摘要:
A method of routing messages may include providing a listener registry of a plurality of listeners and associated namespaces so that at least one namespace is associated with each of the plurality of listeners. A message may be received from an originating application, and the message may include a message namespace. The message may be stored in a message queue, and a determination may be made to determine if a listener from the listener registry is associated with the message namespace. If no listener from the listener registry is associated with the message namespace, the message may be stored in a parked message queue separate from the message queue. After the message has been in the parked message queue for a predetermined period of time, the message may be deleted from the parked message queue.
摘要:
A method of routing messages may include providing a listener registry of a plurality of listeners and associated namespaces so that at least one namespace is associated with each of the plurality of listeners. A message may be received from an originating application, and the message may include a message namespace. The message may be stored in a message queue, and a determination may be made to determine if a listener from the listener registry is associated with the message namespace. If no listener from the listener registry is associated with the message namespace, the message may be stored in a parked message queue separate from the message queue. After the message has been in the parked message queue for a predetermined period of time, the message may be deleted from the parked message queue.
摘要:
A diamine absorbent that contains heat stable salts is regenerated using an ion exchange process wherein the cation exchange resin is regenerated using sulfurous acid reflux.
摘要:
Therapeutically active anthranilic acid derivatives of Formula (I), processes for the preparation of said derivatives, pharmaceutical formulations containing the compounds and the use of the compounds in therapy, particularly in the treatment of diseases in which under-activation of the HM74A receptor contributes to the disease or in which activation of the receptor will be beneficial, are disclosed.
摘要:
Compounds of formula (I): wherein; R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O—, or C1-6alkoxy; R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl; R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6 alkyl; A is C—R5 or N; B is C—R6 or N; D is C—R7 or N; with the proviso that at least one of A, B, and D, is N; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy; R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen; R9 is hydrogen or hydroxy; R10 is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.
摘要翻译:式(I)的化合物:其中; R1是氢或C1-6烷基; R 2是氢,C 1-6烷基,全卤代甲基C 0-5烷基-O-或C 1-6烷氧基; R3是氢,C1-6烷基或C1-6烷氧基C1-6烷基; R 4是氢,C 1-6烷基,全卤代甲基C 1-6烷基; 或未取代的C 3-6环烷基C 1-6烷基; A为C-R5或N; B为C-R6或N; D为C-R7或N; 条件是A,B和D中的至少一个为N; R5是氢或C1-6烷基; R6是氢或C1-6烷基; R7是氢,C1-6烷基,C1-6烷氧基或羟基; R8是氢或C1-6烷基,条件是R4和R8中的一个是氢; R9是氢或羟基; R 10是氢或C 1-6烷基; 其盐是PAD4抑制剂,并且可用于治疗各种疾病,例如类风湿性关节炎,血管炎,系统性红斑狼疮,溃疡性结肠炎,癌症,囊性纤维化,哮喘,皮肤红斑狼疮和牛皮癣。
摘要:
The present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier.
摘要:
Structures constructed from an artificial material facilitate the setting and growing of oysters, other mollusks, and other organisms for the purposes of food production, artificial reefs/breakwaters, and the like. The artificial material is a composite that acts as both an attractant and nutrient environment for mollusks and other aquatic organisms. The binder for the composite material includes both cement and an organic material. The organic material is selected to attract and feed the aquatic organisms.
摘要:
Structures constructed from an artificial material facilitate the setting and growing of oysters, other mollusks, and other organisms for the purposes of food production, artificial reefs/breakwaters, and the like. The artificial material is a composite that acts as both an attractant and nutrient environment for mollusks and other aquatic organisms. The binder for the composite material includes both cement and an organic material. The organic material is selected to attract and feed the aquatic organisms.
摘要:
A method for completing a project using a content-generating device. The method includes receiving a task defining a content item to be generated, restricting operation of at least a first component of the content-generating device, operating at least a second component of the content-generating device to generate the content item, and making available the generated content item.
摘要:
A passive skin detection system includes a main body which houses a collection optics system having an image splitting device, a visible light filter mechanism having a plurality of narrow band filters and an image capture system. The image capture system stores visible light data as a plurality of digital images formed from a plurality of pixels. Each of the plurality of digital images is associated with visible light passed through a respective one of the plurality of narrow band filters. An image processing system, operatively connected to the image capture system, compares relative intensities of each of the plurality of digital images to identify one or more of the plurality of pixels having an absorption bandwidth indicating a presence of skin. The processing system determines whether a person, identified by his skin, is present in any of the images captured by the detection system.