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公开(公告)号：US20210290828A1
公开(公告)日：2021-09-23
申请号：US12298287
申请日：2007-05-08
Applicant: Zhihao Yang , Richard Cornelius , Paige Hastings , Bodo Quint , Gerd Seibold , Ib Erling Joergensen , Stevan Nielsen
Inventor： Zhihao Yang , Richard Cornelius , Paige Hastings , Bodo Quint , Gerd Seibold , Ib Erling Joergensen , Stevan Nielsen
Abstract: The present invention generally relates to the use of small particles, such as micro particles or nanoparticles, to produce a therapeutic scar such as “trans-mural” scarring or other desired “deep tissue” scarring. In one preferred embodiment, these particles can be delivered to a target location by an implant. More specifically, these particles can be incorporated into the structure of implants or into the coatings on implants. In another preferred embodiment, these small particles can be delivered directly with a catheter by electrophoresis or hydraulic pressure.
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2.发明授权Apparatus for sealing a puncture by causing a reduction in the circumference of the puncture 有权用于通过引起穿刺周围的减少来密封穿刺的装置公开(公告)号：US09017376B2
公开(公告)日：2015-04-28
申请号：US13174049
申请日：2011-06-30
Applicant: Stevan Nielsen , Bodo Quint , Randolf Von Oepen , Kenneth J. Michlitsch , Gerd Seibold , Tommy Conzelmann , Ib Erling Joergensen
Inventor： Stevan Nielsen , Bodo Quint , Randolf Von Oepen , Kenneth J. Michlitsch , Gerd Seibold , Tommy Conzelmann , Ib Erling Joergensen
CPC classification number: A61B17/00491 , A61B17/0057 , A61B2017/00654 , A61B2017/0472
Abstract: Apparatus is provided for sealing a vascular puncture by causing a reduction in the circumference of the puncture tract through delivery of a closure agent into tissue surrounding the puncture tract. A resultant inflammatory response and volumetric increase cause the tissue to swell into the puncture tract, thereby sealing it.
Abstract translation: 提供了用于通过将封闭剂递送到穿刺道周围的组织中引起穿刺道周围的减少来密封血管穿刺的装置。 产生的炎症反应和体积增加导致组织溶胀到穿刺道中，从而将其密封。
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公开(公告)号：US08709074B2
公开(公告)日：2014-04-29
申请号：US13366540
申请日：2012-02-06
Applicant: Jan Otto Solem , Per-Ola Kimblad , Randolf von Oepen , Bodo Quint , Gerd Seibold , Kenneth J. Michlitsch , Suk-Woo Ha , Karl-Ludwig Eckert , Ib Joergensen , Stevan Nielsen
Inventor： Jan Otto Solem , Per-Ola Kimblad , Randolf von Oepen , Bodo Quint , Gerd Seibold , Kenneth J. Michlitsch , Suk-Woo Ha , Karl-Ludwig Eckert , Ib Joergensen , Stevan Nielsen
IPC: A61F2/06
CPC classification number: A61F2/2451 , A61F2/07 , A61F2/88 , A61F2/90 , A61F2/91 , A61F2002/826 , A61F2002/828 , A61F2002/8483 , A61F2210/0004
Abstract: A device for treatment of mitral annulus dilation is disclosed, wherein the device comprises two states. In a first of these states the device is insertable into the coronary sinus and has a shape of the coronary sinus. When positioned in the coronary sinus, the device is transferable to the second state assuming a reduced radius of curvature, whereby the radius of curvature of the coronary sinus and the radius of curvature as well as the circumference of the mitral annulus is reduced.
Abstract translation: 公开了一种用于治疗二尖瓣环扩张的装置，其中该装置包括两种状态。 在这些状态中的第一个状态下，该装置可插入冠状窦并具有冠状窦的形状。 当定位在冠状窦中时，假设曲率半径减小，装置可转移到第二状态，由此降低冠状窦的曲率半径和曲率半径以及二尖瓣环的圆周。
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公开(公告)号：US08430844B2
公开(公告)日：2013-04-30
申请号：US13023921
申请日：2011-02-09
Applicant: Matthias Wesselmann , Hans Lang , Susanne Pfenninger-Ganz , Adrian Blaser , Christoph Hannes Hoser , Horst Josef Fischer , Bodo Quint
Inventor： Matthias Wesselmann , Hans Lang , Susanne Pfenninger-Ganz , Adrian Blaser , Christoph Hannes Hoser , Horst Josef Fischer , Bodo Quint
IPC: A61M29/00
CPC classification number: A61M25/1011 , A61M25/1034 , A61M25/104 , A61M2025/1013 , A61M2025/1084
Abstract: A balloon catheter, including an outer shaft with a distal end and a fluid line, an inner part located distal anterior to its distal end, as well as a balloon that can be inflated under the influence of a fluid that has been pressurized by the fluid line, that is fastened fluid-tight onto the distal end section of the outer shaft with a first fastening zone at its proximal end, and fluid-tight onto inner part with a second fastening zone at its distal end, whereby the balloon, on at least one of its two ends is designed without cone and with essentially unvarying thin wall thickness, the balloon is provided on at least one of its two ends with respectively one twist anterior to its fastening zone, and a second balloon is placed above the first balloon and is also provided with a twist on at least one of its two ends anterior to the fastening zone, that is directed in the opposite direction of the twist of the first balloon end that is positioned underneath.
