公开(公告)号：US20070074980A1

公开(公告)日：2007-04-05

申请号：US11219512

申请日：2005-09-02

申请人： Brian Bankoski ,  David Evans ,  Dominique Messerli

发明人： Brian Bankoski ,  David Evans ,  Dominique Messerli

IPC分类号： B65D25/08

CPC分类号： B65D77/2024 ,  A61F2/0095 ,  B65D25/082 ,  B65D25/085 ,  B65D81/32 ,  B65D81/3238

摘要： Packages for the rehydration of implants are described, wherein the package may contain a first chamber containing a rehydration fluid, a second chamber containing an implant, and a barrier configured to be affected without compromising the sterility of the package. The rehydration fluid may engage and rehydrate the implant after the barrier is ruptured. Methods of use are also described.

摘要翻译： 描述了用于植入物再水合的包装，其中包装可以包含含有补液的第一室，包含植入物的第二室和被构造成受影响而不影响包装的无菌性的屏障。 补水液体可能会在屏障破裂后接合并再植入植入物。 还描述了使用方法。

公开(公告)号：US20110045087A1

公开(公告)日：2011-02-24

申请号：US12666216

申请日：2009-01-30

申请人： Sean Hamilton Kerr ,  Ali Recber ,  Thomas Pepe ,  Dominique Messerli ,  Lawton Laurence ,  Ryan Walsh ,  Thomas Kueenzi ,  Brandon Randall

发明人： Sean Hamilton Kerr ,  Ali Recber ,  Thomas Pepe ,  Dominique Messerli ,  Lawton Laurence ,  Ryan Walsh ,  Thomas Kueenzi ,  Brandon Randall

IPC分类号： A61K9/16 ,  A61K33/42 ,  A61K33/00 ,  A61K47/30 ,  A61K33/04 ,  A61P19/08 ,  A61F2/44

CPC分类号： A61L27/56 ,  A61B17/86 ,  A61F2/4455 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30064 ,  A61F2002/3008 ,  A61F2002/30387 ,  A61F2002/30426 ,  A61F2002/30578 ,  A61F2002/30604 ,  A61F2002/30841 ,  A61F2002/3092 ,  A61F2002/3097 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2250/0098 ,  A61F2310/00796 ,  A61F2310/00976 ,  A61L27/18 ,  A61L27/26 ,  A61L27/50 ,  A61L2430/02 ,  A61N1/3622 ,  C08G65/00 ,  C08J9/24 ,  C08J9/26

摘要： Embodiments described include devices and methods for forming a porous polymer material. Devices disclosed and formed using the methods described include a spacer for spinal fusion, craniomaxillofacial (CMF) structures, and other structures for tissue implants.

摘要翻译： 所描述的实施例包括用于形成多孔聚合物材料的装置和方法。 使用所述方法公开和形成的装置包括用于脊柱融合的间隔物，颅颌面（CMF）结构以及组织植入物的其它结构。

公开(公告)号：US20100185290A1

公开(公告)日：2010-07-22

申请号：US12601468

申请日：2008-06-30

申请人： Curtis Compton ,  Dennis Chien ,  Robert Delurio ,  Dominique Messerli

发明人： Curtis Compton ,  Dennis Chien ,  Robert Delurio ,  Dominique Messerli

IPC分类号： A61F2/44

CPC分类号： A61F2/442 ,  A61B17/7094 ,  A61F2/28 ,  A61F2/4455 ,  A61F2/4611 ,  A61F2002/30281 ,  A61F2002/30289 ,  A61F2002/30387 ,  A61F2002/30403 ,  A61F2002/30471 ,  A61F2002/30472 ,  A61F2002/30476 ,  A61F2002/30504 ,  A61F2002/30594 ,  A61F2002/4415 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2220/0025 ,  A61F2220/0041 ,  A61F2220/0091 ,  A61F2230/0086 ,  A61F2230/0091 ,  A61F2310/00359

摘要： A flexible chain implant for insertion into an interior volume of a vertebral body. The implant may be implanted in an insertion position for sliding through a cannula and is flexible for packing into the interior volume in an implanted configuration. The implant randomly separates in the implanted configuration. The implant includes a top member and a bottom member, wherein the top and bottom members are coupled to one another at a coupled portion. The top and bottom members preferably each include an inner surface such that the inner surfaces include a plurality of alternating projections and recesses so that the projections are received within the recesses in an insertion position. Alternatively, the implant may include a plurality of substantially non-flexible bodies and a plurality of substantially flexible links interconnecting the bodies. The non-flexible bodies include a plurality of facets and/or abutment surfaces.

