还提供了微流体嵌入式真空绝缘生物量热计。 量热器室包含聚对二甲苯膜。 在测量样品期间，室的两侧都处于真空状态。 使用微流控管（由聚对二甲苯构建）将样品输送到室中。 用作温度计的热电堆位于两层聚对二甲苯之间。
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公开(公告)号：US08476005B2
公开(公告)日：2013-07-02
申请号：US12364666
申请日：2009-02-03
CPC分类号： C12Q1/02 , G01N33/502 , G01N2500/10
摘要： A method of screening one or more cells is described; the method includes: (i) providing one or more cells to a nanoelectromechanical system (NEMS) force sensor; (ii) applying at least one reagent to the one or more cells; and (iii) observing a response of the one or more cells to the reagent with the force sensor, thereby screening the one or more cells.
摘要翻译： 描述了筛选一个或多个细胞的方法; 该方法包括：（i）向纳米机电系统（NEMS）力传感器提供一个或多个单元; （ii）向所述一个或多个细胞施加至少一种试剂; 和（iii）用力传感器观察一个或多个细胞对试剂的反应，从而筛选该一个或多个细胞。
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公开(公告)号：US08378758B2
公开(公告)日：2013-02-19
申请号：US13095692
申请日：2011-04-27
申请人： Luis Guillermo Villanueva Torrijo , Rassul Karabalin , Matthew Matheny , Philip X.-L. Feng , Michael C. Cross , Michael L. Roukes
发明人： Luis Guillermo Villanueva Torrijo , Rassul Karabalin , Matthew Matheny , Philip X.-L. Feng , Michael C. Cross , Michael L. Roukes
IPC分类号： H03B5/36
CPC分类号： H03B5/326
摘要： A parametric feedback oscillator includes a resonator which has at least one transduction element and at least one electromechanical resonating element. The resonator is configured to accept as input a parametric excitation signal at a frequency 2ω0 and to provide a resonating output signal at a frequency ω0. A cascaded feedback path in any electrically coupled cascade order includes at least one non-linear element, at least one phase shifter electrically, and at least one amplifier. The cascade feedback path is configured to receive as input the resonating output signal at a frequency ω0 and configured to provide as output a feedback path signal as the parametric excitation signal at a frequency 2ω0 to the resonator. A parametric feedback oscillator output terminal is configured to provide the resonating output signal at the frequency ω0 as an output signal. A method of causing a parametric feedback oscillation is also described.
摘要翻译： 参数反馈振荡器包括具有至少一个换能元件和至少一个机电谐振元件的谐振器。 谐振器被配置为接受频率为2ω0的参量激励信号作为输入，并且以频率ω0提供谐振输出信号。 任何电耦合级联阶段中的级联反馈路径包括至少一个非线性元件，至少一个移相器和至少一个放大器。 级联反馈路径被配置为接收频率为ω0的谐振输出信号作为输入，并且被配置为向谐振器提供作为频率为2ω0的参量激励信号作为输出的反馈路径信号。 参数反馈振荡器输出端子被配置为以频率ω0提供作为输出信号的谐振输出信号。 还描述了引起参数反馈振荡的方法。
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公开(公告)号：US07762719B2
公开(公告)日：2010-07-27
申请号：US11578675
申请日：2005-04-20
申请人： Chung-Wah Fon , Michael L. Roukes , Wonhee Lee , Hongxing Tang
发明人： Chung-Wah Fon , Michael L. Roukes , Wonhee Lee , Hongxing Tang
IPC分类号： G01K17/00
CPC分类号： G01K17/006 , B01L3/5027
摘要： Microcalorimeters having low addendum heat capacities and attojoule/Kscale resolutions are provided. These microcalorimeters make use of very small calorimeter bodies composed of materials with very low heat capacities. Also provided are polymer-based microcalorimeters with thermally isolated reagent chambers. These microcalorimeters use a multi-layered polymer membrane structure to provide improved thermal isolation of a reagent chamber.
摘要翻译： 提供了具有低附加热容量和attojoule / Kscale分辨率的微量热计。 这些微量热计使用非常小的由热容量非常低的材料组成的量热仪。 还提供了具有热分离的试剂室的基于聚合物的微量热计。 这些微量热计使用多层聚合物膜结构来提供试剂室的改进的热隔离。
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9.发明申请VERY LOW VOLTAGE, ULTRAFAST NANOELECTROMECHANICAL SWITCHES AND RESONANT SWITCHES 有权非常低电压，超高频纳米电子开关和谐波开关公开(公告)号：US20100140066A1
公开(公告)日：2010-06-10
申请号：US12546485
申请日：2009-08-24
IPC分类号： H01H59/00
CPC分类号： H01H1/0094 , H01H59/0009 , H01H2001/0078 , Y10T307/74
摘要： The invention provides lateral nanoelectromechanical switches useful for integration into circuitry fabricated using standard semiconductor processing methods, or using techniques compatible with the mainstream semiconductor processing technologies. Methods of fabricating the switches are described. Some exemplary designs for two and three terminal switches are provided. Descriptions of structural features and the operating parameters for some exemplary switches are given. The switches are expected to be compatible with circuitry that is operable in computer-based systems.
摘要翻译： 本发明提供了侧向纳米机电开关，其用于集成到使用标准半导体处理方法制造的电路中，或者使用与主流半导体处理技术兼容的技术。 描述制造开关的方法。 提供了两个和三个端子开关的一些示例性设计。 给出了一些示例性开关的结构特征和操作参数的描述。 这些开关预期与在基于计算机的系统中可操作的电路兼容。
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公开(公告)号：US20100041091A1
公开(公告)日：2010-02-18
申请号：US12364666
申请日：2009-02-03
IPC分类号： C12Q1/02
CPC分类号： C12Q1/02 , G01N33/502 , G01N2500/10
摘要： A method of screening one or more cells is described; the method includes: (i) providing one or more cells to a nanoelectromechanical system (NEMS) force sensor; (ii) applying at least one reagent to the one or more cells; and (iii) observing a response of the one or more cells to the reagent with the force sensor, thereby screening the one or more cells.
摘要翻译： 描述了筛选一个或多个细胞的方法; 该方法包括：（i）向纳米机电系统（NEMS）力传感器提供一个或多个单元; （ii）向所述一个或多个细胞施加至少一种试剂; 和（iii）用力传感器观察一个或多个细胞对试剂的反应，从而筛选该一个或多个细胞。
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