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    Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
    3.
    发明申请
    Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders 有权
    用于治疗癌症，代谢疾病和皮肤病症的新型治疗剂

    公开(公告)号：US20070129392A1

    公开(公告)日：2007-06-07

    申请号：US10514381

    申请日：2004-06-03

    申请人： Borcherng Hong ,  Sepehr Sarshar ,  Bruno Tse

    发明人： Borcherng Hong ,  Sepehr Sarshar ,  Bruno Tse

    IPC分类号： A61K31/44 ,  A61K31/336 ,  A61K31/4433

    CPC分类号： C07D213/53 ,  C07C17/16 ,  C07C17/2632 ,  C07C45/46 ,  C07C45/64 ,  C07C45/68 ,  C07C45/72 ,  C07C49/747 ,  C07C49/83 ,  C07C49/835 ,  C07C251/48 ,  C07C251/86 ,  C07C2601/02 ,  C07C2601/10 ,  C07C2601/16 ,  C07C2602/10 ,  C07D213/50 ,  C07D303/32 ,  C07D317/26 ,  C07D319/06 ,  C07D405/04 ,  C07C19/01 ,  C07C25/24 ,  C07C49/813

    摘要： The present invention is directed to compounds having the structure (I) wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

    摘要翻译： 本发明涉及具有结构（I）的化合物，其中R 1，R 2，R 3，R 4， R 5和M如本文所定义。 本发明的化合物是用于治疗哺乳动物受试者的癌症，代谢疾病和皮肤病症的新型治疗剂。 这些化合物也是基因表达的有用调节剂。 它们通过干扰某些细胞信号转导级联发挥其活性。 因此，本发明的化合物也可用于调节由各种激素或细胞因子控制或调节的细胞分化和细胞周期过程。 特别地，本发明涉及诱导癌细胞凋亡的化合物，因此可用于治疗或预防癌症，包括晚期癌症和癌前细胞。 本发明还公开了哺乳动物疾病的药物组合物和治疗方法。

    Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
    6.
    发明申请
    Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders 失效
    用于治疗癌症，代谢疾病和皮肤病症的新型治疗剂

    公开(公告)号：US20060014800A1

    公开(公告)日：2006-01-19

    申请号：US10514383

    申请日：2004-07-21

    申请人： Bruno Tse ,  Sepehr Sarshar

    发明人： Bruno Tse ,  Sepehr Sarshar

    IPC分类号： A61K31/4439 ,  A61K31/4015 ,  C07D403/02 ,  A61K31/12

    CPC分类号： C07D233/72 ,  C07D277/34

    摘要： The present invention is directed to compounds having the structure wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

    摘要翻译： 本发明涉及具有以下结构的化合物：其中R 1，R 2，R 3，R 4， R 5和m如本文所定义。 本发明的化合物是用于治疗哺乳动物受试者的癌症，代谢疾病和皮肤病症的新型治疗剂。 这些化合物也是基因表达的有用调节剂。 它们通过干扰某些细胞信号转导级联发挥其活性。 因此，本发明的化合物也可用于调节由各种激素或细胞因子控制或调节的细胞分化和细胞周期过程。 特别地，本发明涉及诱导癌细胞凋亡的化合物，因此可用于治疗或预防癌症，包括晚期癌症和癌前细胞。 本发明还公开了哺乳动物疾病的药物组合物和治疗方法。

    Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
    7.
    发明授权
    Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders 失效
    用于治疗癌症，代谢疾病和皮肤病症的治疗剂

    公开(公告)号：US07572816B2

    公开(公告)日：2009-08-11

    申请号：US10514383

    申请日：2004-07-21

    申请人： Bruno Tse ,  Sepehr Sarshar

    发明人： Bruno Tse ,  Sepehr Sarshar

    IPC分类号： A61K31/47 ,  A61K31/425 ,  A61K31/415 ,  C07D295/00 ,  C07D207/00 ,  C07D401/00 ,  C07D233/00 ,  C07D277/00 ,  C07D409/00 ,  C07D403/00 ,  C07D239/02 ,  C07D215/02 ,  C07D271/00 ,  C07D285/02 ,  C07D257/04 ,  C07D487/00

    CPC分类号： C07D233/72 ,  C07D277/34

    摘要： The present invention is directed to compounds having the structure wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals

    摘要翻译： 本发明涉及具有其中R 1，R 2，R 3，R 4，R 5和m如本文所定义的结构的化合物。 本发明的化合物是用于治疗哺乳动物受试者的癌症，代谢疾病和皮肤病症的新型治疗剂。 这些化合物也是基因表达的有用调节剂。 它们通过干扰某些细胞信号转导级联发挥其活性。 因此，本发明的化合物也可用于调节由各种激素或细胞因子控制或调节的细胞分化和细胞周期过程。 特别地，本发明涉及诱导癌细胞凋亡的化合物，因此可用于治疗或预防癌症，包括晚期癌症和癌前细胞。 本发明还公开了哺乳动物疾病的药物组合物和治疗方法

    Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
    9.
    发明授权
    Preparation and utility of substituted imidazopyridine compounds with hypnotic effects 有权
    具有催眠作用的取代咪唑并吡啶化合物的制备和应用

    公开(公告)号：US07772248B2

    公开(公告)日：2010-08-10

    申请号：US11755634

    申请日：2007-05-30

    申请人： Thomas G. Gant ,  Sepehr Sarshar

    发明人： Thomas G. Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/4745 ,  A61K31/4184 ,  C07D235/02 ,  C07D471/02

    CPC分类号： C07D471/04

    摘要： The present disclosure is directed to modulators of GABAA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of sleep disorders and/or for providing a patient in need with a hypnotic, anxiolytic or anti-convulsive effect are described.

    摘要翻译： 本公开涉及GABA A受体及其药学上可接受的盐和前药的调节剂，其化学合成以及这些化合物用于治疗和/或治疗睡眠障碍和/或提供需要的患者的医学用途 描述了催眠，抗焦虑或抗惊厥作用。

    Substituted amino alcohols
    10.
    发明授权
    Substituted amino alcohols 有权
    取代的氨基醇

    公开(公告)号：US07767860B2

    公开(公告)日：2010-08-03

    申请号：US12203581

    申请日：2008-09-03

    申请人： Thomas G. Gant ,  Sepehr Sarshar

    发明人： Thomas G. Gant ,  Sepehr Sarshar

    IPC分类号： C07C215/18 ,  A61K31/131

    CPC分类号： C07B59/001 ,  C07B2200/05 ,  C07C215/14

    摘要： Disclosed herein are substituted amino alcohol anti-mycobacterial agents and/or chelation therapy agents of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

    摘要翻译： 本文公开了式I的取代的氨基醇抗分枝杆菌和/或螯合治疗剂，其制备方法，其药物组合物及其使用方法。