Text message authentication system
    3.
    发明授权
    Text message authentication system 有权
    短信认证系统

    公开(公告)号:US08943561B2

    公开(公告)日:2015-01-27

    申请号:US13548640

    申请日:2012-07-13

    IPC分类号: H04L29/06 H04W12/06

    摘要: Systems and method for authenticating users are presented. A system can send a passkey to a user interface of a known device. A user can then send a messaging service message with the passkey from a second device to the system. After receiving the message from the user, the system can extract the passkey from the message, and compare the received passkey against the passkey originally sent to the user. The known device and the second device can each have separate and unique device identifiers.

    摘要翻译: 介绍了用户认证的系统和方法。 系统可以向已知设备的用户界面发送密钥。 然后,用户可以将具有密钥的消息服务消息从第二设备发送到系统。 从用户收到消息后,系统可以从消息中提取密钥,并将接收到的密钥与最初发送给用户的密钥进行比较。 已知的设备和第二设备可以各自具有分离且唯一的设备标识符。

    Water removal device
    4.
    发明申请
    Water removal device 审中-公开
    除水装置

    公开(公告)号:US20140069538A1

    公开(公告)日:2014-03-13

    申请号:US13998552

    申请日:2013-11-08

    申请人: Robert Foster

    发明人: Robert Foster

    IPC分类号: E03B5/00

    摘要: A water removal device to withdraw virtually all the water from the drain in the bottom of a swimming pool comprising an elongated lower suction or vacuum housing including a plurality of perforations or holes formed therein to receive water from a pool drain and an upper suction or vacuum source to create a suction or vacuum to draw water from the pool drain through the perforations or holes into and through the lower suction or vacuum housing to remove the water from the pool drain.

    摘要翻译: 一种除水装置,用于从游泳池底部的排水口几乎抽出所有的水,包括细长的下部抽吸或真空壳体,其包括形成在其中的多个穿孔或孔,以从池排水口和上部抽吸或真空吸收水 来源以产生吸力或真空,以通过穿孔或孔从池排水口吸入水并通过下抽吸或真空壳体以从池排水口移除水。

    Novel cyclosporine analog formulations
    5.
    发明申请
    Novel cyclosporine analog formulations 有权
    新型环孢菌素类似物制剂

    公开(公告)号:US20060217309A1

    公开(公告)日:2006-09-28

    申请号:US11375532

    申请日:2006-03-13

    摘要: The present invention relates to formulations containing cyclosporin analogs that are structurally similar to cyclosporin A, in particular isomeric mixtures of cyclosporin analogs that are structurally similar to cyclosporin A. The formulations form stable microemulsion preconcentrates and may provide superior drug bioavailability and/or may reduce one or more adverse effects associated with the administration of cyclosporin. Also disclosed are methods for using and preparing the formulations.

    摘要翻译: 本发明涉及结构上类似于环孢菌素A的环孢菌素类似物的制剂,特别是在结构上类似于环孢菌素A的环孢菌素类似物的异构体混合物中。制剂形成稳定的微乳液预浓缩物,并可提供优异的药物生物利用度和/或减少一种 或更多与施用环孢菌素相关的不良反应。 还公开了使用和制备制剂的方法。

    Rapamycin carbohydrate derivatives
    7.
    发明申请
    Rapamycin carbohydrate derivatives 审中-公开
    雷帕霉素碳水化合物衍生物

    公开(公告)号:US20060079466A1

    公开(公告)日:2006-04-13

    申请号:US11229007

    申请日:2005-09-15

    IPC分类号: A61K31/7052 C07H17/02

    摘要: This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin carbohydrate derivatives having enhanced pharmacokinetic and/or pharmacodynamic profiles. For example, administration of the rapamycin carbohydrate derivative results in altered pharmacokinetic profiles and reduced toxicities. Thus, the present invention provides compounds with characteristics that are distinct from other drugs in its class such as rapamycin.

    摘要翻译: 本发明提供了具有通过连接体连接的具有增强的药代动力学和/或药效学特征的雷帕霉素碳水化合物衍生物的特异性单糖,寡糖,假糖或其衍生物的修饰的雷帕霉素。 例如,雷帕霉素碳水化合物衍生物的施用导致药代动力学特征改变和毒性降低。 因此,本发明提供具有与其同类其他药物不同的特征的化合物,例如雷帕霉素。

    Deuterated cyclosporin analogs and their use as immunomodulating agents
    8.
    发明申请
    Deuterated cyclosporin analogs and their use as immunomodulating agents 有权
    氘代环孢菌素类似物及其作为免疫调节剂的用途

    公开(公告)号:US20060052290A1

    公开(公告)日:2006-03-09

    申请号:US11245775

    申请日:2005-10-06

    IPC分类号: A61K38/13 C07K7/64

    摘要: Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabolism of the cyclosporine A molecule such as amino acids 1, 4, 9. Also disclosed are methods of producing the cyclosporine derivatives and method of producing immunosuppression with reduced toxicity with the disclosed cyclosporine derivatives.

    摘要翻译: 公开了与天然存在的和其他目前已知的环孢菌素和环孢菌素衍生物相比具有增强的功效和降低的毒性的环孢菌素衍生物。 本发明的环孢菌素衍生物通过以下方式通过环孢菌素A(CsA)分子的化学和同位素取代产生:(1)氨基酸1的化学取代和任选的氘取代; 和(2)在环孢菌素A分子的代谢关键位置的氘代替,例如氨基酸1,4,9。还公开了产生环孢菌素衍生物的方法和与所公开的环孢菌素衍生物一起产生具有降低的毒性的免疫抑制的方法。

    Keg topping device
    10.
    发明申请
    Keg topping device 审中-公开
    开顶装置

    公开(公告)号:US20050072034A1

    公开(公告)日:2005-04-07

    申请号:US10686702

    申请日:2003-10-17

    IPC分类号: G09F7/12 G09F3/10 G09F3/00

    CPC分类号: G09F7/12

    摘要: A keg topping device for emplacing an advertising component on top of a keg includes a flat disc surface with an opening therein to fit the device around the mouth of a keg. The opining in the disc forms an inner rim, the perimeter of which, can be fastened to the base around the mouth of the keg by an adhesive. The advertising component is disposed on a surface of the disc member, and in place on the keg, is exposed to view from above. The surface of the disc member, surrounding the opening, is a continuous surface that is free from perforations.

    摘要翻译: 用于在小桶顶部放置广告组件的小桶顶部装置包括其中具有开口的平坦盘表面,以使装置围绕小桶的口部。 在圆盘中形成一个内边缘,其内周边可通过粘合剂固定在小桶口周围的底座上。 广告组件设置在盘构件的表面上,并且在小桶上的适当位置从上方暴露出来。 围绕开口的盘构件的表面是没有穿孔的连续表面。