Abstract translation: 包括具有远端和流体管线的外轴的气囊导管，位于其远端前方远端的内部部分，以及可在被流体加压的流体的影响下膨胀的气囊 线，其被紧密地紧固到外轴的远端部分上，在其近端具有第一紧固区域，并且在其远端处具有第二紧固区域的流体密封到内部部分，由此气囊 其两端中的至少一端被设计成没有锥体并且具有基本上不变的薄壁厚度，所述气囊在其两端中的至少一个上设置有分别在其紧固区之前的一个扭曲，并且第二气球被放置在第一气球的上方 并且还在其紧固区域之前的两个端部中的至少一个上具有扭转，该扭转部分沿着位于下方的第一气囊端部的扭转的相反方向。
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公开(公告)号：US08114125B2
公开(公告)日：2012-02-14
申请号：US12117581
申请日：2008-05-08
Applicant: Gerd Seibold , Kenneth J. Michlitsch , Randolf Von Oepen , Bodo Quint , Ib Erling Joergensen , Stevan Nielsen , Tommy Conzelmann
Inventor： Gerd Seibold , Kenneth J. Michlitsch , Randolf Von Oepen , Bodo Quint , Ib Erling Joergensen , Stevan Nielsen , Tommy Conzelmann
IPC: A61B17/08
CPC classification number: A61B17/0057 , A61B17/0643 , A61B2017/00004 , A61B2017/00477 , A61B2017/00659
Abstract: Apparatus is provided for sealing a puncture within a vessel or tissue to provide hemostasis, comprising a first disk coupled to either a second disk or a spring, and sealingly engaged to the vessel or tissue surrounding the puncture. At least the first disk is preferably configured to substantially conform to the profile of the vessel or tissue when deployed. In one embodiment, the disks may be released from engagement with the vessel or tissue to reposition the disks after deployment.
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Patent Agency Ranking
6.发明申请Shape-Changing Medical Device, Kit, Method Of Production, And Method Of Use 审中-公开形状变化医疗器械，套件，生产方法和使用方法公开(公告)号：US20100305603A1
公开(公告)日：2010-12-02
申请号：US12738623
申请日：2007-10-17
Applicant: Stevan Nielsen , Bodo Quint , Gerd Seibold , Ib Erling Joergensen
Inventor： Stevan Nielsen , Bodo Quint , Gerd Seibold , Ib Erling Joergensen
IPC: A61M29/00
CPC classification number: A61B17/12022 , A61B17/12109 , A61B17/12122 , A61B17/12172 , A61B17/1219 , A61B2017/00243 , A61B2017/00526 , A61B2017/00884 , A61B2017/00898 , A61B2017/12081 , A61M25/104
Abstract: The present disclosure relates to treatment of disorders in the heart rhythm regulation system and, more particularly, to a medical device for tissue cutting and/or migrating wherein the cutting and/or migrating is at least partly actuated by the swelling of a swellable material. The disclosure furthermore relates to a method of producing such a medical device, a kit of such medical devices, and a method for treating such disorders.
Abstract translation: 本公开涉及治疗心律调节系统中的疾病，更具体地，涉及用于组织切割和/或迁移的医疗装置，其中切割和/或迁移至少部分地由可溶胀材料的溶胀致动。 本公开还涉及生产这种医疗装置的方法，这种医疗装置的套件以及用于治疗这种疾病的方法。
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公开(公告)号：US20100286608A1
公开(公告)日：2010-11-11
申请号：US12767462
申请日：2010-04-26
Applicant: Michael Tittelbach , Raimund Moehl , Alwin Schwitzer , Matthias Wesselmann , Bodo Quint , Patrice Bachmann
Inventor： Michael Tittelbach , Raimund Moehl , Alwin Schwitzer , Matthias Wesselmann , Bodo Quint , Patrice Bachmann
CPC classification number: A61L29/16 , A61L2/085 , A61L29/085 , A61L2300/606 , A61L2420/02 , A61L2420/06 , C08L77/00 , C08L75/04
Abstract: The invention relates to a drug-coated balloon catheter and to a method for producing the same. The balloon of the catheter includes (i) a main membrane, and (ii) an asymmetrical polymer membrane which is applied to an outside of the main membrane and into which at least one pharmaceutical active ingredient is introduced.