摘要翻译： 用于插入椎体内部体积的柔性链植入物。 植入物可以植入插入位置以滑动通过插管，并且是柔性的，以植入构型包装到内部容积中。 植入物在植入构型中随机分离。 植入物包括顶部构件和底部构件，其中顶部构件和底部构件在联接部分处彼此联接。 顶部和底部构件优选地各自包括内表面，使得内表面包括多个交替的突起和凹部，使得突起在插入位置中容纳在凹部内。 或者，植入物可以包括多个基本上非柔性的主体和互连主体的多个基本上柔性的链接。 非柔性体包括多个面和/或邻接表面。

公开(公告)号：US07491237B2

公开(公告)日：2009-02-17

申请号：US11093111

申请日：2005-03-28

申请人： Brandon L Randall ,  Roger D Goodwin ,  Dominique Messerli ,  Jacqueline Myer ,  Robert J Delurio ,  Michael L Boyer, II ,  Christopher M Angelucci

发明人： Brandon L Randall ,  Roger D Goodwin ,  Dominique Messerli ,  Jacqueline Myer ,  Robert J Delurio ,  Michael L Boyer, II ,  Christopher M Angelucci

IPC分类号： A61F2/44

CPC分类号： A61F2/44 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/4455 ,  A61F2/4611 ,  A61F2002/2835 ,  A61F2002/30057 ,  A61F2002/30266 ,  A61F2002/30383 ,  A61F2002/30387 ,  A61F2002/30492 ,  A61F2002/30507 ,  A61F2002/30571 ,  A61F2002/30604 ,  A61F2002/30617 ,  A61F2002/30782 ,  A61F2002/30795 ,  A61F2002/3082 ,  A61F2002/30843 ,  A61F2002/30904 ,  A61F2002/4622 ,  A61F2002/4628 ,  A61F2002/4629 ,  A61F2220/0025 ,  A61F2230/0082 ,  A61F2250/0097 ,  A61F2310/00359

摘要： An allogenic implant for use in intervertebral fusion is formed from one or more two pieces. The pieces are made from bone, and are joined together to form an implant having sufficient strength and stability to maintain a desired distance between first and second vertebrae in a spinal fusion procedure. The implant pieces may be formed of cortical bone and connected by dovetail joints, and at least one cortical bone pin may be provided to lock the pieces together and to add strength to the implant. Teeth are formed on the vertebra engaging surfaces of the implant prevent short-term slippage of the implant.

摘要翻译： 用于椎间融合的同种异体植入物由一个或多个两片形成。 这些片由骨制成，并且连接在一起以形成具有足够强度和稳定性的植入物，以在脊柱融合程序中保持第一和第二椎骨之间的期望距离。 植入物片可以由皮质骨形成并且通​​过燕尾接头连接，并且可以提供至少一个皮质骨针将锁定在一起并增加植入物的强度。 牙齿形成在植入物的椎骨接合表面上，防止植入物的短期滑动。

公开(公告)号：US20060106460A1

公开(公告)日：2006-05-18

申请号：US11301759

申请日：2005-12-12

申请人： Dominique Messerli ,  David Gerber ,  David Paul ,  Kenneth Kobayashi

发明人： Dominique Messerli ,  David Gerber ,  David Paul ,  Kenneth Kobayashi

IPC分类号： A61F2/44

CPC分类号： A61F2/446 ,  A61B17/1604 ,  A61B17/1659 ,  A61B17/1671 ,  A61F2/28 ,  A61F2/4465 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/2835 ,  A61F2002/3008 ,  A61F2002/30133 ,  A61F2002/30383 ,  A61F2002/30492 ,  A61F2002/30507 ,  A61F2002/30538 ,  A61F2002/30594 ,  A61F2002/30599 ,  A61F2002/30604 ,  A61F2002/30785 ,  A61F2002/30787 ,  A61F2002/30797 ,  A61F2002/30843 ,  A61F2002/30904 ,  A61F2002/30975 ,  A61F2002/4475 ,  A61F2002/4628 ,  A61F2220/0025 ,  A61F2230/0015 ,  A61F2250/0006 ,  A61F2250/0063 ,  A61F2250/0098 ,  A61F2310/00017 ,  A61F2310/00359

