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1.发明授权公开(公告)号：US11155576B2
公开(公告)日：2021-10-26
申请号：US15303172
申请日：2015-04-09
Applicant: BRANDEIS UNIVERSITY
Inventor： Bing Xu , Junfeng Shi , Yi Kuang
Abstract: Disclosed are peptides that contain up to about 35 amino acids, including a plurality of aromatic amino acid residues and either (i) an amino acid residue that is phosphorylated or sulfated, or (ii) an amino acid comprising an ester-moiety linked via peptide bond, or both (i) and (ii), wherein the peptide is capable of self-assembly to form nanofibrils in the presence of an enzyme that hydrolyzes the phosphate group, the sulfate group, or the ester-moiety. These peptides are enzymatically responsive hydrogelators, and they can be used to form pericellular hydrogels/nanofibrils upon exposure to target cells that secrete or express a surface bound ectoenzyme having hydrolase activity suitable to induce peptide gelation. These materials, and compositions containing the same, can be used for in vitro and in vivo cellular imaging, treating cancerous conditions, collecting a secretome from a cell upon which the pericellular hydrogels/nanofibrils form, and screening the collected secretome.
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公开(公告)号：US11191724B2
公开(公告)日：2021-12-07
申请号：US16648295
申请日：2018-09-18
Applicant: BRANDEIS UNIVERSITY
Inventor： Hongjian He , Bing Xu
Abstract: The present invention relates to a branched peptide that includes a first peptide chain and a second peptide chain having its C-terminal amino acid covalently linked to a sidechain of an amino acid residue of the first peptide chain, wherein the first peptide chain includes a plurality of aromatic amino acids and, optionally, an aromatic group linked to an amino terminus of the first peptide chain; and the second peptide chain includes a plurality of hydrophilic amino acids and an enzyme cleavage site. Pharmaceutical compositions containing the branched peptide and one or more therapeutic agents in an aqueous medium are disclosed, where the branched peptides form micelle structures in the aqueous medium. Methods of using the pharmaceutical composition to deliver therapeutic agents, and for treating various disease conditions are also described.
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公开(公告)号：US11834517B2
公开(公告)日：2023-12-05
申请号：US17537418
申请日：2021-11-29
Applicant: BRANDEIS UNIVERSITY
Inventor： Hongjian He , Bing Xu
Abstract: The present invention relates to a branched peptide that includes a first peptide chain and a second peptide chain having its C-terminal amino acid covalently linked to a sidechain of an amino acid residue of the first peptide chain, wherein the first peptide chain includes a plurality of aromatic amino acids and, optionally, an aromatic group linked to an amino terminus of the first peptide chain; and the second peptide chain includes a plurality of hydrophilic amino acids and an enzyme cleavage site. Pharmaceutical compositions containing the branched peptide and one or more therapeutic agents in an aqueous medium are disclosed, where the branched peptides form micelle structures in the aqueous medium. Methods of using the pharmaceutical composition to deliver therapeutic agents, and for treating various disease conditions are also described.
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公开(公告)号：US10308682B2
公开(公告)日：2019-06-04
申请号：US14773690
申请日：2014-03-06
Applicant: BRANDEIS UNIVERSITY
IPC: C07K5/072 , A61K38/00 , A61P35/00 , A61K31/195
Abstract: Disclosed herein are fibrillar molecular aggregates, which are morphologically and phenotypically similar to oligomers of aberrant proteins. The molecular aggregates, formed by self-assembly of small hydrophobic molecules, prevent the growth of microtubules. This unprecedented mechanism of “self-assembly to interfere with self-organization” allows inhibition of the growth of cancer cells.
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公开(公告)号：US10232037B2
公开(公告)日：2019-03-19
申请号：US15115385
申请日：2014-05-29
Applicant: BRANDEIS UNIVERSITY , CHILDREN'S MEDICAL CENTER CORPORATION
Inventor： Fan Zhao , Jingyu Li , Hongbo R. Luo , Bing Xu
IPC: A61K39/00 , A61K39/02 , A61K49/00 , A61K39/39 , A01N37/46 , A61K45/06 , C07K14/00 , A61K9/00 , A61K9/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/16 , C07K5/08 , C07K5/10 , C07K7/06 , C07K7/08 , A61K38/00
Abstract: The invention relates to the application of peptides that can self-assemble to form supramolecular nanofibrils and hydrogels, hydrogel compositions containing the self-assembled supramolecular nanofibrils, and methods of uses and making the hydrogel compositions.