Abstract translation: 本发明涉及药物包衣球囊导管及其制造方法。 导管的气囊包括（i）主膜，和（ii）施加到主膜外部并且引入至少一种药物活性成分的不对称聚合物膜。
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公开(公告)号：US07794448B2
公开(公告)日：2010-09-14
申请号：US11439596
申请日：2006-05-23
Applicant: Axel Grandt , Randolf Von Oepen , Andrew Jeffrey , Bodo Quint , Stevan Nielsen , Thomas Rieth
Inventor： Axel Grandt , Randolf Von Oepen , Andrew Jeffrey , Bodo Quint , Stevan Nielsen , Thomas Rieth
IPC: A61M25/00
CPC classification number: A61M25/0032 , A61F2/958 , A61M25/0009 , A61M25/0023 , A61M25/0045 , A61M25/005 , A61M25/0053 , A61M25/0054 , A61M25/008 , A61M25/10 , A61M2025/0183
Abstract: The invention provides a catheter and method of making the same including an outer tubular member having a length, an outer surface, an inner surface and a lumen therethrough. The catheter also includes an inner tubular member having an outer surface, an inner surface and a lumen therethrough, at least a length of the inner lumen is disposed in the lumen of the outer tubular member. The catheter also includes a support member biasing a portion of the outer surface of the inner tubular member against a portion of the inner surface of the outer tubular member.
Abstract translation: 本发明提供一种导管及其制造方法，其包括具有长度，外表面，内表面和通过其的内腔的外管状构件。 导管还包括具有外表面，内表面和通过其的内腔的内管状构件，内管腔的至少一段长度设置在外管状构件的内腔中。 导管还包括支撑构件，该支撑构件偏压内管状构件的外表面的一部分抵靠外管状构件的内表面的一部分。
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公开(公告)号：US20090182418A1
公开(公告)日：2009-07-16
申请号：US12347974
申请日：2008-12-31
Applicant: Jan Otto Solem , Per-Ola Kimblad , Randolf Von Oepen , Bodo Quint , Gerd Seibold , Kenneth J. Michlitsch , Suk-Woo Ha , Karl-Ludwig Eckert , Ib Joergensen , Stevan Nielsen
Inventor： Jan Otto Solem , Per-Ola Kimblad , Randolf Von Oepen , Bodo Quint , Gerd Seibold , Kenneth J. Michlitsch , Suk-Woo Ha , Karl-Ludwig Eckert , Ib Joergensen , Stevan Nielsen
CPC classification number: A61F2/2451 , A61F2/07 , A61F2/88 , A61F2/90 , A61F2/91 , A61F2002/826 , A61F2002/828 , A61F2002/8483 , A61F2210/0004
Abstract: A device for treatment of mitral annulus dilation is disclosed, wherein the device comprises two states. In a first of these states the device is insertable into the coronary sinus and has a shape of the coronary sinus. When positioned in the coronary sinus, the device is transferable to the second state assuming a reduced radius of curvature, whereby the radius of curvature of the coronary sinus and the radius of curvature as well as the circumference of the mitral annulus is reduced.
Abstract translation: 公开了一种用于治疗二尖瓣环扩张的装置，其中该装置包括两种状态。 在这些状态中的第一个状态下，该装置可插入冠状窦并具有冠状窦的形状。 当定位在冠状窦中时，假设曲率半径减小，装置可转移到第二状态，由此降低冠状窦的曲率半径和曲率半径以及二尖瓣环的圆周。
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公开(公告)号：US20080208226A1
公开(公告)日：2008-08-28
申请号：US12117581
申请日：2008-05-08
Applicant: Gerd Seibold , Kenneth J. Michlitsch , Rudolf Von Oepen , Bodo Quint , Ib Erling Joergensen , Stevan Nielsen , Tommy Conzelmann
Inventor： Gerd Seibold , Kenneth J. Michlitsch , Rudolf Von Oepen , Bodo Quint , Ib Erling Joergensen , Stevan Nielsen , Tommy Conzelmann
IPC: A61B17/12
CPC classification number: A61B17/0057 , A61B17/0643 , A61B2017/00004 , A61B2017/00477 , A61B2017/00659
Abstract: Apparatus is provided for sealing a puncture within a vessel or tissue to provide hemostasis, comprising a first disk coupled to either a second disk or a spring, and sealingly engaged to the vessel or tissue surrounding the puncture. At least the first disk is preferably configured to substantially conform to the profile of the vessel or tissue when deployed. In one embodiment, the disks may be released from engagement with the vessel or tissue to reposition the disks after deployment.
Abstract translation: 提供了用于密封容器或组织内的穿刺以提供止血的装置，包括联接到第二盘或弹簧的第一盘，并密封地接合到围绕穿刺的容器或组织。 至少第一盘优选地构造成在展开时基本上符合血管或组织的轮廓。 在一个实施例中，盘可以从与血管或组织的接合中释放，以在部署之后重新定位椎间盘。
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