摘要： An intervertebral implant for fusing vertebrae is disclosed. The implant has a body with curved, substantially parallel posterior and anterior faces separated by two narrow implant ends, superior and inferior faces having a plurality of undulating surfaces for contacting upper and lower vertebral endplates, and at least one depression in the anterior or posterior face for engagement by an insertion tool, at least two vertical through-channels extending through the implant from the superior face to the inferior face, a chamfer on the superior and inferior surfaces at one of the narrow implant ends, and a beveled edge along a perimeter of the superior and inferior faces. The arcuate implant configuration and the chamfers on the superior and inferior faces at the narrow end facilitate insertion of the implant from a transforaminal approach into a symmetric position about the midline of the spine so that a single implant provides balanced support to the spinal column. The implant may include radiopaque markers extending through the thickness of the implant to indicate the location and size of the implant. The implant may be formed of a plurality of interconnecting bodies assembled to form a single unit. An implantation kit and method are also disclosed.

公开(公告)号：US08673010B2

公开(公告)日：2014-03-18

申请号：US12601468

申请日：2008-06-30

申请人： Curtis Compton ,  Dennis Chien ,  Robert Delurio ,  Dominique Messerli

发明人： Curtis Compton ,  Dennis Chien ,  Robert Delurio ,  Dominique Messerli

IPC分类号： A61F2/44

CPC分类号： A61F2/442 ,  A61B17/7094 ,  A61F2/28 ,  A61F2/4455 ,  A61F2/4611 ,  A61F2002/30281 ,  A61F2002/30289 ,  A61F2002/30387 ,  A61F2002/30403 ,  A61F2002/30471 ,  A61F2002/30472 ,  A61F2002/30476 ,  A61F2002/30504 ,  A61F2002/30594 ,  A61F2002/4415 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2220/0025 ,  A61F2220/0041 ,  A61F2220/0091 ,  A61F2230/0086 ,  A61F2230/0091 ,  A61F2310/00359

摘要： A flexible chain implant for insertion into an interior volume of a vertebral body. The implant may be implanted in an insertion position for sliding through a cannula and is flexible for packing into the interior volume in an implanted configuration. The implant randomly separates in the implanted configuration. The implant includes a top member and a bottom member, wherein the top and bottom members are coupled to one another at a coupled portion. The top and bottom members preferably each include an inner surface such that the inner surfaces include a plurality of alternating projections and recesses so that the projections are received within the recesses in an insertion position. Alternatively, the implant may include a plurality of substantially non-flexible bodies and a plurality of substantially flexible links interconnecting the bodies. The non-flexible bodies include a plurality of facets and/or abutment surfaces.

摘要翻译： 用于插入椎体内部体积的柔性链植入物。 植入物可以植入插入位置以滑动通过插管，并且是柔性的，以植入构型包装到内部容积中。 植入物在植入构型中随机分离。 植入物包括顶部构件和底部构件，其中顶部构件和底部构件在联接部分处彼此联接。 顶部和底部构件优选地各自包括内表面，使得内表面包括多个交替的突起和凹部，使得突起在插入位置中容纳在凹部内。 或者，植入物可以包括多个基本上非柔性的主体和互连主体的多个基本上柔性的链接。 非柔性体包括多个面和/或邻接表面。

公开(公告)号：US08435300B2

公开(公告)日：2013-05-07

申请号：US13042097

申请日：2011-03-07

申请人： Dominique Messerli ,  David Gerber ,  David Paul ,  Kenneth Isamu Kobayashi

发明人： Dominique Messerli ,  David Gerber ,  David Paul ,  Kenneth Isamu Kobayashi

IPC分类号： A61F2/44

CPC分类号： A61F2/446 ,  A61B17/1604 ,  A61B17/1659 ,  A61B17/1671 ,  A61F2/28 ,  A61F2/4465 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/2835 ,  A61F2002/3008 ,  A61F2002/30133 ,  A61F2002/30383 ,  A61F2002/30492 ,  A61F2002/30507 ,  A61F2002/30538 ,  A61F2002/30594 ,  A61F2002/30599 ,  A61F2002/30604 ,  A61F2002/30785 ,  A61F2002/30787 ,  A61F2002/30797 ,  A61F2002/30843 ,  A61F2002/30904 ,  A61F2002/30975 ,  A61F2002/4475 ,  A61F2002/4628 ,  A61F2220/0025 ,  A61F2230/0015 ,  A61F2250/0006 ,  A61F2250/0063 ,  A61F2250/0098 ,  A61F2310/00017 ,  A61F2310/00359