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Patent Agency Ranking
公开(公告)号：US10857243B2
公开(公告)日：2020-12-08
申请号：US15303117
申请日：2015-04-09
Applicant: BRANDEIS UNIVERSITY
IPC: A61K9/00 , A61K49/18 , G01N33/543 , G01N33/574 , C12Q1/42 , A61K47/52 , A61K47/69 , A61K47/64 , A61K38/08 , A61K41/00 , A61K45/06 , B82Y5/00 , A61B17/00
Abstract: The invention relates to an enzymatically responsive product that includes an amino acid residue conjugated to a magnetic particle, wherein the amino acid residue is phosphorylated or sulfated or comprises an ester-moiety linked via peptide bond. Compositions containing the enzymatically responsive product, and the use thereof for separating distinct types of mammalian cells (e.g., cancer cells from normal cells), for treating a cancerous condition, and imaging cancer cells are also disclosed.
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7.发明授权公开(公告)号：US10093674B2
公开(公告)日：2018-10-09
申请号：US14093974
申请日：2013-12-02
Applicant: Brandeis University
Inventor： Bing Xu
IPC: C07H15/203 , C07D473/34 , C07D239/54 , C07D473/18 , C07F9/6512 , C07F9/6561 , C07H13/04
Abstract: Disclosed are nucleopeptide compounds that include a nucleobase, and an amino acid. Certain compounds further comprise a glycoside. The compounds may self-assemble to form supramolecular hydrogels. Also, the compounds may be used as a platform to examine specific biological functions (e.g., binding to DNA and RNA) of a dynamic supramolecular system that is able to interact with both proteins and nucleic acids. Other uses include: methods of growing cells and methods of delivering a substance to a cell.
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8.发明授权公开(公告)号：US11839661B2
公开(公告)日：2023-12-12
申请号：US16639467
申请日：2018-08-15
Applicant: BRANDEIS UNIVERSITY
Inventor： Bing Xu , Huaimin Wang
IPC: A61K47/69 , A61P35/00 , A61K9/00 , A61K31/573 , A61K31/704 , A61K39/39 , A61K45/06 , C07K7/06 , C07K7/08 , A61K39/00
CPC classification number: A61K47/6903 , A61K9/0014 , A61K31/573 , A61K31/704 , A61K39/39 , A61K45/06 , A61P35/00 , C07K7/06 , C07K7/08 , A61K2039/6031
Abstract: Disclosed are a peptide capable of induced self-assembly by a bioactive molecule comprising a (i) hydrogelation-promoting amino acid sequence and (ii) an oligomerization sequence; compositions containing the peptide and, optionally, bioactive molecule; hydrogels formed thereby; and various methods of using the same.
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公开(公告)号：US11040108B2
公开(公告)日：2021-06-22
申请号：US16097325
申请日：2017-04-28
Applicant: BRANDEIS UNIVERSITY
Inventor： Huaimin Wang , Bing Xu
IPC: A61K47/64 , C12N15/62 , A61K45/06 , A61K47/55 , A61K47/00 , A61K47/54 , A61P35/04 , A61K31/282 , A61K31/337 , A61K31/351 , A61K31/506
Abstract: This invention relates to a conjugate of formula (I): (A-Z1-)n-Q-Z2-D (I), wherein Z1, Z2, Q, A, D, and n are as described herein. This invention also relates to a pharmaceutical composition including a pharmaceutically acceptable carrier and a conjugate of formula (I). This invention also relates to a method making a conjugate of formula (I), and the use of the conjugate for treating cancerous conditions, modulating cell membrane microheterogeneity, stimulating an immunoresponse, and forming a network on or near the inner or outer surface of target cells.
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10.发明授权公开(公告)号：US10519265B2
公开(公告)日：2019-12-31
申请号：US15923755
申请日：2018-03-16
Applicant: BRANDEIS UNIVERSITY
IPC: C08F220/54 , C08K5/20 , C08F226/02 , C08L33/26 , C08K5/00 , C07F15/00
Abstract: The present technology relates to a polymeric material including a plurality of polymer subunits and an active cross-linker, wherein the active cross-linker is covalently linked to the plurality of polymer subunits. The active cross-linker offers a key building block for constructing novel molecular architecture in chemomechanical soft materials and illustrates a new approach to tailor material properties.
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