摘要： An intervertebral implant for fusing vertebrae is disclosed. The implant may have a body with curved, posterior and anterior faces separated by two narrow implant ends, superior and inferior faces having a plurality of undulating surfaces for contacting vertebral endplates, and at least one depression in the anterior or posterior face for engagement by an insertion tool. The implant may also have one or more vertical through-channels extending through the implant from the superior face to the inferior face, a chamfer on the superior and inferior surfaces at one of the narrow implant ends, and/or a beveled edge along a perimeter of the superior and inferior faces. The implant configuration facilitates transforaminal insertion of the implant into a symmetric position about the midline of the spine so that a single implant provides balanced support to the spinal column. The implant may be formed of a plurality of interconnecting bodies assembled to form a single unit. An implantation kit and method are also disclosed.

摘要翻译： 公开了一种用于融合椎骨的椎间植入物。 植入物可以具有由两个狭窄的植入物端部分开的弯曲的，后部和前部面的主体，上部和下部面具有多个用于接触椎骨终板的起伏表面，以及前部或后部的至少一个凹陷，用于通过 插入工具。 植入物还可以具有一个或多个垂直通道，从上表面到下表面延伸穿过植入物，在一个窄植入物端部处的上表面和下表面上的倒角，和/或沿着周边的斜边 的上下面。 植入物构造有助于将植入物的椎间孔插入围绕脊柱中线的对称位置，使得单个植入物为脊柱提供平衡的支撑。 植入物可以由组装成单个单元的多个互连体形成。 还公开了植入试剂盒和方法。

公开(公告)号：US20110160864A1

公开(公告)日：2011-06-30

申请号：US13042097

申请日：2011-03-07

申请人： Dominique Messerli ,  David Gerber ,  David Paul ,  Kenneth Isarrai Kobayashi

发明人： Dominique Messerli ,  David Gerber ,  David Paul ,  Kenneth Isarrai Kobayashi

IPC分类号： A61F2/44

CPC分类号： A61F2/446 ,  A61B17/1604 ,  A61B17/1659 ,  A61B17/1671 ,  A61F2/28 ,  A61F2/4465 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/2835 ,  A61F2002/3008 ,  A61F2002/30133 ,  A61F2002/30383 ,  A61F2002/30492 ,  A61F2002/30507 ,  A61F2002/30538 ,  A61F2002/30594 ,  A61F2002/30599 ,  A61F2002/30604 ,  A61F2002/30785 ,  A61F2002/30787 ,  A61F2002/30797 ,  A61F2002/30843 ,  A61F2002/30904 ,  A61F2002/30975 ,  A61F2002/4475 ,  A61F2002/4628 ,  A61F2220/0025 ,  A61F2230/0015 ,  A61F2250/0006 ,  A61F2250/0063 ,  A61F2250/0098 ,  A61F2310/00017 ,  A61F2310/00359

摘要： An intervertebral implant for fusing vertebrae is disclosed. The implant may have a body with curved, posterior and anterior faces separated by two narrow implant ends, superior and inferior faces having a plurality of undulating surfaces for contacting vertebral endplates, and at least one depression in the anterior or posterior face for engagement by an insertion tool. The implant may also have one or more vertical through-channels extending through the implant from the superior face to the inferior face, a chamfer on the superior and inferior surfaces at one of the narrow implant ends, and/or a beveled edge along a perimeter of the superior and inferior faces. The implant configuration facilitates transforaminal insertion of the implant into a symmetric position about the midline of the spine so that a single implant provides balanced support to the spinal column. The implant may be formed of a plurality of interconnecting bodies assembled to form a single unit. An implantation kit and method are also disclosed.

摘要翻译： 公开了一种用于融合椎骨的椎间植入物。 植入物可以具有由两个狭窄的植入物端部分开的弯曲的，后部和前部面的主体，上部和下部面具有多个用于接触椎骨终板的起伏表面，以及前部或后部的至少一个凹陷，用于通过 插入工具。 植入物还可以具有一个或多个垂直通道，从上表面到下表面延伸穿过植入物，在一个窄植入物端部处的上表面和下表面上的倒角，和/或沿着周边的斜边 的上下面。 植入物构造有助于将植入物的椎间孔插入围绕脊柱的中线的对称位置，使得单个植入物为脊柱提供平衡的支撑。 植入物可以由组装成单个单元的多个互连体形成。 还公开了植入试剂盒和方法。

公开(公告)号：US20100249809A1

公开(公告)日：2010-09-30

申请号：US12722134

申请日：2010-03-11

申请人： Wamis Singhatat ,  Jamie Manos ,  Brian Rick Delamarter ,  Dominique Messerli ,  Brian Schmidt ,  William Miller ,  James Talbot ,  Garland Fussell ,  Nigel G. Smith

发明人： Wamis Singhatat ,  Jamie Manos ,  Brian Rick Delamarter ,  Dominique Messerli ,  Brian Schmidt ,  William Miller ,  James Talbot ,  Garland Fussell ,  Nigel G. Smith

IPC分类号： A61B17/04

CPC分类号： A61B17/0485 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/0469 ,  A61B2017/0472 ,  A61B2017/0474 ,  A61B2017/0475 ,  A61B2017/0477 ,  A61B2017/06052

摘要： A soft tissue defect repair system for approximating defects, such as defects in the annulus fibrosus of an intervertebral disc, includes a cannulated rod through which is disposed a suture retrieval device. A strand of suture includes a locking or ratcheting knot pre-tied around the outside of the cannulated rod and a free end that is guided in and out of the soft tissue. A knot pusher fits around the cannulated rod, which is used to push the knot off of the cannulated rod after the stitching of the tissue is accomplished. The defect is approximated by tensioning the free end. Various suturing methods or patterns are disclosed for defect approximation.

摘要翻译： 用于近似缺陷的软组织缺损修复系统，例如椎间盘纤维环中的缺陷，包括插管杆，通过该插管杆设置缝合线取出装置。 一股缝合线包括预先束缚在插管杆的外侧的锁定或棘轮结，以及引导进出软组织的自由端。 一个结推动器围绕插管杆，用于在组织的缝合完成之后将结从推杆上推出。 通过张紧自由端近似缺陷。 公开了各种缝合方法或图案用于缺陷近似。

公开(公告)号：US20060241760A1

公开(公告)日：2006-10-26

申请号：US11114556

申请日：2005-04-26

申请人： Brandon Randall ,  Kenneth Kobayashi ,  Dominique Messerli

发明人： Brandon Randall ,  Kenneth Kobayashi ,  Dominique Messerli

IPC分类号： A61F2/44

CPC分类号： A61F2/447 ,  A61F2/4611 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30133 ,  A61F2002/30617 ,  A61F2002/3071 ,  A61F2002/30828 ,  A61F2002/30841 ,  A61F2002/30843 ,  A61F2002/4475 ,  A61F2002/4629 ,  A61F2210/0004 ,  A61F2230/0015 ,  A61F2250/0085 ,  A61F2250/0097 ,  A61F2250/0098 ,  A61F2310/00017 ,  A61F2310/00023

摘要： The present invention is directed to a spinal implant, preferably a bioresorbable spinal implant, for insertion between vertebrae bodies. The implant preferably includes an anterior surface, a posterior surface, first and second lateral surfaces extending therebetween, a superior surface for engaging one of the vertebrae bodies, an inferior surface for engaging the other vertebrae body, and a central bore which extends from the superior surface to the inferior surface. The central bore preferably has a generally lobe-shaped footprint. The anterior surface of the implant preferably includes a pair of vertical channels sized and configured to engage an insertion instrument and the superior surface preferably has a convexly curved surface extending substantially from the anterior surface to the posterior surface while the inferior surface preferably has a substantially constant taper extending from the anterior surface to the posterior surface.

摘要翻译： 本发明涉及用于在椎骨体之间插入的脊柱植入物，优选为生物可再吸收的脊柱植入物。 植入物优选地包括前表面，后表面，在其间延伸的第一和第二侧表面，用于接合椎骨体之一的上表面，用于接合另一个椎骨体的下表面和从上部延伸的中心孔 表面到下表面。 中心孔优选地具有通常为凸起的足迹。 植入物的前表面优选地包括一对垂直通道，其大小和构造成与插入器具接合，并且上表面优选地具有基本上从前表面延伸到后表面延伸的凸形曲面，而下表面优选具有基本上恒定的 锥形从前表面延伸到后表面。